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Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
PROKR2 (Prokineticin Receptor 2) is a Protein Coding gene. Diseases associated with PROKR2 include Hypogonadotropic Hypogonadism 3 With Or Without Anosmia and Kallmann Syndrome 3. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20J005316 | Promoter | 0.7 | EPDnew | 600.7 | 0.0 | -7 | 0.1 | HNRNPL EZH2 ZBTB20 CTCF ZBTB26 ZNF335 GLIS2 | ENSG00000266908 PROKR2 GPCPD1 | |
GH20J005317 | Enhancer | 0.5 | ENCODE | 600.7 | -0.2 | -248 | 0.1 | HNRNPL CTCF EZH2 ZBTB20 RAD21 ZBTB26 ZNF335 ZNF143 GLIS2 | ENSG00000266908 PROKR2 GPCPD1 | |
GH20J005314 | Promoter | 0.4 | EPDnew | 600.7 | +2.3 | 2323 | 0.1 | CEBPG | PROKR2 piR-30465-020 CDS2 | |
GH20J005648 | Enhancer | 1.6 | FANTOM5 ENCODE CraniofacialAtlas dbSUPER | 2.3 | -338.1 | -338074 | 11.7 | CREB1 ZNF629 TFE3 RFX1 ZNF692 BACH1 JUND PKNOX1 POLR2A REST | GPCPD1 TRMT6 SHLD1 PROKR2 piR-41306-159 piR-50308-370 | |
GH20J005292 | Promoter | 0.5 | Ensembl | 6.5 | +23.9 | 23931 | 0.4 | HLF CBX8 | MN297787 UBE2D3P1 lnc-PROKR2-1 PROKR2 CDS2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004983 | neuropeptide Y receptor activity | IEA | -- |
GO:0042277 | peptide binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Circadian rythm related genes | ||
5 | GPCRs, Other |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007218 | neuropeptide signaling pathway | IEA | -- |
GO:0007623 | circadian rhythm | IEA,IBA | 21873635 |
GO:0032870 | cellular response to hormone stimulus | IBA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PROKR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PROKR2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | PROKR2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prokr2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Prokr2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | PROKR2 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prokr2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC798231 30 |
|
||
CU929052.1 31 |
|
ManyToMany | |||
prokr1a 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638189 | Uncertain Significance: Kallmann syndrome 3 | 5,302,306(-) | C/A | MISSENSE_VARIANT | |
695243 | Benign: Kallmann syndrome 3; not provided | 5,313,995(-) | G/A | SYNONYMOUS_VARIANT | |
696415 | Likely Benign: not provided | 5,302,505(-) | G/A | SYNONYMOUS_VARIANT | |
696699 | Likely Benign: not provided | 5,314,335(-) | G/C | MISSENSE_VARIANT | |
697733 | Benign: not provided | 5,302,688(-) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypogonadotropic hypogonadism 3 with or without anosmia |
|
|
kallmann syndrome 3 |
|
|
kallmann syndrome |
|
|
septooptic dysplasia |
|
|
normosmic congenital hypogonadotropic hypogonadism |
|
|