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This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
PRLR (Prolactin Receptor) is a Protein Coding gene. Diseases associated with PRLR include Hyperprolactinemia and Multiple Fibroadenomas Of The Breast. Among its related pathways are Growth hormone receptor signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and peptide hormone binding. An important paralog of this gene is GHR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004896 | cytokine receptor activity | IBA | 21873635 |
GO:0004923 | leukemia inhibitory factor receptor activity | IBA | 21873635 |
GO:0004924 | contributes_to oncostatin-M receptor activity | IBA | 21873635 |
GO:0004925 | prolactin receptor activity | IBA,IDA | 10585417 |
GO:0005127 | ciliary neurotrophic factor receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IDA | 10585417 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Prolactin Signaling Pathway |
Development Prolactin receptor signaling
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2 | Growth hormone receptor signaling | ||
3 | NF-kappaB Signaling | ||
4 | PEDF Induced Signaling | ||
5 | JAK-STAT signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006694 | steroid biosynthetic process | NAS | 10585417 |
GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IDA | 10585417 |
GO:0007566 | embryo implantation | TAS | 9009200 |
GO:0007595 | lactation | TAS | 9009200 |
GO:0008284 | positive regulation of cell proliferation | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP11: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRLR 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PRLR 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRLR 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prlr 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gm21973 31 |
|
OneToMany | |
Prlr 30 17 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | PRLR 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRLR 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRLR 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRLR 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prlr 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | prlr-B 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | prlra 30 31 |
|
OneToMany | |
prlrb 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8049 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
929748 | Likely Pathogenic: Premature ovarian failure | 35,068,220(-) |
A/C NM_000949.7(PRLR):c.851T>G (p.Leu284Trp) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON | |
rs142331784 | Benign: not provided | 35,070,117(-) |
C/T NM_000949.7(PRLR):c.685+7G>A |
INTRON | |
rs376188691 | Pathogenic: Hyperprolactinemia | 35,072,607(-) |
G/A NM_000949.7(PRLR):c.511C>T (p.Arg171Ter) |
NONSENSE,NON_CODING_TRANSCRIPT | |
rs398122522 | Pathogenic: Hyperprolactinemia. Hyperprolactinemia (HPRL) [MIM:615555] | 35,070,174(-) |
T/Cp.His212Arg NM_000949.7(PRLR):c.635A>G (p.His212Arg) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
rs62355478 | Benign: not provided | 35,065,548(-) |
C/T NM_000949.7(PRLR):c.1410G>A (p.Glu470=) |
SYNONYMOUS_VARIANT,INTRON |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperprolactinemia |
|
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multiple fibroadenomas of the breast |
|
|
galactorrhoea-hyperprolactinaemia |
|
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breast disease |
|
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cerebral meningioma |
|
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