Aliases for PROCA1 Gene

Aliases for PROCA1 Gene

  • Protein Interacting With Cyclin A1 2 3 4 5
  • Proline-Rich Cyclin A1-Interacting Protein 2 3
  • Protein PROCA1 3 4

External Ids for PROCA1 Gene

Previous GeneCards Identifiers for PROCA1 Gene

  • GC17M024054
  • GC17M027030
  • GC17M023239

Summaries for PROCA1 Gene

GeneCards Summary for PROCA1 Gene

PROCA1 (Protein Interacting With Cyclin A1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G3.

Additional gene information for PROCA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PROCA1 Gene

Genomics for PROCA1 Gene

GeneHancer (GH) Regulatory Elements for PROCA1 Gene

Promoters and enhancers for PROCA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028709 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 772.6 +0.6 605 3.7 ZNF785 SP1 ZBTB6 MLX SMARCE1 POLR2A ZNF362 RUNX1 ZNF133 NFYC PROCA1 RF00017-2326 lnc-RAB34-1 ENSG00000264577 NUFIP2 ENSG00000265908 ENSG00000265205 ENSG00000264290 SUPT6H PHF12
GH17J028715 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22.4 -10.9 -10853 14.4 PPP1R10 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 ENSG00000264577 RPL23A NEK8 RAB34 SNORD42A SNORD4A SNORD4B X96641 piR-31970 TLCD1
GH17J028737 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.3 -32.1 -32149 13.9 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 FOXA1 ZBTB6 MLX TRAF4 ENSG00000265073 piR-43105-269 ENSG00000264577 NUFIP2 ENSG00000265205 SUPT6H ENSG00000264290 RPL23A ENSG00000265908
GH17J028643 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.7 +66.4 66350 4.4 ZNF24 SP1 ZBTB40 CTCF RBPJ SMARCE1 POLR2A MCM5 HCFC1 MIXL1 KIAA0100 lnc-SUPT6H-5 piR-54674 ENSG00000264577 NUFIP2 SUPT6H LOC101927018 PROCA1 PHF12 RAB34
GH17J028569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 21.3 +140.8 140831 2.9 SIN3A SP1 ZBTB40 SMARCE1 POLR2A HCFC1 MYC NFYC ELF1 L3MBTL2 ENSG00000265168 PIGS lnc-ALDOC-1 PROCA1 LOC101927018 ENSG00000264577 NUFIP2 ENSG00000264044 ENSG00000265205 ENSG00000265908
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PROCA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PROCA1 gene promoter:
  • ATF-2
  • CRE-BP1
  • E47
  • FOXI1
  • HFH-3
  • PPAR-gamma1
  • PPAR-gamma2
  • Spz1
  • STAT3
  • Tal-1beta

Genomic Locations for PROCA1 Gene

Genomic Locations for PROCA1 Gene
chr17:28,703,197-28,712,071
(GRCh38/hg38)
Size:
8,875 bases
Orientation:
Minus strand
chr17:27,030,215-27,038,872
(GRCh37/hg19)
Size:
8,658 bases
Orientation:
Minus strand

Genomic View for PROCA1 Gene

Genes around PROCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCA1 Gene

Proteins for PROCA1 Gene

  • Protein details for PROCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ7-PRCA1_HUMAN
    Recommended name:
    Protein PROCA1
    Protein Accession:
    Q8NCQ7
    Secondary Accessions:
    • B4DX95
    • G5E9R8
    • Q6PKN3

    Protein attributes for PROCA1 Gene

    Size:
    364 amino acids
    Molecular mass:
    40506 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAT09159.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAT09159.1; Type=Frameshift; Positions=10, 44; Evidence={ECO:0000305};

    Alternative splice isoforms for PROCA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROCA1 Gene

Post-translational modifications for PROCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PROCA1 Gene

Domains & Families for PROCA1 Gene

Gene Families for PROCA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROCA1 Gene

Suggested Antigen Peptide Sequences for PROCA1 Gene

GenScript: Design optimal peptide antigens:
  • Protein PROCA1 (PRCA1_HUMAN)
  • Proline-rich cyclin A1 interacting protein (Q6PKN3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCQ7

UniProtKB/Swiss-Prot:

PRCA1_HUMAN :
  • Belongs to the PROCA1 family.
Family:
  • Belongs to the PROCA1 family.
genes like me logo Genes that share domains with PROCA1: view

Function for PROCA1 Gene

Phenotypes From GWAS Catalog for PROCA1 Gene

Gene Ontology (GO) - Molecular Function for PROCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with PROCA1: view
genes like me logo Genes that share phenotypes with PROCA1: view

Animal Model Products

CRISPR Products

miRNA for PROCA1 Gene

miRTarBase miRNAs that target PROCA1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROCA1 Gene

Localization for PROCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROCA1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
extracellular 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PROCA1 Gene

Pathways & Interactions for PROCA1 Gene

PathCards logo

SuperPathways for PROCA1 Gene

No Data Available

Interacting Proteins for PROCA1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000301039 Q8NCQ7-PRCA1_HUMAN for PROCA1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PROCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PROCA1: view

No data available for Pathways by source and SIGNOR curated interactions for PROCA1 Gene

Drugs & Compounds for PROCA1 Gene

No Compound Related Data Available

Transcripts for PROCA1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROCA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - -

Relevant External Links for PROCA1 Gene

GeneLoc Exon Structure for
PROCA1
ECgene alternative splicing isoforms for
PROCA1

Expression for PROCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCA1 Gene

This gene is overexpressed in Testis (x26.7).

NURSA nuclear receptor signaling pathways regulating expression of PROCA1 Gene:

PROCA1

SOURCE GeneReport for Unigene cluster for PROCA1 Gene:

Hs.207471

mRNA Expression by UniProt/SwissProt for PROCA1 Gene:

Q8NCQ7-PRCA1_HUMAN
Tissue specificity: High expressed in testis.
genes like me logo Genes that share expression patterns with PROCA1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROCA1 Gene

Orthologs for PROCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROCA1 33 32
  • 94.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PROCA1 33 32
  • 81.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PROCA1 33 32
  • 79.74 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Proca1 32
  • 68.21 (n)
mouse
(Mus musculus)
Mammalia Proca1 17 33 32
  • 60.16 (n)
chicken
(Gallus gallus)
Aves PROCA1 33
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROCA1 33
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii proca1 33
  • 9 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sPLA2 33
  • 14 (a)
ManyToMany
GIIIspla2 33
  • 12 (a)
ManyToMany
CG30503 33
  • 12 (a)
ManyToMany
CG3009 33
  • 8 (a)
ManyToMany
CG42237 33
  • 4 (a)
ManyToMany
Species where no ortholog for PROCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROCA1 Gene

ENSEMBL:
Gene Tree for PROCA1 (if available)
TreeFam:
Gene Tree for PROCA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PROCA1: view image

Paralogs for PROCA1 Gene

Paralogs for PROCA1 Gene

genes like me logo Genes that share paralogs with PROCA1: view

Variants for PROCA1 Gene

Sequence variations from dbSNP and Humsavar for PROCA1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000544647 -- 28,706,106(-) C/T intron_variant
rs1000789179 -- 28,705,097(-) C/T intron_variant
rs1000847800 -- 28,709,494(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000879019 -- 28,709,877(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001158659 -- 28,713,224(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PROCA1 Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958

Variation tolerance for PROCA1 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROCA1 Gene

Human Gene Mutation Database (HGMD)
PROCA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCA1 Gene

Disorders for PROCA1 Gene

Additional Disease Information for PROCA1

No disorders were found for PROCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROCA1 Gene

Publications for PROCA1 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S … Müller-Tidow C (The Journal of biological chemistry 2004) 2 3 4 56
  2. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. (PMID: 29449217) Noguchi A … Kawahara H (Biology open 2018) 3 56
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 56
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 56

Products for PROCA1 Gene

  • Biorbyt antibodies for PROCA1

Sources for PROCA1 Gene