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Aliases for PRPS2 Gene

Aliases for PRPS2 Gene

  • Phosphoribosyl Pyrophosphate Synthetase 2 2 3 5
  • Phosphoribosyl Pyrophosphate Synthase II 3 4
  • Ribose-Phosphate Diphosphokinase 2 2 3
  • PRS-II 3 4
  • Ribose-Phosphate Pyrophosphokinase 2 3
  • Testicular Secretory Protein Li 41 3
  • PPRibP Synthetase 3
  • EC 2.7.6.1 4
  • PPRibP 4
  • PRS II 2
  • PRSII 3

External Ids for PRPS2 Gene

Previous GeneCards Identifiers for PRPS2 Gene

  • GC0XP012002
  • GC0XP011575
  • GC0XP012105
  • GC0XP012170
  • GC0XP012569
  • GC0XP010576

Summaries for PRPS2 Gene

Entrez Gene Summary for PRPS2 Gene

  • This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRPS2 Gene

PRPS2 (Phosphoribosyl Pyrophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is PRPS1.

UniProtKB/Swiss-Prot for PRPS2 Gene

  • Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Additional gene information for PRPS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPS2 Gene

Genomics for PRPS2 Gene

GeneHancer (GH) Regulatory Elements for PRPS2 Gene

Promoters and enhancers for PRPS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ012790 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 657.6 +0.4 437 2 HDGF SIN3A POLR2B GLIS2 RUNX3 ZNF263 SP3 SP5 MAFF ZNF610 PRPS2 OFD1 TLR8 TLR8-AS1 PSMA6P2
GH0XJ012969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 +187.4 187384 17.7 HDGF PKNOX1 SMAD1 ARNT SIN3A IRF4 YY1 POLR2B ZNF207 FOS TMSB4X FAM9C TLR8-AS1 PRPS2 TLR7 TLR8 LOC105373133
GH0XJ012779 Enhancer 0.5 ENCODE 5.4 -11.6 -11617 1.2 SP1 HNF1A CREB1 ATF7 ATF2 YY1 PRPS2 RN7SKP290
GH0XJ012992 Enhancer 0.2 dbSUPER 5 +201.4 201445 1.3 FAM9C TLR8-AS1 TLR8 PRPS2 TMSB4X LOC105373133
GH0XJ012771 Enhancer 0.7 ENCODE 0.4 -19.7 -19718 0.2 ZNF768 CTCF RB1 PYGO2 ZIC2 ZNF2 RAD21 ZFHX2 BRD9 EGR1 PRPS2 RN7SKP290
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRPS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRPS2 gene promoter:
  • RP58
  • FOXO1a
  • FOXO1
  • Arnt
  • AhR
  • MZF-1
  • MIF-1
  • Lhx3a
  • LHX3b
  • STAT1beta

Genomic Locations for PRPS2 Gene

Genomic Locations for PRPS2 Gene
chrX:12,791,355-12,824,227
(GRCh38/hg38)
Size:
32,873 bases
Orientation:
Plus strand
chrX:12,809,474-12,842,346
(GRCh37/hg19)
Size:
32,873 bases
Orientation:
Plus strand

Genomic View for PRPS2 Gene

Genes around PRPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPS2 Gene

Proteins for PRPS2 Gene

  • Protein details for PRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11908-PRPS2_HUMAN
    Recommended name:
    Ribose-phosphate pyrophosphokinase 2
    Protein Accession:
    P11908
    Secondary Accessions:
    • Q0VDH9
    • Q0VDI0
    • Q15245
    • Q2TAK7

    Protein attributes for PRPS2 Gene

    Size:
    318 amino acids
    Molecular mass:
    34769 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
    SequenceCaution:
    • Sequence=AAH30019.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPS2 Gene

Post-translational modifications for PRPS2 Gene

  • Ubiquitination at posLast=235235 and posLast=3434
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPS2 Gene

No data available for DME Specific Peptides for PRPS2 Gene

Domains & Families for PRPS2 Gene

Gene Families for PRPS2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11908

UniProtKB/Swiss-Prot:

PRPS2_HUMAN :
  • Belongs to the ribose-phosphate pyrophosphokinase family.
Family:
  • Belongs to the ribose-phosphate pyrophosphokinase family.
genes like me logo Genes that share domains with PRPS2: view

Function for PRPS2 Gene

Molecular function for PRPS2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP.
GENATLAS Biochemistry:
phosphoribosyl pyrophosphate synthetase 2

Enzyme Numbers (IUBMB) for PRPS2 Gene

Phenotypes From GWAS Catalog for PRPS2 Gene

Gene Ontology (GO) - Molecular Function for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004749 ribose phosphate diphosphokinase activity IEA,ISS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
GO:0016208 AMP binding IEA --
genes like me logo Genes that share ontologies with PRPS2: view
genes like me logo Genes that share phenotypes with PRPS2: view

Animal Models for PRPS2 Gene

MGI Knock Outs for PRPS2:
  • Prps2 Prps2<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRPS2

miRNA for PRPS2 Gene

miRTarBase miRNAs that target PRPS2

Clone Products

  • Addgene plasmids for PRPS2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRPS2 Gene

Localization for PRPS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRPS2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002189 ribose phosphate diphosphokinase complex IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with PRPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRPS2 Gene

Pathways & Interactions for PRPS2 Gene

genes like me logo Genes that share pathways with PRPS2: view

Pathways by source for PRPS2 Gene

UniProtKB/Swiss-Prot P11908-PRPS2_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Gene Ontology (GO) - Biological Process for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 2538352
GO:0006167 AMP biosynthetic process IEA --
GO:0009116 nucleoside metabolic process IEA --
GO:0009156 ribonucleoside monophosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with PRPS2: view

No data available for SIGNOR curated interactions for PRPS2 Gene

Drugs & Compounds for PRPS2 Gene

(4) Drugs for PRPS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(6) Additional Compounds for PRPS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Ribose 5-phosphate
  • D-Ribose 5'-phosphate
  • D-Ribose-5-P
  • Ribose 5-phosphate
  • D-Ribose 5'-phosphoric acid
  • D-Ribose 5-phosphoric acid
3615-55-2
D-Ribulose 5-phosphate
  • D-erythro-Pent-2-ulose 5-(dihydrogen phosphate)
  • D-erythro-Pent-2-ulose 5-(dihydrogen phosphoric acid)
  • D-Ribulose 5-phosphoric acid
4151-19-3
Phosphoribosyl pyrophosphate
  • 5-phospho-alpha-D-Ribose 1-diphosphate
  • 5-Phosphoribosyl 1-pyrophosphate
  • 5-Phosphoribosyl diphosphate
  • alpha-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
  • ALPHA-PHOSPHORIBOSYLPYROphosphORIC ACID
7540-64-9
Phosphoribosyl-ATP
  • 1-(5-phospho-D-Ribofuranosyl)adenosine 5'-(tetrahydrogen triphosphate)
  • 1-(5-phospho-D-Ribosyl)-ATP
  • 1-(5-Phosphoribosyl)-ATP
  • N1-(5-phospho-D-Ribosyl)-ATP
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with PRPS2: view

Transcripts for PRPS2 Gene

mRNA/cDNA for PRPS2 Gene

Unigene Clusters for PRPS2 Gene

Phosphoribosyl pyrophosphate synthetase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRPS2

Alternative Splicing Database (ASD) splice patterns (SP) for PRPS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for PRPS2 Gene

GeneLoc Exon Structure for
PRPS2
ECgene alternative splicing isoforms for
PRPS2

Expression for PRPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRPS2 Gene

This gene is overexpressed in Ovary (x8.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PRPS2 Gene

This gene is overexpressed in Testis (28.9), Lymph node (8.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRPS2 Gene



Protein tissue co-expression partners for PRPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRPS2 Gene:

PRPS2

SOURCE GeneReport for Unigene cluster for PRPS2 Gene:

Hs.654581

Evidence on tissue expression from TISSUES for PRPS2 Gene

  • Blood(4.3)
  • Nervous system(2.6)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with PRPS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRPS2 Gene

Orthologs for PRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPS2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPS2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRPS2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPS2 34 33
  • 90.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRPS2 34 33
  • 89.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prps2 16 34 33
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Prps2 33
  • 88.47 (n)
chicken
(Gallus gallus)
Aves PRPS2 34 33
  • 84.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPS2 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prps2 33
  • 80.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6767 34 35
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R151.2c 35
  • 80 (a)
R151.2b 35
  • 80 (a)
R151.2a 35
  • 80 (a)
R151.2 34 33
  • 68.97 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRS2 34
  • 62 (a)
ManyToMany
PRS4 34
  • 61 (a)
ManyToMany
PRS3 36 34 33
  • 57.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25718g 33
  • 59.68 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL080C 33
  • 59.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2559 34
  • 85 (a)
OneToMany
Species where no ortholog for PRPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRPS2 Gene

ENSEMBL:
Gene Tree for PRPS2 (if available)
TreeFam:
Gene Tree for PRPS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRPS2: view image

Paralogs for PRPS2 Gene

Paralogs for PRPS2 Gene

(4) SIMAP similar genes for PRPS2 Gene using alignment to 4 proteins:

  • PRPS2_HUMAN
  • A6NMS2_HUMAN
  • D3YTJ7_HUMAN
  • H7C540_HUMAN
genes like me logo Genes that share paralogs with PRPS2: view

Variants for PRPS2 Gene

Sequence variations from dbSNP and Humsavar for PRPS2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000033968 -- 12,800,638(+) A/G intron_variant
rs1000074318 -- 12,810,696(+) G/A intron_variant
rs1000121268 -- 12,794,162(+) C/T intron_variant
rs1000140580 -- 12,800,820(+) C/G intron_variant
rs1000367946 -- 12,805,186(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRPS2 Gene

Variant ID Type Subtype PubMed ID
esv3573585 CNV loss 25503493
nsv520250 CNV gain 19592680

Variation tolerance for PRPS2 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRPS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPS2 Gene

Disorders for PRPS2 Gene

Additional Disease Information for PRPS2

No disorders were found for PRPS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRPS2 Gene

Publications for PRPS2 Gene

  1. Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms. (PMID: 1314091) Ishizuka T … Tatibana M (Biochimica et biophysica acta 1992) 3 4 22 58
  2. Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. (PMID: 1962753) Becker MA … Roessler BJ (Genomics 1990) 2 3 22 58
  3. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. (PMID: 18677108) Mannava S … Nikiforov MA (Cell cycle (Georgetown, Tex.) 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Molecular cloning and sequencing of human cDNA for phosphoribosyl pyrophosphate synthetase subunit II. (PMID: 2538352) Iizasa T … Tatibana M (FEBS letters 1989) 3 4 58

Products for PRPS2 Gene

  • Addgene plasmids for PRPS2

Sources for PRPS2 Gene

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