Aliases for PRLR Gene
Aliases for PRLR Gene
External Ids for PRLR Gene
- HGNC: 9446
- Entrez Gene: 5618
- Ensembl: ENSG00000113494
- OMIM: 176761
- UniProtKB: P16471
Previous GeneCards Identifiers for PRLR Gene
- GC05M035082
- GC05M036075
- GC05M035094
Summaries for PRLR Gene
-
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
GeneCards Summary for PRLR Gene
PRLR (Prolactin Receptor) is a Protein Coding gene. Diseases associated with PRLR include Hyperprolactinemia and Multiple Fibroadenomas Of The Breast. Among its related pathways are Cytokine Signaling in Immune system and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and peptide hormone binding. An important paralog of this gene is GHR.
UniProtKB/Swiss-Prot for PRLR Gene
-
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Additional gene information for PRLR Gene
- Monarch Initiative
- Search for PRLR at DataMed
- Search for PRLR at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLR Gene
Genomics for PRLR Gene
GeneHancer (GH) Regulatory Elements for PRLR Gene
Promoters and enhancers for PRLR Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I035228 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 556.5 | +0.8 | 812 | 2.8 | HDGF PKNOX1 SIN3A YY1 ZNF143 ATF7 RXRA REST MIER3 ETV4 | PRLR PIR44028 PIR49347 | |
| GH05I035118 | Promoter/Enhancer | 1.1 | EPDnew dbSUPER | 550.1 | +112.5 | 112450 | 0.1 | ZNF687 JUNB BATF IRF4 RELA BCL11A FOS SPI1 | PRLR ENSG00000250886 PIR49347 | |
| GH05I035193 | Enhancer | 1 | Ensembl ENCODE | 19.7 | +35.1 | 35111 | 3.3 | DRAP1 PKNOX1 ZNF792 SAP130 ARID4B BMI1 DMAP1 ZNF644 KMT2B IRF4 | PRLR PIR49347 ENSG00000250886 | |
| GH05I035212 | Enhancer | 1.1 | FANTOM5 ENCODE | 8.8 | +16.6 | 16598 | 3.6 | SMAD1 NEUROD1 SIN3A BMI1 BATF RAD21 RFX5 ATF7 ETV6 FOS | PRLR PIR49347 PIR44028 | |
| GH05I035134 | Enhancer | 1.2 | FANTOM5 ENCODE dbSUPER | 7.4 | +94.7 | 94740 | 2.2 | ELF3 SOX13 TFAP4 TAF1 SAP130 MAX EBF1 CEBPG KMT2B ZNF48 | PRLR ENSG00000250886 PIR49347 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRLR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRLR gene promoter:
Regulatory Element Products
Genomic Locations for PRLR Gene
Genomic Locations for PRLR Gene
- chr5:35,048,756-35,230,589
- (GRCh38/hg38)
- Size:
- 181,834 bases
- Orientation:
- Minus strand
- chr5:35,048,861-35,230,823
- (GRCh37/hg19)
Genomic View for PRLR Gene
Genes around PRLR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.2 by Ensembl
- 5p13.2 by Entrez Gene
- 5p13.2 by HGNC
PRLR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRLR Gene
Proteins for PRLR Gene
-
Protein details for PRLR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16471-PRLR_HUMAN
- Recommended name:
- Prolactin receptor
- Protein Accession:
- P16471
- B2R882
- D1MDP1
- Q16354
- Q8TD75
- Q8TD78
- Q96P35
- Q96P36
- Q9BX87
- Q9UHJ5
Protein attributes for PRLR Gene
- Size:
- 622 amino acids
- Molecular mass:
- 69506 Da
- Quaternary structure:
-
- Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
Three dimensional structures from OCA and Proteopedia for PRLR Gene
Protein Expression for PRLR Gene
Post-translational modifications for PRLR Gene
Other Protein References for PRLR Gene
- ENSEMBL proteins:
-
- ENSP00000231423
- ENSP00000309008
- ENSP00000311613
- ENSP00000380546
- ENSP00000421864
- ENSP00000422385
- ENSP00000422556
- ENSP00000422867
- ENSP00000422935
- ENSP00000423493
- ENSP00000424841
- ENSP00000425300
- ENSP00000427060
- ENSP00000427236
- ENSP00000441813
- ENSP00000479077
- ENSP00000482689
- ENSP00000482954
- ENSP00000484768
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRLR (Prolactin R)
- Novus Biologicals Antibodies for PRLR
-
Abcam antibodies for PRLR
-
Cloud-Clone Corp. Antibodies for PRLR
- Invitrogen Antibodies for PRLR
- antibodies-online: Search results for 237 available Prolactin Receptor Antibodies ranked by validation data
- Compare Top Prolactin Receptor Antibodies
-
Recommended
- 149 WB Antibodies (anti-human)
- 15 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 49 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 21 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- GeneTex PRLR antibody for PRLR
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRLR
- Sino Biological Antibodies for PRLR
Protein Products
- R&D Systems Proteins and Enzymes for PRLR (Prolactin R)
-
OriGene Purified Proteins for PRLR
- Search Origene for MassSpec and Protein Over-expression Lysates for PRLR
- Origene Custom Protein Services for PRLR
- Sino Biological Cell Lysates for PRLR
- Sino Biological Recombinant Proteins for PRLR
- ProSpec Recombinant Proteins for PRLR
-
Cloud-Clone Corp. Proteins for PRLR
- GeneTex Proteins for PRLR
-
Abcam proteins for PRLR
No data available for DME Specific Peptides for PRLR Gene
Domains & Families for PRLR Gene
Gene Families for PRLR Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- FDA approved drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PRLR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRLR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16471UniProtKB/Swiss-Prot:
PRLR_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 1 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 1 subfamily.
Function for PRLR Gene
Molecular function for PRLR Gene
- GENATLAS Biochemistry:
- prolactin receptor with two alternatively spliced isoforms,expressed in breast cancer,breast normal tissue,gonad and liver
- UniProtKB/Swiss-Prot Function:
- This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Phenotypes From GWAS Catalog for PRLR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004925 | prolactin receptor activity | NAS,TAS | 10585417 |
| GO:0005515 | protein binding | IPI | 12819209 |
| GO:0017046 | peptide hormone binding | IPI | 7984244 |
| GO:0042803 | protein homodimerization activity | NAS | 10585417 |
| GO:0042978 | ornithine decarboxylase activator activity | NAS | 10585417 |
Phenotypes for PRLR Gene
- MGI mutant phenotypes for PRLR:
-
inferred from 1 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- skeleton phenotype
- adipose tissue phenotype
- limbs/digits/tail phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for PRLR:
Animal Models for PRLR Gene
- MGI Knock Outs for PRLR:
-
- Prlr tm1Cnp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRLR
-
- Search ViGene Biosciences for PRLR
CRISPR Products
-
OriGene CRISPR knockouts for PRLR
- Applied Biological Materials CRISPR for PRLR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRLR
- GenScript: Design CRISPR guide RNA sequences for PRLR
miRNA for PRLR Gene
- miRTarBase miRNAs that target PRLR
-
- hsa-mir-181a-5p (MIRT025183)
- hsa-mir-218-5p (MIRT449869)
- hsa-mir-1273e (MIRT449870)
- hsa-mir-6807-5p (MIRT449871)
- hsa-mir-5701 (MIRT449872)
- hsa-mir-636 (MIRT449873)
- hsa-mir-2277-3p (MIRT449874)
- hsa-mir-7157-5p (MIRT449875)
- hsa-mir-4310 (MIRT449876)
- hsa-mir-760 (MIRT496392)
- hsa-mir-518c-5p (MIRT496393)
- hsa-mir-4496 (MIRT496394)
- hsa-mir-587 (MIRT497553)
- hsa-mir-5585-3p (MIRT497554)
- hsa-mir-5581-3p (MIRT497555)
- hsa-mir-6720-3p (MIRT497556)
- hsa-mir-668-5p (MIRT497557)
- hsa-mir-6872-3p (MIRT497558)
- hsa-mir-4787-3p (MIRT497559)
- hsa-mir-5582-3p (MIRT497560)
- hsa-mir-548f-3p (MIRT497561)
- hsa-mir-548e-3p (MIRT497562)
- hsa-mir-548az-3p (MIRT497563)
- hsa-mir-548ar-3p (MIRT497564)
- hsa-mir-548a-3p (MIRT497565)
- hsa-mir-4279 (MIRT529566)
- hsa-mir-3925-3p (MIRT529567)
- hsa-mir-554 (MIRT529568)
- hsa-mir-205-5p (MIRT529569)
- hsa-mir-770-5p (MIRT529570)
- hsa-mir-4712-5p (MIRT529571)
- hsa-mir-4753-3p (MIRT654730)
- hsa-mir-6873-3p (MIRT654731)
- hsa-mir-130b-5p (MIRT654732)
- hsa-mir-6817-3p (MIRT654733)
- hsa-mir-7110-3p (MIRT654734)
- hsa-mir-6769b-3p (MIRT654735)
- hsa-mir-4723-3p (MIRT654736)
- hsa-mir-3183 (MIRT654737)
- hsa-mir-4719 (MIRT654738)
- hsa-mir-6800-3p (MIRT654739)
- hsa-mir-548e-5p (MIRT654740)
- hsa-mir-6726-3p (MIRT666804)
- hsa-mir-211-5p (MIRT666805)
- hsa-mir-204-5p (MIRT666806)
- hsa-mir-584-5p (MIRT666807)
- hsa-mir-4290 (MIRT666808)
- hsa-mir-4685-3p (MIRT666809)
- hsa-mir-4287 (MIRT666810)
- hsa-mir-1181 (MIRT666811)
- hsa-mir-1249-3p (MIRT666812)
- hsa-mir-6832-3p (MIRT666813)
- hsa-mir-5579-5p (MIRT666814)
- hsa-mir-5680 (MIRT666815)
miRNA Products
- Search ViGene Biosciences for PRLR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRLR
- Browse OriGene Inhibitory RNA Products For PRLR
Clone Products
- Sino Biological Human cDNA Clone for PRLR
- VectorBuilder custom plasmid, inducible vectors for PRLR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRLR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
- orf clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
- Applied Biological Materials Clones for PRLR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRLR
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PRLR Gene
Localization for PRLR Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRLR Gene
- Membrane; Single-pass type I membrane protein.
- Isoform 7: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| peroxisome | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009986 | cell surface | IDA | 10585417 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRLR Gene
Pathways & Interactions for PRLR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Prolactin Signaling Pathway | ||
| 2 | Growth hormone receptor signaling | ||
| 3 | PEDF Induced Signaling | ||
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Peptide ligand-binding receptors | ||
Pathways by source for PRLR Gene
5 BioSystems pathways for PRLR Gene
4 Reactome pathways for PRLR Gene
2 GeneGo (Thomson Reuters) pathways for PRLR Gene
2 Qiagen pathways for PRLR Gene
1 Cell Signaling Technology pathway for PRLR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006694 | steroid biosynthetic process | NAS | 10585417 |
| GO:0007166 | cell surface receptor signaling pathway | NAS | 10585417 |
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IDA | 10585417 |
| GO:0007259 | JAK-STAT cascade | IEA | -- |
| GO:0007566 | embryo implantation | TAS | 9009200 |
Drugs & Compounds for PRLR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Somatotropin | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Fluoxymesterone | Approved, Illicit | Pharma | Target, antagonist | 0 | ||
| choriomammotropin | Pharma | Agonist | 0 | |||
| chorionic somatomammotropin hormone-like 1 | Pharma | Agonist | 0 | |||
| prolactin | Pharma | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PRLR Gene
mRNA/cDNA for PRLR Gene
- (11) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PRLR
- Applied Biological Materials CRISPR for PRLR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRLR
- GenScript: Design CRISPR guide RNA sequences for PRLR
miRNA Products
- Search ViGene Biosciences for PRLR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRLR
- Browse OriGene Inhibitory RNA Products For PRLR
Clone Products
- Sino Biological Human cDNA Clone for PRLR
- VectorBuilder custom plasmid, inducible vectors for PRLR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRLR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
- orf clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
- Applied Biological Materials Clones for PRLR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
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| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP11: |
Expression for PRLR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Medulla Oblongata
- Hypothalamus
- Mature Choroid Plexus Cells Choroid Plexus
-
Ovary (Reproductive System)
- Mature follicles(Skory RM et. al. 2012)
- Granulosa Cells Primary Follicle
-
Dermis (Integumentary System)
- Guard Dermal Papilla Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
-
Hair (Integumentary System)
- Guard Dermal Papilla Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
- Adipose (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
mRNA differential expression in normal tissues according to GTEx for PRLR Gene
This gene is overexpressed in Cervix - Ectocervix (x7.9), Adrenal Gland (x6.3), Uterus (x5.7), and Cervix - Endocervix (x4.5).
This gene is overexpressed in Urine (62.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRLR Gene
NURSA nuclear receptor signaling pathways regulating expression of PRLR Gene:
PRLRSOURCE GeneReport for Unigene cluster for PRLR Gene:
Hs.368587mRNA Expression by UniProt/SwissProt for PRLR Gene:
P16471-PRLR_HUMAN
Tissue specificity:
Expressed in breast, placenta, kidney, liver and pancreas.
Evidence on tissue expression from TISSUES for PRLR Gene
- Nervous system(2.7)
- Kidney(2.3)
- Thyroid gland(2.1)
- Liver(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLR Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- endocrine
- nervous
- reproductive
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- pituitary gland
- skull
Thorax:
- breast
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- ovary
- pelvis
- penis
- testicle
- uterus
- vagina
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for PRLR
-
OriGene qPCR primer pairs and template standards for PRLR
Gene Expression Assay Products
Orthologs for PRLR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRLR 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRLR 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PRLR 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prlr 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gm21973 34 |
|
OneToMany | |
| Prlr 33 16 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | PRLR 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRLR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRLR 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRLR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prlr 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | prlr-B 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prlra 33 34 |
|
||
| prlrb 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8049 33 |
|
- Species where no ortholog for PRLR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PRLR Gene
(1) SIMAP similar genes for PRLR Gene using alignment to 10 proteins:
Variants for PRLR Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs398122522 | pathogenic, Hyperprolactinemia, Hyperprolactinemia (HPRL) [MIM:615555] | 35,070,174(-) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs72478580 | pathogenic, Multiple fibroadenomas of the breast, Multiple fibroadenomas of the breast (MFAB) [MIM:615554] | 35,072,610(-) | T/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000003658 | -- | 35,098,890(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000004965 | -- | 35,054,632(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000016688 | -- | 35,078,478(-) | C/G/T | intron_variant |
Residual Variation Intolerance Score:
78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.95;
59.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRLR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLR Gene
Disorders for PRLR Gene
(15) MalaCards diseases for PRLR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperprolactinemia |
|
|
| multiple fibroadenomas of the breast |
|
|
| galactorrhoea-hyperprolactinaemia |
|
|
| breast disease |
|
|
| cerebral meningioma |
|
Search PRLR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PRLR_HUMAN- Hyperprolactinemia (HPRL) [MIM:615555]: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. {ECO:0000269 PubMed:24195502}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Multiple fibroadenomas of the breast (MFAB) [MIM:615554]: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. {ECO:0000269 PubMed:18779591}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PRLR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PRLR Gene
Publications for PRLR Gene
- Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors. (PMID: 18779591) Bogorad RL … Benign Breast Diseases Study Group (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22 44 58
- A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort. (PMID: 18053149) Lee SA … Stram DO (BMC medical genetics 2007) 3 22 44 58
- Association of prolactin and its receptor gene regions with familial breast cancer. (PMID: 16434456) Vaclavicek A … Försti A (The Journal of clinical endocrinology and metabolism 2006) 3 22 44 58
- Could prolactin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? (PMID: 15119991) Canbay E … Bardakci F (Current medical research and opinion 2004) 3 22 44 58
- Functional characterization of the intermediate isoform of the human prolactin receptor. (PMID: 10585417) Kline JB … Clevenger CV (The Journal of biological chemistry 1999) 3 4 22 58
Products for PRLR Gene
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- ProSpec Recombinant Proteins for PRLR
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRLR
- VectorBuilder custom plasmid, inducible vectors for PRLR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRLR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 237 available Prolactin Receptor Antibodies ranked by validation data
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- 149 WB Antibodies (anti-human)
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- 12 IF (p) Antibodies (anti-human)
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- 6 FACS Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 49 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 21 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- antibodies-online: Search results for 11 available Prolactin Receptor Elisa Kits ranked by validation data
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- antibodies-online: Search results for 62 available Prolactin Receptor Proteins ranked by validation data
- Compare Top Prolactin Receptor Proteins
- GeneTex PRLR antibody for PRLR
- GeneTex Proteins for PRLR
- Search ViGene Biosciences for PRLR
- Santa Cruz Biotechnology (SCBT) Antibodies for PRLR
- Search Santa Cruz Biotechnology (SCBT) for PRLR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRLR
- Horizon Cell Lines for PRLR
- genomics-online: cdna clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
- orf clones - Search results for 171 available Prolactin Receptor gene related products
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- Overview of 171 available Prolactin Receptor gene related products
- genomics-online: shRNA clones - Search results for 171 available Prolactin Receptor gene related products
- Overview of 171 available Prolactin Receptor gene related products
Sources for PRLR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
