Aliases for PRLR Gene
External Ids for PRLR Gene
Previous GeneCards Identifiers for PRLR Gene
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
GeneCards Summary for PRLR Gene
PRLR (Prolactin Receptor) is a Protein Coding gene. Diseases associated with PRLR include Hyperprolactinemia and Multiple Fibroadenomas Of The Breast. Among its related pathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and peptide hormone binding. An important paralog of this gene is GHR.
UniProtKB/Swiss-Prot Summary for PRLR Gene
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.