Aliases for PRM1 Gene
Aliases for PRM1 Gene
External Ids for PRM1 Gene
- HGNC: 9447
- Entrez Gene: 5619
- Ensembl: ENSG00000175646
- OMIM: 182880
- UniProtKB: P04553
Previous GeneCards Identifiers for PRM1 Gene
- GC16M011149
- GC16M011526
- GC16M011341
- GC16M011282
- GC16M011374
- GC16M011292
- GC16M011285
- GC16M011289
- GC16M011293
- GC16M011296
Summaries for PRM1 Gene
GeneCards Summary for PRM1 Gene
PRM1 (Protamine 1) is a Protein Coding gene. Diseases associated with PRM1 include Male Infertility and Male Reproductive System Disease.
UniProtKB/Swiss-Prot for PRM1 Gene
-
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRM1 Gene
Genomics for PRM1 Gene
GeneHancer (GH) Regulatory Elements for PRM1 Gene
Promoters and enhancers for PRM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRM1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRM1 Gene
Genomic Locations for PRM1 Gene
- chr16:11,280,836-11,281,350
- (GRCh38/hg38)
- Size:
- 515 bases
- Orientation:
- Minus strand
- chr16:11,374,693-11,375,207
- (GRCh37/hg19)
Genomic View for PRM1 Gene
Genes around PRM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by Ensembl
- 16p13.13 by Entrez Gene
- 16p13.13 by HGNC
PRM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRM1 Gene
Proteins for PRM1 Gene
-
Protein details for PRM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04553-HSP1_HUMAN
- Recommended name:
- Sperm protamine P1
- Protein Accession:
- P04553
Protein attributes for PRM1 Gene
- Size:
- 51 amino acids
- Molecular mass:
- 6823 Da
- Quaternary structure:
-
- Cross-linked by interchain disulfide bonds around the DNA-helix.
Post-translational modifications for PRM1 Gene
- Phosphorylated by SRPK1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRM1
-
Abcam antibodies for PRM1
-
Cloud-Clone Corp. Antibodies for PRM1
- Invitrogen Antibodies for PRM1
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Protein Products
-
OriGene Purified Proteins for PRM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRM1
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-
Cloud-Clone Corp. Proteins for PRM1
- Search GeneTex for Proteins for PRM1
-
Abcam proteins for PRM1
Assay Products
-
Cloud-Clone Corp. Assay Kits for PRM1
No data available for DME Specific Peptides for PRM1 Gene
Domains & Families for PRM1 Gene
Gene Families for PRM1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PRM1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04553- Family:
-
- Belongs to the protamine P1 family.
Function for PRM1 Gene
Molecular function for PRM1 Gene
- GENATLAS Biochemistry:
- protamine 1
- UniProtKB/Swiss-Prot Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Phenotypes From GWAS Catalog for PRM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS,IEA | -- |
Phenotypes for PRM1 Gene
Animal Model Products
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-
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for PRM1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRM1 gene related products
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- Applied Biological Materials Clones for PRM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
-
Cloud-CloneCorp. cDNA clones for PRM1
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Cell Line Products
-
Horizon Cell Lines for PRM1
-
ViGene Biosciences adenoviral particle packaged cDNA for PRM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRM1 gene
- Search ViGene Biosciences for PRM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM1 Gene
Localization for PRM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRM1 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | 2081589 |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRM1 Gene
Pathways & Interactions for PRM1 Gene
No Data Available
Interacting Proteins for PRM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006323 | DNA packaging | TAS | 2081589 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | TAS,IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030261 | chromosome condensation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRM1 Gene
Transcripts for PRM1 Gene
mRNA/cDNA for PRM1 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (140) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PRM1
- genomics-online: gRNA clones - Search results for available PRM1 gene related products
- Applied Biological Materials CRISPR for PRM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRM1
- GenScript: Design CRISPR guide RNA sequences for PRM1
miRNA Products
- Search ViGene Biosciences for PRM1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for PRM1
- Browse OriGene Inhibitory RNA Products For PRM1
- genomics-online: shRNA clones - Search results for available PRM1 gene related products
- Search ViGene Biosciences for PRM1
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PRM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRM1 gene related products
- orf clones - Search results for available PRM1 gene related products
- Applied Biological Materials Clones for PRM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
-
Cloud-CloneCorp. cDNA clones for PRM1
- Browse primers at Cloud-Clone Corp.
Expression for PRM1 Gene
mRNA differential expression in normal tissues according to GTEx for PRM1 Gene
This gene is overexpressed in Testis (x52.7).
NURSA nuclear receptor signaling pathways regulating expression of PRM1 Gene:
PRM1SOURCE GeneReport for Unigene cluster for PRM1 Gene:
Hs.2909mRNA Expression by UniProt/SwissProt for PRM1 Gene:
P04553-HSP1_HUMAN
Tissue specificity:
Testis.
Primer Products
-
OriGene qPCR primer pairs and template standards for PRM1
- genomics-online: primer clones - Search results for available PRM1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM1 Gene
Orthologs for PRM1 Gene
No data available for Orthologs for PRM1 Gene
Paralogs for PRM1 Gene
(1) SIMAP similar genes for PRM1 Gene using alignment to 1 proteins:
No data available for Paralogs for PRM1 Gene
Variants for PRM1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000597076 | -- | 11,281,510(-) | G/A | upstream_transcript_variant | |
| rs1001032733 | -- | 11,281,347(-) | C/A | upstream_transcript_variant | |
| rs1001106297 | -- | 11,281,200(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1001366235 | -- | 11,282,222(-) | C/A/G | upstream_transcript_variant | |
| rs1002296372 | -- | 11,280,709(-) | A/G | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1040428 | CNV | gain | 25217958 |
| nsv571453 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRM1 Gene
Disorders for PRM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| male infertility |
|
|
| male reproductive system disease |
|
|
| pelvic varices |
|
|
| reproductive system disease |
|
|
| infertility |
|
Search PRM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRM1 Gene
Publications for PRM1 Gene
- A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) Tüttelmann F … Simoni M (International journal of andrology 2010) 3 22 44 58
- Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L … McElreavey K (Molecular human reproduction 2009) 3 22 44 58
- A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. (PMID: 18390561) Gázquez C … Oliva R (Journal of andrology 2008) 3 22 44 58
- Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki VW … Carrell DT (Fertility and sterility 2006) 3 22 44 58
- Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered. (PMID: 2081589) Domenjoud L … Engel W (Genomics 1990) 3 4 22 58
Products for PRM1 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRM1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 8 available PRM1 Antibodies ranked by validation data
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Sources for PRM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
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- (132) FANTOM5
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- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
