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Aliases for PRR13 Gene

Aliases for PRR13 Gene

  • Proline Rich 13 2 3 5
  • Taxane-Resistance Protein 3 4
  • TXR1 3 4
  • Proline-Rich Protein 13 3

External Ids for PRR13 Gene

Previous GeneCards Identifiers for PRR13 Gene

  • GC12P052125
  • GC12P053835
  • GC12P050875

Summaries for PRR13 Gene

GeneCards Summary for PRR13 Gene

PRR13 (Proline Rich 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PRR13 Gene

  • Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

Additional gene information for PRR13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR13 Gene

Genomics for PRR13 Gene

GeneHancer (GH) Regulatory Elements for PRR13 Gene

Promoters and enhancers for PRR13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053440 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 676.6 +1.0 979 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PRR13 PCBP2 ENSG00000257379 SP1 AAAS
GH12J053378 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.7 -60.7 -60678 5.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 SP1 PIR43704 PRR13 AAAS HOXC8 HOXC9 ENSG00000258086 AMHR2 SP7 HOXC5
GH12J053498 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.3 +59.0 59001 5 CLOCK ZFP64 DMAP1 YY1 ZNF213 ZNF143 ZNF548 ZNF263 SP3 NFYC MAP3K12 ENSG00000270175 TARBP2 KRT1 ZNF740 HNRNPA1 ATF7 PCBP2 SP1 AAAS
GH12J053423 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 24.9 -16.5 -16522 2.6 HDAC1 HDGF ATF1 BMI1 GLIS2 GATA2 EGR1 SCRT2 CREM EGR2 AMHR2 PRR13 SP1 AAAS GC12P053422
GH12J053492 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 20.9 +51.8 51821 2.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 PRR13 AMHR2 AAAS ATF7 SP1 MAP3K12 ENSG00000273658
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRR13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR13 gene promoter:
  • GR-alpha
  • GR
  • HFH-1
  • GR-beta
  • NF-E2
  • LUN-1
  • MZF-1
  • NF-E2 p45
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PRR13 Gene

Genomic Locations for PRR13 Gene
chr12:53,441,605-53,446,645
(GRCh38/hg38)
Size:
5,041 bases
Orientation:
Plus strand
chr12:53,835,389-53,840,429
(GRCh37/hg19)
Size:
5,041 bases
Orientation:
Plus strand

Genomic View for PRR13 Gene

Genes around PRR13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR13 Gene

Proteins for PRR13 Gene

  • Protein details for PRR13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ81-PRR13_HUMAN
    Recommended name:
    Proline-rich protein 13
    Protein Accession:
    Q9NZ81
    Secondary Accessions:
    • Q0V8U0
    • Q6FIG7
    • Q6MZP8
    • Q6NXQ6
    • Q6PKF9

    Protein attributes for PRR13 Gene

    Size:
    148 amino acids
    Molecular mass:
    15385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR13 Gene

Post-translational modifications for PRR13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR13 Gene

Domains & Families for PRR13 Gene

Gene Families for PRR13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR13: view

No data available for UniProtKB/Swiss-Prot for PRR13 Gene

Function for PRR13 Gene

Molecular function for PRR13 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

Phenotypes From GWAS Catalog for PRR13 Gene

Gene Ontology (GO) - Molecular Function for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PRR13: view
genes like me logo Genes that share phenotypes with PRR13: view

Animal Model Products

CRISPR Products

miRNA for PRR13 Gene

miRTarBase miRNAs that target PRR13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR13 Gene

Localization for PRR13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR13 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PRR13: view

Pathways & Interactions for PRR13 Gene

SuperPathways for PRR13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRR13: view

No data available for Pathways by source and SIGNOR curated interactions for PRR13 Gene

Drugs & Compounds for PRR13 Gene

No Compound Related Data Available

Transcripts for PRR13 Gene

mRNA/cDNA for PRR13 Gene

Unigene Clusters for PRR13 Gene

Proline rich 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR13 Gene

No ASD Table

Relevant External Links for PRR13 Gene

GeneLoc Exon Structure for
PRR13
ECgene alternative splicing isoforms for
PRR13

Expression for PRR13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR13 Gene

This gene is overexpressed in Whole Blood (x9.0).

NURSA nuclear receptor signaling pathways regulating expression of PRR13 Gene:

PRR13

SOURCE GeneReport for Unigene cluster for PRR13 Gene:

Hs.744894

Evidence on tissue expression from TISSUES for PRR13 Gene

  • Nervous system(4.6)
  • Bone marrow(4.4)
  • Lung(2.8)
  • Stomach(2.7)
  • Pancreas(2.4)
  • Kidney(2.2)
  • Blood(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PRR13: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR13 Gene

Orthologs for PRR13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR13 34 33
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRR13 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRR13 34
  • 80 (a)
OneToOne
Species where no ortholog for PRR13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR13 Gene

ENSEMBL:
Gene Tree for PRR13 (if available)
TreeFam:
Gene Tree for PRR13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR13: view image

Paralogs for PRR13 Gene

genes like me logo Genes that share paralogs with PRR13: view

No data available for Paralogs for PRR13 Gene

Variants for PRR13 Gene

Sequence variations from dbSNP and Humsavar for PRR13 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000542752 -- 53,445,364(+) A/T intron_variant
rs1001094261 -- 53,444,317(+) A/G intron_variant
rs1001544409 -- 53,440,184(+) T/C upstream_transcript_variant
rs1001819118 -- 53,446,952(+) C/T downstream_transcript_variant
rs1002223040 -- 53,444,971(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR13 Gene

Variant ID Type Subtype PubMed ID
nsv975495 CNV duplication 23825009

Variation tolerance for PRR13 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR13 Gene

Disorders for PRR13 Gene

Additional Disease Information for PRR13

No disorders were found for PRR13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR13 Gene

Publications for PRR13 Gene

  1. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. (PMID: 16847352) Lih CJ … Cohen SN (Genes & development 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for PRR13 Gene

Sources for PRR13 Gene

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