This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type ... See more...

Aliases for PRMT1 Gene

Aliases for PRMT1 Gene

  • Protein Arginine Methyltransferase 1 2 3 5
  • HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 2 2 3
  • Histone-Arginine N-Methyltransferase PRMT1 3 4
  • Protein Arginine N-Methyltransferase 1 3 4
  • Interferon Receptor 1-Bound Protein 4 3 4
  • HRMT1L2 3 4
  • IR1B4 3 4
  • ANM1 2 3
  • HCP1 2 3
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase 1-Like 2 3
  • HMT1 HnRNP Methyltransferase-Like 2 (S. Cerevisiae) 2
  • EC 2.1.1.319 4
  • EC 2.1.1.77 51
  • EC 2.1.1 51
  • PRMT1 5
  • HMT2 4

External Ids for PRMT1 Gene

Previous HGNC Symbols for PRMT1 Gene

  • HRMT1L2

Previous GeneCards Identifiers for PRMT1 Gene

  • GC19P054873
  • GC19P050181
  • GC19P046557

Summaries for PRMT1 Gene

Entrez Gene Summary for PRMT1 Gene

  • This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRMT1 Gene

PRMT1 (Protein Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with PRMT1 include Ewing Sarcoma and Nemaline Myopathy 5. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRMT8.

UniProtKB/Swiss-Prot Summary for PRMT1 Gene

  • Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Tocris Summary for PRMT1 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRMT1 Gene

Genomics for PRMT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRMT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRMT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRMT1

Top Transcription factor binding sites by QIAGEN in the PRMT1 gene promoter:
  • AP-1
  • ATF-2
  • NF-kappaB
  • NF-kappaB1
  • p300
  • p53
  • STAT1

Genomic Locations for PRMT1 Gene

Latest Assembly
chr19:49,675,786-49,689,029
(GRCh38/hg38)
Size:
13,244 bases
Orientation:
Plus strand

Previous Assembly
chr19:50,180,528-50,191,704
(GRCh37/hg19 by Entrez Gene)
Size:
11,177 bases
Orientation:
Plus strand

chr19:50,179,043-50,192,286
(GRCh37/hg19 by Ensembl)
Size:
13,244 bases
Orientation:
Plus strand

Genomic View for PRMT1 Gene

Genes around PRMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT1 Gene

Proteins for PRMT1 Gene

  • Protein details for PRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99873-ANM1_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 1
    Protein Accession:
    Q99873
    Secondary Accessions:
    • A0A087X1W2
    • B4E3C3
    • G5E9B6
    • H7C2I1
    • Q15529
    • Q2VP93
    • Q6LEU5
    • Q8WUW5
    • Q99872
    • Q99874
    • Q9NZ04
    • Q9NZ05
    • Q9NZ06

    Protein attributes for PRMT1 Gene

    Size:
    371 amino acids
    Molecular mass:
    42462 Da
    Quaternary structure:
    • Homodimer (PubMed:16879614, PubMed:26876602). Homooctamer; individual homodimers associates to form a homooctamer (PubMed:26876602). Individual homodimers can associate to form a homohexamer. Heterodimer with PRMT8. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress. Interacts with and probably methylates ATXN2L (PubMed:25748791). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with DHX9 (via RGG region) (PubMed:15084609). Interacts (via N-terminus) with HABP4 (PubMed:16879614).
    SequenceCaution:
    • Sequence=AAF62894.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF62895.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI09283.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI09284.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA11029.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA71764.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA71765.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT1 Gene

    Alternative splice isoforms for PRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT1 Gene

Selected DME Specific Peptides for PRMT1 Gene

Q99873:
  • HEEMLKD
  • LDFKGQLC
  • VTNACLIKEVDIYTVK
  • IISEWMGY
  • FPDRATLYV
  • GTGILCMFAA
  • VLDVGSG
  • DYYFDSY
  • LYVTAIED
  • GIHEEML
  • KVVLDVG

Post-translational modifications for PRMT1 Gene

  • Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation. Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.
  • Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex. Acetylated at Lys-233 by p300/EP300. Deacetylated at Lys-228 and Lys-233 by SIRT1.
  • Ubiquitination at Lys113, Lys134, Lys145, Lys183, Lys276, Lys233, Lys243, Lys313, and Lys342
  • Modification sites at PhosphoSitePlus

Domains & Families for PRMT1 Gene

Gene Families for PRMT1 Gene

Protein Domains for PRMT1 Gene

Suggested Antigen Peptide Sequences for PRMT1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon receptor 1-bound protein 4 (ANM1_HUMAN)
  • cDNA FLJ60588, highly similar to Protein arginine N-methyltransferase 1 (EC 2.1.1.-) (B4DJ87_HUMAN)
  • Protein arginine methyltransferase 1 isoform 4 (Q5U8W9_HUMAN)
  • PRMT1 protein (Q8WUW5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99873

UniProtKB/Swiss-Prot:

ANM1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT1: view

Function for PRMT1 Gene

Molecular function for PRMT1 Gene

UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence={ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:11448779, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:28040436};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1 uM for AdoMet {ECO:0000269|PubMed:19405910}; KM=4.2 uM for H4 {ECO:0000269|PubMed:19405910}; Vmax=1.2 nmol/min/mg enzyme toward AdoMet {ECO:0000269|PubMed:19405910}; Vmax=1.24 nmol/min/mg enzyme toward H4 {ECO:0000269|PubMed:19405910};
UniProtKB/Swiss-Prot EnzymeRegulation:
By BTG1, BTG2 and ILF3.

Enzyme Numbers (IUBMB) for PRMT1 Gene

Phenotypes From GWAS Catalog for PRMT1 Gene

Gene Ontology (GO) - Molecular Function for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 8663146
GO:0008168 methyltransferase activity IEA,TAS 9545638
GO:0008170 N-methyltransferase activity TAS,IMP 19124016
GO:0008276 protein methyltransferase activity IEA,IMP 28040436
genes like me logo Genes that share ontologies with PRMT1: view
genes like me logo Genes that share phenotypes with PRMT1: view

Animal Models for PRMT1 Gene

MGI Knock Outs for PRMT1:
  • Prmt1 Prmt1<tm1a(EUCOMM)Wtsi>
  • Prmt1 Prmt1<tm1.1Rchd>

Animal Models for research

  • Taconic Biosciences Mouse Models for PRMT1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT1

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT1 Gene

Localization for PRMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT1 Gene

Nucleus. Nucleus, nucleoplasm. Cytoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250 UniProtKB:Q9JIF0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10749851
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm TAS,IDA 26876602
GO:0005829 cytosol IEA --
GO:0034709 methylosome IDA 25284789
genes like me logo Genes that share ontologies with PRMT1: view

Pathways & Interactions for PRMT1 Gene

genes like me logo Genes that share pathways with PRMT1: view

Pathways by source for PRMT1 Gene

2 KEGG pathways for PRMT1 Gene
1 GeneGo (Thomson Reuters) pathway for PRMT1 Gene
  • Immune response IFN alpha/beta signaling pathway
3 Qiagen pathways for PRMT1 Gene
  • Cell Cycle Control by BTG Proteins
  • Crosstalk Between CARM1 and ESRs
  • Nuclear Receptor Activation by Vitamin-A
1 Cell Signaling Technology pathway for PRMT1 Gene
1 GeneTex pathway for PRMT1 Gene

SIGNOR curated interactions for PRMT1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006479 protein methylation TAS,IMP 26876602
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9029147
GO:0008284 positive regulation of cell proliferation IMP 28040436
genes like me logo Genes that share ontologies with PRMT1: view

Drugs & Compounds for PRMT1 Gene

(12) Drugs for PRMT1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma Target 0
AMI-1 Pharma PRMT1 inhibitor 0
C 21 Pharma Protein arginine methyltransferase 1 (PRMT1) inhibitor, Selective PRMT1 inhibitor 0
C7280948 Pharma Novel PRMT1 inhibitor 0
TC-E 5003 Pharma PRMT1 inhibitor, potent, Selective PRMT1 inhibitor 0

(4) Additional Compounds for PRMT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3

(4) ApexBio Compounds for PRMT1 Gene

Compound Action Cas Number
AMI-1 PRMT1 inhibitor
C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor 1229236-78-5
C7280948 Novel PRMT1 inhibitor 587850-67-7
TC-E 5003 PRMT1 inhibitor, potent 17328-16-4
genes like me logo Genes that share compounds with PRMT1: view

Drug products for research

Transcripts for PRMT1 Gene

mRNA/cDNA for PRMT1 Gene

4 REFSEQ mRNAs :
105 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: -
SP13: - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - -
SP20: - - -
SP21:
SP22:

ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for PRMT1 Gene

GeneLoc Exon Structure for
PRMT1

Expression for PRMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRMT1 Gene

This gene is overexpressed in Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRMT1 Gene



Protein tissue co-expression partners for PRMT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRMT1

SOURCE GeneReport for Unigene cluster for PRMT1 Gene:

Hs.20521

mRNA Expression by UniProt/SwissProt for PRMT1 Gene:

Q99873-ANM1_HUMAN
Tissue specificity: Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).

Evidence on tissue expression from TISSUES for PRMT1 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Skin(4.1)
  • Muscle(3.3)
  • Eye(3.1)
  • Heart(2.9)
  • Intestine(2.8)
  • Kidney(2.8)
  • Blood(2.6)
  • Thyroid gland(2.6)
  • Liver(2.5)
  • Adrenal gland(2.5)
  • Lymph node(2.5)
  • Spleen(2.5)
  • Bone marrow(2.4)
  • Pancreas(2.2)
  • Bone(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with PRMT1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT1 Gene

Orthologs for PRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia PRMT1 30 31
  • 95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRMT1 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PRMT1 30 31
  • 93.62 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prmt1 30 17 31
  • 92.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prmt1 30
  • 90.75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia PRMT1 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prmt1 30
  • 78.56 (n)
Str.4974 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.23295 30
Zebrafish
(Danio rerio)
Actinopterygii prmt1 30 31
  • 78.43 (n)
OneToOne
zgc66201 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2791 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003462 30
  • 73.96 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Art1 30 31
  • 68.95 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea prmt-1 30 31
  • 67.37 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR190W 30
  • 59.5 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 30 31
  • 55.05 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07117g 30
  • 54.79 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PRMT1A 30
  • 58.84 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0359800 30
  • 59.16 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2169 31
  • 70 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU07459 30
  • 64.41 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt1 30
  • 55.87 (n)
Species where no ortholog for PRMT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRMT1 Gene

ENSEMBL:
Gene Tree for PRMT1 (if available)
TreeFam:
Gene Tree for PRMT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRMT1: view image

Paralogs for PRMT1 Gene

Paralogs for PRMT1 Gene

(7) SIMAP similar genes for PRMT1 Gene using alignment to 11 proteins:

  • ANM1_HUMAN
  • E9PI83_HUMAN
  • E9PIE2_HUMAN
  • E9PIX6_HUMAN
  • E9PKG1_HUMAN
  • E9PMW9_HUMAN
  • E9PMZ2_HUMAN
  • E9PNR9_HUMAN
  • E9PQ98_HUMAN
  • H0YDE4_HUMAN
  • H7C2I1_HUMAN

Pseudogenes.org Pseudogenes for PRMT1 Gene

genes like me logo Genes that share paralogs with PRMT1: view

Variants for PRMT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRMT1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs79863139 Benign: not provided 49,680,531(+) G/A
NM_001536.5(PRMT1):c.135G>A (p.Glu45=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs11673683 - p.Leu168Phe
rs1804486 - p.Lys88Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRMT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRMT1 Gene

Variant ID Type Subtype PubMed ID
esv24796 CNV loss 19812545
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv7308 OTHER inversion 18451855
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for PRMT1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT1 Gene

Disorders for PRMT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRMT1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
nemaline myopathy 5
  • nem5
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search PRMT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRMT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PRMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT1 Gene

Publications for PRMT1 Gene

  1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott HS … Henry MF (Genomics 1998) 2 3 4 23
  2. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski TM … Frankel A (The Biochemical journal 2009) 3 4 23
  3. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PMID: 19124016) Jobert L … Tora L (Experimental cell research 2009) 3 4 23
  4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41
  5. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. (PMID: 18773938) Miyata S … Tohyama M (Neuroscience letters 2008) 3 4 23

Products for PRMT1 Gene