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Aliases for PROCR Gene

Aliases for PROCR Gene

  • Protein C Receptor 2 3 5
  • Protein C Receptor, Endothelial 2 3
  • Activated Protein C Receptor 3 4
  • CD201 Antigen 3 4
  • APC Receptor 3 4
  • EPCR 3 4
  • Cell Cycle, Centrosome-Associated Protein 3
  • Endothelial Cell Protein C Receptor 4
  • Endothelial Protein C Receptor 3
  • Centrocyclin 3
  • CCD41 3
  • CCCA 3

External Ids for PROCR Gene

Previous GeneCards Identifiers for PROCR Gene

  • GC20P033518
  • GC20P034428
  • GC20P034476
  • GC20P034477
  • GC20P033223
  • GC20P033758
  • GC20P030537

Summaries for PROCR Gene

Entrez Gene Summary for PROCR Gene

  • The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

GeneCards Summary for PROCR Gene

PROCR (Protein C Receptor) is a Protein Coding gene. Diseases associated with PROCR include Purpura Fulminans and Arteriovenous Fistula. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades.

UniProtKB/Swiss-Prot for PROCR Gene

  • Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Gene Wiki entry for PROCR Gene

Additional gene information for PROCR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROCR Gene

Genomics for PROCR Gene

GeneHancer (GH) Regulatory Elements for PROCR Gene

Promoters and enhancers for PROCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J035170 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 669.5 +0.2 169 2.3 SIN3A YBX1 TCF12 ZNF121 GLIS2 GATA2 ZNF263 SP3 REST SMARCB1 PROCR RBM39 RBM12 CPNE1 TRPC4AP ERGIC3 RPL36P4 NCOA6 EDEM2 MMP24OS
GH20J035764 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.7 +597.6 597608 9.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 ZNF548 SP3 PHF20 ENSG00000283527 CPNE1 RBM12 RBM39 NCOA6 ERGIC3 TRPC4AP AAR2 DLGAP4-AS1
GH20J034954 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.6 -216.0 -215992 2.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MYH7B GSS RBM12 CPNE1 NCOA6 ERGIC3 RPL36P4 TRPC4AP ENSG00000272945 PROCR
GH20J035615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +445.9 445890 5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF143 ZNF548 GC20P035617 SPAG4 CPNE1 RBM12 RBM39 AAR2 C20orf173 RPF2P1 HMGB3P2 ENSG00000242507
GH20J035146 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.7 -24.3 -24297 2.9 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 EDEM2 RBM12 NCOA6 ENSG00000201151 MMP24 ERGIC3 MMP24OS PROCR PIGU EIF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PROCR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PROCR gene promoter:
  • POU3F1
  • NF-YB
  • NF-YA
  • NF-Y
  • CP1A
  • CBF-B
  • CBF-A
  • CBF(2)
  • Pax-5
  • AREB6

Genomic Locations for PROCR Gene

Genomic Locations for PROCR Gene
chr20:35,171,937-35,216,240
(GRCh38/hg38)
Size:
44,304 bases
Orientation:
Plus strand
chr20:33,759,774-33,765,165
(GRCh37/hg19)
Size:
5,392 bases
Orientation:
Plus strand

Genomic View for PROCR Gene

Genes around PROCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCR Gene

Proteins for PROCR Gene

  • Protein details for PROCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNN8-EPCR_HUMAN
    Recommended name:
    Endothelial protein C receptor
    Protein Accession:
    Q9UNN8
    Secondary Accessions:
    • B2RC04
    • Q14218
    • Q6IB56
    • Q96CB3
    • Q9ULX1

    Protein attributes for PROCR Gene

    Size:
    238 amino acids
    Molecular mass:
    26671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PROCR Gene

neXtProt entry for PROCR Gene

Post-translational modifications for PROCR Gene

  • N-glycosylated.
  • A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
  • Glycosylation at Asn172, posLast=136136, posLast=6464, and Asn47
  • Modification sites at PhosphoSitePlus

Other Protein References for PROCR Gene

No data available for DME Specific Peptides for PROCR Gene

Domains & Families for PROCR Gene

Gene Families for PROCR Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PROCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROCR: view

No data available for UniProtKB/Swiss-Prot for PROCR Gene

Function for PROCR Gene

Molecular function for PROCR Gene

UniProtKB/Swiss-Prot Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Phenotypes From GWAS Catalog for PROCR Gene

Gene Ontology (GO) - Molecular Function for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17299037
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with PROCR: view
genes like me logo Genes that share phenotypes with PROCR: view

Animal Models for PROCR Gene

MGI Knock Outs for PROCR:
  • Procr Procr<tm1Cte>
  • Procr Procr<tm1.1(cre/ERT2)Yaz>

Animal Model Products

  • Taconic Biosciences Mouse Models for PROCR

miRNA for PROCR Gene

miRTarBase miRNAs that target PROCR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROCR Gene

Localization for PROCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROCR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROCR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005813 centrosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7929370
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with PROCR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PROCR Gene

Pathways & Interactions for PROCR Gene

genes like me logo Genes that share pathways with PROCR: view

Interacting Proteins for PROCR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216968%0d%0a9606.ENSP00000226524%0d%0a9606.ENSP00000377783%0d%0a9606.ENSP00000308541%0d%0a9606.ENSP00000234347%0d%0a9606.ENSP00000296029%0d%0a
Selected Interacting proteins: ENSP00000216968 Q9UNN8-EPCR_HUMAN for PROCR Gene via STRING IID UniProtKB

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
F2R

Gene Ontology (GO) - Biological Process for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0007599 hemostasis IEA --
GO:0050819 negative regulation of coagulation IMP 19696402
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with PROCR: view

No data available for SIGNOR curated interactions for PROCR Gene

Drugs & Compounds for PROCR Gene

(9) Drugs for PROCR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Drotrecogin alfa Approved, Investigational, Withdrawn Pharma Target 0
Tetradecyl hydrogen sulfate (ester) Approved Pharma Target, antagonist 0
Phosphatidylethanolamine Experimental Pharma Target 0
GED-APC Pharma 0

(8) Additional Compounds for PROCR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROCR: view

Transcripts for PROCR Gene

mRNA/cDNA for PROCR Gene

Unigene Clusters for PROCR Gene

Protein C receptor, endothelial:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROCR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for PROCR Gene

GeneLoc Exon Structure for
PROCR
ECgene alternative splicing isoforms for
PROCR

Expression for PROCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCR Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.3).

Protein differential expression in normal tissues from HIPED for PROCR Gene

This gene is overexpressed in Urine (25.1) and Serum (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PROCR Gene



NURSA nuclear receptor signaling pathways regulating expression of PROCR Gene:

PROCR

SOURCE GeneReport for Unigene cluster for PROCR Gene:

Hs.647450

mRNA Expression by UniProt/SwissProt for PROCR Gene:

Q9UNN8-EPCR_HUMAN
Tissue specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Evidence on tissue expression from TISSUES for PROCR Gene

  • Heart(4.6)
  • Pancreas(4.1)
  • Lung(3)
  • Blood(2.5)
  • Skin(2.5)
  • Nervous system(2.2)
  • Intestine(2.1)
  • Kidney(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PROCR: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROCR Gene

Orthologs for PROCR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROCR 34 33
  • 99.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PROCR 34 33
  • 85.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PROCR 34 33
  • 79.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Procr 33
  • 79.67 (n)
mouse
(Mus musculus)
Mammalia Procr 16 34 33
  • 78.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PROCR 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROCR 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROCR 34 33
  • 56.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROCR 34
  • 34 (a)
OneToOne
Species where no ortholog for PROCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROCR Gene

ENSEMBL:
Gene Tree for PROCR (if available)
TreeFam:
Gene Tree for PROCR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PROCR: view image

Paralogs for PROCR Gene

No data available for Paralogs for PROCR Gene

Variants for PROCR Gene

Sequence variations from dbSNP and Humsavar for PROCR Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000032424 -- 35,188,934(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000108047 -- 35,212,590(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000207485 -- 35,182,896(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000311052 -- 35,172,641(+) G/A/T intron_variant
rs1000418473 -- 35,170,866(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PROCR Gene

Variant ID Type Subtype PubMed ID
esv3645712 CNV gain 21293372

Variation tolerance for PROCR Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROCR Gene

Human Gene Mutation Database (HGMD)
PROCR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCR Gene

Disorders for PROCR Gene

MalaCards: The human disease database

(8) MalaCards diseases for PROCR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
purpura fulminans
  • purpura gangrenosa
arteriovenous fistula
thrombophilia
  • hypercoagulability state
thrombophilia due to thrombin defect
  • thph1
purpura
  • purpuric disorder
- elite association - COSMIC cancer census association via MalaCards
Search PROCR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PROCR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PROCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROCR Gene

Publications for PROCR Gene

  1. The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples. (PMID: 19806250) Cochery-Nouvellon E … Gris JC (Thrombosis and haemostasis 2009) 3 22 44 58
  2. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. (PMID: 18680534) Reiner AP … Lange LA (Journal of thrombosis and haemostasis : JTH 2008) 3 22 44 58
  3. Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation. (PMID: 18403391) Navarro S … España F (Haematologica 2008) 3 22 44 58
  4. Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss. (PMID: 18539144) Hopmeier P … Dossenbach-Glaninger A (Clinical biochemistry 2008) 3 22 44 58
  5. Endothelial protein C receptor polymorphisms and risk of myocardial infarction. (PMID: 18757851) Medina P … RECAVA Thrombosis Groups (Haematologica 2008) 3 22 44 58

Products for PROCR Gene

Sources for PROCR Gene