PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008] See more...

Aliases for PRLHR Gene

Aliases for PRLHR Gene

  • Prolactin Releasing Hormone Receptor 2 3 5
  • Prolactin-Releasing Peptide Receptor 3 4
  • G-Protein Coupled Receptor 10 3 4
  • PrRP Receptor 3 4
  • GPR10 3 4
  • PrRPR 3 4
  • HGR3 3 4
  • GR3 3 4
  • G Protein-Coupled Receptor 10 2

External Ids for PRLHR Gene

Previous HGNC Symbols for PRLHR Gene

  • GPR10

Previous GeneCards Identifiers for PRLHR Gene

  • GC10M120344
  • GC10M113981

Summaries for PRLHR Gene

Entrez Gene Summary for PRLHR Gene

  • PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRLHR Gene

PRLHR (Prolactin Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with PRLHR include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPY4R2.

UniProtKB/Swiss-Prot Summary for PRLHR Gene

  • Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

Gene Wiki entry for PRLHR Gene

Additional gene information for PRLHR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRLHR Gene

Genomics for PRLHR Gene

GeneHancer (GH) Regulatory Elements for PRLHR Gene

Promoters and enhancers for PRLHR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J118595 Promoter 0.5 EPDnew 500.7 +4.2 4232 0.1 EZH2 RBBP5 PRLHR piR-49400-012 HSALNG0080989
GH10J118568 Enhancer 0.8 Ensembl ENCODE 18.8 +31.1 31095 1.2 CTCF REST RAD21 SMC3 ZNF384 ZNF335 ZNF654 RCOR1 HNF4A ZNF362 PRLHR SLC25A18P1 lnc-NANOS1-6 piR-52008-002
GH10J118564 Enhancer 0.7 Ensembl ENCODE 17.4 +36.2 36249 2.9 CTCF TEAD4 REST SMC3 YY1 POLR2A TCF12 RAD21 PRLHR CACUL1 SLC25A18P1 lnc-NANOS1-6 piR-52008-002
GH10J118729 Promoter/Enhancer 1.1 Ensembl ENCODE 10.7 -131.5 -131498 4.5 ZBTB40 ZNF10 OSR2 WT1 GATA3 ZNF263 SPI1 NR2C1 ELF1 GABPA CACUL1 PRLHR AB372778-007 lnc-PRLHR-4
GH10J118571 Enhancer 0.6 Ensembl ENCODE 18.7 +28.6 28589 0.7 REST NR3C1 RAD21 SLC25A18P1 lnc-NANOS1-6 PRLHR piR-52008-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRLHR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRLHR

Top Transcription factor binding sites by QIAGEN in the PRLHR gene promoter:
  • AP-2gamma
  • COMP1
  • CREB
  • deltaCREB
  • FOXC1
  • FOXF2
  • HFH-1
  • NRSF form 1
  • NRSF form 2
  • Pax-5

Genomic Locations for PRLHR Gene

Genomic Locations for PRLHR Gene
chr10:118,589,997-118,599,895
(GRCh38/hg38)
Size:
9,899 bases
Orientation:
Minus strand
chr10:120,352,916-120,355,160
(GRCh37/hg19)
Size:
2,245 bases
Orientation:
Minus strand

Genomic View for PRLHR Gene

Genes around PRLHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLHR Gene

Proteins for PRLHR Gene

  • Protein details for PRLHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49683-PRLHR_HUMAN
    Recommended name:
    Prolactin-releasing peptide receptor
    Protein Accession:
    P49683
    Secondary Accessions:
    • O75194
    • Q502U8
    • Q5VXR9

    Protein attributes for PRLHR Gene

    Size:
    370 amino acids
    Molecular mass:
    41121 Da
    Quaternary structure:
    • Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
    SequenceCaution:
    • Sequence=AAC50504.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for PRLHR Gene

Post-translational modifications for PRLHR Gene

  • Glycosylation at Asn27 and Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for PRLHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLHR Gene

Domains & Families for PRLHR Gene

Gene Families for PRLHR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for PRLHR Gene

Blocks:
  • Probable G protein-coupled receptor GPR10 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRLHR Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77977, highly similar to Homo sapiens G protein-coupled receptor 10 (GPR10), mRNA (A5JUU5_HUMAN)
  • hGR3 (PRLHR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49683

UniProtKB/Swiss-Prot:

PRLHR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PRLHR: view

Function for PRLHR Gene

Molecular function for PRLHR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
UniProtKB/Swiss-Prot Induction:
Repressed by bromocriptine, a dopamine agonist.

Phenotypes From GWAS Catalog for PRLHR Gene

Gene Ontology (GO) - Molecular Function for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 8666380
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 11641419
GO:0008188 neuropeptide receptor activity TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view
genes like me logo Genes that share phenotypes with PRLHR: view

Animal Models for PRLHR Gene

MGI Knock Outs for PRLHR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRLHR

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRLHR Gene

Localization for PRLHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLHR gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8666380
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRLHR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRLHR Gene

Pathways & Interactions for PRLHR Gene

genes like me logo Genes that share pathways with PRLHR: view

Pathways by source for PRLHR Gene

SIGNOR curated interactions for PRLHR Gene

Gene Ontology (GO) - Biological Process for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS 8666380
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007565 female pregnancy TAS 9607765
GO:0007631 feeding behavior IEA --
genes like me logo Genes that share ontologies with PRLHR: view

Drugs & Compounds for PRLHR Gene

(8) Drugs for PRLHR Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Full agonist, Agonist, Antagonist 0
[<sup>125</sup>I]PrRP-20 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]PrRP31 Pharma 0
NPY-(18-36) (human, pig) Pharma Full agonist, Agonist, Partial agonist 0
PrRP-(24-31) (human) Pharma Full agonist, Agonist 0

(1) Additional Compounds for PRLHR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLHR: view

Transcripts for PRLHR Gene

mRNA/cDNA for PRLHR Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLHR Gene

No ASD Table

Relevant External Links for PRLHR Gene

GeneLoc Exon Structure for
PRLHR

Expression for PRLHR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRLHR Gene

mRNA differential expression in normal tissues according to GTEx for PRLHR Gene

This gene is overexpressed in Pituitary (x15.6), Vagina (x6.7), Uterus (x5.2), and Brain - Hypothalamus (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRLHR

SOURCE GeneReport for Unigene cluster for PRLHR Gene:

Hs.248119

mRNA Expression by UniProt/SwissProt for PRLHR Gene:

P49683-PRLHR_HUMAN
Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas.
genes like me logo Genes that share expression patterns with PRLHR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLHR Gene

Orthologs for PRLHR Gene

This gene was present in the common ancestor of animals.

Orthologs for PRLHR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRLHR 31 30
  • 99.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRLHR 31 30
  • 91.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRLHR 31 30
  • 90.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prlhr 30
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Prlhr 17 31 30
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia PRLHR 31
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PRLHR 31 30
  • 59.28 (n)
OneToMany
-- 31
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRLHR 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prlhr 30
  • 60.84 (n)
zebrafish
(Danio rerio)
Actinopterygii prlhr2b 31
  • 53 (a)
OneToMany
prlhr2a 31
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sNPF-R 31 30
  • 55.86 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-6 31
  • 25 (a)
OneToOne
Species where no ortholog for PRLHR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRLHR Gene

ENSEMBL:
Gene Tree for PRLHR (if available)
TreeFam:
Gene Tree for PRLHR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRLHR: view image

Paralogs for PRLHR Gene

(25) SIMAP similar genes for PRLHR Gene using alignment to 2 proteins:

  • PRLHR_HUMAN
  • A5JUU5_HUMAN
genes like me logo Genes that share paralogs with PRLHR: view

Variants for PRLHR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRLHR Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1613448 - p.Ile283Val
rs8192523 - p.Asp302Gly

Additional dbSNP identifiers (rs#s) for PRLHR Gene

Structural Variations from Database of Genomic Variants (DGV) for PRLHR Gene

Variant ID Type Subtype PubMed ID
nsv7569 CNV insertion 18451855
nsv832006 CNV gain 17160897
nsv951861 CNV deletion 24416366

Variation tolerance for PRLHR Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRLHR Gene

Human Gene Mutation Database (HGMD)
PRLHR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRLHR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLHR Gene

Disorders for PRLHR Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRLHR Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search PRLHR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRLHR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRLHR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRLHR Gene

Publications for PRLHR Gene

  1. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PMID: 15885496) Lagerström MC … Schiöth HB (Genomics 2005) 2 3 23 54
  2. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (PMID: 12716769) Bhattacharyya S … O'Rahilly S (Diabetes 2003) 3 23 41 54
  3. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PMID: 11923475) Ozawa A … Mori M (Molecular endocrinology (Baltimore, Md.) 2002) 3 4 23 54
  4. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin SH … Civelli O (Molecular pharmacology 2001) 3 4 23 54
  5. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S … Fujino M (Nature 1998) 3 4 23 54

Products for PRLHR Gene

Sources for PRLHR Gene