Aliases for PRR15L Gene

Aliases for PRR15L Gene

  • Proline Rich 15 Like 2 3 5
  • ATPase Family, AAA Domain Containing 4 2 3
  • Proline-Rich Protein 15-Like Protein 3 4
  • ATAD4 3 4
  • Testicular Tissue Protein Li 157 3
  • Proline Rich 15-Like 2
  • Protein ATAD4 4
  • MGC11242 2
  • PRR15L 5

External Ids for PRR15L Gene

Previous HGNC Symbols for PRR15L Gene

  • ATAD4

Previous GeneCards Identifiers for PRR15L Gene

  • GC17M043386
  • GC17M046030
  • GC17M041398

Summaries for PRR15L Gene

GeneCards Summary for PRR15L Gene

PRR15L (Proline Rich 15 Like) is a Protein Coding gene. An important paralog of this gene is PRR15.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR15L Gene

Genomics for PRR15L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR15L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR15L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR15L

Genomic Locations for PRR15L Gene

Latest Assembly
5,939 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,917 bases
Minus strand

(GRCh37/hg19 by Ensembl)
5,912 bases
Minus strand

Genomic View for PRR15L Gene

Genes around PRR15L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR15L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR15L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR15L Gene

Proteins for PRR15L Gene

  • Protein details for PRR15L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 15-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DTU0

    Protein attributes for PRR15L Gene

    103 amino acids
    Molecular mass:
    11705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR15L Gene

Post-translational modifications for PRR15L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR15L Gene

No data available for DME Specific Peptides for PRR15L Gene

Domains & Families for PRR15L Gene

Gene Families for PRR15L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR15L Gene


Suggested Antigen Peptide Sequences for PRR15L Gene

GenScript: Design optimal peptide antigens:
  • Protein ATAD4 (PR15L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRR15 family.
  • Belongs to the PRR15 family.
genes like me logo Genes that share domains with PRR15L: view

Function for PRR15L Gene

Phenotypes From GWAS Catalog for PRR15L Gene

genes like me logo Genes that share phenotypes with PRR15L: view

Animal Models for PRR15L Gene

MGI Knock Outs for PRR15L:
  • Prr15l Prr15l<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR15L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRR15L Gene

Localization for PRR15L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR15L gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR15L Gene

Pathways & Interactions for PRR15L Gene

PathCards logo

SuperPathways for PRR15L Gene

No Data Available

Interacting Proteins for PRR15L Gene

Gene Ontology (GO) - Biological Process for PRR15L Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR15L Gene

Drugs & Compounds for PRR15L Gene

No Compound Related Data Available

Transcripts for PRR15L Gene

mRNA/cDNA for PRR15L Gene

7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR15L

Alternative Splicing Database (ASD) splice patterns (SP) for PRR15L Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for PRR15L Gene

GeneLoc Exon Structure for

Expression for PRR15L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR15L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR15L Gene

This gene is overexpressed in Colon - Transverse (x9.6), Pancreas (x9.2), Stomach (x6.5), Small Intestine - Terminal Ileum (x5.3), Minor Salivary Gland (x4.3), and Thyroid (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRR15L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR15L

SOURCE GeneReport for Unigene cluster for PRR15L Gene:


Evidence on tissue expression from TISSUES for PRR15L Gene

  • Intestine(2.4)
genes like me logo Genes that share expression patterns with PRR15L: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR15L Gene

Orthologs for PRR15L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR15L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRR15L 29 30
  • 100 (n)
(Mus musculus)
Mammalia Prr15l 29 16 30
  • 86.67 (n)
(Bos Taurus)
Mammalia PRR15L 29 30
  • 86.67 (n)
(Canis familiaris)
Mammalia PRR15L 29 30
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Prr15l 29
  • 84.91 (n)
(Monodelphis domestica)
Mammalia PRR15L 30
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia PRR15L 30
  • 62 (a)
(Gallus gallus)
Aves PRR15L 29 30
  • 70.29 (n)
(Anolis carolinensis)
Reptilia PRR15L 30
  • 62 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prr15l 29
  • 61.8 (n)
(Danio rerio)
Actinopterygii prr15la 29 30
  • 67.41 (n)
prr15lb 30
  • 50 (a)
Species where no ortholog for PRR15L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRR15L Gene

Gene Tree for PRR15L (if available)
Gene Tree for PRR15L (if available)
Evolutionary constrained regions (ECRs) for PRR15L: view image
Alliance of Genome Resources:
Additional Orthologs for PRR15L

Paralogs for PRR15L Gene

Paralogs for PRR15L Gene

genes like me logo Genes that share paralogs with PRR15L: view

Variants for PRR15L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRR15L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRR15L Gene

Variant ID Type Subtype PubMed ID
esv1000014 CNV deletion 20482838
nsv518892 CNV loss 19592680

Variation tolerance for PRR15L Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR15L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR15L Gene

Disorders for PRR15L Gene

Additional Disease Information for PRR15L

No disorders were found for PRR15L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR15L Gene

Publications for PRR15L Gene

  1. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
  2. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PMID: 22949513) EPICURE Consortium … Sander T (Human molecular genetics 2012) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for PRR15L Gene

Sources for PRR15L Gene