Aliases for PROK2 Gene
External Ids for PROK2 Gene
Previous GeneCards Identifiers for PROK2 Gene
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PROK2 Gene
PROK2 (Prokineticin 2) is a Protein Coding gene. Diseases associated with PROK2 include Hypogonadotropic Hypogonadism 4 With Or Without Anosmia and Kallmann Syndrome 4. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor binding. An important paralog of this gene is PROK1.
UniProtKB/Swiss-Prot Summary for PROK2 Gene
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.