Aliases for PRMT1 Gene
Aliases for PRMT1 Gene
External Ids for PRMT1 Gene
- HGNC: 5187
- Entrez Gene: 3276
- Ensembl: ENSG00000126457
- OMIM: 602950
- UniProtKB: Q99873
Previous HGNC Symbols for PRMT1 Gene
- HRMT1L2
Previous GeneCards Identifiers for PRMT1 Gene
- GC19P054873
- GC19P050181
- GC19P046557
Summaries for PRMT1 Gene
-
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
GeneCards Summary for PRMT1 Gene
PRMT1 (Protein Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with PRMT1 include Ewing Sarcoma. Among its related pathways are Gene Expression and FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRMT8.
UniProtKB/Swiss-Prot for PRMT1 Gene
-
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
-
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT1 Gene
Genomics for PRMT1 Gene
GeneHancer (GH) Regulatory Elements for PRMT1 Gene
Promoters and enhancers for PRMT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRMT1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRMT1 gene promoter:
-
- STAT1
- p53
- AP-1
- p300
- ATF-2
- NF-kappaB1
- NF-kappaB
Regulatory Element Products
Genomic Locations for PRMT1 Gene
Genomic Locations for PRMT1 Gene
- chr19:49,675,786-49,689,029
- (GRCh38/hg38)
- Size:
- 13,244 bases
- Orientation:
- Plus strand
- chr19:50,179,043-50,192,286
- (GRCh37/hg19)
- Size:
- 13,244 bases
- Orientation:
- Plus strand
Genomic View for PRMT1 Gene
Genes around PRMT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
- 19q13.33 by Ensembl
PRMT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRMT1 Gene
Proteins for PRMT1 Gene
-
Protein details for PRMT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99873-ANM1_HUMAN
- Recommended name:
- Protein arginine N-methyltransferase 1
- Protein Accession:
- Q99873
- A0A087X1W2
- B4E3C3
- G5E9B6
- H7C2I1
- Q15529
- Q2VP93
- Q6LEU5
- Q8WUW5
- Q99872
- Q99874
- Q9NZ04
- Q9NZ05
- Q9NZ06
Protein attributes for PRMT1 Gene
- Size:
- 371 amino acids
- Molecular mass:
- 42462 Da
- Quaternary structure:
-
- Homodimer (PubMed:16879614). Heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress. Interacts with and probably methylates ATXN2L (PubMed:25748791). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with DHX9 (via RGG region) (PubMed:15084609). Interacts (via N-terminus) with HABP4 (PubMed:16879614).
- SequenceCaution:
-
- Sequence=AAF62894.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF62895.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI09283.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI09284.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA11029.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA71764.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA71765.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PRMT1 Gene
Post-translational modifications for PRMT1 Gene
Other Protein References for PRMT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRMT1 (PRMT1)
-
Custom Antibody ServicesOriGene Antibodies for PRMT1
- Novus Biologicals Antibodies for PRMT1
-
Abcam antibodies for PRMT1
- Invitrogen Antibodies for PRMT1
- GeneTex PRMT1 Antibody for PRMT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRMT1
- Sino Biological Antibodies for PRMT1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRMT1
- Origene Custom Protein Services for PRMT1
- ProSpec Recombinant Proteins for PRMT1
- Search GeneTex for Proteins for PRMT1
-
ProSci Proteins for PRMT1
-
Abcam proteins for PRMT1
Assay Products
No data available for DME Specific Peptides for PRMT1 Gene
Domains & Families for PRMT1 Gene
Gene Families for PRMT1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRMT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRMT1 Gene
Graphical View of Domain Structure for InterPro Entry
Q99873UniProtKB/Swiss-Prot:
ANM1_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Function for PRMT1 Gene
Molecular function for PRMT1 Gene
- UniProtKB/Swiss-Prot Function:
- Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- By BTG1, BTG2 and ILF3.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=4.2 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.2 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.24 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
Enzyme Numbers (IUBMB) for PRMT1 Gene
Phenotypes From GWAS Catalog for PRMT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0005515 | protein binding | IPI | 8663146 |
| GO:0008168 | methyltransferase activity | IEA,TAS | 9545638 |
| GO:0008170 | N-methyltransferase activity | TAS,IMP | 19124016 |
| GO:0008276 | protein methyltransferase activity | IMP | 28040436 |
Phenotypes for PRMT1 Gene
- MGI mutant phenotypes for PRMT1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for PRMT1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased G1 DNA content
- Increased cell size
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Nucleoplasmic pre-40S maturation defects
- Decreased centriole number
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for PRMT1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRMT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRMT1
-
CRISPR Products
-
OriGene CRISPR knockouts for PRMT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT1
- genomics-online: gRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- Applied Biological Materials CRISPR for PRMT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT1
- GenScript: Design CRISPR guide RNA sequences for PRMT1
miRNA for PRMT1 Gene
- miRTarBase miRNAs that target PRMT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT1
- Browse OriGene Inhibitory RNA Products For PRMT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT1
- genomics-online: shRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
Clone Products
-
OriGene ORF clones in human for PRMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT1
- VectorBuilder custom plasmid, inducible vectors for PRMT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRMT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT1
- Applied Biological Materials Clones for PRMT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT1 Gene
Localization for PRMT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRMT1 Gene
- Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 10749851 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9029147 |
| GO:0005829 | cytosol | IBA | -- |
| GO:0034709 | methylosome | IDA | 25284789 |
Pathways & Interactions for PRMT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Gene Expression |
.48
|
|
| 3 | TP53 Regulates Transcription of Cell Cycle Genes | ||
| 4 | FoxO signaling pathway | ||
| 5 | Glucagon signaling pathway | ||
Pathways by source for PRMT1 Gene
1 GeneTex pathway for PRMT1 Gene
4 BioSystems pathways for PRMT1 Gene
8 Reactome pathways for PRMT1 Gene
2 KEGG pathways for PRMT1 Gene
1 GeneGo (Thomson Reuters) pathway for PRMT1 Gene
3 Qiagen pathways for PRMT1 Gene
1 Cell Signaling Technology pathway for PRMT1 Gene
Interacting Proteins for PRMT1 Gene
Selected Interacting proteins:
Q99873-ANM1_HUMAN
ENSP00000406162
for PRMT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PRMT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IBA | -- |
| GO:0006479 | protein methylation | IEA,IMP | 28040436 |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 9029147 |
| GO:0008284 | positive regulation of cell proliferation | IMP | 28040436 |
Drugs & Compounds for PRMT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | Target | 0 | ||
| AMI-1 | Pharma | PRMT1 inhibitor | 0 | |||
| C 21 | Pharma | Protein arginine methyltransferase 1 (PRMT1) inhibitor, Selective PRMT1 inhibitor | 0 | |||
| C7280948 | Pharma | Novel PRMT1 inhibitor | 0 | |||
| TC-E 5003 | Pharma | PRMT1 inhibitor, potent, Selective PRMT1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
Drug Products
Transcripts for PRMT1 Gene
mRNA/cDNA for PRMT1 Gene
- (8) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (738) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000529284 1182 bps (uc061bhn.1)
- ENST00000532489 1686 bps (uc061bho.1)
- ENST00000527382 699 bps (uc061bhp.1)
- ENST00000528623 543 bps (uc061bhq.1)
- ENST00000534465 779 bps (uc284pmu.1)
Unigene Clusters for PRMT1 Gene
- Protein arginine methyltransferase 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PRMT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT1
- genomics-online: gRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- Applied Biological Materials CRISPR for PRMT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRMT1
- GenScript: Design CRISPR guide RNA sequences for PRMT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRMT1
- Browse OriGene Inhibitory RNA Products For PRMT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRMT1
- genomics-online: shRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
Clone Products
-
OriGene ORF clones in human for PRMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRMT1
- VectorBuilder custom plasmid, inducible vectors for PRMT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRMT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT1
- Applied Biological Materials Clones for PRMT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||
| SP22: |
Expression for PRMT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Testis (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRMT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PRMT1 Gene:
PRMT1SOURCE GeneReport for Unigene cluster for PRMT1 Gene:
Hs.20521mRNA Expression by UniProt/SwissProt for PRMT1 Gene:
Q99873-ANM1_HUMAN
Tissue specificity:
Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).
Evidence on tissue expression from TISSUES for PRMT1 Gene
- Nervous system(4.9)
- Lung(4.7)
- Skin(3.6)
- Muscle(3.1)
- Eye(2.7)
- Heart(2.5)
- Kidney(2.3)
- Adrenal gland(2.2)
- Blood(2.2)
- Intestine(2.1)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for PRMT1
-
OriGene qPCR primer pairs for PRMT1
- genomics-online: primer clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT1 Gene
Orthologs for PRMT1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | PRMT1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PRMT1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PRMT1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Prmt1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prmt1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | PRMT1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prmt1 33 |
|
||
| Str.4974 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23295 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prmt1 34 33 |
|
OneToOne | |
| zgc66201 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2791 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003462 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Art1 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | prmt-1 34 33 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAR190W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 34 33 |
|
OneToMany | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B07117g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PRMT1A 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0359800 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2169 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07459 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rmt1 33 |
|
- Species where no ortholog for PRMT1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PRMT1 Gene
- ENSEMBL:
- Gene Tree for PRMT1 (if available)
- TreeFam:
- Gene Tree for PRMT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRMT1: view image
Paralogs for PRMT1 Gene
(7) SIMAP similar genes for PRMT1 Gene using alignment to 11 proteins:
- ANM1_HUMAN
- E9PI83_HUMAN
- E9PIE2_HUMAN
- E9PIX6_HUMAN
- E9PKG1_HUMAN
- E9PMW9_HUMAN
- E9PMZ2_HUMAN
- E9PNR9_HUMAN
- E9PQ98_HUMAN
- H0YDE4_HUMAN
- H7C2I1_HUMAN
Pseudogenes.org Pseudogenes for PRMT1 Gene
Variants for PRMT1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000096176 | -- | 49,683,508(+) | G/A | intron_variant | |
| rs1000163817 | -- | 49,686,890(+) | C/T | intron_variant | |
| rs1000196752 | -- | 49,687,133(+) | C/T | intron_variant | |
| rs1000295101 | -- | 49,688,085(+) | C/T | intron_variant | |
| rs1000491710 | -- | 49,683,722(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv24796 | CNV | loss | 19812545 |
| nsv1160655 | CNV | deletion | 26073780 |
| nsv469715 | CNV | gain+loss | 16826518 |
| nsv470150 | CNV | gain | 18288195 |
| nsv7308 | OTHER | inversion | 18451855 |
| nsv817854 | CNV | gain | 17921354 |
| nsv828578 | CNV | loss | 20364138 |
| nsv833864 | CNV | gain | 17160897 |
| nsv833865 | CNV | gain+loss | 17160897 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.67;
14.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRMT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRMT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT1 Gene
Disorders for PRMT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ewing sarcoma |
|
Search PRMT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRMT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT1 Gene
Publications for PRMT1 Gene
- Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott HS … Henry MF (Genomics 1998) 2 3 4 22 58
- PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PMID: 19124016) Jobert L … Tora L (Experimental cell research 2009) 3 4 22 58
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 44 58
- Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski TM … Frankel A (The Biochemical journal 2009) 3 4 22 58
- Regulation of estrogen rapid signaling through arginine methylation by PRMT1. (PMID: 18657504) Le Romancer M … Corbo L (Molecular cell 2008) 3 4 22 58
Products for PRMT1 Gene
- R&D Systems Antibodies for PRMT1 (PRMT1)
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Human Proteins and Enzymes
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for PRMT1
- Taconic Biosciences Mouse Models for PRMT1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRMT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRMT1
- VectorBuilder custom plasmid, inducible vectors for PRMT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRMT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 142 available PRMT1 Antibodies ranked by validation data
- Compare Top PRMT1 Antibodies
- Quality Products:
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- antibodies-online: Search results for 36 available PRMT1 Proteins ranked by validation data
- Compare Top PRMT1 Proteins
- GeneTex PRMT1 Antibody for PRMT1
- Search GeneTex for Proteins for PRMT1
- Santa Cruz Biotechnology (SCBT) Antibodies for PRMT1
- Search Santa Cruz Biotechnology (SCBT) for PRMT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRMT1
- Search for PRMT1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRMT1
- genomics-online: cdna clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- orf clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- genomics-online: gRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- genomics-online: primer clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- genomics-online: shRNA clones - Search results for 175 available PRMT1 gene related products
- Overview of 175 available PRMT1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRMT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRMT1
- GeneCopoeia miRNA 3'UTR Target clone products for PRMT1
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Sources for PRMT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD