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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Inflammatory Bowel Disease 1 and Gastrointestinal Stromal Tumor. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCD.
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,TAS | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,NAS | 8444877 |
GO:0004697 | protein kinase C activity | IEA | -- |
GO:0004698 | calcium-dependent protein kinase C activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001772 | immunological synapse | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
|
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
PACAP Signaling
.37
|
2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
Signal transduction Activation of PKC via G-Protein coupled receptor
.42
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Huntington's Disease Pathway
.31
|
3 | T cell receptor signaling pathway | ||
4 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
5 | Sweet Taste Signaling |
Melatonin Signaling
.72
Sweet Taste Signaling
.72
|
Bitter Taste Signaling
.44
Sperm Motility
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | NAS | 8444877 |
GO:0002376 | immune system process | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006509 | membrane protein ectodomain proteolysis | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Tamoxifen | Approved | Pharma | Agonist, Antagonist, Target, inhibitor | TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens | 451 | |
Ingenol mebutate | Approved | Pharma | 0 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Phosphonothreonine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
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Diglycerides Group A |
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Diglycerides Group B |
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Diglycerides Group C |
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Diglycerides Group D |
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Compound | Action | Cas Number |
---|---|---|
Calphostin C | Potent, selective and photo-dependent PKC inhibitor | 121263-19-2 |
CGP 53353 | Selective inhibitor of PKCbetaII | 145915-60-2 |
GF 109203X | Protein kinase C inhibitor | 133052-90-1 |
Oncrasin 1 | Induces abnormal nuclear aggregation of PKCiota; proapoptotic | 75629-57-1 |
Rottlerin | Reported PKCdelta inhibitor | 82-08-6 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRKCQ 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PRKCQ 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRKCQ 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prkcq 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Prkcq 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRKCQ 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRKCQ 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRKCQ 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRKCQ 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | prkcq 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Pk17E 32 |
|
|
|
Pkcdelta 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | tpa-1 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727330 | Benign: not provided | 6,497,055(-) | T/C | MISSENSE_VARIANT | |
776493 | Benign: not provided | 6,464,322(-) | G/C | MISSENSE_VARIANT | |
784651 | Benign: not provided | 6,479,019(-) | C/T | SYNONYMOUS_VARIANT | |
rs2236379 | Pathogenic: Inflammatory bowel disease 1. - | 6,485,181(-) | G/Ap.Pro330Leu | MISSENSE_VARIANT | |
VAR_042319 | A colorectal adenocarcinoma sample | p.Lys240Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1047309 | CNV | gain | 25217958 |
nsv1053177 | CNV | loss | 25217958 |
nsv1161925 | CNV | deletion | 26073780 |
nsv507533 | OTHER | sequence alteration | 20534489 |
nsv515823 | CNV | loss | 19592680 |
nsv549912 | CNV | gain | 21841781 |
nsv5687 | CNV | deletion | 18451855 |
nsv5698 | CNV | insertion | 18451855 |
nsv7198 | OTHER | inversion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
inflammatory bowel disease 1 |
|
|
gastrointestinal stromal tumor |
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|
t-cell lymphoblastic leukemia/lymphoma |
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breast cancer |
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