Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Fur... See more...

Aliases for PRKCZ Gene

Aliases for PRKCZ Gene

  • Protein Kinase C Zeta 2 3 5
  • PKC2 2 3 4
  • Protein Kinase C Zeta Type 3 4
  • EC 2.7.11.13 4 51
  • NPKC-Zeta 3 4
  • Protein Kinase C, Zeta 2
  • EC 2.7.11 51
  • PKC-ZETA 3
  • PRKCZ 5

External Ids for PRKCZ Gene

Previous GeneCards Identifiers for PRKCZ Gene

  • GC01P001538
  • GC01P001939
  • GC01P9M0003
  • GC01P001260
  • GC01P001982

Summaries for PRKCZ Gene

Entrez Gene Summary for PRKCZ Gene

  • Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCZ Gene

PRKCZ (Protein Kinase C Zeta) is a Protein Coding gene. Diseases associated with PRKCZ include Chromosome 1P36 Deletion Syndrome and Colorectal Cancer. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCI.

UniProtKB/Swiss-Prot Summary for PRKCZ Gene

  • Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
  • [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance.

Tocris Summary for PRKCZ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCZ Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCZ Gene

Genomics for PRKCZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCZ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J002045 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 610.7 -0.3 -346 8.8 SP1 HNRNPL GATAD2A CTCF ZBTB33 PRDM10 TFE3 RFX5 ZNF692 RCOR2 PRKCZ LOC105378591 ENSG00000271806 ANKRD65 FNDC10 SLC35E2B UBE2J2 NADK LOC105378590 GABRD
GH01J002069 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 605.4 +21.7 21682 4.9 JUND POLR2A NR2C1 ATF1 BCL11A ZNF205 ZFHX2 NR2F1 RCOR1 CREM PRKCZ ENSG00000233542 GABRD CFAP74 SCNN1D ENSG00000271806 FAAP20
GH01J002145 Promoter 0.3 EPDnew 600.2 +95.0 94957 0.1 ENSG00000271806 PRKCZ HSALNG0000223 FAAP20
GH01J001989 Enhancer 0.9 Ensembl ENCODE 11.5 -60.2 -60210 2.4 ATF7 PKNOX1 REST HDAC1 SOX6 TCF12 HMBOX1 MTA3 EGR1 CTBP1 GABRD ENSG00000233542 TMEM52 CALML6 LOC105378591 PRKCZ ENSG00000272512 CFAP74 piR-51077
GH01J002104 Enhancer 1 Ensembl ENCODE 5.3 +54.6 54638 2.5 HNRNPL CREB1 GATAD2A ZIC2 RBFOX2 GABPA ZNF341 CEBPA SOX13 ETS1 FAAP20 ENSG00000271806 PRKCZ ANKRD65 SKI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCZ

Top Transcription factor binding sites by QIAGEN in the PRKCZ gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • NF-kappaB1

Genomic Locations for PRKCZ Gene

Genomic Locations for PRKCZ Gene
chr1:2,050,411-2,185,399
(GRCh38/hg38)
Size:
134,989 bases
Orientation:
Plus strand
chr1:1,981,909-2,116,834
(GRCh37/hg19)
Size:
134,926 bases
Orientation:
Plus strand

Genomic View for PRKCZ Gene

Genes around PRKCZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCZ Gene

Proteins for PRKCZ Gene

  • Protein details for PRKCZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05513-KPCZ_HUMAN
    Recommended name:
    Protein kinase C zeta type
    Protein Accession:
    Q05513
    Secondary Accessions:
    • A8K4N0
    • A8MU64
    • B7Z2J7
    • E9PCW2
    • Q15207
    • Q5SYT5
    • Q969S4

    Protein attributes for PRKCZ Gene

    Size:
    592 amino acids
    Molecular mass:
    67660 Da
    Quaternary structure:
    • Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with PDPK1 (via N-terminal region). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with WDFY2 and VAMP2 (PubMed:17313651). Interacts with APPL1 (PubMed:26583432).
    SequenceCaution:
    • Sequence=CAA78813.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Produced by alternative promoter usage.

    Alternative splice isoforms for PRKCZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCZ Gene

Selected DME Specific Peptides for PRKCZ Gene

Q05513:
  • DEDIDWVQTEK
  • VNGGDLM
  • HPLTLKWVDSEGDP
  • GIIYRDLK
  • AYCGQCSERIWGL
  • CINCKLLVHK
  • TVSSQMEL
  • FLNKDPKERLGC
  • EGDPCTVSSQ
  • YRRGARRW
  • YAMKVVKKELV
  • FQAKRFNR
  • TSTFCGTPNYIAPEILRG
  • LIIHVFP
  • RVIGRGSYAKVLLVRLKK
  • NTEDYLFQ
  • IDQSEFEGFEYINPLL
  • YRDLKLDN
  • VDWWALGVL
  • GHIKLTD
  • LHSCFQT
  • EPVQLTPDD
  • YIAPEIL
  • YGFSVDWWALGVLMFEMMAGRSPFDI
  • RDLKLDN
  • CGTPNYIAPE

Post-translational modifications for PRKCZ Gene

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PRKCZ Gene

Gene Families for PRKCZ Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRKCZ Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
  • Octicosapeptide/Phox/Bem1p
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCZ Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C, zeta (A6PVX6_HUMAN)
  • cDNA FLJ53316, highly similar to Protein kinase C zeta type (EC 2.7.11.13) (A8MU64_HUMAN)
  • nPKC-zeta (KPCZ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05513

UniProtKB/Swiss-Prot:

KPCZ_HUMAN :
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • The C1 domain does not bind the diacylglycerol (DAG).
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCZ: view

Function for PRKCZ Gene

Molecular function for PRKCZ Gene

UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:18321849};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:18321849};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity). Isoform 2: Constitutively active (By similarity).

Enzyme Numbers (IUBMB) for PRKCZ Gene

Phenotypes From GWAS Catalog for PRKCZ Gene

Gene Ontology (GO) - Molecular Function for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IDA 10770950
GO:0004674 protein serine/threonine kinase activity IEA,IDA 15069075
GO:0004697 protein kinase C activity IEA --
GO:0004698 calcium-dependent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCZ: view
genes like me logo Genes that share phenotypes with PRKCZ: view

Animal Models for PRKCZ Gene

MGI Knock Outs for PRKCZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRKCZ

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCZ

Clone Products

  • Addgene plasmids for PRKCZ

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCZ Gene

Localization for PRKCZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCZ Gene

Cytoplasm. Endosome. Cell junction. Membrane. Peripheral membrane protein. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). {ECO:0000250 UniProtKB:P09217, ECO:0000269 PubMed:17313651, ECO:0000269 PubMed:7597083, ECO:0000269 PubMed:9566925}.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCZ gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
nucleus 4
endosome 4
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm TAS 7925449
genes like me logo Genes that share ontologies with PRKCZ: view

Pathways & Interactions for PRKCZ Gene

PathCards logo

SuperPathways for PRKCZ Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.49
.49
.48
.47
.44
.37
.35
2 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
3 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.59
.51
.44
4 CCR5 Pathway in Macrophages
.52
.52
.33
5 VEGF Signaling
genes like me logo Genes that share pathways with PRKCZ: view

Pathways by source for PRKCZ Gene

21 GeneGo (Thomson Reuters) pathways for PRKCZ Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Cell adhesion Gap junctions
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Development A2A receptor signaling
  • Development Thrombopoietin-regulated cell processes
2 Tocris pathways for PRKCZ Gene
74 Qiagen pathways for PRKCZ Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
  • Alpha-Adrenergic Signaling
  • Alzheimers Disease Pathway
1 Cell Signaling Technology pathway for PRKCZ Gene
2 GeneTex pathways for PRKCZ Gene

SIGNOR curated interactions for PRKCZ Gene

Gene Ontology (GO) - Biological Process for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IEA,IDA 10770950
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 8224878
genes like me logo Genes that share ontologies with PRKCZ: view

Drugs & Compounds for PRKCZ Gene

(34) Drugs for PRKCZ Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Agonist, Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
Ingenol mebutate Approved Pharma 0
arachidonic acid Experimental Pharma Activator, Agonist, Inhibitor, Activation, Potentiation 40
Staurosporine Experimental Pharma Allosteric regulator, Positive, Neutral Protein kinase inhibitor,potent and cell permeable 9
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(21) Additional Compounds for PRKCZ Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCZ Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(12) ApexBio Compounds for PRKCZ Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
ZIP, Biotinylated
genes like me logo Genes that share compounds with PRKCZ: view

Transcripts for PRKCZ Gene

mRNA/cDNA for PRKCZ Gene

8 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCZ

Clone Products

  • Addgene plasmids for PRKCZ

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - -
SP18: -
SP19: - - - - - - - - - - - -
SP20: - - - -
SP21: -
SP22:

ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - - -
SP18:
SP19:
SP20: - - - - -
SP21: -
SP22:

Relevant External Links for PRKCZ Gene

GeneLoc Exon Structure for
PRKCZ

Expression for PRKCZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCZ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCZ Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8), Brain - Cerebellum (x4.6), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for PRKCZ Gene

This gene is overexpressed in Lung (38.3), Placenta (8.0), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCZ Gene



Protein tissue co-expression partners for PRKCZ Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCZ

SOURCE GeneReport for Unigene cluster for PRKCZ Gene:

Hs.496255

mRNA Expression by UniProt/SwissProt for PRKCZ Gene:

Q05513-KPCZ_HUMAN
Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.

Evidence on tissue expression from TISSUES for PRKCZ Gene

  • Nervous system(5)
  • Liver(4.5)
  • Intestine(4.5)
  • Kidney(3.1)
  • Muscle(2.7)
  • Skin(2.7)
  • Lung(2.6)
  • Heart(2.6)
  • Blood(2.6)
  • Pancreas(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with PRKCZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCZ Gene

Orthologs for PRKCZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCZ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKCZ 30
  • 99.24 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKCZ 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia PRKCZ 30 31
  • 89.11 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prkcz 30 17 31
  • 88.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkcz 30
  • 88.74 (n)
Cow
(Bos Taurus)
Mammalia PRKCZ 30 31
  • 88.74 (n)
OneToOne
Chicken
(Gallus gallus)
Aves PRKCZ 30 31
  • 78.43 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkcz 30
  • 75.13 (n)
Zebrafish
(Danio rerio)
Actinopterygii prkcz 30 31
  • 74.04 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta aPKC 31 32
  • 37 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea pkc-3 31
  • 56 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
OneToMany
Species where no ortholog for PRKCZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKCZ Gene

ENSEMBL:
Gene Tree for PRKCZ (if available)
TreeFam:
Gene Tree for PRKCZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCZ: view image

Paralogs for PRKCZ Gene

Paralogs for PRKCZ Gene

(71) SIMAP similar genes for PRKCZ Gene using alignment to 16 proteins:

  • KPCZ_HUMAN
  • D6RAN5_HUMAN
  • D6RAU1_HUMAN
  • D6RBD4_HUMAN
  • D6RC84_HUMAN
  • D6RCN4_HUMAN
  • D6RD31_HUMAN
  • D6RDM0_HUMAN
  • D6REZ8_HUMAN
  • D6RG01_HUMAN
  • D6RGG1_HUMAN
  • D6RJG4_HUMAN
  • E9PBE1_HUMAN
  • F2Z2H9_HUMAN
  • F2Z3C5_HUMAN
  • J3KRP7_HUMAN
genes like me logo Genes that share paralogs with PRKCZ: view

Variants for PRKCZ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKCZ Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714063 Benign: not provided 2,055,515(+) G/A MISSENSE_VARIANT
718387 Benign: not provided 2,150,781(+) C/T INTRON_VARIANT
718957 Benign: not provided 2,172,067(+) C/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
723573 Benign: not provided 2,184,994(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
764698 Likely Benign: not provided 2,150,864(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PRKCZ Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKCZ Gene

Variant ID Type Subtype PubMed ID
dgv18e59 CNV duplication 20981092
dgv1e194 CNV deletion 18987734
dgv44n54 CNV loss 21841781
dgv45n54 CNV gain 21841781
dgv46n54 CNV gain+loss 21841781
dgv47n54 CNV loss 21841781
dgv48n54 CNV loss 21841781
dgv49n54 CNV loss 21841781
esv1002714 CNV insertion 20482838
esv1008133 CNV gain 20482838
esv1138741 CNV deletion 17803354
esv1162822 CNV insertion 17803354
esv2196740 CNV deletion 18987734
esv2313378 CNV deletion 18987734
esv2492368 CNV insertion 19546169
esv2505453 CNV deletion 19546169
esv2668737 CNV deletion 23128226
esv26913 CNV gain+loss 19812545
esv27078 CNV loss 19812545
esv2758913 CNV gain+loss 17122850
esv3388837 CNV duplication 20981092
esv3585020 CNV loss 21293372
esv3585021 CNV loss 21293372
esv3585022 CNV gain 21293372
esv4294 CNV loss 18987735
esv4759 CNV loss 18987735
esv4841 CNV loss 18987735
nsv1074070 CNV deletion 25765185
nsv1074479 CNV deletion 25765185
nsv1075767 CNV duplication 25765185
nsv1113061 CNV deletion 24896259
nsv1121435 CNV deletion 24896259
nsv1121436 CNV deletion 24896259
nsv1122280 CNV deletion 24896259
nsv1130941 CNV deletion 24896259
nsv1137181 CNV deletion 24896259
nsv1140401 CNV tandem duplication 24896259
nsv1143429 CNV deletion 24896259
nsv1153893 CNV deletion 26484159
nsv160060 CNV insertion 16902084
nsv2520 CNV insertion 18451855
nsv3631 CNV insertion 18451855
nsv460616 CNV loss 19166990
nsv461727 CNV loss 19166990
nsv470681 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509479 CNV insertion 20534489
nsv545045 CNV loss 21841781
nsv545055 CNV gain