Aliases for PROX2 Gene

Aliases for PROX2 Gene

  • Prospero Homeobox 2 2 3 5
  • Homeobox Prospero-Like Protein PROX2 3 4
  • Prospero Homeobox Protein 2 3 4
  • PROX-2 3 4

External Ids for PROX2 Gene

Previous GeneCards Identifiers for PROX2 Gene

  • GC14M074391
  • GC14M075320
  • GC14M055489

Summaries for PROX2 Gene

GeneCards Summary for PROX2 Gene

PROX2 (Prospero Homeobox 2) is a Protein Coding gene. An important paralog of this gene is PROX1.

UniProtKB/Swiss-Prot Summary for PROX2 Gene

  • Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).

Additional gene information for PROX2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PROX2 Gene

Genomics for PROX2 Gene

GeneHancer (GH) Regulatory Elements for PROX2 Gene

Promoters and enhancers for PROX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PROX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PROX2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ER-alpha
  • Nkx2-5
  • Sp1

Genomic Locations for PROX2 Gene

Genomic Locations for PROX2 Gene
chr14:74,852,806-74,876,419
(GRCh38/hg38)
Size:
23,614 bases
Orientation:
Minus strand
chr14:75,319,736-75,330,537
(GRCh37/hg19)
Size:
10,802 bases
Orientation:
Minus strand

Genomic View for PROX2 Gene

Genes around PROX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROX2 Gene

Proteins for PROX2 Gene

  • Protein details for PROX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B8N5-PROX2_HUMAN
    Recommended name:
    Prospero homeobox protein 2
    Protein Accession:
    Q3B8N5
    Secondary Accessions:
    • C9J5W1
    • Q8N9Q3

    Protein attributes for PROX2 Gene

    Size:
    592 amino acids
    Molecular mass:
    65586 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PROX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROX2 Gene

Post-translational modifications for PROX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROX2 Gene

No data available for DME Specific Peptides for PROX2 Gene

Domains & Families for PROX2 Gene

Gene Families for PROX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for PROX2 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox prospero-like protein PROX2 (PROX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3B8N5

UniProtKB/Swiss-Prot:

PROX2_HUMAN :
  • The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Domain:
  • The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
  • Belongs to the Prospero homeodomain family.
genes like me logo Genes that share domains with PROX2: view

Function for PROX2 Gene

Molecular function for PROX2 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).

Phenotypes From GWAS Catalog for PROX2 Gene

Gene Ontology (GO) - Molecular Function for PROX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with PROX2: view
genes like me logo Genes that share phenotypes with PROX2: view

Animal Models for PROX2 Gene

MGI Knock Outs for PROX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PROX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROX2 Gene

Localization for PROX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROX2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PROX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with PROX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PROX2 Gene

Pathways & Interactions for PROX2 Gene

PathCards logo

SuperPathways for PROX2 Gene

No Data Available

Interacting Proteins for PROX2 Gene

Gene Ontology (GO) - Biological Process for PROX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001946 lymphangiogenesis IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0060836 lymphatic endothelial cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with PROX2: view

No data available for Pathways by source and SIGNOR curated interactions for PROX2 Gene

Drugs & Compounds for PROX2 Gene

No Compound Related Data Available

Transcripts for PROX2 Gene

mRNA/cDNA for PROX2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PROX2

Alternative Splicing Database (ASD) splice patterns (SP) for PROX2 Gene

No ASD Table

Relevant External Links for PROX2 Gene

GeneLoc Exon Structure for
PROX2
ECgene alternative splicing isoforms for
PROX2

Expression for PROX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PROX2 Gene:

PROX2

SOURCE GeneReport for Unigene cluster for PROX2 Gene:

Hs.675293
genes like me logo Genes that share expression patterns with PROX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROX2 Gene

Orthologs for PROX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROX2 33 32
  • 98.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PROX2 33 32
  • 83.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PROX2 33 32
  • 79.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prox2 32
  • 77.01 (n)
mouse
(Mus musculus)
Mammalia Prox2 17 33 32
  • 76.14 (n)
oppossum
(Monodelphis domestica)
Mammalia PROX2 33
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROX2 33
  • 29 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROX2 33 32
  • 56.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROX2 33
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prox2 33
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pros 33
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pros-1 33
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 21 (a)
OneToMany
Species where no ortholog for PROX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PROX2 Gene

ENSEMBL:
Gene Tree for PROX2 (if available)
TreeFam:
Gene Tree for PROX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PROX2: view image

Paralogs for PROX2 Gene

Paralogs for PROX2 Gene

(1) SIMAP similar genes for PROX2 Gene using alignment to 2 proteins:

  • PROX2_HUMAN
  • G3V3G0_HUMAN
genes like me logo Genes that share paralogs with PROX2: view

Variants for PROX2 Gene

Sequence variations from dbSNP and Humsavar for PROX2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000042726 -- 74,858,335(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000114281 -- 74,868,745(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000174504 -- 74,871,341(-) AAAAAA/AAA/AAAAAAA genic_upstream_transcript_variant, intron_variant
rs1000215899 -- 74,865,172(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000232943 -- 74,864,301(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PROX2 Gene

Variant ID Type Subtype PubMed ID
nsv1355 CNV deletion 18451855
nsv832832 CNV gain+loss 17160897

Variation tolerance for PROX2 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROX2 Gene

Human Gene Mutation Database (HGMD)
PROX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROX2 Gene

Disorders for PROX2 Gene

Additional Disease Information for PROX2

No disorders were found for PROX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROX2 Gene

Publications for PROX2 Gene

  1. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis MC … Caporaso NE (PLoS genetics 2011) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G … Rudan I (PLoS genetics 2013) 3 56
  4. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4 56
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for PROX2 Gene

Sources for PROX2 Gene