This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reprod... See more...

Aliases for PROKR1 Gene

Aliases for PROKR1 Gene

  • Prokineticin Receptor 1 2 3 4 5
  • GPR73a 2 3 4
  • PKR1 2 3 4
  • G Protein-Coupled Receptor 73 2 3
  • GPR73 3 4
  • PK-R1 3 4
  • ZAQ 2 3
  • G Protein-Coupled Receptor ZAQ 3
  • G-Protein Coupled Receptor ZAQ 4
  • G-Protein Coupled Receptor 73 4
  • PROKR1 5

External Ids for PROKR1 Gene

Previous HGNC Symbols for PROKR1 Gene

  • GPR73

Previous GeneCards Identifiers for PROKR1 Gene

  • GC02P068727
  • GC02P068614
  • GC02P068870

Summaries for PROKR1 Gene

Entrez Gene Summary for PROKR1 Gene

  • This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

GeneCards Summary for PROKR1 Gene

PROKR1 (Prokineticin Receptor 1) is a Protein Coding gene. Diseases associated with PROKR1 include Hirschsprung Disease 1 and Kallmann Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR2.

UniProtKB/Swiss-Prot Summary for PROKR1 Gene

  • Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Gene Wiki entry for PROKR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PROKR1 Gene

Genomics for PROKR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PROKR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J068642 Promoter 0.9 Ensembl 250.7 -0.1 -78 1.4 ZNF600 ZNF592 POLR2A REST SP2 SKIL ZBTB48 ZNF189 TAF1 NRF1 HSALNG0015704 PROKR1 lnc-PROKR1-1 APLF
GH02J068487 Enhancer 0.5 Ensembl 11.5 -155.6 -155563 0.4 ZNF654 REST KLF11 TRIM22 RAD21 SMC3 CTCF MEIS2 KLF16 FBXO48 APLF PROKR1 LINC01888 HSALNG0015697 HSALNG0015699
GH02J068423 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 3.2 -217.6 -217570 5 BCLAF1 SP1 IKZF1 CEBPA ATF3 YY1 BCL11A CEBPB ZNF592 SMAD5 APLF PROKR1 PLEK FBXO48 HSALNG0015693 HSALNG0015694
GH02J068440 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 2.3 -202.3 -202331 2.4 BCLAF1 SP1 ZNF207 ZNF654 MYC IKZF1 ZNF592 CEBPA YY1 MXD4 PLEK ENSG00000203395 PROKR1 APLF C1D HSALNG0015694 lnc-FBXO48-1 FBXO48
GH02J069136 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +500.0 500027 14.1 ZNF600 JUND ZIC2 NFIC CEBPB ZNF341 EP300 RFX5 STAT3 TBP ANTXR1 RNA5SP96 RNU6-1216P GKN1 PROKR1 lnc-GFPT1-3 MIR3126 GFPT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PROKR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PROKR1

Top Transcription factor binding sites by QIAGEN in the PROKR1 gene promoter:
  • AML1a
  • CREB
  • HFH-1
  • HTF
  • POU2F1
  • POU2F1a
  • RORalpha1

Genomic Locations for PROKR1 Gene

Latest Assembly
chr2:68,643,579-68,658,251
(GRCh38/hg38)
Size:
14,673 bases
Orientation:
Plus strand

Previous Assembly
chr2:68,870,711-68,885,383
(GRCh37/hg19 by Entrez Gene)
Size:
14,673 bases
Orientation:
Plus strand

chr2:68,870,721-68,882,708
(GRCh37/hg19 by Ensembl)
Size:
11,988 bases
Orientation:
Plus strand

Genomic View for PROKR1 Gene

Genes around PROKR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROKR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROKR1 Gene

Proteins for PROKR1 Gene

  • Protein details for PROKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCW9-PKR1_HUMAN
    Recommended name:
    Prokineticin receptor 1
    Protein Accession:
    Q8TCW9
    Secondary Accessions:
    • A5JUU2
    • Q53QT9
    • Q8NFJ7

    Protein attributes for PROKR1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PROKR1 Gene

Post-translational modifications for PROKR1 Gene

  • Glycosylation at Asn11, Asn14, and Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for PROKR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROKR1 Gene

Domains & Families for PROKR1 Gene

Gene Families for PROKR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for PROKR1 Gene

Suggested Antigen Peptide Sequences for PROKR1 Gene

GenScript: Design optimal peptide antigens:
  • GPR73a (PKR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCW9

UniProtKB/Swiss-Prot:

PKR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PROKR1: view

Function for PROKR1 Gene

Molecular function for PROKR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Phenotypes From GWAS Catalog for PROKR1 Gene

Gene Ontology (GO) - Molecular Function for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with PROKR1: view
genes like me logo Genes that share phenotypes with PROKR1: view

Animal Models for PROKR1 Gene

MGI Knock Outs for PROKR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for PROKR1

miRNA for PROKR1 Gene

miRTarBase miRNAs that target PROKR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PROKR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROKR1 Gene

Localization for PROKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROKR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROKR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PROKR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PROKR1 Gene

Pathways & Interactions for PROKR1 Gene

genes like me logo Genes that share pathways with PROKR1: view

Interacting Proteins for PROKR1 Gene

SIGNOR curated interactions for PROKR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with PROKR1: view

Drugs & Compounds for PROKR1 Gene

(8) Drugs for PROKR1 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MIT1 Pharma Agonist, Full agonist 0
prokineticin-1 Pharma Agonist, Full agonist 0
prokineticin-2 Pharma Agonist, Full agonist 0
prokineticin-2β Pharma Agonist, Full agonist 0
triazine compound 1 Pharma 0

(1) Additional Compounds for PROKR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROKR1: view

Transcripts for PROKR1 Gene

mRNA/cDNA for PROKR1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PROKR1

Alternative Splicing Database (ASD) splice patterns (SP) for PROKR1 Gene

No ASD Table

Relevant External Links for PROKR1 Gene

GeneLoc Exon Structure for
PROKR1

Expression for PROKR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PROKR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROKR1 Gene

This gene is overexpressed in Testis (x11.5), Adipose - Visceral (Omentum) (x5.8), and Breast - Mammary Tissue (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PROKR1

SOURCE GeneReport for Unigene cluster for PROKR1 Gene:

Hs.683430

mRNA Expression by UniProt/SwissProt for PROKR1 Gene:

Q8TCW9-PKR1_HUMAN
Tissue specificity: Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.

Evidence on tissue expression from TISSUES for PROKR1 Gene

  • Eye(4.7)
  • Pancreas(3.4)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with PROKR1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROKR1 Gene

Orthologs for PROKR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROKR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PROKR1 29 30
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PROKR1 29 30
  • 89.31 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PROKR1 29 30
  • 87.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 87 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 85 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Prokr1 29 16 30
  • 83.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prokr1 29
  • 83.46 (n)
Chicken
(Gallus gallus)
Aves PROKR2 30
  • 76 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 81 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii prokr1a 29 30
  • 63.93 (n)
ManyToMany
CU929052.1 30
  • 62 (a)
ManyToMany
Species where no ortholog for PROKR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PROKR1 Gene

ENSEMBL:
Gene Tree for PROKR1 (if available)
TreeFam:
Gene Tree for PROKR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PROKR1: view image
Alliance of Genome Resources:
Additional Orthologs for PROKR1

Paralogs for PROKR1 Gene

(3) SIMAP similar genes for PROKR1 Gene using alignment to 1 proteins:

  • PKR1_HUMAN
genes like me logo Genes that share paralogs with PROKR1: view

Variants for PROKR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PROKR1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs144018404 Likely Pathogenic: Hirschsprung disease 68,655,413(+) T/A
NM_138964.3(PROKR1):c.1019T>A (p.Leu340Gln)
MISSENSE
rs796052145 Likely Benign: Long QT syndrome 68,655,083(+) A/C
NM_138964.3(PROKR1):c.689A>C (p.Lys230Thr)
MISSENSE
rs7570797 -- p.Ser40Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PROKR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PROKR1 Gene

Variant ID Type Subtype PubMed ID
nsv1003458 CNV loss 25217958
nsv582174 CNV loss 21841781

Variation tolerance for PROKR1 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROKR1 Gene

Human Gene Mutation Database (HGMD)
PROKR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROKR1
Leiden Open Variation Database (LOVD)
PROKR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROKR1 Gene

Disorders for PROKR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PROKR1 Gene - From: CVR and COP

Disorder Aliases PubMed IDs
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PROKR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PROKR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROKR1 Gene

Publications for PROKR1 Gene

  1. Prokineticin 1 signaling and gene regulation in early human pregnancy. (PMID: 18339712) Evans J … Jabbour HN (Endocrinology 2008) 3 4 22
  2. Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss. (PMID: 20847187) Su MT … Kuo PL (Human reproduction (Oxford, England) 2010) 3 40
  3. Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway. (PMID: 19801577) Cook IH … Jabbour HN (Molecular human reproduction 2010) 3 22
  4. Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. (PMID: 20023120) Guilini C … Nebigil CG (American journal of physiology. Heart and circulatory physiology 2010) 3 22
  5. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. (PMID: 16763065) Pasquali D … Sinisi AA (Endocrinology 2006) 3 22

Products for PROKR1 Gene

Sources for PROKR1 Gene