Aliases for PRODH Gene
External Ids for PRODH Gene
Previous GeneCards Identifiers for PRODH Gene
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
GeneCards Summary for PRODH Gene
PRODH (Proline Dehydrogenase 1) is a Protein Coding gene. Diseases associated with PRODH include Hyperprolinemia, Type I and Schizophrenia 4. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include FAD binding and proline dehydrogenase activity. An important paralog of this gene is LOC102724788.
UniProtKB/Swiss-Prot Summary for PRODH Gene
Converts proline to delta-1-pyrroline-5-carboxylate.