This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, ... See more...

Aliases for PRMT7 Gene

Aliases for PRMT7 Gene

  • Protein Arginine Methyltransferase 7 2 3 5
  • [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7 3 4
  • Histone-Arginine N-Methyltransferase PRMT7 3 4
  • Protein Arginine N-Methyltransferase 7 3 4
  • EC 2.1.1.321 4
  • KIAA1933 4
  • EC 2.1.1 52
  • SBIDDS 3

External Ids for PRMT7 Gene

Previous GeneCards Identifiers for PRMT7 Gene

  • GC16P068122
  • GC16P066902
  • GC16P068344
  • GC16P054218
  • GC16P068321

Summaries for PRMT7 Gene

Entrez Gene Summary for PRMT7 Gene

  • This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]

GeneCards Summary for PRMT7 Gene

PRMT7 (Protein Arginine Methyltransferase 7) is a Protein Coding gene. Diseases associated with PRMT7 include Short Stature, Brachydactyly, Intellectual Developmental Disability, And Seizures and Acanthosis Nigricans. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and ribonucleoprotein complex binding. An important paralog of this gene is PRMT9.

UniProtKB/Swiss-Prot Summary for PRMT7 Gene

  • Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Tocris Summary for PRMT7 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Additional gene information for PRMT7 Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRMT7 Gene

Genomics for PRMT7 Gene

GeneHancer (GH) Regulatory Elements for PRMT7 Gene

Promoters and enhancers for PRMT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J068309 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 543.8 +0.0 27 3.2 ZBTB40 ZNF217 EP300 CTCF SIN3A POLR2G SP1 NCOR1 PHF8 PHB2 PRMT7 SLC7A6OS lnc-SLC7A6-3 piR-60232 EDC4 CENPT NFATC3 DUS2 L13708-003
GH16J068315 Promoter 0.3 EPDnew 500.7 +5.0 4973 0.1 ENSG00000259797 PRMT7 RF01210-152 lnc-SLC7A6-3 L13708-003
GH16J068263 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 41.7 -46.0 -45973 3.6 RXRA EP300 FOXK2 ZNF217 CTCF TCF12 NRF1 POLR2G PHF8 ZFX SLC7A6 PRMT7 ZFP90 CTCF SNTB2 ZDHHC1 SLC12A4 DUS2 TSNAXIP1 ACD
GH16J067992 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 36.7 -316.1 -316095 4.1 HNRNPK ZNF217 CTCF NRF1 POLR2G SP1 ZIC2 CLOCK ZNF263 ZNF423 DPEP2 PRMT7 ACD DDX28 KIAA0895L RNU6-359P SLC12A4 LCAT DUS2 NFATC3
GH16J068279 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 44.6 -24.5 -24513 13.5 EP300 FOXK2 SIN3A POLR2G NCOR1 FOS KDM6A TCF7 FOXA1 ZNF740 PRMT7 SLC7A6 NFATC3 SLC7A6OS RNU4-30P DUS2 RANBP10 DPEP2 PSMB10 LRRC36
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRMT7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRMT7

Top Transcription factor binding sites by QIAGEN in the PRMT7 gene promoter:
  • AML1a
  • ARP-1
  • GR
  • GR-alpha
  • MRF-2
  • Pax-5
  • POU3F1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1

Genomic Locations for PRMT7 Gene

Genomic Locations for PRMT7 Gene
chr16:68,310,974-68,358,829
(GRCh38/hg38)
Size:
47,856 bases
Orientation:
Plus strand
chr16:68,344,877-68,392,466
(GRCh37/hg19)
Size:
47,590 bases
Orientation:
Plus strand

Genomic View for PRMT7 Gene

Genes around PRMT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT7 Gene

Proteins for PRMT7 Gene

  • Protein details for PRMT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM4-ANM7_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 7
    Protein Accession:
    Q9NVM4
    Secondary Accessions:
    • B3KPR0
    • B3KUG9
    • B4E379
    • Q96PV5
    • Q9H9L0

    Protein attributes for PRMT7 Gene

    Size:
    692 amino acids
    Molecular mass:
    78459 Da
    Quaternary structure:
    • Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
    Miscellaneous:
    • May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
    SequenceCaution:
    • Sequence=BAB14215.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRMT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT7 Gene

Selected DME Specific Peptides for PRMT7 Gene

Q9NVM4:
  • VLDIGTG
  • DTELIGEGA

Post-translational modifications for PRMT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRMT7 Gene

Gene Families for PRMT7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PRMT7 Gene

Suggested Antigen Peptide Sequences for PRMT7 Gene

GenScript: Design optimal peptide antigens:
  • [Myelin basic protein]-arginine N-methyltransferase PRMT7 (ANM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVM4

UniProtKB/Swiss-Prot:

ANM7_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
genes like me logo Genes that share domains with PRMT7: view

Function for PRMT7 Gene

Molecular function for PRMT7 Gene

UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48100, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11990, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65280; EC=2.1.1.321; Evidence=. ;.

Enzyme Numbers (IUBMB) for PRMT7 Gene

Phenotypes From GWAS Catalog for PRMT7 Gene

Gene Ontology (GO) - Molecular Function for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008469 histone-arginine N-methyltransferase activity IDA 15494416
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 15044439
GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity IDA 15494416
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PRMT7: view
genes like me logo Genes that share phenotypes with PRMT7: view

Human Phenotype Ontology for PRMT7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRMT7 Gene

MGI Knock Outs for PRMT7:
  • Prmt7 Prmt7<tm1a(EUCOMM)Wtsi>
  • Prmt7 Prmt7<tm1.2Rchd>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRMT7

CRISPR Products

Clone Products

  • Addgene plasmids for PRMT7

No data available for Transcription Factor Targets and HOMER Transcription for PRMT7 Gene

Localization for PRMT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT7 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,IEA 15494416
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 15494416
genes like me logo Genes that share ontologies with PRMT7: view

Pathways & Interactions for PRMT7 Gene

genes like me logo Genes that share pathways with PRMT7: view

Pathways by source for PRMT7 Gene

1 Cell Signaling Technology pathway for PRMT7 Gene
1 GeneTex pathway for PRMT7 Gene

Gene Ontology (GO) - Biological Process for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly IMP 17709427
GO:0006325 chromatin organization IEA --
GO:0006349 regulation of gene expression by genetic imprinting IEA,ISS --
GO:0006479 protein methylation IEA --
GO:0016571 histone methylation IDA 15494416
genes like me logo Genes that share ontologies with PRMT7: view

No data available for SIGNOR curated interactions for PRMT7 Gene

Drugs & Compounds for PRMT7 Gene

(2) Drugs for PRMT7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(3) Additional Compounds for PRMT7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with PRMT7: view

Transcripts for PRMT7 Gene

mRNA/cDNA for PRMT7 Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PRMT7

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for PRMT7 Gene

GeneLoc Exon Structure for
PRMT7

Expression for PRMT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT7 Gene

Protein differential expression in normal tissues from HIPED for PRMT7 Gene

This gene is overexpressed in Fetal ovary (49.8) and Retina (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRMT7 Gene



Protein tissue co-expression partners for PRMT7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRMT7

SOURCE GeneReport for Unigene cluster for PRMT7 Gene:

Hs.653193

Evidence on tissue expression from TISSUES for PRMT7 Gene

  • Nervous system(4.8)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with PRMT7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT7 Gene

Orthologs for PRMT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT7 31 30
  • 97.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRMT7 31 30
  • 87.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT7 31 30
  • 86.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt7 17 31 30
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Prmt7 30
  • 83.12 (n)
oppossum
(Monodelphis domestica)
Mammalia PRMT7 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT7 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRMT7 31 30
  • 67.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT7 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt7 30
  • 63.14 (n)
Str.95 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68979 30
zebrafish
(Danio rerio)
Actinopterygii prmt7 31 30
  • 64.55 (n)
OneToOne
zgc66172 30
fruit fly
(Drosophila melanogaster)
Insecta Art7 31 30
  • 50.65 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta ANM7_ANOGA 30
  • 50.03 (n)
worm
(Caenorhabditis elegans)
Secernentea prmt-7 31 30
  • 44.64 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT7 30
  • 44.95 (n)
rice
(Oryza sativa)
Liliopsida Os06g0105500 30
  • 44.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for PRMT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT7 Gene

ENSEMBL:
Gene Tree for PRMT7 (if available)
TreeFam:
Gene Tree for PRMT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRMT7: view image

Paralogs for PRMT7 Gene

Paralogs for PRMT7 Gene

(1) SIMAP similar genes for PRMT7 Gene using alignment to 8 proteins:

  • ANM7_HUMAN
  • H3BNC0_HUMAN
  • H3BNS2_HUMAN
  • H3BPZ8_HUMAN
  • H3BRD3_HUMAN
  • H3BRQ9_HUMAN
  • H3BSS9_HUMAN
  • H3BTY1_HUMAN
genes like me logo Genes that share paralogs with PRMT7: view

Variants for PRMT7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRMT7 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
638359 Uncertain Significance: Short stature, brachydactyly, intellectual developmental disability, and seizures 68,357,094(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
712114 Benign: not provided 68,339,549(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
712115 Likely Benign: not provided 68,357,094(+) ACTT/A NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION
714708 Benign: not provided 68,345,728(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
715535 Likely Benign: not provided 68,357,090(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for PRMT7 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRMT7 Gene

Variant ID Type Subtype PubMed ID
esv3582280 CNV loss 25503493
esv3638905 CNV loss 21293372
nsv510691 CNV deletion 20534489
nsv519368 CNV loss 19592680

Variation tolerance for PRMT7 Gene

Residual Variation Intolerance Score: 4.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRMT7 Gene

Human Gene Mutation Database (HGMD)
PRMT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT7 Gene

Disorders for PRMT7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for PRMT7 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
short stature, brachydactyly, intellectual developmental disability, and seizures
  • sbidds
acanthosis nigricans
  • an
renal hypoplasia
familial hyperlipidemia
  • familial hyperlipoproteinemia
fatty liver disease, nonalcoholic 1
  • fatty liver disease, nonalcoholic, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search PRMT7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANM7_HUMAN
  • Short stature, brachydactyly, intellectual developmental disability, and seizures (SBIDDS) [MIM:617157]: An autosomal recessive disease characterized by developmental delay, learning disabilities, mild mental retardation, delayed speech, and skeletal abnormalities. Skeletal features include short stature, brachydactyly, and short metacarpals and metatarsals. {ECO:0000269 PubMed:26437029}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRMT7

genes like me logo Genes that share disorders with PRMT7: view

No data available for Genatlas for PRMT7 Gene

Publications for PRMT7 Gene

  1. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. (PMID: 15044439) Miranda TB … Clarke S (The Journal of biological chemistry 2004) 2 3 4 23 54
  2. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. (PMID: 19110445) Wang H … Qu J (Journal of the American Society for Mass Spectrometry 2009) 3 4 23 54
  3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PMID: 17709427) Gonsalvez GB … Matera AG (The Journal of cell biology 2007) 3 4 23 54
  4. Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. (PMID: 26437029) Akawi N … DDD study (Nature genetics 2015) 3 4 54
  5. Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop. (PMID: 25294873) Feng Y … Clarke SG (The Journal of biological chemistry 2014) 3 4 54

Products for PRMT7 Gene

Sources for PRMT7 Gene