PRMT6 Gene (Protein Coding)

Protein Arginine Methyltransferase 6

GC01P107056
GIFtS:
40
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginin... See more...

Aliases for PRMT6 Gene

Aliases for PRMT6 Gene

  • Protein Arginine Methyltransferase 6 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6 3 4
  • Histone-Arginine N-Methyltransferase PRMT6 3 4
  • Protein Arginine N-Methyltransferase 6 3 4
  • HRMT1L6 3 4
  • HMT1 HnRNP Methyltransferase-Like 6 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 6 3
  • EC 2.1.1.319 4
  • FLJ10559 2
  • PRMT6 5

External Ids for PRMT6 Gene

Previous HGNC Symbols for PRMT6 Gene

  • HRMT1L6

Previous GeneCards Identifiers for PRMT6 Gene

  • GC01P108100
  • GC01P106581
  • GC01P106756
  • GC01P106954
  • GC01P107400
  • GC01P107599
  • GC01P105545

Summaries for PRMT6 Gene

Entrez Gene Summary for PRMT6 Gene

  • The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

GeneCards Summary for PRMT6 Gene

PRMT6 (Protein Arginine Methyltransferase 6) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and protein methyltransferase activity. An important paralog of this gene is PRMT2.

UniProtKB/Swiss-Prot Summary for PRMT6 Gene

  • Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).

Tocris Summary for PRMT6 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT6 Gene

Additional gene information for PRMT6 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRMT6 Gene

Genomics for PRMT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PRMT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J107055 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 293.5 +0.7 685 3.3 TBP ZBTB10 SIX5 NR2C1 MNT IKZF1 SMAD5 ETS1 MBD2 POLR2A PRMT6 HSALNG0005767 lnc-VAV3-11 NTNG1 HSALNG0005769
GH01J106978 Enhancer 0.5 ENCODE 11 -77.8 -77848 0.7 CEBPB GATA2 NFRKB CHD2 CEBPG PRMT6 HSALNG0005762 piR-58297-019
GH01J107019 Enhancer 0.3 Ensembl 9 -37.1 -37074 0.4 ZFX FOS PRMT6 piR-58297-019 HSALNG0005762
GH01J107009 Enhancer 0.3 ENCODE 10 -47.3 -47266 0.4 ZFX PRMT6 piR-58297-019 HSALNG0005762
GH01J107015 Enhancer 0.3 Ensembl 4.6 -40.7 -40673 0.4 PRDM1 PRMT6 piR-58297-019 HSALNG0005762
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRMT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRMT6

Top Transcription factor binding sites by QIAGEN in the PRMT6 gene promoter:
  • Egr-2
  • Egr-3
  • FOXJ2
  • FOXJ2 (long isoform)
  • HSF2
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PRMT6 Gene

Latest Assembly
chr1:107,056,674-107,067,636
(GRCh38/hg38)
Size:
10,963 bases
Orientation:
Plus strand

Previous Assembly
chr1:107,599,296-107,601,916
(GRCh37/hg19 by Entrez Gene)
Size:
2,621 bases
Orientation:
Plus strand

chr1:107,599,267-107,601,916
(GRCh37/hg19 by Ensembl)
Size:
2,650 bases
Orientation:
Plus strand

Genomic View for PRMT6 Gene

Genes around PRMT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRMT6 Gene

Proteins for PRMT6 Gene

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  • Protein details for PRMT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA8-ANM6_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 6
    Protein Accession:
    Q96LA8
    Secondary Accessions:
    • A3KME1
    • B4DID8
    • Q5T5Y5
    • Q6DKI4
    • Q9NVR8

    Protein attributes for PRMT6 Gene

    Size:
    375 amino acids
    Molecular mass:
    41938 Da
    Quaternary structure:
    • Interacts with EPB41L3 and NCOA1.
    • (Microbial infection) Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL69.
    SequenceCaution:
    • Sequence=AAH02729.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH63446.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT6 Gene

    Alternative splice isoforms for PRMT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT6 Gene

Protein Expression for PRMT6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PRMT6 Gene

  • Automethylation enhances its stability and antiretroviral activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRMT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRMT6 Gene

Domains & Families for PRMT6 Gene

Gene Families for PRMT6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRMT6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRMT6 Gene

GenScript: Design optimal peptide antigens:
  • Histone-arginine N-methyltransferase PRMT6 (ANM6_HUMAN)
  • cDNA FLJ51478 (B4DNF6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LA8

UniProtKB/Swiss-Prot:

ANM6_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
genes like me logo Genes that share domains with PRMT6: view

Function for PRMT6 Gene

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Molecular function for PRMT6 Gene

UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence={ECO:0000269|PubMed:17898714, ECO:0000269|PubMed:18077460, ECO:0000269|PubMed:18079182, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:30420520};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=18.6 uM for AdoMet {ECO:0000269|PubMed:18263580}; KM=501 uM for WGGYSRGGYGGW peptide {ECO:0000269|PubMed:18263580}; KM=183.7 uM for WGGYSR(MMA)GGYGGW monomethylated peptide {ECO:0000269|PubMed:18263580}; Vmax=3.3 nmol/min/mg enzyme with AdoMet as substrate {ECO:0000269|PubMed:18263580}; Vmax=1.8 nmol/min/mg enzyme with WGGYSRGGYGGW peptide as substrate {ECO:0000269|PubMed:18263580}; Vmax=3.2 nmol/min/mg enzyme with WGGYSR(MMA)GGYGGW monomethylated peptide as substrate {ECO:0000269|PubMed:18263580};

Enzyme Numbers (IUBMB) for PRMT6 Gene

Phenotypes From GWAS Catalog for PRMT6 Gene

Gene Ontology (GO) - Molecular Function for PRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16157300
GO:0008168 methyltransferase activity IEA --
GO:0008469 histone-arginine N-methyltransferase activity IEA,TAS --
GO:0016274 protein-arginine N-methyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with PRMT6: view
genes like me logo Genes that share phenotypes with PRMT6: view

Animal Models for PRMT6 Gene

MGI Knock Outs for PRMT6:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT6 Gene

Localization for PRMT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT6 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT6 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11724789
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with PRMT6: view

Pathways & Interactions for PRMT6 Gene

genes like me logo Genes that share pathways with PRMT6: view

Pathways by source for PRMT6 Gene

1 Cell Signaling Technology pathway for PRMT6 Gene
1 GeneTex pathway for PRMT6 Gene

Gene Ontology (GO) - Biological Process for PRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS 16600869
GO:0006325 chromatin organization IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with PRMT6: view

No data available for SIGNOR curated interactions for PRMT6 Gene

Drugs & Compounds for PRMT6 Gene

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(7) Drugs for PRMT6 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Entacapone Approved, Investigational Pharma COMT inhibitor, Potent COMT inhibitor; blocks alpha-synuclein aggregation 55
s-adenosylhomocysteine Experimental Pharma 0
EPZ004777 Pharma DOT1L inhibitor 0
PFI-2 Pharma 0
SGI-1027 Pharma DNMT inhibitor 0

(2) Additional Compounds for PRMT6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3

(4) ApexBio Compounds for PRMT6 Gene

Compound Action Cas Number
Entacapone COMT inhibitor 130929-57-6
EPZ004777 DOT1L inhibitor 1338466-77-5
PFI-2 1627676-59-8
SGI-1027 DNMT inhibitor 1020149-73-8
genes like me logo Genes that share compounds with PRMT6: view

Drug products for research

Transcripts for PRMT6 Gene

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mRNA/cDNA for PRMT6 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT6

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT6 Gene

No ASD Table

Relevant External Links for PRMT6 Gene

GeneLoc Exon Structure for
PRMT6

Expression for PRMT6 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT6 Gene

mRNA expression in normal human tissues for PRMT6 Gene
mRNA expression by GTEx for PRMT6 Gene

Protein differential expression in normal tissues from HIPED for PRMT6 Gene

This gene is overexpressed in Adrenal (37.3) and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRMT6 Gene



Protein tissue co-expression partners for PRMT6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRMT6

SOURCE GeneReport for Unigene cluster for PRMT6 Gene:

Hs.26006

mRNA Expression by UniProt/SwissProt for PRMT6 Gene:

Q96LA8-ANM6_HUMAN
Tissue specificity: Highly expressed in kidney and testis.

Evidence on tissue expression from TISSUES for PRMT6 Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Blood(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with PRMT6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT6 Gene

Orthologs for PRMT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PRMT6 30 31
  • 99.56 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PRMT6 30 31
  • 92.09 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Prmt6 30 17 31
  • 89.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Prmt6 30
  • 89.6 (n)
Dog
(Canis familiaris)
 Mammalia PRMT6 30 31
  • 86.13 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PRMT6 31
  • 83 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 13 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 25 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia prmt6 30
  • 61.13 (n)
Str.3505 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.25304 30
Zebrafish
(Danio rerio)
 Actinopterygii prmt6 30 31
  • 61.26 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008846 30
  • 50.97 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Art8 30
  • 50.46 (n)
CG16840 32
  • 40 (a)
Art2 31
  • 31 (a)
 ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HMT1 31
  • 32 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons PRMT6 30
  • 52 (n)
Rice
(Oryza sativa)
 Liliopsida Os10g0489100 30
  • 52 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9497 31
  • 35 (a)
 OneToOne
Species where no ortholog for PRMT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRMT6 Gene

ENSEMBL:
Gene Tree for PRMT6 (if available)
TreeFam:
Gene Tree for PRMT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRMT6: view image

Paralogs for PRMT6 Gene

Paralogs for PRMT6 Gene

(6) SIMAP similar genes for PRMT6 Gene using alignment to 1 proteins:

  • ANM6_HUMAN
genes like me logo Genes that share paralogs with PRMT6: view

Variants for PRMT6 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRMT6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2232016 - p.Ala194Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRMT6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRMT6 Gene

Variant ID Type Subtype PubMed ID
esv2758957 CNV loss 17122850
nsv482070 CNV gain 20164927
nsv547330 CNV gain 21841781

Variation tolerance for PRMT6 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRMT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT6 Gene

Disorders for PRMT6 Gene

Additional Disease Information for PRMT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PRMT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRMT6 Gene

Publications for PRMT6 Gene

  1. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PMID: 11724789) Frankel A … Bedford MT (The Journal of biological chemistry 2002) 2 3 4 23
  2. Thrombospondin-1 is a transcriptional repression target of PRMT6. (PMID: 19509293) Michaud-Levesque J … Richard S (The Journal of biological chemistry 2009) 3 4 23
  3. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. (PMID: 18079182) Hyllus D … Bauer UM (Genes & development 2007) 3 4 23
  4. Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. (PMID: 17415034) Invernizzi CF … Wainberg MA (AIDS (London, England) 2007) 3 4 23
  5. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. (PMID: 16157300) Miranda TB … Clarke S (Biochemical and biophysical research communications 2005) 3 4 23

ExternalLinks

View latest publications for PRMT6 gene in Mastermind

Products for PRMT6 Gene

  • Addgene plasmids for PRMT6

Sources for PRMT6 Gene