PRM3 Gene (Protein Coding)

Protamine 3

GC16M011273
GIFtS:
29
See more...

Aliases for PRM3 Gene

Aliases for PRM3 Gene

  • Protamine 3 2 3 5
  • Sperm Protamine P3 3 4
  • Protamine-3 3 4
  • Gene 4 3
  • PRM3 5

External Ids for PRM3 Gene

Previous GeneCards Identifiers for PRM3 Gene

  • GC16M011141
  • GC16M011518
  • GC16M011333
  • GC16M011274
  • GC16U900519
  • GC16M011368
  • GC16M011284
  • GC16M011370
  • GC16M011372
  • GC16M011373
  • GC16M011375
  • GC16M011376
  • GC16M011378
  • GC16M011380

Summaries for PRM3 Gene

GeneCards Summary for PRM3 Gene

PRM3 (Protamine 3) is a Protein Coding gene. Diseases associated with PRM3 include Progressive Relapsing Multiple Sclerosis and Male Infertility.

UniProtKB/Swiss-Prot Summary for PRM3 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).

Additional gene information for PRM3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRM3 Gene

Genomics for PRM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

GeneHancers around PRM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRM3

Top Transcription factor binding sites by QIAGEN in the PRM3 gene promoter:
  • AML1a
  • AP-1
  • Bach1
  • Brachyury
  • Evi-1
  • MIF-1
  • STAT3

Genomic Locations for PRM3 Gene

Latest Assembly
chr16:11,273,199-11,273,629
(GRCh38/hg38)
Size:
431 bases
Orientation:
Minus strand

Previous Assembly
chr16:11,367,056-11,367,486
(GRCh37/hg19 by Entrez Gene)
Size:
431 bases
Orientation:
Minus strand

chr16:11,367,144-11,367,452
(GRCh37/hg19 by Ensembl)
Size:
309 bases
Orientation:
Minus strand

Genomic View for PRM3 Gene

Genes around PRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRM3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRM3 Gene

Proteins for PRM3 Gene

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  2. Protein products for research
  3. Assay products for research

  • Protein details for PRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNZ6-PRM3_HUMAN
    Recommended name:
    Protamine-3
    Protein Accession:
    Q9NNZ6

    Protein attributes for PRM3 Gene

    Size:
    103 amino acids
    Molecular mass:
    11232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRM3 Gene

Protein Expression for PRM3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PRM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRM3 Gene

Domains & Families for PRM3 Gene

Gene Families for PRM3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRM3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRM3 Gene

GenScript: Design optimal peptide antigens:
  • Sperm protamine P3 (PRM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NNZ6

UniProtKB/Swiss-Prot:

PRM3_HUMAN :
  • Belongs to the protamine P3 family.
Family:
  • Belongs to the protamine P3 family.
genes like me logo Genes that share domains with PRM3: view

Function for PRM3 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for PRM3 Gene

UniProtKB/Swiss-Prot Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).

Phenotypes From GWAS Catalog for PRM3 Gene

Gene Ontology (GO) - Molecular Function for PRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with PRM3: view
genes like me logo Genes that share phenotypes with PRM3: view

Animal Models for PRM3 Gene

MGI Knock Outs for PRM3:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRM3 Gene

Localization for PRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRM3 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRM3 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA,IBA 21873635
genes like me logo Genes that share ontologies with PRM3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRM3 Gene

Pathways & Interactions for PRM3 Gene

PathCards logo

SuperPathways for PRM3 Gene

No Data Available

Interacting Proteins for PRM3 Gene

Selected Interacting proteins: Q9NNZ6-PRM3_HUMAN for PRM3 Gene via IID

GPS-Prot Interaction Network for PRM3

Gene Ontology (GO) - Biological Process for PRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with PRM3: view

No data available for Pathways by source and SIGNOR curated interactions for PRM3 Gene

Drugs & Compounds for PRM3 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for PRM3 Gene

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mRNA/cDNA for PRM3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM3

Alternative Splicing Database (ASD) splice patterns (SP) for PRM3 Gene

No ASD Table

Relevant External Links for PRM3 Gene

GeneLoc Exon Structure for
PRM3

Expression for PRM3 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRM3 Gene

mRNA expression in normal human tissues for PRM3 Gene
mRNA expression by GTEx for PRM3 GenemRNA expression by BioGPS for PRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for PRM3 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for PRM3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (60.4) and Testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRM3 Gene



Protein tissue co-expression partners for PRM3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRM3

SOURCE GeneReport for Unigene cluster for PRM3 Gene:

Hs.259636
genes like me logo Genes that share expression patterns with PRM3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM3 Gene

Orthologs for PRM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PRM3 30 31
  • 97.73 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PRM3 30 31
  • 84.27 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PRM3 30 31
  • 82.05 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Prm3 30 17 31
  • 81.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Prm3 30
  • 80.5 (n)
Species where no ortholog for PRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRM3 Gene

ENSEMBL:
Gene Tree for PRM3 (if available)
TreeFam:
Gene Tree for PRM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRM3: view image

Paralogs for PRM3 Gene

No data available for Paralogs for PRM3 Gene

Variants for PRM3 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRM3 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs429744 - p.Gln100Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRM3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRM3 Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv476523 CNV novel sequence insertion 20440878
nsv510412 OTHER sequence alteration 20534489
nsv571453 CNV loss 21841781

Variation tolerance for PRM3 Gene

Gene Damage Index Score: 0.47; 10.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRM3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRM3 Gene

Disorders for PRM3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRM3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
progressive relapsing multiple sclerosis
  • prms
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards
Search PRM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRM3 Gene

Publications for PRM3 Gene

  1. Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L … McElreavey K (Molecular human reproduction 2009) 3 23 41
  2. Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. (PMID: 8720108) Schlüter G … Engel W (Molecular reproduction and development 1996) 2 3 4
  3. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 41
  4. Genesis of a novel human sequence from the protamine PRM1 gene. (PMID: 9827065) Kramer JA … Krawetz SA (Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998) 2 3
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3

ExternalLinks

View latest publications for PRM3 gene in Mastermind

Products for PRM3 Gene

Sources for PRM3 Gene