Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor... See more...

Aliases for PRKCQ Gene

Aliases for PRKCQ Gene

  • Protein Kinase C Theta 2 3 5
  • Protein Kinase C Theta Type 3 4
  • EC 2.7.11.13 4 51
  • NPKC-Theta 3 4
  • PRKCT 3 4
  • Protein Kinase C, Theta 2
  • EC 2.7.11 51
  • PRKCQ 5

External Ids for PRKCQ Gene

Previous GeneCards Identifiers for PRKCQ Gene

  • GC10M006413
  • GC10M006619
  • GC10M006473
  • GC10M006509

Summaries for PRKCQ Gene

Entrez Gene Summary for PRKCQ Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCQ Gene

PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Inflammatory Bowel Disease 1 and Gastrointestinal Stromal Tumor. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCD.

UniProtKB/Swiss-Prot Summary for PRKCQ Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302).

Tocris Summary for PRKCQ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCQ Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCQ Gene

Genomics for PRKCQ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCQ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J006573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 608.6 +0.4 365 13.8 HNRNPL PRDM10 IKZF1 CTCF ZNF692 ZNF7 BACH1 ETV6 JUND LARP7 PRKCQ-AS1 PRKCQ lnc-PRKCQ-3 lnc-IL2RA-7 PFKFB3
GH10J006541 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 19.9 +36.7 36714 5.1 FOXA1 LARP7 TCF12 IKZF2 TRIM22 PKNOX1 DPF2 RELB RUNX3 FOXA2 PRKCQ PRKCQ-AS1 piR-41525-044 lnc-IL2RA-6 PFKFB3
GH10J006590 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -12.2 -12193 3.7 POLR2A IKZF2 TRIM22 SCRT2 RELB SCRT1 ZFP91 TBX21 ATF7 MTA2 PRKCQ lnc-PRKCQ-3 PRKCQ-AS1 LINC02648 LOC107984203
GH10J006470 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +107.0 106983 5.5 LEF1 IKZF1 JUND DDX20 ZNF143 MTA2 PHF21A PKNOX1 MTA1 REST TASOR2 PRKCQ PRKCQ-AS1 ENSG00000232807 RBM17 FBH1 ENSG00000226647 NRBF2P5 PFKFB3 IL15RA
GH10J006528 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 27.3 +50.0 49991 4.1 RFX5 PRKCQ PRKCQ-AS1 lnc-IL2RA-6 piR-41525-044 PFKFB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCQ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCQ

Top Transcription factor binding sites by QIAGEN in the PRKCQ gene promoter:
  • AML1a
  • FOXF2
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • Nkx2-2
  • Nkx2-5
  • Nkx5-1
  • Pbx1a

Genomic Locations for PRKCQ Gene

Genomic Locations for PRKCQ Gene
chr10:6,393,038-6,580,646
(GRCh38/hg38)
Size:
187,609 bases
Orientation:
Minus strand
chr10:6,469,105-6,622,263
(GRCh37/hg19)
Size:
153,159 bases
Orientation:
Minus strand

Genomic View for PRKCQ Gene

Genes around PRKCQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCQ Gene

Proteins for PRKCQ Gene

  • Protein details for PRKCQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04759-KPCT_HUMAN
    Recommended name:
    Protein kinase C theta type
    Protein Accession:
    Q04759
    Secondary Accessions:
    • B4DF52
    • Q14DH6
    • Q3MJF1
    • Q64FY5
    • Q9H508
    • Q9H549

    Protein attributes for PRKCQ Gene

    Size:
    706 amino acids
    Molecular mass:
    81865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB (PubMed:16356855). Interacts with GLRX3 (via N-terminus) (PubMed:10636891). Interacts with ECT2 (PubMed:15254234). Interacts with CCDC88A/GIV; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (PubMed:23509302).

    Three dimensional structures from OCA and Proteopedia for PRKCQ Gene

    Alternative splice isoforms for PRKCQ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCQ Gene

Selected DME Specific Peptides for PRKCQ Gene

Q04759:
  • KVANLCGINQKL
  • PPFRPKVKSP
  • GKGSFGKV
  • GHIKIAD
  • DDDVECTMVEKRVL
  • WGLNKQGY
  • GVLLYEM
  • DFGMCKE
  • IDMPHRFK
  • VMEYLNGGD
  • HCGTLLWGL
  • FAIKALKK
  • YRDLKLDN
  • GTPDYIAPE
  • LDKDGHIK
  • CNAAIHKKCIDK
  • TFCGTPDYIAPEI
  • QKKPTMYP
  • VDWWSFGVLLYEML
  • YIAPEIL
  • GQSPFHG
  • RDLKLDN

Post-translational modifications for PRKCQ Gene

  • Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.
  • Ubiquitination at Lys77, Lys110, Lys286, Lys325, Lys384, and Lys527
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PRKCQ Gene

Gene Families for PRKCQ Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRKCQ Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCQ Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60459, highly similar to Protein kinase C theta type (EC 2.7.11.13) (B4DF52_HUMAN)
  • nPKC-theta (KPCT_HUMAN)
  • Protein kinase C, theta (Q5JUN8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04759

UniProtKB/Swiss-Prot:

KPCT_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCQ: view

Function for PRKCQ Gene

Molecular function for PRKCQ Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:23509302};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.
GENATLAS Biochemistry:
protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T lymphocytes

Enzyme Numbers (IUBMB) for PRKCQ Gene

Phenotypes From GWAS Catalog for PRKCQ Gene

Gene Ontology (GO) - Molecular Function for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS --
GO:0004674 protein serine/threonine kinase activity IEA,NAS 8444877
GO:0004697 protein kinase C activity IEA --
GO:0004698 calcium-dependent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCQ: view

Phenotypes for PRKCQ Gene

MGI mutant phenotypes for PRKCQ:
inferred from 7 alleles
GenomeRNAi human phenotypes for PRKCQ:
genes like me logo Genes that share phenotypes with PRKCQ: view

Animal Models for PRKCQ Gene

MGI Knock Outs for PRKCQ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCQ

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRKCQ Gene

Localization for PRKCQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCQ Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCQ gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 3
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRKCQ: view

Pathways & Interactions for PRKCQ Gene

PathCards logo

SuperPathways for PRKCQ Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.49
.49
.48
.47
.44
.37
2 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
3 T cell receptor signaling pathway
4 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
5 Sweet Taste Signaling
.72
.72
.44
.37
genes like me logo Genes that share pathways with PRKCQ: view

Pathways by source for PRKCQ Gene

1 Sino Biological pathway for PRKCQ Gene
18 GeneGo (Thomson Reuters) pathways for PRKCQ Gene
  • Cell adhesion Gap junctions
  • Development EGFR signaling pathway
  • Development VEGF signaling and activation
  • Development VEGF signaling via VEGFR2 - generic cascades
  • G-protein signaling_K-RAS regulation pathway
2 Tocris pathways for PRKCQ Gene
79 Qiagen pathways for PRKCQ Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
2 Cell Signaling Technology pathways for PRKCQ Gene
1 GeneTex pathway for PRKCQ Gene

SIGNOR curated interactions for PRKCQ Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8444877
GO:0002376 immune system process IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006468 protein phosphorylation IEA --
GO:0006509 membrane protein ectodomain proteolysis ISS --
genes like me logo Genes that share ontologies with PRKCQ: view

Drugs & Compounds for PRKCQ Gene

(16) Drugs for PRKCQ Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tamoxifen Approved Pharma Agonist, Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
Ingenol mebutate Approved Pharma 0
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphonothreonine Experimental Pharma Target 0

(10) Additional Compounds for PRKCQ Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCQ Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6
genes like me logo Genes that share compounds with PRKCQ: view

Transcripts for PRKCQ Gene

mRNA/cDNA for PRKCQ Gene

7 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCQ

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCQ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PRKCQ Gene

GeneLoc Exon Structure for
PRKCQ

Expression for PRKCQ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCQ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCQ Gene

This gene is overexpressed in Muscle - Skeletal (x18.3) and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for PRKCQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.7) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCQ Gene



Protein tissue co-expression partners for PRKCQ Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCQ

SOURCE GeneReport for Unigene cluster for PRKCQ Gene:

Hs.498570

mRNA Expression by UniProt/SwissProt for PRKCQ Gene:

Q04759-KPCT_HUMAN
Tissue specificity: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.

Evidence on tissue expression from TISSUES for PRKCQ Gene

  • Blood(4.6)
  • Nervous system(4.6)
  • Liver(4.4)
  • Muscle(2.9)
  • Lymph node(2.4)
  • Spleen(2.3)
  • Intestine(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with PRKCQ: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCQ Gene

Orthologs for PRKCQ Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCQ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKCQ 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKCQ 30 31
  • 90.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKCQ 30 31
  • 89.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkcq 30
  • 87.57 (n)
Mouse
(Mus musculus)
Mammalia Prkcq 30 17 31
  • 87.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKCQ 31
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRKCQ 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRKCQ 30 31
  • 77.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKCQ 31
  • 68 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii prkcq 30 31
  • 69.98 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pk17E 32
  • 33 (a)
Pkcdelta 31
  • 15 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tpa-1 31 32
  • 46 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Species where no ortholog for PRKCQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PRKCQ Gene

ENSEMBL:
Gene Tree for PRKCQ (if available)
TreeFam:
Gene Tree for PRKCQ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCQ: view image

Paralogs for PRKCQ Gene

Variants for PRKCQ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKCQ Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
727330 Benign: not provided 6,497,055(-) T/C MISSENSE_VARIANT
776493 Benign: not provided 6,464,322(-) G/C MISSENSE_VARIANT
784651 Benign: not provided 6,479,019(-) C/T SYNONYMOUS_VARIANT
rs2236379 Pathogenic: Inflammatory bowel disease 1. - 6,485,181(-) G/Ap.Pro330Leu MISSENSE_VARIANT
VAR_042319 A colorectal adenocarcinoma sample p.Lys240Asn

Additional dbSNP identifiers (rs#s) for PRKCQ Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKCQ Gene

Variant ID Type Subtype PubMed ID
nsv1047309 CNV gain 25217958
nsv1053177 CNV loss 25217958
nsv1161925 CNV deletion 26073780
nsv507533 OTHER sequence alteration 20534489
nsv515823 CNV loss 19592680
nsv549912 CNV gain 21841781
nsv5687 CNV deletion 18451855
nsv5698 CNV insertion 18451855
nsv7198 OTHER inversion 18451855

Variation tolerance for PRKCQ Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKCQ Gene

Human Gene Mutation Database (HGMD)
PRKCQ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCQ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCQ Gene

Disorders for PRKCQ Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRKCQ Gene - From: ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • ibd1
gastrointestinal stromal tumor
  • gist
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PRKCQ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRKCQ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PRKCQ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCQ Gene

Publications for PRKCQ Gene

  1. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). (PMID: 15364919) Li Y … Polakiewicz RD (The Journal of biological chemistry 2004) 3 4 23
  2. Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. (PMID: 11772397) Liu Y … Shaw S (The Biochemical journal 2002) 3 4 23
  3. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. (PMID: 11342610) Villalba M … Altman A (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23
  4. Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. (PMID: 10652356) Liu Y … Altman A (The Journal of biological chemistry 2000) 3 4 23
  5. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PMID: 8444877) Baier G … Altman A (The Journal of biological chemistry 1993) 2 3 4

Products for PRKCQ Gene

  • Addgene plasmids for PRKCQ