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Aliases for PRKD2 Gene

Aliases for PRKD2 Gene

  • Protein Kinase D2 2 3 5
  • EC 2.7.11.13 4 56
  • NPKC-D2 3 4
  • PKD2 3 4
  • Serine/Threonine-Protein Kinase D2 3
  • EC 2.7.11 56
  • HSPC187 3

External Ids for PRKD2 Gene

Previous GeneCards Identifiers for PRKD2 Gene

  • GC19M047568
  • GC19M051853
  • GC19M051869
  • GC19M047177
  • GC19M043602

Summaries for PRKD2 Gene

Entrez Gene Summary for PRKD2 Gene

  • The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKD2 Gene

PRKD2 (Protein Kinase D2) is a Protein Coding gene. Diseases associated with PRKD2 include Polycystic Kidney Disease 2. Among its related pathways are Transcription_Transcription factor Tubby signaling pathways and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot for PRKD2 Gene

  • Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467).

Tocris Summary for PRKD2 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.

Gene Wiki entry for PRKD2 Gene

Additional gene information for PRKD2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD2 Gene

Genomics for PRKD2 Gene

GeneHancer (GH) Regulatory Elements for PRKD2 Gene

Promoters and enhancers for PRKD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I046713 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.2 -0.1 -112 8.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 IRF4 ZNF143 FOS SP3 NFYC PRKD2 FKRP STRN4 ZC3H4 GC19M046720
GH19I046782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.3 -68.7 -68655 6.8 MLX FEZF1 DMAP1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZFP41 SLC1A5 CCDC61 ZC3H4 CCDC9 BICRA NOP53-AS1 ENSG00000269148 PRKD2 SNORD23 ENSG00000268810
GH19I047105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.2 -393.2 -393170 9.2 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZC3H4 ENSG00000268810 BICRA C5AR2 PRKD2 CCDC9 NOP53-AS1 SNORD23 ENSG00000268746 DHX34
GH19I047225 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 27.1 -512.3 -512254 8.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 BBC3 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 SNORD23 PPP5D1 ENSG00000269124
GH19I046848 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21 -132.8 -132774 3.3 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B AP2S1 CCDC61 ZC3H4 BICRA ENSG00000268810 PRKD2 SNORD23 IRF2BP1 STRN4 FKRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKD2 gene promoter:

Genomic Locations for PRKD2 Gene

Genomic Locations for PRKD2 Gene
chr19:46,674,275-46,717,127
(GRCh38/hg38)
Size:
42,853 bases
Orientation:
Minus strand
chr19:47,177,532-47,220,384
(GRCh37/hg19)

Genomic View for PRKD2 Gene

Genes around PRKD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD2 Gene

Proteins for PRKD2 Gene

  • Protein details for PRKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL6-KPCD2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D2
    Protein Accession:
    Q9BZL6
    Secondary Accessions:
    • M0R2R2
    • Q8NCK8
    • Q8TB08
    • Q9P0T6
    • Q9Y3X8

    Protein attributes for PRKD2 Gene

    Size:
    878 amino acids
    Molecular mass:
    96750 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts (via C-terminus) with LCK (PubMed:19192391). Interacts (via N-terminal AP-rich region) with CIB1 isoform 2 (PubMed:23503467). Interacts (via N-terminus and zing-finger domain 1 and 2) with PRKCD in response to oxidative stress; the interaction is independent of PRKD2 tyrosine phosphorylation (PubMed:28428613).
    SequenceCaution:
    • Sequence=AAF36107.1; Type=Frameshift; Positions=604, 606, 738, 744, 755, 758, 833, 854; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKD2 Gene

    Alternative splice isoforms for PRKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD2 Gene

Selected DME Specific Peptides for PRKD2 Gene

Q9BZL6:
  • AIDLINNLLQVKMRKRYSVDK
  • QCKDCKFNCHKRCA
  • LHFKNIVHCDLKPENVLLASA
  • GCGLNYHKRCAF
  • QIQENVDI
  • VFVVMEKLHGDMLEMILSSEKGRLPE
  • HSYTRPT
  • GLVRQGL
  • AVKVIDK
  • YLAPEVL
  • YDKILLF
  • VNLECMFETPE
  • IPNNCSG
  • VKVPHTF
  • RQGLQCK
  • LLKGLFRQG
  • EDFQIRPH
  • GYNRSLDMWSVGVI
  • GERYITHESDD
  • QKFPECGF
  • EGDLVEVVLSA
  • YYKEIPLSEIL
  • TQILVALR
  • VYGGKHRKTGRDVA
  • YVSLSGTFPFNEDEDI
  • DMWSVGVI
  • LSHPWLQ
  • DQIQNAAFMYP
  • AIRQALMPV
  • KCITLFQN

Post-translational modifications for PRKD2 Gene

  • Phosphorylation of Ser-876 correlates with the activation status of the kinase (PubMed:11062248). Ser-706 or/and Ser-710 are probably phosphorylated by PKC (PubMed:12058027, PubMed:28428613). Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting (PubMed:17962809). Phosphorylation at Ser-244, Ser-706 and Ser-710 is required for nuclear localization (PubMed:17962809). Phosphorylated at Tyr-438 by ABL1 in response to oxidative stress (PubMed:15604256). Phosphorylated at Tyr-717 by ABL1 specifically in response to oxidative stress; requires prior phosphorylation at Ser-706 or/and Ser-710 (PubMed:28428613).
  • Ubiquitination at isoforms=2178
  • Modification sites at PhosphoSitePlus

Domains & Families for PRKD2 Gene

Gene Families for PRKD2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZL6

UniProtKB/Swiss-Prot:

KPCD2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
genes like me logo Genes that share domains with PRKD2: view

Function for PRKD2 Gene

Molecular function for PRKD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by DAG and phorbol esters (PubMed:12058027, PubMed:17962809, PubMed:28428613). Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes (PubMed:17962809). Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain (PubMed:17962809). Catalytic activity is further increased by phosphorylation at Tyr-717 in response to oxidative stress (PubMed:28428613).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467).

Enzyme Numbers (IUBMB) for PRKD2 Gene

Phenotypes From GWAS Catalog for PRKD2 Gene

Gene Ontology (GO) - Molecular Function for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17077180
GO:0004674 protein serine/threonine kinase activity IDA,TAS --
GO:0004697 protein kinase C activity IEA --
GO:0005080 protein kinase C binding IPI 28428613
GO:0005515 protein binding IPI 17962809
genes like me logo Genes that share ontologies with PRKD2: view
genes like me logo Genes that share phenotypes with PRKD2: view

Animal Model Products

Clone Products

  • Addgene plasmids for PRKD2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKD2 Gene

Localization for PRKD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD2 Gene

Cytoplasm. Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000269 PubMed:17962809}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKD2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 17077180
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 17077180
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PRKD2: view

Pathways & Interactions for PRKD2 Gene

genes like me logo Genes that share pathways with PRKD2: view

SIGNOR curated interactions for PRKD2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IMP 19001381
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IDA,NAS 11062248
genes like me logo Genes that share ontologies with PRKD2: view

Drugs & Compounds for PRKD2 Gene

(11) Drugs for PRKD2 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
ATP Investigational Nutra Agonist 0
CID 2011756 Pharma PKD inhibitor, Pan protein kinase D (PKD) inhibitor; cell permeable 0
CID 755673 Pharma PKD inhibitor, Selective protein kinase D inhibitor 0
bryostatin Pharma inhibitor 0

(5) Additional Compounds for PRKD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(4) Tocris Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable 638156-11-3
CID 755673 Selective protein kinase D inhibitor 521937-07-5
CRT 0066101 Potent protein kinase D (PKD) inhibitor 1883545-60-5
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) 1233533-04-4

(2) ApexBio Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 PKD inhibitor 638156-11-3
CID 755673 PKD inhibitor 521937-07-5
genes like me logo Genes that share compounds with PRKD2: view

Drug Products

Transcripts for PRKD2 Gene

Unigene Clusters for PRKD2 Gene

Protein kinase D2:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRKD2

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD2 Gene

No ASD Table

Relevant External Links for PRKD2 Gene

GeneLoc Exon Structure for
PRKD2
ECgene alternative splicing isoforms for
PRKD2

Expression for PRKD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKD2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for PRKD2 Gene

This gene is overexpressed in CD8 Tcells (18.0), Lymph node (15.6), and CD4 Tcells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRKD2 Gene



Protein tissue co-expression partners for PRKD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKD2 Gene:

PRKD2

SOURCE GeneReport for Unigene cluster for PRKD2 Gene:

Hs.466987

mRNA Expression by UniProt/SwissProt for PRKD2 Gene:

Q9BZL6-KPCD2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PRKD2 Gene

  • Blood(4.3)
  • Liver(4.1)
  • Pancreas(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with PRKD2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKD2 Gene

Orthologs for PRKD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD2 33 34
  • 96.48 (n)
cow
(Bos Taurus)
Mammalia bta-mir-2897 34
  • 95 (a)
OneToOne
PRKD2 33
  • 90.43 (n)
dog
(Canis familiaris)
Mammalia PRKD2 33 34
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Prkd2 33 16 34
  • 88.56 (n)
rat
(Rattus norvegicus)
Mammalia Prkd2 33
  • 88.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD2 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKD2 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 87