Aliases for PRR11 Gene

Aliases for PRR11 Gene

  • Proline Rich 11 2 3 5
  • Proline-Rich Protein 11 3 4
  • Transcription Repressor Of MHCII 3
  • FLJ11029 2
  • PRR11 5

External Ids for PRR11 Gene

Previous GeneCards Identifiers for PRR11 Gene

  • GC17P054588
  • GC17P057233
  • GC17P052593

Summaries for PRR11 Gene

GeneCards Summary for PRR11 Gene

PRR11 (Proline Rich 11) is a Protein Coding gene. Diseases associated with PRR11 include Klatskin's Tumor and Chromosome 22Q11.2 Deletion Syndrome, Distal. An important paralog of this gene is JMY.

UniProtKB/Swiss-Prot Summary for PRR11 Gene

Additional gene information for PRR11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR11 Gene

Genomics for PRR11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR11

Top Transcription factor binding sites by QIAGEN in the PRR11 gene promoter:
  • ATF-2
  • CBF(2)
  • CRE-BP1
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • NF-Y
  • POU3F2

Genomic Locations for PRR11 Gene

Genomic Locations for PRR11 Gene
chr17:59,155,355-59,206,709
(GRCh38/hg38)
Size:
51,355 bases
Orientation:
Plus strand
chr17:57,232,860-57,284,070
(GRCh37/hg19)
Size:
51,211 bases
Orientation:
Plus strand

Genomic View for PRR11 Gene

Genes around PRR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR11 Gene

Proteins for PRR11 Gene

  • Protein details for PRR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HE9-PRR11_HUMAN
    Recommended name:
    Proline-rich protein 11
    Protein Accession:
    Q96HE9
    Secondary Accessions:
    • Q9NUZ7
    • Q9NXE9

    Protein attributes for PRR11 Gene

    Size:
    360 amino acids
    Molecular mass:
    40085 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91064.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for PRR11 Gene

Post-translational modifications for PRR11 Gene

  • Ubiquitinated (Probable). Rapidly degraded by the proteasome; degradation may involve FBXW7-specific phosphorylated phosphodegron motifs.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR11 Gene

Domains & Families for PRR11 Gene

Gene Families for PRR11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR11 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR11 Gene

GenScript: Design optimal peptide antigens:
  • Transcription repressor of MHCII (D2SNZ4_HUMAN)
  • Proline-rich protein 11 (PRR11_HUMAN)
genes like me logo Genes that share domains with PRR11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR11 Gene

Function for PRR11 Gene

Molecular function for PRR11 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Expression increases from G1 to G2/M phase.

Phenotypes From GWAS Catalog for PRR11 Gene

genes like me logo Genes that share phenotypes with PRR11: view

Animal Model Products

CRISPR Products

miRNA for PRR11 Gene

miRTarBase miRNAs that target PRR11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR11 Gene

Localization for PRR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR11 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 23246489
GO:0005737 cytoplasm IBA,IDA 23246489
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PRR11: view

Pathways & Interactions for PRR11 Gene

PathCards logo

SuperPathways for PRR11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IBA 21873635
GO:0051726 regulation of cell cycle IDA 23246489
genes like me logo Genes that share ontologies with PRR11: view

No data available for Pathways by source and SIGNOR curated interactions for PRR11 Gene

Drugs & Compounds for PRR11 Gene

No Compound Related Data Available

Transcripts for PRR11 Gene

mRNA/cDNA for PRR11 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR11

Alternative Splicing Database (ASD) splice patterns (SP) for PRR11 Gene

No ASD Table

Relevant External Links for PRR11 Gene

GeneLoc Exon Structure for
PRR11

Expression for PRR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRR11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR11

SOURCE GeneReport for Unigene cluster for PRR11 Gene:

Hs.631750

mRNA Expression by UniProt/SwissProt for PRR11 Gene:

Q96HE9-PRR11_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for PRR11 Gene

  • Eye(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PRR11: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR11 Gene

Orthologs for PRR11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRR11 30 31
  • 99.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRR11 30 31
  • 87.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRR11 30 31
  • 85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prr11 30
  • 81.2 (n)
Mouse
(Mus musculus)
Mammalia Prr11 30 17 31
  • 79.63 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRR11 31
  • 55 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRR11 31
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRR11 30 31
  • 60.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRR11 31
  • 33 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prr11 30
  • 52.58 (n)
Zebrafish
(Danio rerio)
Actinopterygii prr11 31
  • 31 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToOne
Species where no ortholog for PRR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRR11 Gene

ENSEMBL:
Gene Tree for PRR11 (if available)
TreeFam:
Gene Tree for PRR11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR11: view image

Paralogs for PRR11 Gene

Paralogs for PRR11 Gene

Pseudogenes.org Pseudogenes for PRR11 Gene

genes like me logo Genes that share paralogs with PRR11: view

Variants for PRR11 Gene

Additional dbSNP identifiers (rs#s) for PRR11 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR11 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
dgv38n82 CNV duplication 23825009
esv25721 CNV gain 19812545
esv2662575 CNV deletion 23128226
esv2667720 CNV deletion 23128226
esv2716081 CNV deletion 23290073
esv2758699 CNV gain 17122850
esv28194 CNV loss 19812545
esv3573764 CNV gain 25503493
esv3640902 CNV loss 21293372
nsv1057152 CNV gain 25217958
nsv1062736 CNV gain 25217958
nsv1065063 CNV gain 25217958
nsv1065442 CNV gain 25217958
nsv1109092 CNV deletion 24896259
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Variation tolerance for PRR11 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR11 Gene

Disorders for PRR11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRR11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
klatskin's tumor
  • hilar cholangiocarcinoma
chromosome 22q11.2 deletion syndrome, distal
  • distal chromosome 22q11.2 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRR11 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PRR11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR11 Gene

Publications for PRR11 Gene

  1. PRR11 is a novel gene implicated in cell cycle progression and lung cancer. (PMID: 23246489) Ji Y … Bu Y (The international journal of biochemistry & cell biology 2013) 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. (PMID: 11799066) Weinmann AS … Farnham PJ (Genes & development 2002) 2 3

Products for PRR11 Gene

  • Signalway Proteins for PRR11

Sources for PRR11 Gene