PRM1 Gene (Protein Coding)

Protamine 1

GC16M011332
GIFtS:
31
See more...

Aliases for PRM1 Gene

Aliases for PRM1 Gene

  • Protamine 1 2 3 5
  • Cancer/Testis Antigen Family 94, Member 1 2 3
  • Cysteine-Rich Protamine 3 4
  • Sperm Protamine P1 3 4
  • CT94.1 2 3
  • Testicular Tissue Protein Li 91 3
  • Testis Specific Protamine 1 3
  • PRM1 5
  • P1 3

External Ids for PRM1 Gene

Previous GeneCards Identifiers for PRM1 Gene

  • GC16M011149
  • GC16M011526
  • GC16M011341
  • GC16M011282
  • GC16M011374
  • GC16M011292
  • GC16M011285
  • GC16M011289
  • GC16M011300
  • GC16M011312
  • GC16M011315
  • GC16M011320
  • GC16M011293
  • GC16M011296
  • GC16M011325

Summaries for PRM1 Gene

GeneCards Summary for PRM1 Gene

PRM1 (Protamine 1) is a Protein Coding gene. Diseases associated with PRM1 include Male Infertility and Pelvic Varices.

UniProtKB/Swiss-Prot Summary for PRM1 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

Additional gene information for PRM1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRM1 Gene

Genomics for PRM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PRM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J011280 Enhancer 1.1 Ensembl ENCODE 250.7 +1.7 1695 1.7 MXD4 CEBPA FOXA1 ZIC2 HOMEZ KDM6A THAP11 FOXA2 ZNF511 SMAD4 HSALNG0109586 PRM1 RMI2 LOC105371083 PRM2 LOC105371082
GH16J011281 Promoter/Enhancer 0.6 EPDnew Ensembl 250.7 +0.1 129 0.4 SRF HSALNG0109586 PRM1 RMI2 PRM2 LOC105371082
GH16J011291 Enhancer 0.8 FANTOM5 Ensembl ENCODE 12.1 -9.3 -9271 2.8 TEAD3 OSR2 ERF ZMYM3 ENSG00000287429 RMI2 TNP2 PRM2 PRM3 PRM1 CLEC16A HSALNG0109587 LOC105371082 LOC400499
GH16J011306 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -30.6 -30558 10.7 SP1 BCL11A MXD4 CEBPA FOXA1 MNT ETS1 IRF2 ZFP64 POLR2A RMI2 HSALNG0109588 HNRNPCP4 NPIPB2 ENSG00000261560 RSL1D1-DT SOCS1 COX6CP1 CIITA ENSG00000261216
GH16J011296 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.4 -16.9 -16920 4.2 SP1 MXD4 BCL11A CEBPA HES1 BHLHE40 HOMEZ KDM6A THAP11 SIN3A piR-35646 RMI2 SOCS1 PRM2 ENSG00000212228 PRM3 TNP2 CLEC16A DEXI LOC105371083
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRM1

Top Transcription factor binding sites by QIAGEN in the PRM1 gene promoter:
  • AP-1
  • Bach1
  • Brachyury
  • Evi-1
  • HEN1
  • Ik-2
  • Meis-1
  • MIF-1
  • STAT3

Genomic Locations for PRM1 Gene

Latest Assembly
chr16:11,280,841-11,281,330
(GRCh38/hg38)
Size:
490 bases
Orientation:
Minus strand

Previous Assembly
chr16:11,374,698-11,375,187
(GRCh37/hg19 by Entrez Gene)
Size:
490 bases
Orientation:
Minus strand

chr16:11,374,693-11,375,207
(GRCh37/hg19 by Ensembl)
Size:
515 bases
Orientation:
Minus strand

Genomic View for PRM1 Gene

Genes around PRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRM1 Gene

Proteins for PRM1 Gene

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  3. Assay products for research

  • Protein details for PRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04553-HSP1_HUMAN
    Recommended name:
    Sperm protamine P1
    Protein Accession:
    P04553

    Protein attributes for PRM1 Gene

    Size:
    51 amino acids
    Molecular mass:
    6823 Da
    Quaternary structure:
    • Cross-linked by interchain disulfide bonds around the DNA-helix.

    Three dimensional structures from OCA and Proteopedia for PRM1 Gene

neXtProt entry for PRM1 Gene

Post-translational modifications for PRM1 Gene

Other Protein References for PRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRM1 Gene

Domains & Families for PRM1 Gene

Gene Families for PRM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRM1 Gene

InterPro:
Blocks:
  • Protamine P1
ProtoNet:

Suggested Antigen Peptide Sequences for PRM1 Gene

GenScript: Design optimal peptide antigens:
  • Cysteine-rich protamine (HSP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04553

UniProtKB/Swiss-Prot:

HSP1_HUMAN :
  • Belongs to the protamine P1 family.
Family:
  • Belongs to the protamine P1 family.
genes like me logo Genes that share domains with PRM1: view

Function for PRM1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for PRM1 Gene

UniProtKB/Swiss-Prot Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
GENATLAS Biochemistry:
protamine 1

Phenotypes From GWAS Catalog for PRM1 Gene

Gene Ontology (GO) - Molecular Function for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with PRM1: view
genes like me logo Genes that share phenotypes with PRM1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM1 Gene

Localization for PRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRM1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRM1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PRM1: view

Pathways & Interactions for PRM1 Gene

PathCards logo

SuperPathways for PRM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 2081589
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0030154 cell differentiation IEA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with PRM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRM1 Gene

Drugs & Compounds for PRM1 Gene

Products:

  1. Drug products for research

(3) Drugs for PRM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PRM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRM1: view

Transcripts for PRM1 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for PRM1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM1

Alternative Splicing Database (ASD) splice patterns (SP) for PRM1 Gene

No ASD Table

Relevant External Links for PRM1 Gene

GeneLoc Exon Structure for
PRM1

Expression for PRM1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRM1 Gene

mRNA expression in normal human tissues for PRM1 Gene
mRNA expression by BioGPS for PRM1 GenemRNA expression by GTEx for PRM1 Gene

mRNA differential expression in normal tissues according to GTEx for PRM1 Gene

This gene is overexpressed in Testis (x52.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRM1

SOURCE GeneReport for Unigene cluster for PRM1 Gene:

Hs.2909

mRNA Expression by UniProt/SwissProt for PRM1 Gene:

P04553-HSP1_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with PRM1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM1 Gene

Orthologs for PRM1 Gene

Evolution for PRM1 Gene

ENSEMBL:
Gene Tree for PRM1 (if available)
TreeFam:
Gene Tree for PRM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRM1: view image

No data available for Orthologs for PRM1 Gene

Paralogs for PRM1 Gene

(1) SIMAP similar genes for PRM1 Gene using alignment to 1 proteins:

  • HSP1_HUMAN
genes like me logo Genes that share paralogs with PRM1: view

No data available for Paralogs for PRM1 Gene

Variants for PRM1 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRM1 Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571453 CNV loss 21841781

Variation tolerance for PRM1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRM1 Gene

Human Gene Mutation Database (HGMD)
PRM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRM1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRM1 Gene

Disorders for PRM1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PRM1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
male infertility
  • infertility male
pelvic varices
azoospermia
  • spermatogenic failure
infertility
hyperoxaluria, primary, type iii
  • hp3
- elite association - COSMIC cancer census association via MalaCards
Search PRM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRM1 Gene

Publications for PRM1 Gene

  1. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) Tüttelmann F … Simoni M (International journal of andrology 2010) 3 23 41
  2. Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L … McElreavey K (Molecular human reproduction 2009) 3 23 41
  3. A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. (PMID: 18390561) Gázquez C … Oliva R (Journal of andrology 2008) 3 23 41
  4. Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki VW … Carrell DT (Fertility and sterility 2006) 3 23 41
  5. Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered. (PMID: 2081589) Domenjoud L … Engel W (Genomics 1990) 3 4 23

ExternalLinks

View latest publications for PRM1 gene in Mastermind

Products for PRM1 Gene

Sources for PRM1 Gene