This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to ... See more...

Aliases for PRKD3 Gene

Aliases for PRKD3 Gene

  • Protein Kinase D3 2 3 5
  • EPK2 2 3 4
  • Serine/Threonine-Protein Kinase D3 3 4
  • Protein Kinase C Nu Type 3 4
  • Protein Kinase EPK2 3 4
  • EC 2.7.11.13 4 51
  • PRKCN 3 4
  • Protein Kinase C, Nu 2
  • EC 2.7.11 51
  • NPKC-NU 3
  • NPKC-Nu 4
  • PKC-NU 3
  • PRKD3 5
  • PKD3 3

External Ids for PRKD3 Gene

Previous HGNC Symbols for PRKD3 Gene

  • PRKCN

Previous GeneCards Identifiers for PRKD3 Gene

  • GC02M037389
  • GC02M037477
  • GC02M037217

Summaries for PRKD3 Gene

Entrez Gene Summary for PRKD3 Gene

  • This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

GeneCards Summary for PRKD3 Gene

PRKD3 (Protein Kinase D3) is a Protein Coding gene. Diseases associated with PRKD3 include Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease and Cystic Kidney Disease. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot Summary for PRKD3 Gene

  • Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Tocris Summary for PRKD3 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.

Gene Wiki entry for PRKD3 Gene

Additional gene information for PRKD3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKD3 Gene

Genomics for PRKD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKD3

Top Transcription factor binding sites by QIAGEN in the PRKD3 gene promoter:
  • AML1a
  • Cart-1
  • En-1
  • Evi-1
  • Gfi-1
  • ITF-2
  • Lmo2
  • Pbx1a
  • POU6F1 (c2)
  • Tal-1beta

Genomic Locations for PRKD3 Gene

Genomic Locations for PRKD3 Gene
chr2:37,250,502-37,324,833
(GRCh38/hg38)
Size:
74,332 bases
Orientation:
Minus strand
chr2:37,477,645-37,551,951
(GRCh37/hg19)
Size:
74,307 bases
Orientation:
Minus strand

Genomic View for PRKD3 Gene

Genes around PRKD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD3 Gene

Proteins for PRKD3 Gene

  • Protein details for PRKD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94806-KPCD3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D3
    Protein Accession:
    O94806
    Secondary Accessions:
    • D6W587
    • Q53TR7
    • Q8NEL8

    Protein attributes for PRKD3 Gene

    Size:
    890 amino acids
    Molecular mass:
    100471 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRKD3 Gene

    Alternative splice isoforms for PRKD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD3 Gene

Selected DME Specific Peptides for PRKD3 Gene

O94806:
  • AIDLINNLLQVKMRKRYSVDK
  • QCKDCKFNCHKRCA
  • LHFKNIVHCDLKPENVLLASA
  • VNLECMFETPE
  • IPNNCSG
  • VKVPHTF
  • GCGLNYHKRCAF
  • KEGWMVHYTS
  • TISPSTSNNIPLMRVVQS
  • LLKGLFRQG
  • EDFQIRPH
  • QIQENVDI
  • GYNRSLDMWSVGVI
  • GERYITHESDD
  • QKFPECGF
  • EGDLVEVVLSA
  • YYKEIPLSEIL
  • SVPRPLQPE
  • TQILVALR
  • VYGGKHRKTGRDVA
  • YVSLSGTFPFNEDEDI
  • LSHPWLQ
  • HSYTRPT
  • DMWSVGVI
  • DQIQNAAFMYP
  • RFPTKQESQLRNEVAILQNLHHPG
  • GLVRQGL
  • VAIKVIDK
  • AIRQALMPV
  • YLAPEVL
  • YDKILLF

Post-translational modifications for PRKD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PRKD3
  • Boster Bio Antibodies for PRKD3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKD3

Domains & Families for PRKD3 Gene

Gene Families for PRKD3 Gene

Suggested Antigen Peptide Sequences for PRKD3 Gene

GenScript: Design optimal peptide antigens:
  • nPKC-nu (KPCD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94806

UniProtKB/Swiss-Prot:

KPCD3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
genes like me logo Genes that share domains with PRKD3: view

Function for PRKD3 Gene

Molecular function for PRKD3 Gene

UniProtKB/Swiss-Prot Function:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain.

Enzyme Numbers (IUBMB) for PRKD3 Gene

Phenotypes From GWAS Catalog for PRKD3 Gene

Gene Ontology (GO) - Molecular Function for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004697 protein kinase C activity TAS 10231560
GO:0004698 calcium-dependent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKD3: view
genes like me logo Genes that share phenotypes with PRKD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRKD3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKD3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKD3 Gene

Localization for PRKD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD3 Gene

Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKD3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Pathways & Interactions for PRKD3 Gene

PathCards logo

SuperPathways for PRKD3 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.49
.49
.48
.47
.44
.37
2 fMLP Pathway
.44
.44
.43
.39
.38
.31
3 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
4 Sweet Taste Signaling
.72
.72
.44
.37
5 Development VEGF signaling via VEGFR2 - generic cascades
.42
.42
genes like me logo Genes that share pathways with PRKD3: view

Pathways by source for PRKD3 Gene

1 BioSystems pathway for PRKD3 Gene
7 GeneGo (Thomson Reuters) pathways for PRKD3 Gene
  • Cell adhesion Gap junctions
  • Development VEGF signaling and activation
  • Development VEGF signaling via VEGFR2 - generic cascades
  • Immune response Function of MEF2 in T lymphocytes
  • Signal transduction cAMP signaling
1 R&D Systems pathway for PRKD3 Gene
74 Qiagen pathways for PRKD3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PRKD3 Gene

SIGNOR curated interactions for PRKD3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS,IEA --
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway TAS 10231560
GO:0016310 phosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Drugs & Compounds for PRKD3 Gene

(11) Drugs for PRKD3 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
CID 2011756 Pharma PKD inhibitor, Pan protein kinase D (PKD) inhibitor; cell permeable 0
CID 755673 Pharma PKD inhibitor, Selective protein kinase D inhibitor 0
bryostatin Pharma inhibitor 0
BRYOSTATIN-1 Pharma 0

(5) Additional Compounds for PRKD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(4) Tocris Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable 638156-11-3
CID 755673 Selective protein kinase D inhibitor 521937-07-5
CRT 0066101 Potent protein kinase D (PKD) inhibitor 1883545-60-5
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) 1233533-04-4

(2) ApexBio Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 PKD inhibitor 638156-11-3
CID 755673 PKD inhibitor 521937-07-5
genes like me logo Genes that share compounds with PRKD3: view

Drug Products

Transcripts for PRKD3 Gene

mRNA/cDNA for PRKD3 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKD3

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD3 Gene

No ASD Table

Relevant External Links for PRKD3 Gene

GeneLoc Exon Structure for
PRKD3

Expression for PRKD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKD3 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (8.6), Pancreas (8.2), and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKD3 Gene



Protein tissue co-expression partners for PRKD3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKD3

SOURCE GeneReport for Unigene cluster for PRKD3 Gene:

Hs.660757

mRNA Expression by UniProt/SwissProt for PRKD3 Gene:

O94806-KPCD3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PRKD3 Gene

  • Lymph node(2.1)
  • Spleen(2.1)
  • Lung(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PRKD3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKD3 Gene

Orthologs for PRKD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKD3 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKD3 30 31
  • 94.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRKD3 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKD3 30 31
  • 93.63 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKD3 31
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkd3 30
  • 89.93 (n)
Mouse
(Mus musculus)
Mammalia Prkd3 30 17 31
  • 89.7 (n)
OneToOne
Chicken
(Gallus gallus)
Aves PRKD3 30 31
  • 82.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKD3 31
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii prkd3 30 31
  • 74.01 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta PKD 30
  • 55.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000070 30
  • 55.19 (n)
Worm
(Caenorhabditis elegans)
Secernentea dkf-2 30
  • 55.75 (n)
dkf-1 31
  • 41 (a)
ManyToMany
R12G8.1 31
  • 33 (a)
ManyToMany
F48G7.9 31
  • 18 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for PRKD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PRKD3 Gene

ENSEMBL:
Gene Tree for PRKD3 (if available)
TreeFam:
Gene Tree for PRKD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKD3: view image

Paralogs for PRKD3 Gene

Paralogs for PRKD3 Gene

(26) SIMAP similar genes for PRKD3 Gene using alignment to 4 proteins:

  • KPCD3_HUMAN
  • C9JKP8_HUMAN
  • H0Y5M6_HUMAN
  • H7C172_HUMAN
genes like me logo Genes that share paralogs with PRKD3: view

Variants for PRKD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKD3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_042336 A glioblastoma multiforme sample p.Val716Met
rs11896614 - p.Asn42Asp
rs17852819 - p.Ala128Thr
rs17856887 - p.Gln546Arg
rs34280934 - p.Pro225Ser

Additional dbSNP identifiers (rs#s) for PRKD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKD3 Gene

Variant ID Type Subtype PubMed ID
nsv828953 CNV loss 20364138
nsv953770 CNV duplication 24416366

Variation tolerance for PRKD3 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD3 Gene

Disorders for PRKD3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRKD3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
polycystic kidney disease 3 with or without polycystic liver disease
  • pkd3
cystic kidney disease
  • renal cyst
prostate cancer
  • prostate cancer, somatic
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PRKD3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRKD3

genes like me logo Genes that share disorders with PRKD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKD3 Gene

Publications for PRKD3 Gene

  1. PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu. (PMID: 10231560) Hayashi A … Saito T (Biochimica et biophysica acta 1999) 2 3 4 23
  2. Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family. (PMID: 18076381) Chen J … Wang QJ (The Biochemical journal 2008) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  4. The nuclear import of protein kinase D3 requires its catalytic activity. (PMID: 16380377) Rey O … Rozengurt E (The Journal of biological chemistry 2006) 3 23
  5. Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes. (PMID: 15496505) Chen J … Wang QJ (Molecular pharmacology 2005) 3 23

Products for PRKD3 Gene

Sources for PRKD3 Gene