Aliases for PRMT3 Gene
External Ids for PRMT3 Gene
Previous HGNC Symbols for PRMT3 Gene
Previous GeneCards Identifiers for PRMT3 Gene
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for PRMT3 Gene
PRMT3 (Protein Arginine Methyltransferase 3) is a Protein Coding gene. Diseases associated with PRMT3 include Myopathy Of Extraocular Muscle. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and histone-arginine N-methyltransferase activity. An important paralog of this gene is PRMT1.
UniProtKB/Swiss-Prot Summary for PRMT3 Gene
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.