Aliases for PROZ Gene
External Ids for PROZ Gene
Previous GeneCards Identifiers for PROZ Gene
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for PROZ Gene
PROZ (Protein Z, Vitamin K Dependent Plasma Glycoprotein) is a Protein Coding gene. Diseases associated with PROZ include Protein Z Deficiency and Cerebral Sinovenous Thrombosis. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is PROC.
UniProtKB/Swiss-Prot Summary for PROZ Gene
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.