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Aliases for PRKX Gene

Aliases for PRKX Gene

  • Protein Kinase, X-Linked 2 3 5
  • Serine/Threonine-Protein Kinase PRKX 3 4
  • Protein Kinase PKX1 3 4
  • Protein Kinase X 3 4
  • PKX1 3 4
  • CAMP-Dependent Protein Kinase Catalytic Subunit PRKX 3
  • Protein Kinase X-Linked 4
  • EC 2.7.11.1 4
  • EC 2.7.11 56
  • PrKX 4

External Ids for PRKX Gene

Previous GeneCards Identifiers for PRKX Gene

  • GC0XU990189
  • GC0XM003052
  • GC0XM003117
  • GC0XM003515
  • GC0XM001474

Summaries for PRKX Gene

Entrez Gene Summary for PRKX Gene

  • This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

GeneCards Summary for PRKX Gene

PRKX (Protein Kinase, X-Linked) is a Protein Coding gene. Diseases associated with PRKX include 47, Xxy and Asbestos-Related Lung Carcinoma. Among its related pathways are GPCR Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKX Gene

  • Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.

Additional gene information for PRKX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKX Gene

Genomics for PRKX Gene

GeneHancer (GH) Regulatory Elements for PRKX Gene

Promoters and enhancers for PRKX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI003710 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 562.3 +0.7 672 4.5 HDGF SIN3A ARID2 ZNF143 IKZF2 SMARCA5 ZBTB2 ELF1 SP1 GMEB1 PRKX PRKX-AS1
GH0XI003697 Enhancer 1.4 FANTOM5 Ensembl ENCODE 30.4 +13.6 13644 6 ATF1 YBX1 TCF12 ZNF766 CAVIN1 ZNF592 MEF2D ATF4 SMARCA4 NBN PRKX PRKX-AS1
GH0XI003743 Enhancer 0.8 FANTOM5 ENCODE 20.7 -30.3 -30333 0.9 ZNF148 ATF1 PKNOX1 ZNF316 ETV1 CEBPG EMSY GABPA PRKX LOC100128355 GC0XP003784
GH0XI003813 Enhancer 1.6 FANTOM5 Ensembl ENCODE 9.4 -102.2 -102212 4.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A YY1 POLR2B E2F8 ZNF207 FAM239B PRKX LOC389906 GC0XP003806 GC0XM003867 TRI-GAT1-1
GH0XI003728 Enhancer 0.7 FANTOM5 ENCODE 8.8 -15.0 -14965 0.6 FOSL1 MEIS2 ATF1 REST CREM PRKX ARSE LOC100128355 GC0XP003784
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKX gene promoter:

Genomic Locations for PRKX Gene

Genomic Locations for PRKX Gene
chrX:3,604,343-3,713,644
(GRCh38/hg38)
Size:
109,302 bases
Orientation:
Minus strand
chrX:3,522,384-3,631,675
(GRCh37/hg19)

Genomic View for PRKX Gene

Genes around PRKX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKX Gene

Proteins for PRKX Gene

  • Protein details for PRKX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51817-PRKX_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit PRKX
    Protein Accession:
    P51817

    Protein attributes for PRKX Gene

    Size:
    358 amino acids
    Molecular mass:
    40896 Da
    Quaternary structure:
    • Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein kinase inhibitor/PKI proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1; involved in differentiation and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain).

neXtProt entry for PRKX Gene

Selected DME Specific Peptides for PRKX Gene

P51817:
  • GTPEYLAPE
  • IKLTDFG
  • RDLKPEN
  • GHIKLTD
  • TDFGFAK
  • LGILIFE
  • KPENILLD
  • DRDGHIK

Post-translational modifications for PRKX Gene

Other Protein References for PRKX Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRKX Gene

Gene Families for PRKX Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51817

UniProtKB/Swiss-Prot:

PRKX_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKX: view

Function for PRKX Gene

Molecular function for PRKX Gene

GENATLAS Biochemistry:
serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=127 uM for ATP (in the presence of 10 mM magnesium chloride) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174}; KM=58 uM for kemptide (in the presence of 10 mM magnesium chloride) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174}; KM=6.7 uM for kemptide (in the presence of 1 uM Br-cAMP at 30 degrees Celsius) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for PRKX Gene

Gene Ontology (GO) - Molecular Function for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004691 cAMP-dependent protein kinase activity IDA 10026146
GO:0005515 protein binding IPI 16491121
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKX: view
genes like me logo Genes that share phenotypes with PRKX: view

Animal Model Products

CRISPR Products

miRNA for PRKX Gene

miRTarBase miRNAs that target PRKX

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKX Gene

Localization for PRKX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKX Gene

Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKX gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10026146
GO:0005737 cytoplasm IDA,IEA 10026146
genes like me logo Genes that share ontologies with PRKX: view

Pathways & Interactions for PRKX Gene

SuperPathway Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with PRKX: view

Pathways by source for PRKX Gene

1 Qiagen pathway for PRKX Gene

SIGNOR curated interactions for PRKX Gene

Activates:

Gene Ontology (GO) - Biological Process for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 21684272
GO:0001935 endothelial cell proliferation IMP,IEA 21684272
GO:0006468 protein phosphorylation IEA --
GO:0007155 cell adhesion IMP,IEA 21684272
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with PRKX: view

Drugs & Compounds for PRKX Gene

(4) Drugs for PRKX Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
ATP Investigational Nutra Agonist 0
GSK690693 Pharma Inhibition, Inhibitor Pan-AKT inhibitor,ATP-competitive and potent 0

(1) Additional Compounds for PRKX Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for PRKX Gene

Compound Action Cas Number
GSK690693 Pan-AKT inhibitor,ATP-competitive and potent 937174-76-0
genes like me logo Genes that share compounds with PRKX: view

Drug Products

Transcripts for PRKX Gene

mRNA/cDNA for PRKX Gene

Unigene Clusters for PRKX Gene

Protein kinase, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKX Gene

No ASD Table

Relevant External Links for PRKX Gene

GeneLoc Exon Structure for
PRKX
ECgene alternative splicing isoforms for
PRKX

Expression for PRKX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKX Gene

mRNA differential expression in normal tissues according to GTEx for PRKX Gene

This gene is overexpressed in Thyroid (x4.5).

Protein differential expression in normal tissues from HIPED for PRKX Gene

This gene is overexpressed in Lung (49.5) and Spleen (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKX Gene



Protein tissue co-expression partners for PRKX Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKX Gene:

PRKX

SOURCE GeneReport for Unigene cluster for PRKX Gene:

Hs.390788

mRNA Expression by UniProt/SwissProt for PRKX Gene:

P51817-PRKX_HUMAN
Tissue specificity: Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.

Evidence on tissue expression from TISSUES for PRKX Gene

  • Nervous system(4.6)
  • Blood(4.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with PRKX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKX Gene

Orthologs for PRKX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
PRKX 33 34
  • 95.9 (n)
dog
(Canis familiaris)
Mammalia PRKX 33 34
  • 86.45 (n)
cow
(Bos Taurus)
Mammalia PRKX 33 34
  • 83.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKX 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKX 34
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkx 33
  • 75.4 (n)
mouse
(Mus musculus)
Mammalia Prkx 33 16 34
  • 74.93 (n)
chicken
(Gallus gallus)
Aves PRKX 33 34
  • 76.32 (n)
lizard
(Anolis carolinensis)
Reptilia PRKX 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkx 33
  • 70.49 (n)
zebrafish
(Danio rerio)
Actinopterygii prkx 34
  • 73 (a)
OneToOne
LOC561941 33
  • 68.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011840 33
  • 63.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pka-C3 35 33 34
  • 62.12 (n)
Pka-C2 35
  • 46 (a)
CG12069 35
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea F47F2.1a 35
  • 53 (a)
F47F2.1 33 34
  • 52.94 (n)
F47F2.1b 35
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK2 34
  • 42 (a)
ManyToMany
TPK1 34
  • 39 (a)
ManyToMany
TPK3 34
  • 38 (a)
ManyToMany
wheat
(Triticum aestivum)
Liliopsida Ta.9503 33
corn
(Zea mays)
Liliopsida Zm.1519 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3024 34
  • 68 (a)
OneToOne
Species where no ortholog for PRKX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRKX Gene

ENSEMBL:
Gene Tree for PRKX (if available)
TreeFam:
Gene Tree for PRKX (if available)

Paralogs for PRKX Gene

Paralogs for PRKX Gene

Pseudogenes.org Pseudogenes for PRKX Gene

genes like me logo Genes that share paralogs with PRKX: view

Variants for PRKX Gene

Sequence variations from dbSNP and Humsavar for PRKX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000011454 -- 3,647,295(-) C/T intron_variant
rs1000019467 -- 3,706,573(-) C/T intron_variant
rs1000048867 -- 3,647,704(-) T/C intron_variant
rs1000138824 -- 3,626,656(-) C/T intron_variant
rs1000166501 -- 3,707,416(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKX Gene

Variant ID Type Subtype PubMed ID
nsv6780 CNV insertion 18451855
nsv508749 CNV insertion 20534489
nsv425475 CNV deletion 16902084
nsv1150572 CNV insertion 26484159
nsv1142564 CNV tandem duplication 24896259
nsv1141044 CNV deletion 24896259
nsv1139388 CNV deletion 24896259
nsv1113033 CNV deletion 24896259
nsv1110592 CNV duplication 24896259
nsv1076242 CNV deletion 25765185
nsv1075305 CNV deletion 25765185
esv3558555 CNV deletion 23714750
esv3558553 CNV deletion 23714750
esv3237607 CNV deletion 24192839
esv2739905 CNV deletion 23290073
esv2739904 CNV deletion 23290073
esv2739903 CNV deletion 23290073
esv2672795 CNV deletion 23128226
esv1734793 CNV deletion 17803354
dgv1393e199 CNV deletion 23128226

Variation tolerance for PRKX Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKX Gene

Disorders for PRKX Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
47, xxy
  • klinefelter syndrome
asbestos-related lung carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PRKX in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PRKX_HUMAN
  • Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Additional Disease Information for PRKX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRKX: view

No data available for Genatlas for PRKX Gene

Publications for PRKX Gene

  1. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. (PMID: 17980165) Li X … Wilson PD (Biochimica et biophysica acta 2008) 3 4 22 58
  2. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D … Huberman E (Oncogene 2006) 3 4 22 58
  3. Profiles of PrKX expression in developmental mouse embryo and human tissues. (PMID: 15879576) Li W … Kotin RM (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005) 3 4 22 58
  4. A lineage-specific protein kinase crucial for myeloid maturation. (PMID: 9860982) Semizarov D … Huberman E (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  5. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K … Rappold GA (Human molecular genetics 1997) 3 4 22 58

Products for PRKX Gene

Sources for PRKX Gene

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