Aliases for PRMT2 Gene
Aliases for PRMT2 Gene
External Ids for PRMT2 Gene
- HGNC: 5186
- Entrez Gene: 3275
- Ensembl: ENSG00000160310
- OMIM: 601961
- UniProtKB: P55345
Previous HGNC Symbols for PRMT2 Gene
- HRMT1L1
Previous GeneCards Identifiers for PRMT2 Gene
- GC21P046880
- GC21P048055
- GC21P033435
Summaries for PRMT2 Gene
GeneCards Summary for PRMT2 Gene
PRMT2 (Protein Arginine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription coactivator activity. An important paralog of this gene is PRMT6.
UniProtKB/Swiss-Prot for PRMT2 Gene
-
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
-
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT2 Gene
Genomics for PRMT2 Gene
GeneHancer (GH) Regulatory Elements for PRMT2 Gene
Promoters and enhancers for PRMT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRMT2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRMT2 gene promoter:
-
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- AP-1
- STAT1
- ATF-2
- c-Jun
- NF-kappaB1
Regulatory Element Products
Genomic Locations for PRMT2 Gene
Genomic Locations for PRMT2 Gene
- chr21:46,635,153-46,665,685
- (GRCh38/hg38)
- Size:
- 30,533 bases
- Orientation:
- Plus strand
- chr21:48,055,079-48,085,155
- (GRCh37/hg19)
- Size:
- 30,077 bases
- Orientation:
- Plus strand
Genomic View for PRMT2 Gene
Genes around PRMT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
- 21q22.3 by Ensembl
PRMT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRMT2 Gene
Proteins for PRMT2 Gene
-
Protein details for PRMT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55345-ANM2_HUMAN
- Recommended name:
- Protein arginine N-methyltransferase 2
- Protein Accession:
- P55345
- B7U630
- B7U631
- B7U632
- P78350
- Q498Y5
- Q5U7D4
- Q6FHF0
- Q99781
- Q9BW15
- Q9UMC2
Protein attributes for PRMT2 Gene
- Size:
- 433 amino acids
- Molecular mass:
- 49042 Da
- Quaternary structure:
-
- Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB. Interacts with HNRNPUL1.
Protein Expression for PRMT2 Gene
Post-translational modifications for PRMT2 Gene
Other Protein References for PRMT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRMT2
-
Abcam antibodies for PRMT2
- Invitrogen Antibodies for PRMT2 (AFLGC-PRMT2)
- GeneTex PRMT2 Antibody for PRMT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRMT2
- Sino Biological Antibodies for PRMT2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRMT2
- Origene Custom Protein Services for PRMT2
- Search GeneTex for Proteins for PRMT2
-
Abcam proteins for PRMT2
Assay Products
- antibodies-online: Search results for 1 available PRMT2 Elisa Kits ranked by validation data
- Compare Top PRMT2 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for PRMT2 Gene
Domains & Families for PRMT2 Gene
Gene Families for PRMT2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PRMT2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRMT2 Gene
Graphical View of Domain Structure for InterPro Entry
P55345UniProtKB/Swiss-Prot:
ANM2_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Function for PRMT2 Gene
Molecular function for PRMT2 Gene
- UniProtKB/Swiss-Prot Function:
- Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.6 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=3.3 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.4 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.5 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
Enzyme Numbers (IUBMB) for PRMT2 Gene
Phenotypes From GWAS Catalog for PRMT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IDA | 12039952 |
| GO:0004871 | obsolete signal transducer activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 11513728 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0008469 | histone-arginine N-methyltransferase activity | ISS | -- |
Phenotypes for PRMT2 Gene
- MGI mutant phenotypes for PRMT2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PRMT2:
Animal Models for PRMT2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRMT2
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRMT2
-
CRISPR Products
-
OriGene CRISPR knockouts for PRMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT2
- genomics-online: gRNA clones - Search results for 145 available PRMT2 gene related products
- Overview of 145 available PRMT2 gene related products
- Applied Biological Materials CRISPR for PRMT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT2
- GenScript: Design CRISPR guide RNA sequences for PRMT2
miRNA for PRMT2 Gene
- miRTarBase miRNAs that target PRMT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT2
- Browse OriGene Inhibitory RNA Products For PRMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT2
- genomics-online: shRNA clones - Search results for 145 available PRMT2 gene related products
- Overview of 145 available PRMT2 gene related products
Clone Products
-
OriGene ORF clones in human for PRMT2
- RC200461
- RC200461L1
- RC200461L2
- RC200461L3
- RC200461L4
- RC218590
- RC218590L1
- RC218590L2
- RC218590L3
- RC218590L4
- RC232360
- RC232497
- RC233644
- RC236728
- RC237221
- RC237309
- RC518590
- RG200461
- RG218590
- RG232360
- RG232497
- RG233644
- RC200461L1V
- RC200461L2V
- RC200461L3V
- RC200461L4V
- RC218590L1V
- RC218590L2V
- RC218590L3V
- RC218590L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT2
- Addgene plasmids for PRMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT2
- Applied Biological Materials Clones for PRMT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRMT2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT2 Gene
Localization for PRMT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRMT2 Gene
- Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
- Isoform PRMT2Alpha: Nucleus. Note=Excluded from nucleolus.
- Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus.
- Isoform PRMT2Gamma: Nucleus. Note=Excluded from nucleolus.
- Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 11513728 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 11513728 |
| GO:0005829 | cytosol | IDA | 17587566 |
Pathways & Interactions for PRMT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.41
|
|
| 2 | Retinoblastoma (RB) in Cancer | ||
Pathways by source for PRMT2 Gene
2 BioSystems pathways for PRMT2 Gene
Interacting Proteins for PRMT2 Gene
Selected Interacting proteins:
P55345-ANM2_HUMAN
ENSP00000347906
for PRMT2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PRMT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IBA | -- |
| GO:0006479 | protein methylation | TAS,IEA | 9545638 |
| GO:0007165 | signal transduction | TAS | 9545638 |
| GO:0016571 | histone methylation | ISS | -- |
| GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | IEA | -- |
No data available for SIGNOR curated interactions for PRMT2 Gene
Drugs & Compounds for PRMT2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
|
Drug Products
Transcripts for PRMT2 Gene
mRNA/cDNA for PRMT2 Gene
- (14) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (674) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000355680 2688 bps (uc002zjx.5)
- ENST00000397638 2131 bps (uc002zjy.5)
- ENST00000291705 1011 bps (uc011agc.4)
- ENST00000397637 2880 bps (uc062bak.1)
- ENST00000334494 1334 bps (uc021wkc.3)
Unigene Clusters for PRMT2 Gene
- Protein arginine methyltransferase 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PRMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT2
- genomics-online: gRNA clones - Search results for 145 available PRMT2 gene related products
- Overview of 145 available PRMT2 gene related products
- Applied Biological Materials CRISPR for PRMT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT2
- GenScript: Design CRISPR guide RNA sequences for PRMT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT2
- Browse OriGene Inhibitory RNA Products For PRMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT2
- genomics-online: shRNA clones - Search results for 145 available PRMT2 gene related products
- Overview of 145 available PRMT2 gene related products
Clone Products
-
OriGene ORF clones in human for PRMT2
- RC200461
- RC200461L1
- RC200461L2
- RC200461L3
- RC200461L4
- RC218590
- RC218590L1
- RC218590L2
- RC218590L3
- RC218590L4
- RC232360
- RC232497
- RC233644
- RC236728
- RC237221
- RC237309
- RC518590
- RG200461
- RG218590
- RG232360
- RG232497
- RG233644
- RC200461L1V
- RC200461L2V
- RC200461L3V
- RC200461L4V
- RC218590L1V
- RC218590L2V
- RC218590L3V
- RC218590L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT2
- Addgene plasmids for PRMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT2
- Applied Biological Materials Clones for PRMT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: |
| ExUns: | 8d | · | 8e | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||
| SP23: | - | - | - | ||||||||||||||||||||||||||||
| SP24: |
Expression for PRMT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Kidney (Urinary System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Fetal Brain (19.3), Peripheral blood mononuclear cells (12.6), Testis (10.3), and Ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRMT2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRMT2 Gene:
PRMT2SOURCE GeneReport for Unigene cluster for PRMT2 Gene:
Hs.154163mRNA Expression by UniProt/SwissProt for PRMT2 Gene:
P55345-ANM2_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Evidence on tissue expression from TISSUES for PRMT2 Gene
- Nervous system(4.9)
- Kidney(4.5)
- Lung(3.7)
- Skin(3.1)
- Eye(2.8)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for PRMT2
-
OriGene qPCR primer pairs and template standards for PRMT2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT2 Gene
Orthologs for PRMT2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRMT2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HRMT1L1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PRMT2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Prmt2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prmt2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRMT2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prmt2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prmt2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Art8 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 34 |
|
OneToMany |
- Species where no ortholog for PRMT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PRMT2 Gene
- ENSEMBL:
- Gene Tree for PRMT2 (if available)
- TreeFam:
- Gene Tree for PRMT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRMT2: view image
Paralogs for PRMT2 Gene
(6) SIMAP similar genes for PRMT2 Gene using alignment to 9 proteins:
- ANM2_HUMAN
- A8MXR3_HUMAN
- B7U630_HUMAN
- B7U631_HUMAN
- B7U632_HUMAN
- D3DSN9_HUMAN
- H7C2H9_HUMAN
- Q49AF9_HUMAN
- Q5U7D4_HUMAN
Variants for PRMT2 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000056257 | -- | 46,659,215(+) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000068805 | -- | 46,635,721(+) | C/T | 5_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000081676 | -- | 46,640,149(+) | C/T | intron_variant | |
| rs1000088438 | -- | 46,659,495(+) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000341565 | -- | 46,647,114(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4441n100 | CNV | gain | 25217958 |
| dgv4442n100 | CNV | gain | 25217958 |
| dgv4443n100 | CNV | gain | 25217958 |
| dgv4444n100 | CNV | gain | 25217958 |
| dgv4446n100 | CNV | gain | 25217958 |
| dgv4447n100 | CNV | loss | 25217958 |
| dgv4448n100 | CNV | gain | 25217958 |
| dgv4449n100 | CNV | gain+loss | 25217958 |
| esv1540677 | CNV | insertion | 17803354 |
| esv2658047 | CNV | deletion | 23128226 |
| esv2758822 | CNV | gain | 17122850 |
| esv34393 | CNV | gain | 17911159 |
| esv3647171 | CNV | gain | 21293372 |
| esv3647172 | CNV | loss | 21293372 |
| esv3647173 | CNV | gain | 21293372 |
| esv3647174 | CNV | loss | 21293372 |
| nsv1059706 | CNV | gain | 25217958 |
| nsv1078938 | CNV | insertion | 25765185 |
| nsv1125229 | CNV | insertion | 24896259 |
| nsv1129228 | CNV | insertion | 24896259 |
| nsv1129684 | CNV | tandem duplication | 24896259 |
| nsv470910 | CNV | gain | 18288195 |
| nsv587999 | CNV | gain | 21841781 |
| nsv588002 | CNV | gain | 21841781 |
| nsv9864 | CNV | gain | 18304495 |
| nsv9865 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.68;
14.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRMT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRMT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT2 Gene
Disorders for PRMT2 Gene
Additional Disease Information for PRMT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PRMT2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRMT2 Gene
Publications for PRMT2 Gene
- Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott HS … Henry MF (Genomics 1998) 2 3 4 22 58
- Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski TM … Frankel A (The Biochemical journal 2009) 3 4 22 58
- Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. (PMID: 9196002) Katsanis N … Fisher EM (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 3 4 22 58
- Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma. (PMID: 22093364) Zhong J … Wen GB (The FEBS journal 2012) 3 4 58
- Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. (PMID: 21820040) Zhong J … Wen GB (Gene 2011) 3 4 58
Products for PRMT2 Gene
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- Taconic Biosciences Mouse Models for PRMT2
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Sources for PRMT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt