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Aliases for PRM1 Gene
Aliases for PRM1 Gene
External Ids for PRM1 Gene
- HGNC: 9447
- Entrez Gene: 5619
- Ensembl: ENSG00000175646
- OMIM: 182880
- UniProtKB: P04553
Previous GeneCards Identifiers for PRM1 Gene
- GC16M011149
- GC16M011526
- GC16M011341
- GC16M011282
- GC16M011374
- GC16M011292
- GC16M011285
- GC16M011289
- GC16M011300
- GC16M011312
- GC16M011315
- GC16M011320
- GC16M011293
- GC16M011296
Summaries for PRM1 Gene
GeneCards Summary for PRM1 Gene
PRM1 (Protamine 1) is a Protein Coding gene. Diseases associated with PRM1 include Male Infertility and Pelvic Varices.
UniProtKB/Swiss-Prot Summary for PRM1 Gene
-
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Additional gene information for PRM1 Gene
- HGNC(9447)
- Entrez Gene(5619)
- Ensembl(ENSG00000175646)
- OMIM(182880)
- UniProtKB(P04553)
- Open Targets Platform(ENSG00000175646)
- Search for PRM1 at DataMed
- Search for PRM1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRM1 Gene
Genomics for PRM1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRM1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRM1
- Top Transcription factor binding sites by QIAGEN in the PRM1 gene promoter:
-
- AP-1
- Bach1
- Brachyury
- Evi-1
- HEN1
- Ik-2
- Meis-1
- MIF-1
- STAT3
Genomic Locations for PRM1 Gene
Genomic Locations for PRM1 Gene
- chr16:11,280,841-11,281,330
- (GRCh38/hg38)
- Size:
- 490 bases
- Orientation:
- Minus strand
- chr16:11,374,693-11,375,207
- (GRCh37/hg19)
- Size:
- 515 bases
- Orientation:
- Minus strand
Genomic View for PRM1 Gene
Genes around PRM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by HGNC
- 16p13.13 by Entrez Gene
- 16p13.13 by Ensembl
PRM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRM1 Gene
Proteins for PRM1 Gene
-
Protein details for PRM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04553-HSP1_HUMAN
- Recommended name:
- Sperm protamine P1
- Protein Accession:
- P04553
Protein attributes for PRM1 Gene
- Size:
- 51 amino acids
- Molecular mass:
- 6823 Da
- Quaternary structure:
-
- Cross-linked by interchain disulfide bonds around the DNA-helix.
Post-translational modifications for PRM1 Gene
- Phosphorylated by SRPK1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRM1
-
Abcam antibodies for PRM1
- Invitrogen Antibodies for PRM1 (AFLGC-PRM1)
- antibodies-online: Show 42 available PRM1 Antibodies ranked by validation data
- Compare Top PRM1 Antibodies
-
Quality Products:
Protein Products
-
OriGene Purified Proteins for PRM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRM1
- Origene Custom Protein Services for PRM1
-
Signalway Proteins for PRM1
-
Abcam proteins for PRM1
Assay Products
- antibodies-online: Show 27 available PRM1 Elisa Kits ranked by validation data
- Compare Top PRM1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PRM1 Gene
Domains & Families for PRM1 Gene
Gene Families for PRM1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PRM1 Gene
- InterPro:
- Blocks:
-
- Protamine P1
- ProtoNet:
Suggested Antigen Peptide Sequences for PRM1 Gene
- GenScript: Design optimal peptide antigens:
-
- Cysteine-rich protamine (HSP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04553- Family:
-
- Belongs to the protamine P1 family.
Function for PRM1 Gene
Molecular function for PRM1 Gene
- UniProtKB/Swiss-Prot Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
- GENATLAS Biochemistry:
- protamine 1
Phenotypes From GWAS Catalog for PRM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS,IEA | -- |
Phenotypes for PRM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRM1 - Select products 50% OFF >
- * PRM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRM1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRM1
- Browse OriGene Inhibitory RNA Products For PRM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM1
Clone Products
- Applied Biological Materials (abm): Clones for PRM1 - Select products 50% OFF >
- * PRM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRM1
Cell Line Products
-
Horizon Cell Lines for PRM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM1 Gene
Localization for PRM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRM1 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | 2081589 |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRM1 Gene
Pathways & Interactions for PRM1 Gene
Interacting Proteins for PRM1 Gene
Selected Interacting proteins:
P04553-HSP1_HUMAN
ENSP00000310515
for PRM1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PRM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006323 | DNA packaging | TAS | 2081589 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | TAS,IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030261 | chromosome condensation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRM1 Gene
Transcripts for PRM1 Gene
mRNA/cDNA for PRM1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000312511 399 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRM1 - Select products 50% OFF >
- * PRM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRM1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRM1
- Browse OriGene Inhibitory RNA Products For PRM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM1
Clone Products
- Applied Biological Materials (abm): Clones for PRM1 - Select products 50% OFF >
- * PRM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRM1
Relevant External Links for PRM1 Gene
- GeneLoc Exon Structure for
- PRM1
Expression for PRM1 Gene
mRNA differential expression in normal tissues according to GTEx for PRM1 Gene
This gene is overexpressed in Testis (x52.7).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRM1
SOURCE GeneReport for Unigene cluster for PRM1 Gene:
Hs.2909mRNA Expression by UniProt/SwissProt for PRM1 Gene:
P04553-HSP1_HUMAN
Tissue specificity:
Testis.
Primer Products
-
OriGene qPCR primer pairs and template standards for PRM1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM1 Gene
Orthologs for PRM1 Gene
Evolution for PRM1 Gene
- ENSEMBL:
- Gene Tree for PRM1 (if available)
- TreeFam:
- Gene Tree for PRM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRM1: view image
No data available for Orthologs for PRM1 Gene
Paralogs for PRM1 Gene
(1) SIMAP similar genes for PRM1 Gene using alignment to 1 proteins:
- HSP1_HUMAN
No data available for Paralogs for PRM1 Gene
Variants for PRM1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1040428 | CNV | gain | 25217958 |
| nsv571453 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRM1 Gene
Disorders for PRM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| male infertility |
|
|
| pelvic varices |
|
|
| infertility |
|
|
| azoospermia |
|
|
| oligoasthenoteratozoospermia |
|
|
Search PRM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PRM1 Gene
Publications for PRM1 Gene
- A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) Tüttelmann F … Simoni M (International journal of andrology 2010) 3 23 41
- Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L … McElreavey K (Molecular human reproduction 2009) 3 23 41
- A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. (PMID: 18390561) Gázquez C … Oliva R (Journal of andrology 2008) 3 23 41
- Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki VW … Carrell DT (Fertility and sterility 2006) 3 23 41
- Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered. (PMID: 2081589) Domenjoud L … Engel W (Genomics 1990) 3 4 23
ExternalLinks
Products for PRM1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRM1
- Origene Custom Protein Services for PRM1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRM1
- Browse OriGene Inhibitory RNA Products For PRM1
- OriGene qPCR primer pairs and template standards for PRM1
- OriGene CRISPR knockouts for PRM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRM1
- Sino Biological Human cDNA Clone for PRM1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRM1
- Novus Biologicals proteins and lysates for PRM1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PRM1
- Abcam proteins for PRM1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PRM1 (AFLGC-PRM1)
- VectorBuilder Custom and pre-made DNA vectors for PRM1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRM1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRM1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRM1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRM1
- antibodies-online: Show 42 available PRM1 Antibodies ranked by validation data
- Compare Top PRM1 Antibodies
- Quality Products:
- antibodies-online: Show 27 available PRM1 Elisa Kits ranked by validation data
- Compare Top PRM1 Elisa Kits
- Quality Products:
- antibodies-online: Show 65 available PRM1 Proteins ranked by validation data
- Compare Top PRM1 Proteins
- Horizon Cell Lines for PRM1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRM1
Sources for PRM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB