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Aliases for PRLHR Gene

Aliases for PRLHR Gene

  • Prolactin Releasing Hormone Receptor 2 3 5
  • G-Protein Coupled Receptor 10 3 4
  • PrRP Receptor 3 4
  • GPR10 3 4
  • PrRPR 3 4
  • HGR3 3 4
  • GR3 3 4
  • Prolactin-Releasing Peptide Receptor 3
  • G Protein-Coupled Receptor 10 2

External Ids for PRLHR Gene

Previous HGNC Symbols for PRLHR Gene

  • GPR10

Previous GeneCards Identifiers for PRLHR Gene

  • GC10M120344
  • GC10M113981

Summaries for PRLHR Gene

Entrez Gene Summary for PRLHR Gene

  • PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRLHR Gene

PRLHR (Prolactin Releasing Hormone Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPY4R.

UniProtKB/Swiss-Prot for PRLHR Gene

  • Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

Gene Wiki entry for PRLHR Gene

Additional gene information for PRLHR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLHR Gene

Genomics for PRLHR Gene

GeneHancer (GH) Regulatory Elements for PRLHR Gene

Promoters and enhancers for PRLHR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J118595 Promoter 0.5 EPDnew 650.7 +4.2 4232 0.1 PRLHR SLC25A18P1
GH10J118725 Enhancer 1 Ensembl ENCODE 10.7 -126.4 -126387 0.9 INSM2 FEZF1 ZNF2 ZNF366 ZSCAN5C RCOR1 KLF13 OVOL3 ZNF398 TSHZ1 CACUL1 PRLHR GC10P118694
GH10J118729 Enhancer 0.9 Ensembl ENCODE 10.7 -131.4 -131424 4.6 JUN FEZF1 IRF4 GATA3 ZNF766 POLR2A ATF7 ETV6 IKZF2 RUNX3 CACUL1 PRLHR GC10P118694
GH10J118568 Enhancer 0.8 Ensembl ENCODE 11.9 +31.3 31333 0.5 CTCF ZNF654 ZNF362 FOXA2 REST MNT ZNF384 RAD21 ZNF335 ZNF143 PRLHR SLC25A18P1 GC10P118534 GC10P118535
GH10J118797 Enhancer 0.5 ENCODE 11.1 -198.7 -198658 1.2 ESRRA ZNF362 RFX1 ZNF189 ZFP37 FOS PRDM1 PRLHR GC10M118785 PIR53333
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRLHR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRLHR gene promoter:
  • deltaCREB
  • CREB
  • NRSF form 2
  • NRSF form 1
  • Pax-5
  • FOXF2
  • FOXC1
  • COMP1
  • HFH-1
  • AP-2gamma

Genomic Locations for PRLHR Gene

Genomic Locations for PRLHR Gene
9,907 bases
Minus strand
2,245 bases
Minus strand

Genomic View for PRLHR Gene

Genes around PRLHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLHR Gene

Proteins for PRLHR Gene

  • Protein details for PRLHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prolactin-releasing peptide receptor
    Protein Accession:
    Secondary Accessions:
    • O75194
    • Q502U8
    • Q5VXR9

    Protein attributes for PRLHR Gene

    370 amino acids
    Molecular mass:
    41121 Da
    Quaternary structure:
    • Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
    • Sequence=AAC50504.1; Type=Frameshift; Positions=168, 175; Evidence={ECO:0000305};

neXtProt entry for PRLHR Gene

Post-translational modifications for PRLHR Gene

  • Glycosylation at Asn36 and posLast=2727
  • Modification sites at PhosphoSitePlus

Other Protein References for PRLHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLHR Gene

Domains & Families for PRLHR Gene

Gene Families for PRLHR Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PRLHR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PRLHR: view

Function for PRLHR Gene

Molecular function for PRLHR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
UniProtKB/Swiss-Prot Induction:
Repressed by bromocriptine, a dopamine agonist.

Phenotypes From GWAS Catalog for PRLHR Gene

Gene Ontology (GO) - Molecular Function for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8666380
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 11641419
GO:0008188 neuropeptide receptor activity TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view
genes like me logo Genes that share phenotypes with PRLHR: view

Animal Models for PRLHR Gene

MGI Knock Outs for PRLHR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRLHR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRLHR Gene

Localization for PRLHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLHR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8666380
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRLHR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRLHR Gene

Pathways & Interactions for PRLHR Gene

genes like me logo Genes that share pathways with PRLHR: view

Pathways by source for PRLHR Gene

Gene Ontology (GO) - Biological Process for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8666380
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007565 female pregnancy TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view

No data available for SIGNOR curated interactions for PRLHR Gene

Drugs & Compounds for PRLHR Gene

(8) Drugs for PRLHR Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Full agonist, Agonist, Antagonist 0
[<sup>125</sup>I]PrRP-20 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]PrRP31 Pharma 0
NPY-(18-36) (human, pig) Pharma Full agonist, Agonist, Partial agonist 0
PrRP-(24-31) (human) Pharma Full agonist, Agonist 0

(1) Additional Compounds for PRLHR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLHR: view

Transcripts for PRLHR Gene

mRNA/cDNA for PRLHR Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRLHR Gene

Prolactin releasing hormone receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLHR Gene

No ASD Table

Relevant External Links for PRLHR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRLHR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRLHR Gene

mRNA differential expression in normal tissues according to GTEx for PRLHR Gene

This gene is overexpressed in Pituitary (x15.6), Vagina (x6.7), Uterus (x5.2), and Brain - Hypothalamus (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PRLHR Gene:


SOURCE GeneReport for Unigene cluster for PRLHR Gene:


mRNA Expression by UniProt/SwissProt for PRLHR Gene:

Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas.
genes like me logo Genes that share expression patterns with PRLHR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLHR Gene

Orthologs for PRLHR Gene

This gene was present in the common ancestor of animals.

Orthologs for PRLHR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRLHR 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia PRLHR 34 33
  • 91.62 (n)
(Bos Taurus)
Mammalia PRLHR 34 33
  • 90.27 (n)
(Rattus norvegicus)
Mammalia Prlhr 33
  • 86.45 (n)
(Mus musculus)
Mammalia Prlhr 16 34 33
  • 86.19 (n)
(Monodelphis domestica)
Mammalia PRLHR 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
(Gallus gallus)
Aves PRLHR 34 33
  • 59.28 (n)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia PRLHR 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prlhr 33
  • 60.84 (n)
(Danio rerio)
Actinopterygii prlhr2b 34
  • 53 (a)
prlhr2a 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta sNPF-R 34 33
  • 55.86 (n)
(Caenorhabditis elegans)
Secernentea npr-6 34
  • 25 (a)
Species where no ortholog for PRLHR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRLHR Gene

Gene Tree for PRLHR (if available)
Gene Tree for PRLHR (if available)
Evolutionary constrained regions (ECRs) for PRLHR: view image

Paralogs for PRLHR Gene

Paralogs for PRLHR Gene

(25) SIMAP similar genes for PRLHR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRLHR: view

Variants for PRLHR Gene

Sequence variations from dbSNP and Humsavar for PRLHR Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001296871 -- 118,594,521(-) G/A coding_sequence_variant, missense_variant
rs1001667502 -- 118,594,304(-) CCAAAGGC/CCAAAGGCCAAAGGC coding_sequence_variant, frameshift
rs1003657331 -- 118,596,007(-) G/T upstream_transcript_variant
rs1004043948 -- 118,593,119(-) C/T downstream_transcript_variant
rs1005602571 -- 118,595,519(-) G/C 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRLHR Gene

Variant ID Type Subtype PubMed ID
nsv7569 CNV insertion 18451855
nsv832006 CNV gain 17160897
nsv951861 CNV deletion 24416366

Variation tolerance for PRLHR Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRLHR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLHR Gene

Disorders for PRLHR Gene

Additional Disease Information for PRLHR

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRLHR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLHR Gene

Publications for PRLHR Gene

  1. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PMID: 15885496) Lagerström MC … Schiöth HB (Genomics 2005) 2 3 22 58
  2. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (PMID: 12716769) Bhattacharyya S … O'Rahilly S (Diabetes 2003) 3 22 44 58
  3. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PMID: 11923475) Ozawa A … Mori M (Molecular endocrinology (Baltimore, Md.) 2002) 3 4 22 58
  4. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin SH … Civelli O (Molecular pharmacology 2001) 3 4 22 58
  5. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S … Fujino M (Nature 1998) 3 4 22 58

Products for PRLHR Gene

Sources for PRLHR Gene

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