Aliases for PRKD3 Gene
External Ids for PRKD3 Gene
Previous HGNC Symbols for PRKD3 Gene
Previous GeneCards Identifiers for PRKD3 Gene
This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
GeneCards Summary for PRKD3 Gene
PRKD3 (Protein Kinase D3) is a Protein Coding gene. Diseases associated with PRKD3 include Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease. Among its related pathways are Development Slit-Robo signaling and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.
UniProtKB/Swiss-Prot for PRKD3 Gene
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.