This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] See more...

Aliases for PRKRA Gene

Aliases for PRKRA Gene

  • Protein Activator Of Interferon Induced Protein Kinase EIF2AK2 2 3 5
  • Protein Activator Of The Interferon-Induced Protein Kinase 2 3 4
  • PACT 2 3 4
  • RAX 2 3 4
  • Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase Activator A 3 4
  • Protein Kinase, Interferon-Inducible Double-Stranded RNA-Dependent Activator 3 4
  • PKR-Associating Protein X 3 4
  • PKR-Associated Protein X 3 4
  • DYT16 2 3
  • HSD14 2 3
  • Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator 2
  • PRKRA 5

External Ids for PRKRA Gene

Previous GeneCards Identifiers for PRKRA Gene

  • GC02M177358
  • GC02M177966
  • GC02M179260
  • GC02M179498
  • GC02M179121
  • GC02M179004

Summaries for PRKRA Gene

Entrez Gene Summary for PRKRA Gene

  • This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GeneCards Summary for PRKRA Gene

PRKRA (Protein Activator Of Interferon Induced Protein Kinase EIF2AK2) is a Protein Coding gene. Diseases associated with PRKRA include Dystonia 16 and Dystonia. Among its related pathways are NF-KappaB Family Pathway and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is TARBP2.

UniProtKB/Swiss-Prot Summary for PRKRA Gene

  • Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Gene Wiki entry for PRKRA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKRA Gene

Genomics for PRKRA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKRA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J178448 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.7 690 3.7 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 RFX1 LEF1 SOX13 PRKRA PJVK FKBP7 CHROMR PLEKHA3 ENSG00000270574 RBM45 ENSG00000271141 ENSG00000237477
GH02J178453 Enhancer 0.5 Ensembl 600.7 -1.6 -1589 0.2 IKZF1 NFIC ZNF189 NFIB DPF2 PRDM6 NFIA LCORL ENSG00000238082 PRKRA NUDCP2 FKBP7 PLEKHA3 PJVK
GH02J178412 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 +37.2 37211 3 ZNF221 CEBPG HNRNPL GATAD2A CTCF ATF7 PRDM10 REST ZNF629 TFE3 CHROMR FKBP7 PLEKHA3 RBM45 PJVK PRKRA lnc-FKBP7-2 OSBPL6
GH02J178477 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 -28.3 -28289 5.6 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 ZNF512 IKZF1 NFKBIZ ZNF692 FKBP7 PLEKHA3 lnc-FKBP7-1 CHROMR RBM45 PJVK PRKRA
GH02J178428 Enhancer 0.9 ENCODE 11.7 +23.0 22985 1 GATAD2A SOX13 RCOR2 JUND FOXA1 MTA2 RXRB MTA1 IRF2 SP1 FKBP7 PJVK PRKRA CHROMR lnc-FKBP7-2 OSBPL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKRA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKRA

Top Transcription factor binding sites by QIAGEN in the PRKRA gene promoter:
  • HTF
  • LyF-1
  • Sox9
  • SRY

Genomic Locations for PRKRA Gene

Genomic Locations for PRKRA Gene
chr2:178,431,414-178,451,512
(GRCh38/hg38)
Size:
20,099 bases
Orientation:
Minus strand
chr2:179,296,141-179,316,239
(GRCh37/hg19)
Size:
20,099 bases
Orientation:
Minus strand

Genomic View for PRKRA Gene

Genes around PRKRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKRA Gene

Proteins for PRKRA Gene

  • Protein details for PRKRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75569-PRKRA_HUMAN
    Recommended name:
    Interferon-inducible double-stranded RNA-dependent protein kinase activator A
    Protein Accession:
    O75569
    Secondary Accessions:
    • A8K3I6
    • Q53G24
    • Q6X7T5
    • Q8NDK4

    Protein attributes for PRKRA Gene

    Size:
    313 amino acids
    Molecular mass:
    34404 Da
    Quaternary structure:
    • Homodimer. Interacts with EIF2AK2/PKR through its DRBM domains. Interacts with DICER1, AGO2 and TARBP2. Also able to interact with dsRNA. Interacts with UBC9 (By similarity). Forms a complex with UBC9 and p53/TP53 (By similarity). Interacts with DUS2L (via DRBM domain). Interacts with DDX58.
    • (Microbial infection) Interacts with ebolavirus protein VP35; this interaction inhibits the interaction between DDX58 and PRKRA. In addition, this interaction disrupts the interaction between VP35 and the viral polymerase L. So the VP35-PRKRA interaction plays a critical role in determining the outcome of ebolavirus infection.

    Three dimensional structures from OCA and Proteopedia for PRKRA Gene

    Alternative splice isoforms for PRKRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKRA Gene

Post-translational modifications for PRKRA Gene

  • Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRKRA Gene

Domains & Families for PRKRA Gene

Gene Families for PRKRA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for PRKRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKRA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60590, highly similar to Interferon-inducible double strandedRNA-dependent protein kinase activator A (B4DJC7_HUMAN)
  • Protein kinase, interferon-inducible double stranded RNA-dependent activator (PRKRA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75569

UniProtKB/Swiss-Prot:

PRKRA_HUMAN :
  • Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3.
  • Belongs to the PRKRA family.
Domain:
  • Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3.
Family:
  • Belongs to the PRKRA family.
genes like me logo Genes that share domains with PRKRA: view

Function for PRKRA Gene

Molecular function for PRKRA Gene

UniProtKB/Swiss-Prot Function:
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Phenotypes From GWAS Catalog for PRKRA Gene

Gene Ontology (GO) - Molecular Function for PRKRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0003725 double-stranded RNA binding IEA,IDA 23661684
GO:0005515 protein binding IPI 16424907
GO:0008047 enzyme activator activity IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PRKRA: view
genes like me logo Genes that share phenotypes with PRKRA: view

Human Phenotype Ontology for PRKRA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKRA Gene

MGI Knock Outs for PRKRA:

Animal Model Products

CRISPR Products

miRNA for PRKRA Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKRA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PRKRA Gene

Localization for PRKRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKRA Gene

Cytoplasm, perinuclear region. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKRA gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 17452327
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PRKRA: view

Pathways & Interactions for PRKRA Gene

PathCards logo

SuperPathways for PRKRA Gene

SuperPathway Contained pathways
1 Mitotic Prophase
2 Translational Control
3 Cellular Transformation by HTLV1
.31
4 NF-KappaB Family Pathway
.72
5 4-1BB Pathway
.36
genes like me logo Genes that share pathways with PRKRA: view

Pathways by source for PRKRA Gene

3 Qiagen pathways for PRKRA Gene
  • Activation of NF-KappaB by PKR
  • NF-KappaB Family Pathway
  • PKR Pathway
1 Cell Signaling Technology pathway for PRKRA Gene

Gene Ontology (GO) - Biological Process for PRKRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006955 immune response TAS 9687506
GO:0008285 negative regulation of cell proliferation TAS 9687506
GO:0009615 response to virus TAS 9687506
GO:0010586 miRNA metabolic process TAS --
genes like me logo Genes that share ontologies with PRKRA: view

No data available for SIGNOR curated interactions for PRKRA Gene

Drugs & Compounds for PRKRA Gene

No Compound Related Data Available

Transcripts for PRKRA Gene

mRNA/cDNA for PRKRA Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKRA

Alternative Splicing Database (ASD) splice patterns (SP) for PRKRA Gene

No ASD Table

Relevant External Links for PRKRA Gene

GeneLoc Exon Structure for
PRKRA

Expression for PRKRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for PRKRA Gene

This gene is overexpressed in Fetal Brain (7.9) and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKRA Gene



Protein tissue co-expression partners for PRKRA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKRA

SOURCE GeneReport for Unigene cluster for PRKRA Gene:

Hs.570274

Evidence on tissue expression from TISSUES for PRKRA Gene

  • Nervous system(4.9)
  • Heart(4.5)
  • Muscle(2.6)
  • Kidney(2.5)
  • Skin(2.2)
  • Liver(2.1)
  • Lung(2.1)
  • Blood(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKRA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • epiglottis
  • head
  • larynx
  • mouth
  • neck
  • pharynx
  • vocal cord
Thorax:
  • esophagus
  • trachea
Abdomen:
  • stomach
Limb:
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with PRKRA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKRA Gene

Orthologs for PRKRA Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKRA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKRA 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKRA 30 31
  • 96.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKRA 30 31
  • 94.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prkra 30 17 31
  • 90.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkra 30
  • 90.2 (n)
Oppossum
(Monodelphis domestica)
Mammalia PRKRA 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKRA 31
  • 42 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKRA 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkra 30
  • 63.65 (n)
Str.5894 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53736 30
Zebrafish
(Danio rerio)
Actinopterygii prkra 30 31
  • 57.32 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta loqs 30 31
  • 48.35 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009781 30
  • 46.5 (n)
Species where no ortholog for PRKRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRKRA Gene

ENSEMBL:
Gene Tree for PRKRA (if available)
TreeFam:
Gene Tree for PRKRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKRA: view image

Paralogs for PRKRA Gene

(2) SIMAP similar genes for PRKRA Gene using alignment to 5 proteins:

  • PRKRA_HUMAN
  • B4DJC7_HUMAN
  • C9JMM3_HUMAN
  • F8WEG8_HUMAN
  • G5E9Q4_HUMAN

Pseudogenes.org Pseudogenes for PRKRA Gene

genes like me logo Genes that share paralogs with PRKRA: view

Variants for PRKRA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKRA Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
653965 Uncertain Significance: Dystonia 16 178,444,483(-) G/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
654323 Uncertain Significance: Dystonia 16 178,450,999(-) G/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
689778 Uncertain Significance: Dystonia 16 178,436,292(-) A/G MISSENSE_VARIANT
704153 Likely Benign: not provided 178,447,561(-) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
836776 Uncertain Significance: Dystonia 16 178,450,244(-) G/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for PRKRA Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKRA Gene

Variant ID Type Subtype PubMed ID
dgv625e201 CNV deletion 23290073
dgv679n67 CNV gain 20364138
esv24835 CNV loss 19812545
esv2721190 CNV deletion 23290073
esv2721191 CNV deletion 23290073
esv2721192 CNV deletion 23290073
esv2721193 CNV deletion 23290073
esv2721194 CNV deletion 23290073
esv2721196 CNV deletion 23290073
esv3560606 CNV deletion 23714750
esv7371 CNV loss 19470904
esv8450 CNV loss 19470904
esv8989 CNV loss 19470904
esv9296 CNV loss 19470904
nsv819025 CNV loss 19587683
nsv819460 CNV loss 19587683
nsv820287 CNV loss 19587683
nsv821160 CNV duplication 20802225
nsv821814 CNV loss 20364138
nsv821827 CNV gain 20364138
nsv834467 CNV loss 17160897

Variation tolerance for PRKRA Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKRA Gene

Human Gene Mutation Database (HGMD)
PRKRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKRA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKRA Gene

Disorders for PRKRA Gene

MalaCards: The human disease database

(15) MalaCards diseases for PRKRA Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dystonia 16
  • dyt16
dystonia
  • dystonic disease
deafness, autosomal recessive 59
  • dfnb59
middle east respiratory syndrome
  • mers
spasmodic dystonia
  • laryngeal dystonia
- elite association - COSMIC cancer census association via MalaCards
Search PRKRA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PRKRA_HUMAN
  • Dystonia 16 (DYT16) [MIM:612067]: An early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features. {ECO:0000269 PubMed:18243799, ECO:0000269 PubMed:18420150}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRKRA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PRKRA: view

No data available for Genatlas for PRKRA Gene

Publications for PRKRA Gene

  1. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. (PMID: 10336432) Ito T … May WS (The Journal of biological chemistry 1999) 2 3 4 23
  2. DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. (PMID: 18243799) Camargos S … Singleton AB (The Lancet. Neurology 2008) 3 4 23
  3. PACT, a protein activator of the interferon-induced protein kinase, PKR. (PMID: 9687506) Patel RC … Sen GC (The EMBO journal 1998) 2 3 4
  4. Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome. (PMID: 23870315) Luthra P … Basler CF (Cell host & microbe 2013) 3 4
  5. The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest. (PMID: 22214662) Bennett RL … May WS (Cell cycle (Georgetown, Tex.) 2012) 3 4

Products for PRKRA Gene

  • Signalway Proteins for PRKRA

Sources for PRKRA Gene