This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chrom... See more...

Aliases for PRKY Gene

Aliases for PRKY Gene

  • Protein Kinase Y-Linked (Pseudogene) 2 3 5
  • Putative Serine/Threonine-Protein Kinase PRKY 4
  • Protein Kinase Y-Linked, Pseudogene 2
  • Protein Kinase, Y-Linked 2
  • EC 2.7.11.1 4
  • EC 2.7.11 52
  • PRKXP3 3
  • PRKYP 3

External Ids for PRKY Gene

Previous GeneCards Identifiers for PRKY Gene

  • GC0YP007107
  • GC0YP006844
  • GC0YP007185
  • GC0YP004701
  • GC0YP007142

Summaries for PRKY Gene

Entrez Gene Summary for PRKY Gene

  • This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]

GeneCards Summary for PRKY Gene

PRKY (Protein Kinase Y-Linked (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PRKX.

Gene Wiki entry for PRKY Gene

Additional gene information for PRKY Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKY Gene

Genomics for PRKY Gene

GeneHancer (GH) Regulatory Elements for PRKY Gene

Promoters and enhancers for PRKY Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YJ007272 Enhancer 0.9 FANTOM5 ENCODE 500.7 +0.7 729 4.3 POLR2G TEAD4 CTCF TGIF2 TEAD1 POLR2A KAT7 MXI1 TFDP1 SAP130 PRKY AMELY HSALNG0141026
GH0YJ007278 Enhancer 0.7 FANTOM5 ENCODE 0.4 +7.1 7141 5.3 FOXA1 SKI TBX3 FOXA2 ZNF205 FOXP1 SOX5 MIXL1 FOXA3 SOX13 HSALNG0141026 PRKY
GH0YJ007311 Enhancer 0.6 ENCODE 0.3 +36.7 36743 0.2 TEAD1 ZSCAN9 FOXA2 SAP130 TEAD3 ARID4B SP1 ZNF644 GATAD2A EP300 piR-41525-726 piR-41405-182 PRKY
GH0YJ007310 Enhancer 0.5 ENCODE 0.3 +37.1 37083 0.3 TEAD1 CEBPB RAD21 TEAD3 ARID4B CEBPG CTCF GATAD2A piR-41525-726 piR-41405-182 PRKY
GH0YJ007289 Enhancer 0.3 ENCODE 0.4 +17.0 17045 3.5 SPI1 HSALNG0141026 PRKY piR-41525-726
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKY gene promoter:
  • RORalpha1

Genomic Locations for PRKY Gene

Genomic Locations for PRKY Gene
chrY:7,273,972-7,381,548
(GRCh38/hg38)
Size:
107,577 bases
Orientation:
Plus strand
chrY:7,142,013-7,249,589
(GRCh37/hg19)
Size:
107,577 bases
Orientation:
Plus strand

Genomic View for PRKY Gene

Genes around PRKY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKY Gene

Proteins for PRKY Gene

  • Protein details for PRKY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43930-PRKY_HUMAN
    Recommended name:
    Putative serine/threonine-protein kinase PRKY
    Protein Accession:
    O43930
    Secondary Accessions:
    • O15348
    • O15349

    Protein attributes for PRKY Gene

    Size:
    277 amino acids
    Molecular mass:
    31708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRKY Gene

Selected DME Specific Peptides for PRKY Gene

O43930:
  • GTPEYLAPE
  • RDLKPEN
  • GHIKLTD
  • TDFGFAK
  • LGILIFE
  • IKLTDFG
  • KPENILLD
  • DRDGHIK

Post-translational modifications for PRKY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKY Gene

ENSEMBL proteins:

Domains & Families for PRKY Gene

Gene Families for PRKY Gene

Protein Domains for PRKY Gene

Suggested Antigen Peptide Sequences for PRKY Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase PRKY (PRKY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43930

UniProtKB/Swiss-Prot:

PRKY_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKY: view

Function for PRKY Gene

Molecular function for PRKY Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
GENATLAS Biochemistry:
serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic recombination with PRKX,leading to XX male

Enzyme Numbers (IUBMB) for PRKY Gene

Gene Ontology (GO) - Molecular Function for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS 9154127
GO:0004691 cAMP-dependent protein kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PRKY: view
genes like me logo Genes that share phenotypes with PRKY: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKY

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRKY Gene

Localization for PRKY Gene

Gene Ontology (GO) - Cellular Components for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005952 cAMP-dependent protein kinase complex IBA 21873635
genes like me logo Genes that share ontologies with PRKY: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PRKY Gene

Pathways & Interactions for PRKY Gene

PathCards logo

SuperPathways for PRKY Gene

No Data Available

Interacting Proteins for PRKY Gene

Selected Interacting proteins: O43930-PRKY_HUMAN for PRKY Gene via IID

;

Gene Ontology (GO) - Biological Process for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9154127
GO:0007165 signal transduction IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PRKY: view

No data available for Pathways by source and SIGNOR curated interactions for PRKY Gene

Drugs & Compounds for PRKY Gene

(2) Drugs for PRKY Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for PRKY Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PRKY: view

Transcripts for PRKY Gene

mRNA/cDNA for PRKY Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKY

Alternative Splicing Database (ASD) splice patterns (SP) for PRKY Gene

No ASD Table

Relevant External Links for PRKY Gene

GeneLoc Exon Structure for
PRKY

Expression for PRKY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKY Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKY

SOURCE GeneReport for Unigene cluster for PRKY Gene:

Hs.584730

mRNA Expression by UniProt/SwissProt for PRKY Gene:

O43930-PRKY_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PRKY: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKY Gene

Orthologs for PRKY Gene

Evolution for PRKY Gene

ENSEMBL:
Gene Tree for PRKY (if available)
TreeFam:
Gene Tree for PRKY (if available)

No data available for Orthologs for PRKY Gene

Paralogs for PRKY Gene

Paralogs for PRKY Gene

genes like me logo Genes that share paralogs with PRKY: view

Variants for PRKY Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKY Gene

Variant ID Type Subtype PubMed ID
esv3577579 CNV gain 25503493
nsv1078153 CNV duplication 25765185
nsv7473 OTHER inversion 18451855

Additional Variant Information for PRKY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKY

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for PRKY Gene

Disorders for PRKY Gene

UniProtKB/Swiss-Prot

PRKY_HUMAN
  • Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Additional Disease Information for PRKY

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRKY Gene.

No data available for MalaCards and Genatlas for PRKY Gene

Publications for PRKY Gene

  1. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K … Rappold GA (Human molecular genetics 1997) 3 4 23 54
  2. Perioperative genomic profiles using structure-specific oligonucleotide probes. (PMID: 19474452) Hogan KJ … Domanico MJ (Clinical medicine & research 2009) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 54
  5. FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13. (PMID: 9154127) Schiebel K … Rappold G (Cytogenetics and cell genetics 1997) 3 4 54

Products for PRKY Gene

Sources for PRKY Gene