Aliases for PRMT8 Gene
- Protein Arginine Methyltransferase 8 2 3 5
- Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 4 3 4
- Protein Arginine N-Methyltransferase 8 3 4
- HRMT1L3 3 4
- HRMT1L4 3 4
- HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae) 2
- HMT1 HnRNP Methyltransferase-Like 4 (S. Cerevisiae) 2
- Protein Arginine N-Methyltransferase 4 3
External Ids for PRMT8 Gene
Previous HGNC Symbols for PRMT8 Gene
Previous GeneCards Identifiers for PRMT8 Gene
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PRMT8 Gene
PRMT8 (Protein Arginine Methyltransferase 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PRMT1.
UniProtKB/Swiss-Prot for PRMT8 Gene
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585).
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.