Aliases for PRMT2 Gene
External Ids for PRMT2 Gene
Previous HGNC Symbols for PRMT2 Gene
Previous GeneCards Identifiers for PRMT2 Gene
GeneCards Summary for PRMT2 Gene
PRMT2 (Protein Arginine Methyltransferase 2) is a Protein Coding gene. Diseases associated with PRMT2 include Breast Cancer. Among its related pathways are Retinoblastoma (RB) in Cancer and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription coactivator activity. An important paralog of this gene is PRMT3.
UniProtKB/Swiss-Prot Summary for PRMT2 Gene
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.