This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, whi... See more...

Aliases for PRLR Gene

Aliases for PRLR Gene

  • Prolactin Receptor 2 3 4 5
  • Secreted Prolactin Binding Protein 3
  • HPRL Receptor 3
  • RI-PRLR 3
  • HPRLrI 3
  • PRL-R 4
  • HPRL 3
  • MFAB 3
  • PRLR 5

External Ids for PRLR Gene

Previous GeneCards Identifiers for PRLR Gene

  • GC05M035082
  • GC05M036075
  • GC05M035094
  • GC05M035084

Summaries for PRLR Gene

Entrez Gene Summary for PRLR Gene

  • This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

GeneCards Summary for PRLR Gene

PRLR (Prolactin Receptor) is a Protein Coding gene. Diseases associated with PRLR include Hyperprolactinemia and Multiple Fibroadenomas Of The Breast. Among its related pathways are Prolactin Signaling Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and peptide hormone binding. An important paralog of this gene is GHR.

UniProtKB/Swiss-Prot Summary for PRLR Gene

  • This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRLR Gene

Genomics for PRLR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRLR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J035228 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 606.4 +1.1 1125 3.2 CEBPG GATAD2A CTCF TFE3 KDM1A ZNF174 BACH1 FOXA1 LARP7 ZIC2 PRLR lnc-DNAJC21-3 piR-50029 AGXT2
GH05J035193 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 619.7 +35.2 35246 3.3 GATAD2A TFE3 TCF12 IKZF2 TRIM22 PKNOX1 TOE1 KMT2B ARID3A DPF2 PRLR L13713-180 lnc-DNAJC21-3 AGXT2
GH05J035237 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.4 -7.4 -7387 1.2 GATAD2A SOX13 RXRB IKZF2 SP1 CEBPA TCF7 DPF2 GATAD2B FOXA2 PRLR HSALNG0041129 SPEF2
GH05J035212 Enhancer 1.2 FANTOM5 Ensembl ENCODE 8.8 +17.5 17523 6.4 CREB1 ATF7 TARDBP FOXA1 JUND RELA RAD21 IKZF2 RCOR1 ZFX PRLR lnc-DNAJC21-3 L13713-180 AGXT2
GH05J035134 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 7.4 +94.3 94324 4.8 GATAD2A REST NFKBIZ RXRB IRF2 SP1 KMT2B SOX13 CEBPB ZKSCAN8 PRLR piR-56612-007 piR-59297-538 AGXT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRLR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRLR

Top Transcription factor binding sites by QIAGEN in the PRLR gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1

Genomic Locations for PRLR Gene

Genomic Locations for PRLR Gene
chr5:35,048,756-35,230,724
(GRCh38/hg38)
Size:
181,969 bases
Orientation:
Minus strand
chr5:35,048,861-35,230,823
(GRCh37/hg19)
Size:
181,963 bases
Orientation:
Minus strand

Genomic View for PRLR Gene

Genes around PRLR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLR Gene

Proteins for PRLR Gene

  • Protein details for PRLR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16471-PRLR_HUMAN
    Recommended name:
    Prolactin receptor
    Protein Accession:
    P16471
    Secondary Accessions:
    • B2R882
    • D1MDP1
    • Q16354
    • Q8TD75
    • Q8TD78
    • Q96P35
    • Q96P36
    • Q9BX87
    • Q9UHJ5

    Protein attributes for PRLR Gene

    Size:
    622 amino acids
    Molecular mass:
    69506 Da
    Quaternary structure:
    • Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
    Miscellaneous:
    • [Isoform 3]: Soluble isoform that appears specific for the BT-474 breast cancer cell line.
    • [Isoform 4]: Includes exon 11. Does not transduce prolactin signaling.
    • [Isoform 5]: Produced by deletion of part of exon 10 and frameshift.
    • [Isoform 6]: Does not transduce prolactin signaling.
    • [Isoform 7]: Splices from exon 7 to exon 11.
    • [Isoform 8]: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for PRLR Gene

    Alternative splice isoforms for PRLR Gene

neXtProt entry for PRLR Gene

Post-translational modifications for PRLR Gene

  • Glycosylation at Asn104, Asn59, and Asn233
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRLR Gene

Domains & Families for PRLR Gene

Gene Families for PRLR Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PRLR Gene

InterPro:
Blocks:
  • Long hematopoietin receptor, single chain
ProtoNet:

Suggested Antigen Peptide Sequences for PRLR Gene

GenScript: Design optimal peptide antigens:
  • Prolactin receptor (PRLR_HUMAN)
  • Prolactin receptor (Q8WWV7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16471

UniProtKB/Swiss-Prot:

PRLR_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 1 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 1 subfamily.
genes like me logo Genes that share domains with PRLR: view

Function for PRLR Gene

Molecular function for PRLR Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
GENATLAS Biochemistry:
prolactin receptor with two alternatively spliced isoforms,expressed in breast cancer,breast normal tissue,gonad and liver

Phenotypes From GWAS Catalog for PRLR Gene

Gene Ontology (GO) - Molecular Function for PRLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0004923 leukemia inhibitory factor receptor activity IBA 21873635
GO:0004924 contributes_to oncostatin-M receptor activity IBA 21873635
GO:0004925 prolactin receptor activity IBA,IDA 10585417
GO:0005127 ciliary neurotrophic factor receptor binding IBA 21873635
genes like me logo Genes that share ontologies with PRLR: view
genes like me logo Genes that share phenotypes with PRLR: view

Human Phenotype Ontology for PRLR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRLR Gene

MGI Knock Outs for PRLR:

Animal Model Products

CRISPR Products

miRNA for PRLR Gene

miRTarBase miRNAs that target PRLR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRLR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PRLR Gene

Localization for PRLR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLR Gene

Membrane. Single-pass type I membrane protein.
[Isoform 7]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLR gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 4
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IDA 10585417
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRLR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRLR Gene

Pathways & Interactions for PRLR Gene

genes like me logo Genes that share pathways with PRLR: view

Pathways by source for PRLR Gene

2 GeneGo (Thomson Reuters) pathways for PRLR Gene
  • Development Prolactin receptor signaling
  • Transcription Ligand-dependent activation of the ESR1/SP pathway
2 Qiagen pathways for PRLR Gene
  • JAK-STAT Pathway
  • Prolactin Signaling
1 Cell Signaling Technology pathway for PRLR Gene

SIGNOR curated interactions for PRLR Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process NAS 10585417
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IDA 10585417
GO:0007259 JAK-STAT cascade IEA --
GO:0007566 embryo implantation TAS 9009200
GO:0007595 lactation TAS,IEA --
genes like me logo Genes that share ontologies with PRLR: view

Drugs & Compounds for PRLR Gene

(34) Drugs for PRLR Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Somatotropin Approved, Investigational Pharma Target, binder 0
choriomammotropin Pharma Agonist 0
chorionic somatomammotropin hormone-like 1 Pharma Agonist 0
prolactin Pharma Agonist 0
SOMATROPIN Pharma 0

(13) Additional Compounds for PRLR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLR: view

Transcripts for PRLR Gene

mRNA/cDNA for PRLR Gene

6 REFSEQ mRNAs :
29 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRLR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - - - -
SP11:

Relevant External Links for PRLR Gene

GeneLoc Exon Structure for
PRLR

Expression for PRLR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRLR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRLR Gene

This gene is overexpressed in Cervix - Ectocervix (x7.9), Adrenal Gland (x6.3), Uterus (x5.7), and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for PRLR Gene

This gene is overexpressed in Urine (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRLR Gene



Protein tissue co-expression partners for PRLR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRLR

SOURCE GeneReport for Unigene cluster for PRLR Gene:

Hs.368587

mRNA Expression by UniProt/SwissProt for PRLR Gene:

P16471-PRLR_HUMAN
Tissue specificity: Expressed in breast, placenta, kidney, liver and pancreas.

Evidence on tissue expression from TISSUES for PRLR Gene

  • Nervous system(3)
  • Kidney(2.7)
  • Thyroid gland(2.5)
  • Liver(2.4)
  • Adrenal gland(2.2)
  • Blood(2.2)
  • Intestine(2.2)
  • Pancreas(2)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLR Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • endocrine
  • nervous
  • reproductive
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • ovary
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with PRLR: view

Orthologs for PRLR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRLR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRLR 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRLR 30 31
  • 83.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRLR 30 31
  • 80.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prlr 30
  • 79.44 (n)
Mouse
(Mus musculus)
Mammalia Gm21973 31
  • 79 (a)
OneToMany
Prlr 30 17 31
  • 78.36 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia PRLR 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRLR 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRLR 30 31
  • 62.43 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRLR 31
  • 36 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prlr 30
  • 58.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia prlr-B 30
Zebrafish
(Danio rerio)
Actinopterygii prlra 30 31
  • 50.38 (n)
OneToMany
prlrb 31
  • 37 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8049 30
Species where no ortholog for PRLR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRLR Gene

ENSEMBL:
Gene Tree for PRLR (if available)
TreeFam:
Gene Tree for PRLR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRLR: view image

Paralogs for PRLR Gene

(1) SIMAP similar genes for PRLR Gene using alignment to 10 proteins:

  • PRLR_HUMAN
  • D6R9E1_HUMAN
  • D6R9P5_HUMAN
  • D6R9V7_HUMAN
  • D6RAN9_HUMAN
  • D6RC67_HUMAN
  • D6RD41_HUMAN
  • D6RJC8_HUMAN
  • Q8TD76_HUMAN
  • Q8WWV7_HUMAN
genes like me logo Genes that share paralogs with PRLR: view

Variants for PRLR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRLR Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
710961 Benign: not provided 35,065,254(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
741379 Likely Benign: not provided 35,065,362(-) G/C MISSENSE_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
779333 Benign: not provided 35,070,117(-) C/T INTRON_VARIANT
781625 Benign: not provided 35,065,548(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs376188691 Pathogenic: Hyperprolactinemia 35,072,607(-) G/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for PRLR Gene

Structural Variations from Database of Genomic Variants (DGV) for PRLR Gene

Variant ID Type Subtype PubMed ID
dgv3074n106 CNV deletion 24896259
esv1008308 CNV deletion 20482838
esv1083244 CNV deletion 17803354
esv1447971 CNV deletion 17803354
esv2092288 CNV deletion 18987734
esv2267873 CNV deletion 18987734
esv2661957 CNV deletion 23128226
esv2730060 CNV deletion 23290073
esv2730061 CNV deletion 23290073
esv2730063 CNV deletion 23290073
esv2730064 CNV deletion 23290073
esv2730065 CNV deletion 23290073
esv3174 CNV loss 18987735
esv3565800 CNV deletion 23714750
esv3565802 CNV deletion 23714750
esv3565803 CNV deletion 23714750
esv3604691 CNV gain 21293372
esv3604694 CNV gain 21293372
esv3604696 CNV loss 21293372
esv992972 CNV deletion 20482838
nsv1028968 CNV gain 25217958
nsv1074291 CNV deletion 25765185
nsv1109688 CNV deletion 24896259
nsv1114680 CNV deletion 24896259
nsv1129746 CNV tandem duplication 24896259
nsv1140530 CNV deletion 24896259
nsv327297 CNV deletion 16902084
nsv327901 CNV deletion 16902084
nsv473087 CNV novel sequence insertion 20440878
nsv473602 CNV novel sequence insertion 20440878
nsv475289 CNV novel sequence insertion 20440878
nsv478095 CNV novel sequence insertion 20440878
nsv4790 CNV deletion 18451855
nsv526901 CNV loss 19592680
nsv597810 CNV gain 21841781

Variation tolerance for PRLR Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRLR Gene

Human Gene Mutation Database (HGMD)
PRLR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRLR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLR Gene

Disorders for PRLR Gene

MalaCards: The human disease database

(20) MalaCards diseases for PRLR Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperprolactinemia
  • hprl
multiple fibroadenomas of the breast
  • mfab
breast disease
  • breast diseases
cerebral meningioma
  • meningioma of cerebrum
galactorrhea
  • galactorrhea not associated with childbirth
- elite association - COSMIC cancer census association via MalaCards
Search PRLR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PRLR_HUMAN
  • Multiple fibroadenomas of the breast (MFAB) [MIM:615554]: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. {ECO:0000269 PubMed:18779591}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hyperprolactinemia (HPRL) [MIM:615555]: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. {ECO:0000269 PubMed:24195502}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRLR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PRLR: view

No data available for Genatlas for PRLR Gene

Publications for PRLR Gene

  1. Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors. (PMID: 18779591) Bogorad RL … Benign Breast Diseases Study Group (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23 41
  2. Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation. (PMID: 20032052) Pujianto DA … Aitken RJ (Endocrinology 2010) 3 4 23
  3. A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort. (PMID: 18053149) Lee SA … Stram DO (BMC medical genetics 2007) 3 23 41
  4. Association of prolactin and its receptor gene regions with familial breast cancer. (PMID: 16434456) Vaclavicek A … Försti A (The Journal of clinical endocrinology and metabolism 2006) 3 23 41
  5. Could prolactin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? (PMID: 15119991) Canbay E … Bardakci F (Current medical research and opinion 2004) 3 23 41

Products for PRLR Gene

Sources for PRLR Gene