The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skelet... See more...

Aliases for PRR14 Gene

Aliases for PRR14 Gene

  • Proline Rich 14 2 3 5
  • Proline-Rich Protein 14 3 4
  • MGC3121 2
  • PRR14 5

External Ids for PRR14 Gene

Previous GeneCards Identifiers for PRR14 Gene

  • GC16P030570
  • GC16P030662
  • GC16P028225

Summaries for PRR14 Gene

Entrez Gene Summary for PRR14 Gene

  • The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for PRR14 Gene

PRR14 (Proline Rich 14) is a Protein Coding gene. An important paralog of this gene is PRR14L.

UniProtKB/Swiss-Prot Summary for PRR14 Gene

  • Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574).

Additional gene information for PRR14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR14 Gene

Genomics for PRR14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR14

Top Transcription factor binding sites by QIAGEN in the PRR14 gene promoter:
  • c-Myb
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-4a
  • Pax-5

Genomic Locations for PRR14 Gene

Genomic Locations for PRR14 Gene
chr16:30,650,717-30,656,440
(GRCh38/hg38)
Size:
5,724 bases
Orientation:
Plus strand
chr16:30,662,038-30,667,761
(GRCh37/hg19)
Size:
5,724 bases
Orientation:
Plus strand

Genomic View for PRR14 Gene

Genes around PRR14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR14 Gene

Proteins for PRR14 Gene

  • Protein details for PRR14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWN1-PRR14_HUMAN
    Recommended name:
    Proline-rich protein 14
    Protein Accession:
    Q9BWN1
    Secondary Accessions:
    • Q8WTX2

    Protein attributes for PRR14 Gene

    Size:
    585 amino acids
    Molecular mass:
    64328 Da
    Quaternary structure:
    • Interacts (via proline-rich region) with GRB2 (via SH3 domain 2) (PubMed:27041574). Interacts (via N-terminus) with CBX5 (PubMed:25906157).

neXtProt entry for PRR14 Gene

Post-translational modifications for PRR14 Gene

  • Ubiquitination at Lys256
  • Modification sites at PhosphoSitePlus

Other Protein References for PRR14 Gene

No data available for DME Specific Peptides for PRR14 Gene

Domains & Families for PRR14 Gene

Gene Families for PRR14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR14 Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich protein 14 (PRR14_HUMAN)
  • PRR14 protein (Q96D88_HUMAN)
genes like me logo Genes that share domains with PRR14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR14 Gene

Function for PRR14 Gene

Molecular function for PRR14 Gene

UniProtKB/Swiss-Prot Function:
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574).

Phenotypes From GWAS Catalog for PRR14 Gene

Gene Ontology (GO) - Molecular Function for PRR14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PRR14: view
genes like me logo Genes that share phenotypes with PRR14: view

Animal Model Products

CRISPR Products

miRNA for PRR14 Gene

miRTarBase miRNAs that target PRR14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR14 Gene

Localization for PRR14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR14 Gene

Chromosome. Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. {ECO:0000269 PubMed:24209742}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR14 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
mitochondrion 1
cytosol 1
plasma membrane 0
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRR14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005652 nuclear lamina IEA --
GO:0005654 nucleoplasm IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PRR14: view

Pathways & Interactions for PRR14 Gene

PathCards logo

SuperPathways for PRR14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with PRR14: view

No data available for Pathways by source and SIGNOR curated interactions for PRR14 Gene

Drugs & Compounds for PRR14 Gene

No Compound Related Data Available

Transcripts for PRR14 Gene

mRNA/cDNA for PRR14 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR14

Alternative Splicing Database (ASD) splice patterns (SP) for PRR14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for PRR14 Gene

GeneLoc Exon Structure for
PRR14

Expression for PRR14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR14 Gene

Protein differential expression in normal tissues from HIPED for PRR14 Gene

This gene is overexpressed in Monocytes (29.3), Lung (24.3), and Bone marrow mesenchymal stem cell (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRR14 Gene



Protein tissue co-expression partners for PRR14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR14

SOURCE GeneReport for Unigene cluster for PRR14 Gene:

Hs.293629

Evidence on tissue expression from TISSUES for PRR14 Gene

  • Eye(4.3)
  • Pancreas(4.2)
  • Liver(4.1)
  • Nervous system(3.9)
  • Skin(2.9)
genes like me logo Genes that share expression patterns with PRR14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR14 Gene

Orthologs for PRR14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRR14 30 31
  • 98.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRR14 30 31
  • 86.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRR14 30 31
  • 85.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prr14 30 17 31
  • 79.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prr14 30
  • 78.53 (n)
Oppossum
(Monodelphis domestica)
Mammalia PRR14 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRR14 31
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRR14 31
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii prr14 31
  • 11 (a)
OneToOne
wufi75a02 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2700 31
  • 23 (a)
OneToMany
Species where no ortholog for PRR14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRR14 Gene

ENSEMBL:
Gene Tree for PRR14 (if available)
TreeFam:
Gene Tree for PRR14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR14: view image

Paralogs for PRR14 Gene

Paralogs for PRR14 Gene

genes like me logo Genes that share paralogs with PRR14: view

Variants for PRR14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR14 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs3747481 - p.Pro359Leu

Additional dbSNP identifiers (rs#s) for PRR14 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR14 Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897

Variation tolerance for PRR14 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.63; 93.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR14 Gene

Human Gene Mutation Database (HGMD)
PRR14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR14 Gene

Disorders for PRR14 Gene

No disorders were found for PRR14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR14 Gene

Publications for PRR14 Gene

  1. The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit. (PMID: 24209742) Poleshko A … Katz RA (Cell reports 2013) 2 3 4
  2. PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis. (PMID: 27041574) Yang M … Yuan ZM (Oncogene 2016) 3 4
  3. A novel role of PRR14 in the regulation of skeletal myogenesis. (PMID: 25906157) Yang M … Yuan ZM (Cell death & disease 2015) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for PRR14 Gene

Sources for PRR14 Gene