This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinas... See more...

Aliases for PRKCI Gene

Aliases for PRKCI Gene

  • Protein Kinase C Iota 2 3 5
  • Atypical Protein Kinase C-Lambda/Iota 3 4
  • Protein Kinase C Iota Type 3 4
  • PRKC-Lambda/Iota 3 4
  • APKC-Lambda/Iota 3 4
  • EC 2.7.11.13 4 51
  • NPKC-Iota 3 4
  • DXS1179E 3 4
  • PKCI 2 3
  • Protein Kinase C, Iota 2
  • EC 2.7.11 51
  • PRKCI 5

External Ids for PRKCI Gene

Previous HGNC Symbols for PRKCI Gene

  • DXS1179E

Previous GeneCards Identifiers for PRKCI Gene

  • GC0XM096083
  • GC03P170989
  • GC03P171342
  • GC03P171261
  • GC03P171422
  • GC03P169940
  • GC03P167310

Summaries for PRKCI Gene

Entrez Gene Summary for PRKCI Gene

  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCI Gene

PRKCI (Protein Kinase C Iota) is a Protein Coding gene. Diseases associated with PRKCI include Lung Cancer and Lung Squamous Cell Carcinoma. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCZ.

UniProtKB/Swiss-Prot Summary for PRKCI Gene

  • Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity).

Tocris Summary for PRKCI Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCI Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCI Gene

Genomics for PRKCI Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCI on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCI

Top Transcription factor binding sites by QIAGEN in the PRKCI gene promoter:
  • AREB6
  • FOXO4
  • NF-1
  • NF-1/L
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-3

Genomic Locations for PRKCI Gene

Genomic Locations for PRKCI Gene
chr3:170,222,424-170,305,981
(GRCh38/hg38)
Size:
83,558 bases
Orientation:
Plus strand
chr3:169,940,153-170,023,770
(GRCh37/hg19)
Size:
83,618 bases
Orientation:
Plus strand

Genomic View for PRKCI Gene

Genes around PRKCI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCI Gene

Proteins for PRKCI Gene

  • Protein details for PRKCI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41743-KPCI_HUMAN
    Recommended name:
    Protein kinase C iota type
    Protein Accession:
    P41743
    Secondary Accessions:
    • D3DNQ4
    • Q8WW06

    Protein attributes for PRKCI Gene

    Size:
    596 amino acids
    Molecular mass:
    68262 Da
    Quaternary structure:
    • Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 ('Thr-359' phosphorylated form). Interacts with VAMP2 (PubMed:17313651). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).
    SequenceCaution:
    • Sequence=AAA60171.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAB17011.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH22016.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKCI Gene

neXtProt entry for PRKCI Gene

Selected DME Specific Peptides for PRKCI Gene

P41743:
  • DEDIDWVQTEK
  • VNGGDLM
  • GIIYRDLK
  • HPFFRNVDWD
  • CINCKLLVHK
  • IHVFPCVPE
  • FLNKDPKERLGC
  • RLYELNKDSEL
  • EGDPCTVSSQ
  • YRRGARRW
  • YAMKVVKKELV
  • FQAKRFNR
  • TSTFCGTPNYIAPEILRG
  • RVIGRGSYAKVLLVRLKK
  • NTEDYLFQ
  • IDQSEFEGFEYINPLL
  • YRDLKLDN
  • KERLGCHPQTGFADI
  • VDWWALGVL
  • QIRIPRSLSV
  • GHIKLTD
  • LHSCFQT
  • MEQKQVVPPFKPNISGEFGLDNFD
  • EPVQLTPDD
  • YIAPEIL
  • YGFSVDWWALGVLMFEMMAGRSPFDI
  • HQVRVKAYYRGDIMITHFEPSIS
  • RDLKLDN
  • CGTPNYIAPE

Post-translational modifications for PRKCI Gene

  • Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334 (PubMed:11713277, PubMed:16452474). Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus (PubMed:11891849). Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation (PubMed:11713277). Phosphorylated at Thr-564 during the initial phase of long term potentiation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKCI Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRKCI Gene

Gene Families for PRKCI Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRKCI Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
  • Octicosapeptide/Phox/Bem1p
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCI Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C iota type (B5BUK7_HUMAN)
  • nPKC-iota (KPCI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41743

UniProtKB/Swiss-Prot:

KPCI_HUMAN :
  • The PB1 domain mediates interaction with SQSTM1.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The PB1 domain mediates interaction with SQSTM1.
  • The C1 zinc finger does not bind diacylglycerol (DAG).
  • The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except the presence of a non-phosphorylatable residue in place of Ser, it modulates activity by competing with substrates.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCI: view

Function for PRKCI Gene

Molecular function for PRKCI Gene

UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.5 uM for ATP (for recombinant purified PRKCI) {ECO:0000269|PubMed:10906326}; Vmax=7.4 pmol/min/mg enzyme {ECO:0000269|PubMed:10906326};
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-412 (activation loop of the kinase domain) and Thr-564 (turn motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion.
GENATLAS Biochemistry:
protein kinase C,iota polypeptide

Enzyme Numbers (IUBMB) for PRKCI Gene

Phenotypes From GWAS Catalog for PRKCI Gene

Gene Ontology (GO) - Molecular Function for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 11724794
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity ISS --
GO:0004698 calcium-dependent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCI: view
genes like me logo Genes that share phenotypes with PRKCI: view

Animal Models for PRKCI Gene

MGI Knock Outs for PRKCI:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCI

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCI Gene

Localization for PRKCI Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCI Gene

Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. {ECO:0000269 PubMed:15695176, ECO:0000269 PubMed:9566925}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCI gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
endosome 3
golgi apparatus 3
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA,IDA 11260256
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with PRKCI: view

Pathways & Interactions for PRKCI Gene

PathCards logo

SuperPathways for PRKCI Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.49
.49
.48
.47
.44
.37
.35
2 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
3 VEGF Signaling
4 Sweet Taste Signaling
.72
.72
.44
.37
5 Cell junction organization
genes like me logo Genes that share pathways with PRKCI: view

Pathways by source for PRKCI Gene

8 GeneGo (Thomson Reuters) pathways for PRKCI Gene
  • Cell adhesion Gap junctions
  • Development VEGF signaling and activation
  • Development VEGF signaling via VEGFR2 - generic cascades
  • Immune response Function of MEF2 in T lymphocytes
  • Signal transduction Activation of PKC via G-Protein coupled receptor
2 R&D Systems pathways for PRKCI Gene
2 Tocris pathways for PRKCI Gene
68 Qiagen pathways for PRKCI Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
  • Alpha-Adrenergic Signaling
  • Alzheimers Disease Pathway
1 Cell Signaling Technology pathway for PRKCI Gene
2 GeneTex pathways for PRKCI Gene

SIGNOR curated interactions for PRKCI Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 8226978
GO:0006612 protein targeting to membrane NAS 11257119
GO:0007010 cytoskeleton organization NAS 11257119
GO:0007015 actin filament organization IEA --
GO:0010976 positive regulation of neuron projection development IMP 10467349
genes like me logo Genes that share ontologies with PRKCI: view

Drugs & Compounds for PRKCI Gene

(10) Drugs for PRKCI Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tamoxifen Approved Pharma Agonist, Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
Ingenol mebutate Approved Pharma 0
Bisindolylmaleimide I Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(8) Additional Compounds for PRKCI Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCI Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(1) ApexBio Compounds for PRKCI Gene

Compound Action Cas Number
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
genes like me logo Genes that share compounds with PRKCI: view

Transcripts for PRKCI Gene

mRNA/cDNA for PRKCI Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCI

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCI Gene

No ASD Table

Relevant External Links for PRKCI Gene

GeneLoc Exon Structure for
PRKCI

Expression for PRKCI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKCI Gene

This gene is overexpressed in Lung (10.6), Placenta (8.1), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCI Gene



Protein tissue co-expression partners for PRKCI Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCI

SOURCE GeneReport for Unigene cluster for PRKCI Gene:

Hs.478199

mRNA Expression by UniProt/SwissProt for PRKCI Gene:

P41743-KPCI_HUMAN
Tissue specificity: Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.

Evidence on tissue expression from TISSUES for PRKCI Gene

  • Kidney(4.4)
  • Liver(4.3)
  • Nervous system(2.6)
  • Skin(2.3)
  • Stomach(2.1)
  • Lung(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PRKCI: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCI Gene

Orthologs for PRKCI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCI Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKCI 30 31
  • 99.89 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKCI 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKCI 30 31
  • 94.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKCI 30 31
  • 94.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prkci 30 17 31
  • 90.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkci 30
  • 89.99 (n)
Oppossum
(Monodelphis domestica)
Mammalia PRKCI 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRKCI 30 31
  • 83.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKCI 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkci 30
  • 80.27 (n)
Str.15038 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.967 30
Zebrafish
(Danio rerio)
Actinopterygii prkci 30 31
  • 76.08 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta aPKC 30 31 32
  • 63.16 (n)
OneToMany
Pk17E 32
  • 33 (a)
Worm
(Caenorhabditis elegans)
Secernentea pkc-3 30 31
  • 60.53 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 31
  • 15 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 70 (a)
OneToMany
Species where no ortholog for PRKCI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKCI Gene

ENSEMBL:
Gene Tree for PRKCI (if available)
TreeFam:
Gene Tree for PRKCI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCI: view image

Paralogs for PRKCI Gene

Paralogs for PRKCI Gene

(51) SIMAP similar genes for PRKCI Gene using alignment to 2 proteins:

  • KPCI_HUMAN
  • B5BUK7_HUMAN