Aliases for PROC Gene
External Ids for PROC Gene
Previous GeneCards Identifiers for PROC Gene
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
GeneCards Summary for PROC Gene
PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa) is a Protein Coding gene. Diseases associated with PROC include Thrombophilia Due To Protein C Deficiency, Autosomal Recessive and Thrombophilia Due To Protein C Deficiency, Autosomal Dominant. Among its related pathways are Metabolism of proteins and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is PROZ.
UniProtKB/Swiss-Prot Summary for PROC Gene
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).