Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each me... See more...

Aliases for PRKCG Gene

Aliases for PRKCG Gene

  • Protein Kinase C Gamma 2 3 5
  • PKC-Gamma 2 3 4
  • Protein Kinase C Gamma Type 3 4
  • EC 2.7.11.13 4 51
  • PKCC 2 3
  • PKCG 3 4
  • Protein Kinase C, Gamma 2
  • EC 2.7.11 51
  • PKCgamma 3
  • MGC57564 2
  • PKCI(3) 3
  • SCA14 3
  • PRKCG 5
  • PKCγ 2

External Ids for PRKCG Gene

Previous HGNC Symbols for PRKCG Gene

  • PKCG
  • SCA14

Previous GeneCards Identifiers for PRKCG Gene

  • GC19P055031
  • GC19P054810
  • GC19P059061
  • GC19P059077
  • GC19P054382
  • GC19P050704

Summaries for PRKCG Gene

Entrez Gene Summary for PRKCG Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRKCG Gene

PRKCG (Protein Kinase C Gamma) is a Protein Coding gene. Diseases associated with PRKCG include Spinocerebellar Ataxia 14 and Autosomal Dominant Cerebellar Ataxia. Among its related pathways are DAG and IP3 signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot Summary for PRKCG Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

Tocris Summary for PRKCG Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCG Gene

Genomics for PRKCG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCG

Top Transcription factor binding sites by QIAGEN in the PRKCG gene promoter:
  • CREB
  • deltaCREB
  • Egr-3
  • GATA-1
  • HSF1 (long)
  • HSF1short
  • Pax-4a
  • Sp1
  • TBP

Genomic Locations for PRKCG Gene

Genomic Locations for PRKCG Gene
chr19:53,879,190-53,907,652
(GRCh38/hg38)
Size:
28,463 bases
Orientation:
Plus strand
chr19:54,382,444-54,410,906
(GRCh37/hg19)
Size:
28,463 bases
Orientation:
Plus strand

Genomic View for PRKCG Gene

Genes around PRKCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCG Gene

Proteins for PRKCG Gene

  • Protein details for PRKCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05129-KPCG_HUMAN
    Recommended name:
    Protein kinase C gamma type
    Protein Accession:
    P05129
    Secondary Accessions:
    • B7Z8Q0

    Protein attributes for PRKCG Gene

    Size:
    697 amino acids
    Molecular mass:
    78448 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIA4 (By similarity). Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53. Interacts with ARNTL/BMAL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRKCG Gene

    Alternative splice isoforms for PRKCG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCG Gene

Selected DME Specific Peptides for PRKCG Gene

P05129:
  • FYAAEIAIGLF
  • GIIYRDLK
  • TTRTFCGT
  • VLGKGSFGKV
  • GKGSFGKV
  • KLLNQEEGE
  • EAVAICKG
  • GVLLYEMLAGQ
  • CKGFLTK
  • EKRVLAL
  • RFFKQPTFCSHC
  • GVLLYEM
  • DFGMCKE
  • GQPPFDGEDE
  • VKLKLIPD
  • RCHEFVTF
  • MNVHRRC
  • RKGALRQK
  • LNPVWNE
  • FYAAEIA
  • FQGFTYVNPDFVHPDARSP
  • TSRNDFMG
  • YRDLKLDN
  • DDPRNKHKF
  • KRLGSGPDGEPTIRAHGFFRWIDW
  • IKITDFG
  • TFCDHCGSLL
  • DRLYFVME
  • FGKVMLAE
  • DHTERRGR
  • PMDPNGL
  • GTPDYIAPE
  • EGEYYNVP
  • TFCGTPDYIAPEI
  • VDWWSFGVLLYEML
  • PYGKSVD
  • FIWGIGKQG
  • ENFDKFFTR
  • RDLKLDN
  • LLQKFEACNYPLELYERVR

Post-translational modifications for PRKCG Gene

Other Protein References for PRKCG Gene

Antibody Products

  • Boster Bio Antibodies for PRKCG

Domains & Families for PRKCG Gene

Gene Families for PRKCG Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PRKCG Gene

InterPro:
Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52648, highly similar to Protein kinase C gamma type (EC 2.7.11.13) (B7Z870_HUMAN)
  • cDNA FLJ50347, highly similar to Protein kinase C gamma type (EC 2.7.11.13) (B7Z8Q0_HUMAN)
  • Protein kinase C gamma type (KPCG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05129

UniProtKB/Swiss-Prot:

KPCG_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCG: view

Function for PRKCG Gene

Molecular function for PRKCG Gene

UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.
GENATLAS Biochemistry:
protein kinase C,gamma polypeptide

Enzyme Numbers (IUBMB) for PRKCG Gene

Phenotypes From GWAS Catalog for PRKCG Gene

Gene Ontology (GO) - Molecular Function for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 15808853
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004697 protein kinase C activity TAS 3755548
GO:0004698 calcium-dependent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCG: view
genes like me logo Genes that share phenotypes with PRKCG: view

Human Phenotype Ontology for PRKCG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKCG Gene

MGI Knock Outs for PRKCG:

Animal Model Products

CRISPR Products

miRNA for PRKCG Gene

miRTarBase miRNAs that target PRKCG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCG

Clone Products

  • Addgene plasmids for PRKCG

No data available for Transcription Factor Targets and HOMER Transcription for PRKCG Gene

Localization for PRKCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCG Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, dendrite. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250 UniProtKB:P63318}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCG gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,TAS --
GO:0005886 plasma membrane ISS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with PRKCG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRKCG Gene

Pathways & Interactions for PRKCG Gene

PathCards logo

SuperPathways for PRKCG Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
.35
2 IL-2 Pathway
.59
.59
.54
.51
.49
.49
.48
.47
.44
.37
3 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
4 RET signaling
5 Aldosterone synthesis and secretion
genes like me logo Genes that share pathways with PRKCG: view

Pathways by source for PRKCG Gene

13 GeneGo (Thomson Reuters) pathways for PRKCG Gene
  • Cell adhesion Gap junctions
  • Development Angiotensin signaling via beta-Arrestin
  • Development EGFR signaling pathway
  • Development VEGF signaling and activation
  • Development VEGF signaling via VEGFR2 - generic cascades
78 Qiagen pathways for PRKCG Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PRKCG Gene
1 GeneTex pathway for PRKCG Gene

SIGNOR curated interactions for PRKCG Gene

Gene Ontology (GO) - Biological Process for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 3755548
GO:0007268 chemical synaptic transmission IEA --
GO:0007611 learning or memory IEA --
GO:0007635 chemosensory behavior IEA --
GO:0016310 phosphorylation IDA 15808853
genes like me logo Genes that share ontologies with PRKCG: view

Drugs & Compounds for PRKCG Gene

(34) Drugs for PRKCG Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tamoxifen Approved Pharma Agonist, Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
Ingenol mebutate Approved Pharma 0
Staurosporine Experimental Pharma Allosteric regulator, Positive, Neutral Protein kinase inhibitor,potent and cell permeable 9
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(16) Additional Compounds for PRKCG Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCG Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(15) ApexBio Compounds for PRKCG Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Midostaurin (PKC412) PKC inhibitor 120685-11-2
Ro 31-8220 pan-PKC inhibitor 125314-64-9
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCG: view

Drug Products

Transcripts for PRKCG Gene

mRNA/cDNA for PRKCG Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCG

Clone Products

  • Addgene plasmids for PRKCG

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCG Gene

No ASD Table

Relevant External Links for PRKCG Gene

GeneLoc Exon Structure for
PRKCG

Expression for PRKCG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCG Gene

This gene is overexpressed in Brain - Hippocampus (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.1), Brain - Cortex (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Amygdala (x4.6), Brain - Caudate (basal ganglia) (x4.6), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for PRKCG Gene

This gene is overexpressed in Frontal cortex (35.7) and Brain (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRKCG Gene



Protein tissue co-expression partners for PRKCG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCG

SOURCE GeneReport for Unigene cluster for PRKCG Gene:

Hs.631564

mRNA Expression by UniProt/SwissProt for PRKCG Gene:

P05129-KPCG_HUMAN
Tissue specificity: Expressed in Purkinje cells of the cerebellar cortex.

Evidence on tissue expression from TISSUES for PRKCG Gene

  • Nervous system(5)
  • Kidney(4.4)
  • Blood(2.1)
  • Eye(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • mouth
  • pharynx
Thorax:
  • esophagus
Abdomen:
  • stomach
Limb:
  • ankle
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with PRKCG: view

Orthologs for PRKCG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKCG 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 99 (a)
OneToMany
LOC100855828 30
  • 91.87 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKCG 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKCG 30 31
  • 91.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkcg 30
  • 89.96 (n)
Mouse
(Mus musculus)
Mammalia Prkcg 30 17 31
  • 89.48 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKCG 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkcg 30
  • 74.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii prkcg 30 31
  • 67.44 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Pkc53E 31 32
  • 63 (a)
ManyToMany
inaC 31 32
  • 48 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea pkc-2 31 32
  • 46 (a)
OneToMany
R12G8.1 32
  • 43 (a)
Species where no ortholog for PRKCG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKCG Gene

ENSEMBL:
Gene Tree for PRKCG (if available)
TreeFam:
Gene Tree for PRKCG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCG: view image

Paralogs for PRKCG Gene

Paralogs for PRKCG Gene

genes like me logo Genes that share paralogs with PRKCG: view

Variants for PRKCG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKCG Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
713543 Likely Benign: not provided 53,906,346(+) G/A SYNONYMOUS_VARIANT
732077 Likely Benign: not provided 53,893,057(+) C/T SYNONYMOUS_VARIANT
734692 Benign: not provided 53,891,667(+) C/T INTRON_VARIANT
738051 Likely Benign: not provided 53,892,530(+) G/A SYNONYMOUS_VARIANT
747511 Likely Benign: not provided 53,900,313(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PRKCG Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKCG Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718846 CNV deletion 23290073
nsv1064558 CNV gain 25217958
nsv1116349 CNV deletion 24896259
nsv2541 CNV deletion 18451855
nsv475269 CNV novel sequence insertion 20440878
nsv478957 CNV novel sequence insertion 20440878
nsv833876 CNV loss 17160897

Variation tolerance for PRKCG Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKCG Gene

Human Gene Mutation Database (HGMD)
PRKCG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCG Gene

Disorders for PRKCG Gene

MalaCards: The human disease database

(14) MalaCards diseases for PRKCG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 14
  • sca14
autosomal dominant cerebellar ataxia
  • spinocerebellar ataxia
hereditary ataxia
  • ataxias hereditary
depression
  • major depressive disorder
cerebellar ataxia type 41
  • sca41
- elite association - COSMIC cancer census association via MalaCards
Search PRKCG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KPCG_HUMAN
  • Spinocerebellar ataxia 14 (SCA14) [MIM:605361]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA). {ECO:0000269 PubMed:12644968, ECO:0000269 PubMed:29053796}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRKCG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PRKCG: view

No data available for Genatlas for PRKCG Gene

Publications for PRKCG Gene

  1. The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. (PMID: 17508994) Schlaepfer IR … Ehringer MA (Addiction biology 2007) 3 23 41
  2. New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14. (PMID: 16193476) Klebe S … Stevanin G (Annals of neurology 2005) 3 23 41
  3. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. (PMID: 12644968) Chen DH … Raskind WH (American journal of human genetics 2003) 3 4 23
  4. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. (PMID: 3755548) Coussens L … Ullrich A (Science (New York, N.Y.) 1986) 2 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

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