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Aliases for PRMT2 Gene
Aliases for PRMT2 Gene
External Ids for PRMT2 Gene
- HGNC: 5186
- Entrez Gene: 3275
- Ensembl: ENSG00000160310
- OMIM: 601961
- UniProtKB: P55345
Previous HGNC Symbols for PRMT2 Gene
- HRMT1L1
Previous GeneCards Identifiers for PRMT2 Gene
- GC21P046880
- GC21P048055
- GC21P033435
Summaries for PRMT2 Gene
GeneCards Summary for PRMT2 Gene
PRMT2 (Protein Arginine Methyltransferase 2) is a Protein Coding gene. Diseases associated with PRMT2 include Breast Cancer. Among its related pathways are Retinoblastoma (RB) in Cancer and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription coactivator activity. An important paralog of this gene is PRMT3.
UniProtKB/Swiss-Prot Summary for PRMT2 Gene
-
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
-
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.
Additional gene information for PRMT2 Gene
- HGNC(5186)
- Entrez Gene(3275)
- Ensembl(ENSG00000160310)
- OMIM(601961)
- UniProtKB(P55345)
- Open Targets Platform(ENSG00000160310)
- Search for PRMT2 at DataMed
- Search for PRMT2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRMT2 Gene
Genomics for PRMT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRMT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRMT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRMT2
- Top Transcription factor binding sites by QIAGEN in the PRMT2 gene promoter:
-
- AP-1
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- ATF-2
- c-Jun
- NF-kappaB1
- STAT1
Genomic Locations for PRMT2 Gene
Genomic Locations for PRMT2 Gene
- chr21:46,635,156-46,665,685
- (GRCh38/hg38)
- Size:
- 30,530 bases
- Orientation:
- Plus strand
- chr21:48,055,079-48,085,155
- (GRCh37/hg19)
- Size:
- 30,077 bases
- Orientation:
- Plus strand
Genomic View for PRMT2 Gene
Genes around PRMT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
PRMT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRMT2 Gene
Proteins for PRMT2 Gene
-
Protein details for PRMT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55345-ANM2_HUMAN
- Recommended name:
- Protein arginine N-methyltransferase 2
- Protein Accession:
- P55345
- B7U630
- B7U631
- B7U632
- P78350
- Q498Y5
- Q5U7D4
- Q6FHF0
- Q99781
- Q9BW15
- Q9UMC2
Protein attributes for PRMT2 Gene
- Size:
- 433 amino acids
- Molecular mass:
- 49042 Da
- Quaternary structure:
-
- Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB. Interacts with HNRNPUL1.
- Miscellaneous:
-
- [Isoform PRMT2Alpha]: Higher expression in breast cancer tissues.
- [Isoform PRMT2Beta]: Higher expression in breast cancer tissues. Doesn't interact with ESR1.
- [Isoform PRMT2Gamma]: Higher expression in breast cancer tissues.
Protein Expression for PRMT2 Gene
Post-translational modifications for PRMT2 Gene
Other Protein References for PRMT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-PRMT2 antibody and Anti-PRMT2 antibody [N1C2]
- NSJ Bioreagents PRMT2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PRMT2
- Novus Biologicals Antibodies for PRMT2
-
Abcam antibodies for PRMT2
- Invitrogen Antibodies for PRMT2 (AFLGC-PRMT2)
-
Boster Bio Antibodies for PRMT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRMT2
- Sino Biological Antibodies for PRMT2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRMT2
- Origene Custom Protein Services for PRMT2
-
Signalway Proteins for PRMT2
-
Abcam proteins for PRMT2
No data available for DME Specific Peptides for PRMT2 Gene
Domains & Families for PRMT2 Gene
Gene Families for PRMT2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PRMT2 Gene
- InterPro:
- Blocks:
-
- SH3 domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PRMT2 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone-arginine N-methyltransferase PRMT2 (ANM2_HUMAN)
- Protein arginine methyltransferase 2, isoform CRA_a (D3DSN9_HUMAN)
- PRMT2 protein (Q49AF9_HUMAN)
- Protein arginine methyltransferase 2, isoform CRA_b (Q5U7D4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P55345UniProtKB/Swiss-Prot:
ANM2_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Function for PRMT2 Gene
Molecular function for PRMT2 Gene
- UniProtKB/Swiss-Prot Function:
- Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence={ECO:0000269|PubMed:19405910};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.6 uM for AdoMet {ECO:0000269|PubMed:19405910}; KM=3.3 uM for H4 {ECO:0000269|PubMed:19405910}; Vmax=1.4 pmol/min/mg enzyme toward S-adenosyl-L-methionine (AdoMet) {ECO:0000269|PubMed:19405910}; Vmax=1.5 pmol/min/mg enzyme toward histone H4 {ECO:0000269|PubMed:19405910};
Enzyme Numbers (IUBMB) for PRMT2 Gene
Phenotypes From GWAS Catalog for PRMT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IDA | 12039952 |
| GO:0005515 | protein binding | IPI | 11513728 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0008469 | histone-arginine N-methyltransferase activity | ISS | -- |
| GO:0016274 | protein-arginine N-methyltransferase activity | ISS | -- |
Phenotypes for PRMT2 Gene
- MGI mutant phenotypes for PRMT2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PRMT2:
Animal Models for PRMT2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRMT2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRMT2 - Select products 50% OFF >
- * PRMT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT2
miRNA for PRMT2 Gene
- miRTarBase miRNAs that target PRMT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT2
- Browse OriGene Inhibitory RNA Products For PRMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT2
Clone Products
- Applied Biological Materials (abm): Clones for PRMT2 - Select products 50% OFF >
- * PRMT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223030
- MR223030
- MR223030L3
- MR223030L4
- MR229945
- MR230097
- RC200461
- RC200461L1
- RC200461L2
- RC200461L3
- RC200461L4
- RC218590
- RC218590L1
- RC218590L2
- RC218590L3
- RC218590L4
- RC232360
- RC232497
- RC233644
- RC236728
- RC237221
- RC237309
- RG200461
- RG218590
- RG232360
- RG232497
- RG233644
- RR209903
- RR209903L3
- RR209903L4
- MR223030L3V
- MR223030L4V
- RC200461L1V
- RC200461L2V
- RC200461L3V
- RC200461L4V
- RC218590L1V
- RC218590L2V
- RC218590L3V
- RC218590L4V
- RR209903L3V
- RR209903L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT2
- Addgene plasmids for PRMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT2
Cell Line Products
-
Horizon Cell Lines for PRMT2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT2 Gene
Localization for PRMT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRMT2 Gene
- [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
- [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.
- [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.
- [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.
- [Isoform PRMT2L2]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 11513728 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 11513728 |
| GO:0005829 | cytosol | IDA | 17587566 |
Pathways & Interactions for PRMT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.41
|
|
| 2 | Retinoblastoma (RB) in Cancer | ||
Pathways by source for PRMT2 Gene
2 BioSystems pathways for PRMT2 Gene
Interacting Proteins for PRMT2 Gene
Selected Interacting proteins:
P55345-ANM2_HUMAN
ENSP00000380759
for PRMT2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PRMT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006479 | protein methylation | IEA,TAS | 9545638 |
| GO:0007165 | signal transduction | TAS | 9545638 |
| GO:0016571 | histone methylation | ISS | -- |
| GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | IEA | -- |
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity | IDA | 16648481 |
No data available for SIGNOR curated interactions for PRMT2 Gene
Drugs & Compounds for PRMT2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
|
Transcripts for PRMT2 Gene
mRNA/cDNA for PRMT2 Gene
- 8 REFSEQ mRNAs :
- 38 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291705 1011 nts (view in UCSC)
- ENST00000334494 1334 nts (view in UCSC)
- ENST00000355680 2354 nts (view in UCSC)
- ENST00000397628 954 nts (view in UCSC)
- ENST00000397637 2880 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRMT2 - Select products 50% OFF >
- * PRMT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT2
- Browse OriGene Inhibitory RNA Products For PRMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT2
Clone Products
- Applied Biological Materials (abm): Clones for PRMT2 - Select products 50% OFF >
- * PRMT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223030
- MR223030
- MR223030L3
- MR223030L4
- MR229945
- MR230097
- RC200461
- RC200461L1
- RC200461L2
- RC200461L3
- RC200461L4
- RC218590
- RC218590L1
- RC218590L2
- RC218590L3
- RC218590L4
- RC232360
- RC232497
- RC233644
- RC236728
- RC237221
- RC237309
- RG200461
- RG218590
- RG232360
- RG232497
- RG233644
- RR209903
- RR209903L3
- RR209903L4
- MR223030L3V
- MR223030L4V
- RC200461L1V
- RC200461L2V
- RC200461L3V
- RC200461L4V
- RC218590L1V
- RC218590L2V
- RC218590L3V
- RC218590L4V
- RR209903L3V
- RR209903L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT2
- Addgene plasmids for PRMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: |
| ExUns: | 8d | · | 8e | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||
| SP23: | - | - | - | ||||||||||||||||||||||||||||
| SP24: |
Relevant External Links for PRMT2 Gene
- GeneLoc Exon Structure for
- PRMT2
Expression for PRMT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Kidney (Urinary System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Fetal Brain (19.3), Peripheral blood mononuclear cells (12.6), Testis (10.3), and Ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRMT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRMT2
SOURCE GeneReport for Unigene cluster for PRMT2 Gene:
Hs.154163mRNA Expression by UniProt/SwissProt for PRMT2 Gene:
P55345-ANM2_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Evidence on tissue expression from TISSUES for PRMT2 Gene
- Nervous system(5)
- Kidney(4.7)
- Lung(3.8)
- Skin(3.6)
- Eye(2.8)
- Heart(2.6)
- Pancreas(2.5)
- Muscle(2.5)
- Intestine(2.4)
- Blood(2.2)
- Lymph node(2.1)
- Spleen(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for PRMT2
-
OriGene qPCR primer pairs and template standards for PRMT2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT2 Gene
Orthologs for PRMT2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PRMT2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HRMT1L1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PRMT2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Prmt2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prmt2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PRMT2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prmt2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | prmt2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Art8 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 31 |
|
OneToMany |
- Species where no ortholog for PRMT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PRMT2 Gene
- ENSEMBL:
- Gene Tree for PRMT2 (if available)
- TreeFam:
- Gene Tree for PRMT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRMT2: view image
Paralogs for PRMT2 Gene
(6) SIMAP similar genes for PRMT2 Gene using alignment to 9 proteins:
- ANM2_HUMAN
- A8MXR3_HUMAN
- B7U630_HUMAN
- B7U631_HUMAN
- B7U632_HUMAN
- D3DSN9_HUMAN
- H7C2H9_HUMAN
- Q49AF9_HUMAN
- Q5U7D4_HUMAN
Variants for PRMT2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRMT2 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710386 | Benign: not provided | 46,644,495(+) | C/T | INTRON_VARIANT | |
| 718694 | Benign: not provided | 46,661,896(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| 743660 | Likely Benign: not provided | 46,660,825(+) | T/C | THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 748626 | Likely Benign: not provided | 46,649,679(+) | T/C | SYNONYMOUS_VARIANT | |
| 764005 | Likely Benign: not provided | 46,661,935(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4441n100 | CNV | gain | 25217958 |
| dgv4442n100 | CNV | gain | 25217958 |
| dgv4443n100 | CNV | gain | 25217958 |
| dgv4444n100 | CNV | gain | 25217958 |
| dgv4446n100 | CNV | gain | 25217958 |
| dgv4447n100 | CNV | loss | 25217958 |
| dgv4448n100 | CNV | gain | 25217958 |
| dgv4449n100 | CNV | gain+loss | 25217958 |
| esv1540677 | CNV | insertion | 17803354 |
| esv2658047 | CNV | deletion | 23128226 |
| esv2758822 | CNV | gain | 17122850 |
| esv34393 | CNV | gain | 17911159 |
| esv3647171 | CNV | gain | 21293372 |
| esv3647172 | CNV | loss | 21293372 |
| esv3647173 | CNV | gain | 21293372 |
| esv3647174 | CNV | loss | 21293372 |
| nsv1059706 | CNV | gain | 25217958 |
| nsv1078938 | CNV | insertion | 25765185 |
| nsv1125229 | CNV | insertion | 24896259 |
| nsv1129228 | CNV | insertion | 24896259 |
| nsv1129684 | CNV | tandem duplication | 24896259 |
| nsv470910 | CNV | gain | 18288195 |
| nsv587999 | CNV | gain | 21841781 |
| nsv588002 | CNV | gain | 21841781 |
| nsv9864 | CNV | gain | 18304495 |
| nsv9865 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRMT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRMT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT2 Gene
Disorders for PRMT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
Search PRMT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRMT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT2 Gene
Publications for PRMT2 Gene
- Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott HS … Henry MF (Genomics 1998) 2 3 4 23
- Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski TM … Frankel A (The Biochemical journal 2009) 3 4 23
- Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. (PMID: 9196002) Katsanis N … Fisher EM (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 3 4 23
- Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma. (PMID: 22093364) Zhong J … Wen GB (The FEBS journal 2012) 3 4
- Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. (PMID: 21820040) Zhong J … Wen GB (Gene 2011) 3 4
ExternalLinks
Products for PRMT2 Gene
- Custom Antibody ServicesOriGene Antibodies for PRMT2
- Browse OriGene ELISA Kits
- Custom Assay Services
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- MG223030
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- MR229945
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- RC232360
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- RG200461
- RG218590
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- RR209903
- RR209903L3
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- MR223030L3V
- MR223030L4V
- RC200461L1V
- RC200461L2V
- RC200461L3V
- RC200461L4V
- RC218590L1V
- RC218590L2V
- RC218590L3V
- RC218590L4V
- RR209903L3V
- RR209903L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRMT2
- Sino Biological Human cDNA Clone for PRMT2
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- Sino Biological Antibodies for PRMT2
- Browse Sino Biological Assays
- Browse Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for PRMT2
- Novus Biologicals proteins and lysates for PRMT2
- Browse Antibodies
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- Abcam antibodies for PRMT2
- Abcam proteins for PRMT2
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- Taconic Biosciences Mouse Models for PRMT2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRMT2 (AFLGC-PRMT2)
- VectorBuilder Custom and pre-made DNA vectors for PRMT2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRMT2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRMT2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRMT2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRMT2
- Addgene plasmids for PRMT2
- antibodies-online: Show 51 available PRMT2 Antibodies ranked by validation data
- Compare Top PRMT2 Antibodies
- antibodies-online: Search results for available PRMT2 related products ranked by validation data
- antibodies-online: Show 8 available PRMT2 Proteins ranked by validation data
- Compare Top PRMT2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PRMT2
- Search Santa Cruz Biotechnology (SCBT) for PRMT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRMT2
- Horizon Cell Lines for PRMT2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT2
- Boster Bio Antibodies for PRMT2
- Browse Boster Bio ELISA Kits
- Signalway Proteins for PRMT2
Sources for PRMT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB