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The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
PRMT6 (Protein Arginine Methyltransferase 6) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein methyltransferase activity. An important paralog of this gene is PRMT2.
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J107055 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas | 293.5 | +0.7 | 685 | 3.3 | TBP ZBTB10 SIX5 NR2C1 MNT IKZF1 SMAD5 ETS1 MBD2 POLR2A | PRMT6 HSALNG0005767 lnc-VAV3-11 NTNG1 HSALNG0005769 | |
GH01J106978 | Enhancer | 0.5 | ENCODE | 11 | -77.8 | -77848 | 0.7 | CEBPB GATA2 NFRKB CHD2 CEBPG | PRMT6 HSALNG0005762 piR-58297-019 | |
GH01J107019 | Enhancer | 0.3 | Ensembl | 9 | -37.1 | -37074 | 0.4 | ZFX FOS | PRMT6 piR-58297-019 HSALNG0005762 | |
GH01J107009 | Enhancer | 0.3 | ENCODE | 10 | -47.3 | -47266 | 0.4 | ZFX | PRMT6 piR-58297-019 HSALNG0005762 | |
GH01J107015 | Enhancer | 0.3 | Ensembl | 4.6 | -40.7 | -40673 | 0.4 | PRDM1 | PRMT6 piR-58297-019 HSALNG0005762 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16157300 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0008469 | histone-arginine N-methyltransferase activity | IEA,TAS | -- |
GO:0016274 | protein-arginine N-methyltransferase activity | IEA,TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 11724789 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | Chromatin Regulation / Acetylation | ||
3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006284 | base-excision repair | TAS | 16600869 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Entacapone | Approved, Investigational | Pharma | COMT inhibitor, Potent COMT inhibitor; blocks alpha-synuclein aggregation | 55 | ||
s-adenosylhomocysteine | Experimental | Pharma | 0 | |||
EPZ004777 | Pharma | DOT1L inhibitor | 0 | |||
PFI-2 | Pharma | 0 | ||||
SGI-1027 | Pharma | DNMT inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 |
|
Compound | Action | Cas Number |
---|---|---|
Entacapone | COMT inhibitor | 130929-57-6 |
EPZ004777 | DOT1L inhibitor | 1338466-77-5 |
PFI-2 | 1627676-59-8 | |
SGI-1027 | DNMT inhibitor | 1020149-73-8 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRMT6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRMT6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Prmt6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prmt6 30 |
|
||
Dog (Canis familiaris) |
Mammalia | PRMT6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRMT6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prmt6 30 |
|
||
Str.3505 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.25304 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | prmt6 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008846 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Art8 30 |
|
||
CG16840 32 |
|
|
|||
Art2 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PRMT6 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0489100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9497 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2232016 | - |
p.Ala194Val |
No disorders were found for PRMT6 Gene.