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Aliases for PRKY Gene

Aliases for PRKY Gene

  • Protein Kinase, Y-Linked, Pseudogene 2 3 5
  • Protein Kinase, Y-Linked 2
  • EC 4
  • EC 2.7.11 56
  • PRKXP3 3
  • PRKYP 3

External Ids for PRKY Gene

Previous GeneCards Identifiers for PRKY Gene

  • GC0YP007107
  • GC0YP006844
  • GC0YP004701
  • GC0YP007142

Summaries for PRKY Gene

Entrez Gene Summary for PRKY Gene

  • This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]

GeneCards Summary for PRKY Gene

PRKY (Protein Kinase, Y-Linked, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include protein serine/threonine kinase activity.

Gene Wiki entry for PRKY Gene

Additional gene information for PRKY Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKY Gene

Genomics for PRKY Gene

GeneHancer (GH) Regulatory Elements for PRKY Gene

Promoters and enhancers for PRKY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI007272 Enhancer 0.9 FANTOM5 ENCODE 550.8 +0.7 729 4.3 ELF3 SOX13 CTCF MXI1 SAP130 ZFP64 ARID4B SIN3A DMAP1 THRB PRKY AMELY RN7SKP282
GH0YI007278 Enhancer 0.8 FANTOM5 ENCODE 0.4 +7.1 7141 5.3 SOX5 SOX13 FOXA2 FOXA3 FOXA1 TBX3 SKI MIXL1 FOXP1 PRKY RN7SKP282
GH0YI007311 Enhancer 0.5 ENCODE 0.3 +36.7 36743 0.2 GATAD2A FOXA2 SAP130 ARID4B MNT ZNF644 RN7SKP282 PRKY
GH0YI007310 Enhancer 0.4 ENCODE 0.3 +37.1 37083 0.3 GATAD2A CEBPB CEBPG RN7SKP282 PRKY
GH0YI007289 Enhancer 0.2 ENCODE 0.4 +17.0 17045 3.5 PRKY RN7SKP282
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKY gene promoter:

Genomic Locations for PRKY Gene

Genomic Locations for PRKY Gene
107,577 bases
Plus strand

Genomic View for PRKY Gene

Genes around PRKY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKY Gene

Proteins for PRKY Gene

  • Protein details for PRKY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative serine/threonine-protein kinase PRKY
    Protein Accession:
    Secondary Accessions:
    • O15348
    • O15349

    Protein attributes for PRKY Gene

    277 amino acids
    Molecular mass:
    31708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRKY Gene

Selected DME Specific Peptides for PRKY Gene


Post-translational modifications for PRKY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRKY Gene

Gene Families for PRKY Gene

Protein Domains for PRKY Gene

Suggested Antigen Peptide Sequences for PRKY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKY: view

Function for PRKY Gene

Molecular function for PRKY Gene

GENATLAS Biochemistry:
serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic recombination with PRKX,leading to XX male
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PRKY Gene

Gene Ontology (GO) - Molecular Function for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKY: view
genes like me logo Genes that share phenotypes with PRKY: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKY

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRKY Gene

Localization for PRKY Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRKY Gene

Pathways & Interactions for PRKY Gene

No Data Available

Interacting Proteins for PRKY Gene

Selected Interacting proteins: O43930-PRKY_HUMAN for PRKY Gene via IID

Gene Ontology (GO) - Biological Process for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PRKY: view

No data available for Pathways by source and SIGNOR curated interactions for PRKY Gene

Drugs & Compounds for PRKY Gene

(2) Drugs for PRKY Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for PRKY Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PRKY: view

Transcripts for PRKY Gene

mRNA/cDNA for PRKY Gene

Unigene Clusters for PRKY Gene

Protein kinase, Y-linked, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKY

Alternative Splicing Database (ASD) splice patterns (SP) for PRKY Gene

No ASD Table

Relevant External Links for PRKY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKY Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKY Gene:


SOURCE GeneReport for Unigene cluster for PRKY Gene:


mRNA Expression by UniProt/SwissProt for PRKY Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PRKY: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKY Gene

Orthologs for PRKY Gene

Evolution for PRKY Gene

Gene Tree for PRKY (if available)
Gene Tree for PRKY (if available)

No data available for Orthologs for PRKY Gene

Paralogs for PRKY Gene

genes like me logo Genes that share paralogs with PRKY: view

No data available for Paralogs for PRKY Gene

Variants for PRKY Gene

Sequence variations from dbSNP and Humsavar for PRKY Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1002556607 -- 7,312,464(+) G/T intron_variant
rs1002758435 -- 7,292,870(+) G/T intron_variant
rs1002913141 -- 7,310,598(+) G/A intron_variant
rs1003505209 -- 7,364,189(+) C/T intron_variant
rs1003963828 -- 7,376,715(+) A/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKY Gene

Variant ID Type Subtype PubMed ID
esv3577579 CNV gain 25503493
nsv1078153 CNV duplication 25765185
nsv7473 OTHER inversion 18451855

Additional Variant Information for PRKY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRKY Gene

Disorders for PRKY Gene


  • Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Additional Disease Information for PRKY

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRKY Gene.

No data available for MalaCards and Genatlas for PRKY Gene

Publications for PRKY Gene

  1. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K … Rappold GA (Human molecular genetics 1997) 3 4 22 58
  2. Perioperative genomic profiles using structure-specific oligonucleotide probes. (PMID: 19474452) Hogan KJ … Domanico MJ (Clinical medicine & research 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  5. FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13. (PMID: 9154127) Schiebel K … Rappold G (Cytogenetics and cell genetics 1997) 3 4 58

Products for PRKY Gene

  • Addgene plasmids for PRKY

Sources for PRKY Gene

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