Aliases for PRM3 Gene
External Ids for PRM3 Gene
- HGNC: 13732
- Entrez Gene: 58531
- Ensembl: ENSG00000178257
- UniProtKB: Q9NNZ6
Previous GeneCards Identifiers for PRM3 Gene
- GC16M011141
- GC16M011518
- GC16M011333
- GC16M011274
- GC16U900519
- GC16M011368
- GC16M011284
- GC16M011370
- GC16M011372
- GC16M011373
- GC16M011375
- GC16M011376
- GC16M011378
- GC16M011380
Summaries for PRM3 Gene
GeneCards Summary for PRM3 Gene
PRM3 (Protamine 3) is a Protein Coding gene. Diseases associated with PRM3 include Suppression Of Tumorigenicity 12.
UniProtKB/Swiss-Prot for PRM3 Gene
-
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRM3 Gene
Genomics for PRM3 Gene
GeneHancer (GH) Regulatory Elements for PRM3 Gene
Promoters and enhancers for PRM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRM3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRM3 Gene
Genomic Locations for PRM3 Gene
- chr16:11,273,199-11,273,641
- (GRCh38/hg38)
- Size:
- 443 bases
- Orientation:
- Minus strand
- chr16:11,367,141-11,367,452
- (GRCh37/hg19)
Genomic View for PRM3 Gene
Genes around PRM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by Ensembl
- 16p13.13 by Entrez Gene
- 16p13.13 by HGNC
PRM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRM3 Gene
Proteins for PRM3 Gene
-
Protein details for PRM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NNZ6-PRM3_HUMAN
- Recommended name:
- Protamine-3
- Protein Accession:
- Q9NNZ6
Protein attributes for PRM3 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11232 Da
- Quaternary structure:
- No Data Available
Protein Expression for PRM3 Gene
Post-translational modifications for PRM3 Gene
No Post-translational modifications
Other Protein References for PRM3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- antibodies-online: Search results for available PRM3 related products ranked by validation data
- Search GeneTex for Antibodies for PRM3
Protein Products
-
OriGene Purified Proteins for PRM3
- Search Origene for MassSpec and Protein Over-expression Lysates for PRM3
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- Novus Biologicals lysates for PRM3
- antibodies-online: Search results for 5 available PRM3 Proteins ranked by validation data
- Compare Top PRM3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for PRM3
Assay Products
- antibodies-online: Search results for available PRM3 related products ranked by validation data
No data available for DME Specific Peptides for PRM3 Gene
Domains & Families for PRM3 Gene
Gene Families for PRM3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PRM3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NNZ6- Family:
-
- Belongs to the protamine P3 family.
Function for PRM3 Gene
Molecular function for PRM3 Gene
- UniProtKB/Swiss-Prot Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
Phenotypes From GWAS Catalog for PRM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for PRM3 Gene
- MGI mutant phenotypes for PRM3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PRM3:
Animal Models for PRM3 Gene
- MGI Knock Outs for PRM3:
-
- Prm3 tm1Grz
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PRM3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRM3 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for PRM3
- genomics-online: gRNA clones - Search results for available PRM3 gene related products
- Applied Biological Materials CRISPR for PRM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRM3
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miRNA Products
- Search ViGene Biosciences for PRM3
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available PRM3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRM3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRM3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRM3 gene related products
- orf clones - Search results for available PRM3 gene related products
- Applied Biological Materials Clones for PRM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRM3
-
ViGene Biosciences adenoviral particle packaged cDNA for PRM3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRM3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRM3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRM3 Gene
Localization for PRM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRM3 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRM3 Gene
Pathways & Interactions for PRM3 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030261 | chromosome condensation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRM3 Gene
Transcripts for PRM3 Gene
mRNA/cDNA for PRM3 Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PRM3
- genomics-online: gRNA clones - Search results for available PRM3 gene related products
- Applied Biological Materials CRISPR for PRM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRM3
- GenScript: Design CRISPR guide RNA sequences for PRM3
miRNA Products
- Search ViGene Biosciences for PRM3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRM3
- Browse OriGene Inhibitory RNA Products For PRM3
- genomics-online: shRNA clones - Search results for available PRM3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRM3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRM3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRM3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRM3 gene related products
- orf clones - Search results for available PRM3 gene related products
- Applied Biological Materials Clones for PRM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PRM3 Gene
mRNA differential expression in normal tissues according to GTEx for PRM3 Gene
This gene is overexpressed in Testis (x52.8).
This gene is overexpressed in Peripheral blood mononuclear cells (60.4) and Testis (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRM3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRM3 Gene:
PRM3SOURCE GeneReport for Unigene cluster for PRM3 Gene:
Hs.259636Primer Products
-
OriGene qPCR primer pairs for PRM3
- genomics-online: primer clones - Search results for available PRM3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM3 Gene
Orthologs for PRM3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRM3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRM3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PRM3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Prm3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prm3 33 |
|
- Species where no ortholog for PRM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PRM3 Gene
No data available for Paralogs for PRM3 Gene
Variants for PRM3 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007335 | -- | 11,273,201(-) | C/A | 3_prime_UTR_variant | |
| rs1001674418 | -- | 11,274,026(-) | C/T | upstream_transcript_variant | |
| rs1002046271 | -- | 11,274,712(-) | G/T | upstream_transcript_variant | |
| rs1002111087 | -- | 11,273,880(-) | A/G | upstream_transcript_variant | |
| rs1002416832 | -- | 11,274,926(-) | C/G | upstream_transcript_variant |
Gene Damage Index Score:
0.47;
10.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRM3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRM3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRM3 Gene
Disorders for PRM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| suppression of tumorigenicity 12 |
|
|
Search PRM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRM3 Gene
Publications for PRM3 Gene
- Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L … McElreavey K (Molecular human reproduction 2009) 3 22 44 58
- Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. (PMID: 8720108) Schlüter G … Engel W (Molecular reproduction and development 1996) 2 3 4 58
- Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 44 58
- Genesis of a novel human sequence from the protamine PRM1 gene. (PMID: 9827065) Kramer JA … Krawetz SA (Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998) 2 3 58
- Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 58
Products for PRM3 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRM3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available PRM3 related products ranked by validation data
- antibodies-online: Search results for available PRM3 related products ranked by validation data
- antibodies-online: Search results for 5 available PRM3 Proteins ranked by validation data
- Compare Top PRM3 Proteins
- Quality Products:
- Search GeneTex for Antibodies for PRM3
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- ViGene Biosciences adenoviral particle packaged cDNA for PRM3 gene
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- Search ViGene Biosciences for PRM3
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- genomics-online: cdna clones - Search results for available PRM3 gene related products
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Sources for PRM3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew