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PRPSAP1 (Phosphoribosyl Pyrophosphate Synthetase Associated Protein 1) is a Protein Coding gene. Diseases associated with PRPSAP1 include Hepatocellular Carcinoma and Bardet-Biedl Syndrome 7. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and enzyme inhibitor activity. An important paralog of this gene is PRPSAP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IEA | -- |
GO:0004749 | ribose phosphate diphosphokinase activity | IEA,IBA | 21873635 |
GO:0004857 | enzyme inhibitor activity | TAS | 8132556 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0042802 | identical protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002189 | ribose phosphate diphosphokinase complex | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process | IBA | 21873635 |
GO:0006139 | nucleobase-containing compound metabolic process | TAS | 8611620 |
GO:0006164 | purine nucleotide biosynthetic process | IBA | 21873635 |
GO:0009116 | nucleoside metabolic process | IEA | -- |
GO:0009165 | nucleotide biosynthetic process | IEA,IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | PRPSAP1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | PRPSAP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PRPSAP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRPSAP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRPSAP1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Prpsap1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prpsap1 30 |
|
||
Chicken (Gallus gallus) |
Aves | PRPSAP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRPSAP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prpsap1 30 |
|
||
MGC75778 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | PRPSAP1 31 |
|
OneToOne | |
prpsap1 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11236 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG2246 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | W04G3.5 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRS3 31 |
|
ManyToMany | |
PRS4 31 |
|
ManyToMany | |||
PRS2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24990 | CNV | loss | 19812545 |
esv2668273 | CNV | deletion | 23128226 |
esv3641284 | CNV | loss | 21293372 |
esv3641285 | CNV | loss | 21293372 |
esv3893045 | CNV | loss | 25118596 |
nsv476936 | CNV | novel sequence insertion | 20440878 |
nsv518967 | CNV | loss | 19592680 |
nsv527075 | CNV | gain | 19592680 |
nsv833547 | CNV | loss | 17160897 |
nsv962367 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|
bardet-biedl syndrome 7 |
|
|
deafness, x-linked 1 |
|
|
charcot-marie-tooth disease, x-linked recessive, 5 |
|
|
arts syndrome |
|
|