This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009] See more...

Aliases for PRPF31 Gene

Aliases for PRPF31 Gene

  • Pre-MRNA Processing Factor 31 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-99 3 4
  • U4/U6 Small Nuclear Ribonucleoprotein Prp31 3 4
  • U4/U6 SnRNP 61 KDa Protein 3 4
  • Protein 61K 3 4
  • HPrp31 3 4
  • PRP31 3 4
  • PRP31 Pre-MRNA Processing Factor 31 Homolog (S. Cerevisiae) 2
  • PRP31 Pre-MRNA Processing Factor 31 Homolog (Yeast) 2
  • PRP31 Pre-MRNA Processing Factor 31 Homolog 3
  • Pre-MRNA-Processing Factor 31 4
  • NY-BR-99 3
  • SNRNP61 3
  • RP11 3

External Ids for PRPF31 Gene

Previous HGNC Symbols for PRPF31 Gene

  • RP11

Previous GeneCards Identifiers for PRPF31 Gene

  • GC19P055264
  • GC19P055043
  • GC19P059294
  • GC19P059310
  • GC19P054618
  • GC19P050934
  • GC19P054116

Summaries for PRPF31 Gene

Entrez Gene Summary for PRPF31 Gene

  • This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]

GeneCards Summary for PRPF31 Gene

PRPF31 (Pre-MRNA Processing Factor 31) is a Protein Coding gene. Diseases associated with PRPF31 include Retinitis Pigmentosa 11 and Retinitis Pigmentosa. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include snRNP binding.

UniProtKB/Swiss-Prot Summary for PRPF31 Gene

  • Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).

Gene Wiki entry for PRPF31 Gene

Additional gene information for PRPF31 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRPF31 Gene

Genomics for PRPF31 Gene

GeneHancer (GH) Regulatory Elements for PRPF31 Gene

Promoters and enhancers for PRPF31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRPF31 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRPF31

Top Transcription factor binding sites by QIAGEN in the PRPF31 gene promoter:
  • AML1a
  • AREB6
  • c-Ets-1
  • COMP1
  • Pax-2
  • Pax-2a
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for PRPF31 Gene

Genomic Locations for PRPF31 Gene
chr19:54,115,376-54,131,719
(GRCh38/hg38)
Size:
16,344 bases
Orientation:
Plus strand
chr19:54,618,790-54,635,150
(GRCh37/hg19)
Size:
16,361 bases
Orientation:
Plus strand

Genomic View for PRPF31 Gene

Genes around PRPF31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRPF31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRPF31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF31 Gene

Proteins for PRPF31 Gene

  • Protein details for PRPF31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWY3-PRP31_HUMAN
    Recommended name:
    U4/U6 small nuclear ribonucleoprotein Prp31
    Protein Accession:
    Q8WWY3
    Secondary Accessions:
    • E7ESA8
    • F1T0A4
    • F1T0A5
    • Q17RB4
    • Q8N7F9
    • Q9H271
    • Q9Y439

    Protein attributes for PRPF31 Gene

    Size:
    499 amino acids
    Molecular mass:
    55456 Da
    Quaternary structure:
    • Identified in the spliceosome B complex (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:11867543, PubMed:16723661, PubMed:26912367). Interacts with a complex formed by SNU13 and U4 snRNA, but not with SNU13 or U4 snRNA alone (PubMed:17412961, PubMed:21784869). The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes (PubMed:21784869). Interacts with PRPF6/U5 snRNP-associated 102 kDa protein (PubMed:11867543, PubMed:17412961, PubMed:26912367). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Interacts (via its NLS) with CTNNBL1 (PubMed:21385873).

    Three dimensional structures from OCA and Proteopedia for PRPF31 Gene

    Alternative splice isoforms for PRPF31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPF31 Gene

Post-translational modifications for PRPF31 Gene

  • Ubiquitination at Lys417, Lys430, and Lys478
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPF31 Gene

Antibody Products

  • Abcam antibodies for PRPF31
  • Boster Bio Antibodies for PRPF31

No data available for DME Specific Peptides for PRPF31 Gene

Domains & Families for PRPF31 Gene

Gene Families for PRPF31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for PRPF31 Gene

Blocks:
  • Pre-mRNA processing ribonucleoprotein, binding region
  • NOSIC
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRPF31 Gene

GenScript: Design optimal peptide antigens:
  • U4/U6 small nuclear ribonucleoprotein Prp31 (F1T0A4_HUMAN)
  • U4/U6 small nuclear ribonucleoprotein Prp31 (F1T0A5_HUMAN)
  • U4/U6 snRNP 61 kDa protein (PRP31_HUMAN)
  • Pre-mRNA splicing factor protein (Q2EFY2_HUMAN)
  • Truncated pre-mRNA splicing factor protein (Q2EKB9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWY3

UniProtKB/Swiss-Prot:

PRP31_HUMAN :
  • Interacts with the snRNP via the Nop domain.
  • Belongs to the PRP31 family.
Domain:
  • Interacts with the snRNP via the Nop domain.
  • The coiled coil domain is formed by two non-contiguous helices.
Family:
  • Belongs to the PRP31 family.
genes like me logo Genes that share domains with PRPF31: view

Function for PRPF31 Gene

Molecular function for PRPF31 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).

Phenotypes From GWAS Catalog for PRPF31 Gene

Gene Ontology (GO) - Molecular Function for PRPF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 21385873
GO:0030621 U4 snRNA binding IDA 16857676
GO:0030622 U4atac snRNA binding IDA 16857676
GO:0043021 ribonucleoprotein complex binding IDA 11867543
genes like me logo Genes that share ontologies with PRPF31: view
genes like me logo Genes that share phenotypes with PRPF31: view

Human Phenotype Ontology for PRPF31 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRPF31 Gene

MGI Knock Outs for PRPF31:

Animal Model Products

CRISPR Products

miRNA for PRPF31 Gene

miRTarBase miRNAs that target PRPF31

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRPF31

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PRPF31 Gene

Localization for PRPF31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF31 Gene

Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies. {ECO:0000269 PubMed:11867543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRPF31 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRPF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 26912367
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005684 U2-type spliceosomal complex IC 17412961
GO:0005687 U4 snRNP IDA 17412961
genes like me logo Genes that share ontologies with PRPF31: view

Pathways & Interactions for PRPF31 Gene

genes like me logo Genes that share pathways with PRPF31: view

Pathways by source for PRPF31 Gene

Gene Ontology (GO) - Biological Process for PRPF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly IMP 15257298
GO:0000398 mRNA splicing, via spliceosome TAS,IC --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0048254 NOT snoRNA localization IMP 17636026
genes like me logo Genes that share ontologies with PRPF31: view

No data available for SIGNOR curated interactions for PRPF31 Gene

Drugs & Compounds for PRPF31 Gene

(1) Drugs for PRPF31 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 2154
genes like me logo Genes that share compounds with PRPF31: view

Transcripts for PRPF31 Gene

mRNA/cDNA for PRPF31 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRPF31

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for PRPF31 Gene

GeneLoc Exon Structure for
PRPF31

Expression for PRPF31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRPF31 Gene

Protein differential expression in normal tissues from HIPED for PRPF31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3) and Blymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRPF31 Gene



Protein tissue co-expression partners for PRPF31 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRPF31

SOURCE GeneReport for Unigene cluster for PRPF31 Gene:

Hs.515598

mRNA Expression by UniProt/SwissProt for PRPF31 Gene:

Q8WWY3-PRP31_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for PRPF31 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Liver(4.3)
  • Eye(3.6)
  • Lung(3.3)
  • Intestine(2.4)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRPF31 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • middle ear
  • nose
  • outer ear
  • skull
Pelvis:
  • penis
  • testicle
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with PRPF31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRPF31 Gene

Orthologs for PRPF31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPF31 31 30
  • 99.27 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPF31 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRPF31 31 30
  • 92.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRPF31 31 30
  • 91.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prpf31 17 31 30
  • 89.58 (n)
rat
(Rattus norvegicus)
Mammalia Prpf31 30
  • 88.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRPF31 31
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPF31 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prpf31 30
  • 75.16 (n)
Str.2964 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5894 30
zebrafish
(Danio rerio)
Actinopterygii prpf31 31 30
  • 75.67 (n)
OneToOne
zgc66177 30
fruit fly
(Drosophila melanogaster)
Insecta Prp31 31 30
  • 65.03 (n)
OneToOne
CG6876 32
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012142 30
  • 53.9 (n)
worm
(Caenorhabditis elegans)
Secernentea prp-31 31 30
  • 50.33 (n)
OneToOne
Y110A7A.8 32
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP31 33 31
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1220 30
  • 50.84 (n)
rice
(Oryza sativa)
Liliopsida Os04g0555400 30
  • 51.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9354 31
  • 59 (a)
OneToOne
Cin.2747 30
bread mold
(Neurospora crassa)
Ascomycetes NCU02716 30
  • 50.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp31 30
  • 45.86 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2747 30
Species where no ortholog for PRPF31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRPF31 Gene

ENSEMBL:
Gene Tree for PRPF31 (if available)
TreeFam:
Gene Tree for PRPF31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRPF31: view image

Paralogs for PRPF31 Gene

(1) SIMAP similar genes for PRPF31 Gene using alignment to 10 proteins:

  • PRP31_HUMAN
  • E7EN72_HUMAN
  • E7ESA8_HUMAN
  • E7ESX0_HUMAN
  • E7EU94_HUMAN
  • E7EVX8_HUMAN
  • F1T0A4_HUMAN
  • F1T0A5_HUMAN
  • Q2EFY2_HUMAN
  • Q2EKB9_HUMAN
genes like me logo Genes that share paralogs with PRPF31: view

No data available for Paralogs for PRPF31 Gene

Variants for PRPF31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRPF31 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
4364 Pathogenic: Retinitis pigmentosa 11 54,124,569(+) C/CA FRAMESHIFT_VARIANT
4365 Pathogenic: Retinitis pigmentosa 11 54,122,499(+) ATCATCCATAAGT/A INFRAME_DELETION
636065 Likely Pathogenic: Retinitis pigmentosa 54,129,097(+) T/TG FRAMESHIFT_VARIANT
636066 Likely Pathogenic: Retinitis pigmentosa 54,129,142(+) AG/A NONSENSE
636067 Likely Pathogenic: Retinitis pigmentosa 54,123,452(+) A/G SPLICE_ACCEPTOR_VARIANT

Additional dbSNP identifiers (rs#s) for PRPF31 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRPF31 Gene

Variant ID Type Subtype PubMed ID
esv1131677 CNV deletion 17803354
esv2718812 CNV deletion 23290073
nsv2543 CNV insertion 18451855
nsv2545 CNV insertion 18451855
nsv470157 CNV loss 18288195
nsv510773 CNV deletion 20534489
nsv515623 CNV loss 19592680
nsv833877 CNV loss 17160897
nsv953613 CNV deletion 24416366

Variation tolerance for PRPF31 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRPF31 Gene

Human Gene Mutation Database (HGMD)
PRPF31
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRPF31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPF31 Gene

Disorders for PRPF31 Gene

MalaCards: The human disease database

(25) MalaCards diseases for PRPF31 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
retinitis pigmentosa
  • retinitis pigmentosa 1
fundus dystrophy
  • retinal dystrophy
inherited retinal disorder
  • retinal dystrophy
retinitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PRP31_HUMAN
  • Retinitis pigmentosa 11 (RP11) [MIM:600138]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:11545739, ECO:0000269 PubMed:12444105, ECO:0000269 PubMed:12923864, ECO:0000269 PubMed:17412961, ECO:0000269 PubMed:8808602}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRPF31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRPF31: view

No data available for Genatlas for PRPF31 Gene

Publications for PRPF31 Gene

  1. A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). (PMID: 11545739) Vithana EN … Bhattacharya SS (Molecular cell 2001) 2 3 4 23 54
  2. Retinitis pigmentosa: mutation analysis of RHO, PRPF31, RP1, and IMPDH1 genes in patients from India. (PMID: 18552984) Gandra M … Govindasamy K (Molecular vision 2008) 3 23 41 54
  3. Mutations in the gene coding for the pre-mRNA splicing factor, PRPF31, in patients with autosomal dominant retinitis pigmentosa. (PMID: 17325180) Waseem NH … Bhattacharya SS (Investigative ophthalmology & visual science 2007) 3 23 41 54
  4. Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing. (PMID: 11867543) Makarova OV … Lührmann R (The EMBO journal 2002) 3 4 23 54
  5. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4 54

Products for PRPF31 Gene

Sources for PRPF31 Gene