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Aliases for PRKRIP1 Gene

Aliases for PRKRIP1 Gene

  • PRKR Interacting Protein 1 2 3 5
  • Likely Ortholog Of Mouse C114 DsRNA-Binding Protein 2 3
  • PRKR Interacting Protein 1 (IL11 Inducible) 2 3
  • KRAB Box Domain Containing 3 2 3
  • PRKR-Interacting Protein 1 3
  • KRBOX3 3
  • C114 3

External Ids for PRKRIP1 Gene

Previous GeneCards Identifiers for PRKRIP1 Gene

  • GC07P101523
  • GC07P101597
  • GC07P101791
  • GC07P101823
  • GC07P102006
  • GC07P102008
  • GC07P096627
  • GC07P102366
  • GC07P102368
  • GC07P102370
  • GC07P102372
  • GC07P102374
  • GC07P102376
  • GC07P102378

Summaries for PRKRIP1 Gene

GeneCards Summary for PRKRIP1 Gene

PRKRIP1 (PRKR Interacting Protein 1) is a Protein Coding gene. Diseases associated with PRKRIP1 include Fructose-1,6-Bisphosphatase Deficiency. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PRKRIP1 Gene

  • Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

Additional gene information for PRKRIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKRIP1 Gene

Genomics for PRKRIP1 Gene

GeneHancer (GH) Regulatory Elements for PRKRIP1 Gene

Promoters and enhancers for PRKRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I102395 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.3 +32.4 32429 2.5 CLOCK FOXA2 SMAD1 ARID4B SIN3A IRF4 YY1 POLR2B E2F8 ZNF143 PRKRIP1 ORAI2 ENSG00000213385 CRYZP1 ENSG00000272949 PMPCB POLR2J DNAJC2 POLR2J2 MIR548O
GH07I102363 Promoter/Enhancer 1.5 Ensembl ENCODE 564.8 +0.3 306 2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 PRKRIP1 ENSG00000239969 LOC100630923 LOC100289561 ORAI2 ALKBH4 ENSG00000239486 GC07P102225
GH07I102571 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49.6 +208.7 208660 1.5 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 E2F8 ZNF416 ZNF207 ZNF143 POLR2J3 CRYZP1 ENSG00000213385 PRKRIP1 DNAJC2 PMPCB ENSG00000239486 FAM185A NAPEPLD ALKBH4
GH07I102987 Enhancer 1.5 Ensembl ENCODE dbSUPER 60.4 +627.5 627493 6.9 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF766 CBX5 PRKRIP1 ENSG00000213385 CRYZP1 ENSG00000239486 DNAJC2 NAPEPLD PMPCB ALKBH4 DPY19L2P2 LRRC17
GH07I102423 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 26.7 +65.5 65513 12.2 HDGF PKNOX1 ATF1 SMAD1 SIN3A DMAP1 GLI4 IRF4 ZNF48 ZNF121 ORAI2 GC07M102430 PRKRIP1 ENSG00000239486 ENSG00000272949 ALKBH4 NAPEPLD POLR2J RASA4DP PIR39315
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKRIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKRIP1 gene promoter:

Genomic Locations for PRKRIP1 Gene

Genomic Locations for PRKRIP1 Gene
62,811 bases
Plus strand

Genomic View for PRKRIP1 Gene

Genes around PRKRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKRIP1 Gene

Proteins for PRKRIP1 Gene

  • Protein details for PRKRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRKR-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DGM2
    • Q8NDM6
    • Q96CF8

    Protein attributes for PRKRIP1 Gene

    184 amino acids
    Molecular mass:
    20997 Da
    Quaternary structure:
    • Interacts with EIF2AK2.

    Three dimensional structures from OCA and Proteopedia for PRKRIP1 Gene

    Alternative splice isoforms for PRKRIP1 Gene


neXtProt entry for PRKRIP1 Gene

Post-translational modifications for PRKRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKRIP1 Gene

Domains & Families for PRKRIP1 Gene

Gene Families for PRKRIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRKRIP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRKRIP1 family.
  • Belongs to the PRKRIP1 family.
genes like me logo Genes that share domains with PRKRIP1: view

Function for PRKRIP1 Gene

Molecular function for PRKRIP1 Gene

UniProtKB/Swiss-Prot Function:
Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

Phenotypes From GWAS Catalog for PRKRIP1 Gene

Gene Ontology (GO) - Molecular Function for PRKRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding ISS,IBA --
GO:0004860 protein kinase inhibitor activity IBA,ISS --
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IBA,ISS --
genes like me logo Genes that share ontologies with PRKRIP1: view
genes like me logo Genes that share phenotypes with PRKRIP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKRIP1 Gene

Localization for PRKRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKRIP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKRIP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA,ISS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with PRKRIP1: view

Pathways & Interactions for PRKRIP1 Gene

SuperPathways for PRKRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRKRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003014 renal system process IDA 21183621
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0042326 negative regulation of phosphorylation ISS --
genes like me logo Genes that share ontologies with PRKRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for PRKRIP1 Gene

Drugs & Compounds for PRKRIP1 Gene

No Compound Related Data Available

Transcripts for PRKRIP1 Gene

Unigene Clusters for PRKRIP1 Gene

PRKR interacting protein 1 (IL11 inducible):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKRIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP5: - -

Relevant External Links for PRKRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKRIP1 Gene

Protein differential expression in normal tissues from HIPED for PRKRIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0), CD8 Tcells (7.8), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKRIP1 Gene

Protein tissue co-expression partners for PRKRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKRIP1 Gene:


SOURCE GeneReport for Unigene cluster for PRKRIP1 Gene:


Evidence on tissue expression from TISSUES for PRKRIP1 Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Thyroid gland(4.2)
  • Kidney(3.6)
genes like me logo Genes that share expression patterns with PRKRIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKRIP1 Gene

Orthologs for PRKRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRKRIP1 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia PRKRIP1 33 34
  • 92.27 (n)
(Mus musculus)
Mammalia Prkrip1 33 16 34
  • 90.22 (n)
(Rattus norvegicus)
Mammalia Prkrip1 33
  • 90.04 (n)
(Bos Taurus)
Mammalia PRKRIP1 33 34
  • 89.86 (n)
(Monodelphis domestica)
Mammalia PRKRIP1 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PRKRIP1 34
  • 68 (a)
(Gallus gallus)
Aves PRKRIP1 34 33
  • 71.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia prkrip1 33
  • 69.43 (n)
Str.20382 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23753 33
(Danio rerio)
Actinopterygii prkrip1 33 34
  • 66.47 (n)
neurog3 33
fruit fly
(Drosophila melanogaster)
Insecta CG8441 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F37A4.2 34
  • 34 (a)
Species where no ortholog for PRKRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKRIP1 Gene

Gene Tree for PRKRIP1 (if available)
Gene Tree for PRKRIP1 (if available)

Paralogs for PRKRIP1 Gene

No data available for Paralogs for PRKRIP1 Gene

Variants for PRKRIP1 Gene

Sequence variations from dbSNP and Humsavar for PRKRIP1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000327248 -- 102,399,369(+) A/G intron_variant
rs1000632699 -- 102,426,327(+) C/T 3_prime_UTR_variant
rs1000664994 -- 102,398,161(+) A/G intron_variant
rs1000779649 -- 102,397,964(+) G/A intron_variant
rs1000917457 -- 102,403,227(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv6538n100 CNV gain 25217958
esv2759548 CNV gain 17122850
nsv428182 CNV gain 18775914
nsv464664 CNV gain 19166990
nsv464665 CNV loss 19166990
nsv607998 CNV gain+loss 21841781
nsv831083 CNV loss 17160897

Variation tolerance for PRKRIP1 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKRIP1 Gene

Disorders for PRKRIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRKRIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fructose-1,6-bisphosphatase deficiency
  • fbp1d
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRKRIP1

genes like me logo Genes that share disorders with PRKRIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKRIP1 Gene

Publications for PRKRIP1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R. (PMID: 12679338) Yin Z … Yang YC (The Journal of biological chemistry 2003) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for PRKRIP1 Gene

Sources for PRKRIP1 Gene

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