This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript ... See more...

Aliases for PRMT3 Gene

Aliases for PRMT3 Gene

  • Protein Arginine Methyltransferase 3 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 3 4
  • Protein Arginine N-Methyltransferase 3 3 4
  • HRMT1L3 3 4
  • HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 3 3
  • EC 2.1.1.- 4
  • EC 2.1.1 52

External Ids for PRMT3 Gene

Previous HGNC Symbols for PRMT3 Gene

  • HRMT1L3

Previous GeneCards Identifiers for PRMT3 Gene

  • GC11M021595
  • GC11U900019
  • GC11P020448
  • GC11P020373
  • GC11P020092

Summaries for PRMT3 Gene

Entrez Gene Summary for PRMT3 Gene

  • This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRMT3 Gene

PRMT3 (Protein Arginine Methyltransferase 3) is a Protein Coding gene. Diseases associated with PRMT3 include Myopathy Of Extraocular Muscle. Among its related pathways are Metabolism of proteins and Chromatin organization. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and histone-arginine N-methyltransferase activity. An important paralog of this gene is PRMT8.

UniProtKB/Swiss-Prot Summary for PRMT3 Gene

  • Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Tocris Summary for PRMT3 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT3 Gene

Additional gene information for PRMT3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRMT3 Gene

Genomics for PRMT3 Gene

GeneHancer (GH) Regulatory Elements for PRMT3 Gene

Promoters and enhancers for PRMT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J020386 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 507.1 +0.9 866 4 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 MYC POLR2G PRMT3 lnc-DBX1-7 HTATIP2 piR-45035-033
GH11J020458 Enhancer 1.1 Ensembl ENCODE 5.1 +71.8 71771 5.8 ZBTB40 PHB2 ZBTB11 AFF1 TARDBP HES1 ZNF740 NR3C1 MYC CTBP1 HTATIP2 PRMT3 piR-45035-033
GH11J020473 Enhancer 1 Ensembl ENCODE 0.2 +88.7 88670 5.2 ZBTB11 FOXA1 CUX1 ZNF740 JUN TAF9B RELA FOXA2 ZNF316 ARNT HTATIP2 piR-45035-033 HSALNG0083094 PRMT3
GH11J020450 Enhancer 0.6 Ensembl 0.2 +64.3 64271 2 OSR2 FOS CEBPB SPI1 RCOR1 ATF4 ATF3 ATF7 FOXA1 CEBPG piR-45035-033 PRMT3
GH11J020479 Enhancer 0.7 Ensembl 0.2 +92.5 92471 0.4 MYC HDAC3 NCOR1 ZNF282 TRIM24 MAX ZNF592 NFE2 KDM4B TAL1 HTATIP2 piR-45035-033 HSALNG0083094 PRMT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRMT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRMT3

Top Transcription factor binding sites by QIAGEN in the PRMT3 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • Lhx3a
  • N-Myc
  • NF-E2
  • NF-E2 p45
  • POU6F1 (c2)
  • TBP
  • TFIID

Genomic Locations for PRMT3 Gene

Genomic Locations for PRMT3 Gene
chr11:20,387,530-20,509,338
(GRCh38/hg38)
Size:
121,809 bases
Orientation:
Plus strand
chr11:20,409,076-20,530,879
(GRCh37/hg19)
Size:
121,804 bases
Orientation:
Plus strand

Genomic View for PRMT3 Gene

Genes around PRMT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT3 Gene

Proteins for PRMT3 Gene

  • Protein details for PRMT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60678-ANM3_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 3
    Protein Accession:
    O60678
    Secondary Accessions:
    • A0A0A0MSN7
    • B4DUC7

    Protein attributes for PRMT3 Gene

    Size:
    531 amino acids
    Molecular mass:
    59903 Da
    Quaternary structure:
    • Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2.

    Three dimensional structures from OCA and Proteopedia for PRMT3 Gene

    Alternative splice isoforms for PRMT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT3 Gene

Selected DME Specific Peptides for PRMT3 Gene

O60678:
  • HEEMLKD
  • FWDDVYGF
  • DVGCGTGILS
  • MLDSVLYA
  • VLDVGCG
  • IISEWMGY
  • GIHEEML
  • KVVLDVG
  • AKAGAKKV

Post-translational modifications for PRMT3 Gene

  • Ubiquitination at Lys187
  • Modification sites at PhosphoSitePlus

Domains & Families for PRMT3 Gene

Gene Families for PRMT3 Gene

Protein Domains for PRMT3 Gene

Blocks:
  • Methyltransferase type 11
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRMT3 Gene

GenScript: Design optimal peptide antigens:
  • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 (ANM3_HUMAN)
  • PRMT3 protein (Q8WUV3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60678

UniProtKB/Swiss-Prot:

ANM3_HUMAN :
  • The zinc-finger is responsible for substrate specificity.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Domain:
  • The zinc-finger is responsible for substrate specificity.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT3: view

Function for PRMT3 Gene

Molecular function for PRMT3 Gene

UniProtKB/Swiss-Prot Function:
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide and high concentrations of zinc chloride.

Enzyme Numbers (IUBMB) for PRMT3 Gene

Phenotypes From GWAS Catalog for PRMT3 Gene

Gene Ontology (GO) - Molecular Function for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 18573314
GO:0008168 methyltransferase activity IDA 18573314
GO:0016274 protein-arginine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PRMT3: view
genes like me logo Genes that share phenotypes with PRMT3: view

Animal Models for PRMT3 Gene

MGI Knock Outs for PRMT3:
  • Prmt3 Prmt3<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PRMT3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT3 Gene

Localization for PRMT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT3 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm NAS 9642256
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRMT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRMT3 Gene

Pathways & Interactions for PRMT3 Gene

genes like me logo Genes that share pathways with PRMT3: view

Gene Ontology (GO) - Biological Process for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0031397 negative regulation of protein ubiquitination IDA 18573314
GO:0032259 methylation IEA --
GO:0035246 peptidyl-arginine N-methylation IEA --
genes like me logo Genes that share ontologies with PRMT3: view

No data available for SIGNOR curated interactions for PRMT3 Gene

Drugs & Compounds for PRMT3 Gene

(8) Drugs for PRMT3 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma Target 0
2-Hydroxyestradiol Experimental Pharma 0
Chloride ion Experimental Pharma 0
2-Methoxyestradiol Investigational Pharma 9
Histidine Investigational Nutra 59

(7) Additional Compounds for PRMT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Methylhistidine
  • (2S)-2-amino-3-(1-Methyl-1H-imidazol-4-yl)propanoic acid
  • 1-Methylhistidine
  • Pi-methylhistidine
  • (2S)-2-amino-3-(1-Methyl-1H-imidazol-4-yl)propanoate
  • 1 Methylhistidine
332-80-9
5-Hydroxyindoleacetaldehyde
  • 5-Hial
  • 5-Hydroxyindole-3-acetaldehyde
  • (5-Hydroxy-1H-indol-3-yl)acetaldehyde
  • (5-Hydroxyindol-3-yl)acetaldehyde
  • 5-Hydroxy-1H-indole-3-acetaldehyde
1892-21-3
5-Methoxytryptamine
  • 2-(5-Methoxyindol-3-yl)ethylamine
  • 3-(2-Aminoethyl)-5-methoxyindole
  • 5-MeOT
  • 5-Methoxy-1H-indole-3-ethanamine
  • 5-MT
608-07-1
Hordenine
  • 4-[2-(dimethylamino)Ethyl]phenol
  • N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamine
  • N,N-Dimethyl-4-hydroxy-beta-phenethylamine
  • N,N-Dimethyltyramine
  • P-(2-Dimethylaminoethyl)phenol
539-15-1
N-Methyltyramine
  • 4-Hydroxy-N-methylphenethylamine
  • Methyl-4-tyramine
  • P-(2-Methylaminoethyl)phenol
  • 4-(2-(methylamino)Ethyl)-phenol
  • 4-(2-Methylaminoethyl)phenol
370-98-9
genes like me logo Genes that share compounds with PRMT3: view

Transcripts for PRMT3 Gene

mRNA/cDNA for PRMT3 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PRMT3

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2: -

Relevant External Links for PRMT3 Gene

GeneLoc Exon Structure for
PRMT3

Expression for PRMT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT3 Gene

Protein differential expression in normal tissues from HIPED for PRMT3 Gene

This gene is overexpressed in Breast (51.6) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRMT3 Gene



Protein tissue co-expression partners for PRMT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRMT3

SOURCE GeneReport for Unigene cluster for PRMT3 Gene:

Hs.152337

Evidence on tissue expression from TISSUES for PRMT3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PRMT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT3 Gene

Orthologs for PRMT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT3 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT3 31 30
  • 92.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRMT3 31 30
  • 91.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt3 17 31 30
  • 87.1 (n)
rat
(Rattus norvegicus)
Mammalia Prmt3 30
  • 86.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT3 31
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRMT3 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRMT3 31 30
  • 73.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT3 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt3 30
  • 66.6 (n)
MGC76034 30
zebrafish
(Danio rerio)
Actinopterygii prmt3 31 30
  • 63.73 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003593 30
  • 51.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Art3 31 30
  • 47.89 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 31
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12267 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt3 30
  • 49.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01669 30
  • 45.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.11923 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11923 30
Species where no ortholog for PRMT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRMT3 Gene

ENSEMBL:
Gene Tree for PRMT3 (if available)
TreeFam:
Gene Tree for PRMT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRMT3: view image

Paralogs for PRMT3 Gene

Paralogs for PRMT3 Gene

(5) SIMAP similar genes for PRMT3 Gene using alignment to 4 proteins:

  • ANM3_HUMAN
  • E9PLF6_HUMAN
  • E9PRB4_HUMAN
  • Q8WUV3_HUMAN
genes like me logo Genes that share paralogs with PRMT3: view

Variants for PRMT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRMT3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
738329 Benign: not provided 20,397,645(+) C/T MISSENSE_VARIANT
rs11025585 - p.Ser470Cys
rs3758805 - p.Leu440Val
rs6483700 - p.Asn508Ser

Additional dbSNP identifiers (rs#s) for PRMT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRMT3 Gene

Variant ID Type Subtype PubMed ID
esv2616116 CNV deletion 19546169
esv2663802 CNV deletion 23128226
esv2744183 CNV deletion 23290073
esv2744184 CNV deletion 23290073
esv3547406 CNV deletion 23714750
esv3723 CNV loss 18987735
nsv1122587 CNV deletion 24896259
nsv467720 CNV gain 19166990
nsv469939 CNV gain 18288195
nsv553678 CNV gain 21841781
nsv832083 CNV gain 17160897

Variation tolerance for PRMT3 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRMT3 Gene

Human Gene Mutation Database (HGMD)
PRMT3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT3 Gene

Disorders for PRMT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy of extraocular muscle
  • myopathy of extraocular muscles
- elite association - COSMIC cancer census association via MalaCards
Search PRMT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRMT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRMT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT3 Gene

Publications for PRMT3 Gene

  1. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PMID: 15334060) Singh V … Newsham IF (Oncogene 2004) 3 4 23 54
  2. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. (PMID: 9642256) Tang J … Herschman HR (The Journal of biological chemistry 1998) 2 3 4 54
  3. Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3). (PMID: 21059412) Handrkova H … Cmejla R (Biochimica et biophysica acta 2011) 3 4 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S … Im DS (Biochimica et biophysica acta 2008) 3 23 54

Products for PRMT3 Gene

Sources for PRMT3 Gene