Aliases for PRKD3 Gene
External Ids for PRKD3 Gene
Previous HGNC Symbols for PRKD3 Gene
Previous GeneCards Identifiers for PRKD3 Gene
This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
GeneCards Summary for PRKD3 Gene
PRKD3 (Protein Kinase D3) is a Protein Coding gene. Diseases associated with PRKD3 include Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease and Cystic Kidney Disease. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.
UniProtKB/Swiss-Prot Summary for PRKD3 Gene
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.