Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor... See more...

Aliases for PRKCE Gene

Aliases for PRKCE Gene

  • Protein Kinase C Epsilon 2 3 5
  • Protein Kinase C Epsilon Type 3 4
  • NPKC-Epsilon 3 4
  • EC 2.7.11.13 4 50
  • PKCE 3 4
  • Protein Kinase C, Epsilon 2
  • EC 2.7.11 50
  • PRKCE 5

External Ids for PRKCE Gene

Previous GeneCards Identifiers for PRKCE Gene

  • GC02P045897
  • GC02P046047
  • GC02P045853
  • GC02P045790
  • GC02P045617

Summaries for PRKCE Gene

Entrez Gene Summary for PRKCE Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCE Gene

PRKCE (Protein Kinase C Epsilon) is a Protein Coding gene. Diseases associated with PRKCE include Ischemia and Anxiety. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCH.

UniProtKB/Swiss-Prot Summary for PRKCE Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Tocris Summary for PRKCE Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCE Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCE Gene

Genomics for PRKCE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J045647 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.6 -578 6.1 BCLAF1 SP1 ZNF207 MYC SSRP1 JUND ZNF580 ATF2 POLR2A CEBPA LOC102724965 Hsa-Mir-574_5p-038 PRKCE lnc-SRBD1-1 SRBD1 RHOQ-AS1 lnc-PRKCE-2
GH02J045609 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 10.5 -39.9 -39870 3.3 BCLAF1 ZNF207 MYC ZNF600 IKZF1 KLF9 POLR2A YY1 MXD4 CTCF SRBD1 HSALNG0014648 lnc-SRBD1-5 lnc-PRKCE-3 PRKCE SIX2
GH02J045719 Enhancer 0.9 Ensembl ENCODE 18 +71.7 71686 8 CEBPA CEBPB SAP130 EBF1 MAX FOXP1 BHLHE40 SOX5 HNF4A RXRB PRKCE PRKCE-AS1 RF00994-480 HSALNG0014654 lnc-EPAS1-3 EPAS1
GH02J045727 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.8 +78.3 78286 4.8 BCLAF1 SP1 ZNF207 POLR2A CTCF BCL11A TRIM22 SMC3 IRF4 EBF1 PRKCE-AS1 PRKCE RF00994-480 lnc-EPAS1-3 HSALNG0014655-001 HSALNG0014655-002 EPAS1
GH02J045698 Enhancer 0.9 Ensembl ENCODE 16.8 +47.3 47286 4.8 REST MAX CTCF SPI1 RAD51 BATF MAFK JUND NFATC1 NR2F1 PRKCE PRKCE-AS1 HSALNG0014653 lnc-EPAS1-3 EPAS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCE

Top Transcription factor binding sites by QIAGEN in the PRKCE gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • CHOP-10
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-1/L
  • Pax-3
  • STAT3

Genomic Locations for PRKCE Gene

Latest Assembly
chr2:45,651,315-46,187,990
(GRCh38/hg38)
Size:
536,676 bases
Orientation:
Plus strand

Previous Assembly
chr2:45,878,814-46,415,129
(GRCh37/hg19 by Entrez Gene)
Size:
536,316 bases
Orientation:
Plus strand

chr2:45,878,484-46,415,129
(GRCh37/hg19 by Ensembl)
Size:
536,646 bases
Orientation:
Plus strand

Genomic View for PRKCE Gene

Genes around PRKCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCE Gene

Proteins for PRKCE Gene

  • Protein details for PRKCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02156-KPCE_HUMAN
    Recommended name:
    Protein kinase C epsilon type
    Protein Accession:
    Q02156
    Secondary Accessions:
    • B0LPH7
    • Q32MQ3
    • Q53SL4
    • Q53SM5
    • Q9UE81

    Protein attributes for PRKCE Gene

    Size:
    737 amino acids
    Molecular mass:
    83674 Da
    Quaternary structure:
    • Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3. Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (PubMed:20353823). Interacts (via phorbol-ester/DAG-type 2 domain) with PRPH and VIM (PubMed:18408015).

    Three dimensional structures from OCA and Proteopedia for PRKCE Gene

neXtProt entry for PRKCE Gene

Selected DME Specific Peptides for PRKCE Gene

Q02156:
  • VNGGDLM
  • RKFDEPR
  • VLGKGSFGKV
  • GKGSFGKV
  • ILKAFMTKN
  • SVDWWALGVLMYEMMAGQPPFEADNED
  • NVAPNCGV
  • DFGMCKE
  • MNVHRRC
  • LSKEAVS
  • YRDLKLDN
  • RQGLQCK
  • VDWWALGVL
  • DRLFFVME
  • CTMTEKR
  • TFCDHCGSLL
  • YAVKVLKKDVILQDDDV
  • FGKVMLAE
  • GTPDYIAPE
  • TFCGTPDYIAPEI
  • YIAPEIL
  • FVMEYVNGG
  • HPFFKEIDW
  • VVHKRCH
  • GAESPQP
  • NGHKFMATYLRQPTYCSHCR
  • FQTKDRL
  • RDLKLDN

Post-translational modifications for PRKCE Gene

  • Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKCE

Domains & Families for PRKCE Gene

Gene Families for PRKCE Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRKCE Gene

InterPro:
Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding

Suggested Antigen Peptide Sequences for PRKCE Gene

GenScript: Design optimal peptide antigens:
  • nPKC-epsilon (KPCE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02156

UniProtKB/Swiss-Prot:

KPCE_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCE: view

Function for PRKCE Gene

Molecular function for PRKCE Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.

Enzyme Numbers (IUBMB) for PRKCE Gene

Phenotypes From GWAS Catalog for PRKCE Gene

Gene Ontology (GO) - Molecular Function for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003785 actin monomer binding IEA,ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 15695813
GO:0004697 protein kinase C activity IDA 18556656
genes like me logo Genes that share ontologies with PRKCE: view
genes like me logo Genes that share phenotypes with PRKCE: view

Animal Models for PRKCE Gene

MGI Knock Outs for PRKCE:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCE Gene

Localization for PRKCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCE Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCE gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
mitochondrion 4
nucleus 4
endoplasmic reticulum 4
extracellular 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Intermediate filaments (3)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 15632189
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 18556656
GO:0005794 colocalizes_with Golgi apparatus IEA,ISS --
genes like me logo Genes that share ontologies with PRKCE: view

Pathways & Interactions for PRKCE Gene

PathCards logo

SuperPathways for PRKCE Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.51
.49
.49
.48
.47
.44
.37
2 RET signaling
3 fMLP Pathway
.44
.44
.43
.42
.39
.38
.30
4 Development Angiotensin activation of ERK
.73
.68
.65
.54
.48
.45
.40
5 VEGF Signaling
genes like me logo Genes that share pathways with PRKCE: view

Pathways by source for PRKCE Gene

30 GeneGo (Thomson Reuters) pathways for PRKCE Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Cell adhesion Gap junctions
  • Cell adhesion Integrin inside-out signaling
  • Development A2B receptor- action via G-protein alpha s
  • Development A3 receptor signaling
2 Tocris pathways for PRKCE Gene
79 Qiagen pathways for PRKCE Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PRKCE Gene
2 GeneTex pathways for PRKCE Gene

SIGNOR curated interactions for PRKCE Gene

Gene Ontology (GO) - Biological Process for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IEA,IDA 18556656
GO:0006915 apoptotic process TAS 10438519
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PRKCE: view

Drugs & Compounds for PRKCE Gene

(37) Drugs for PRKCE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tamoxifen Approved Pharma Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 469
Ingenol mebutate Approved Pharma 0
Staurosporine Experimental Pharma Protein kinase inhibitor,potent and cell permeable 11
KAI-1455 Investigational Pharma Target, activator 0

(16) Additional Compounds for PRKCE Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(5) Tocris Compounds for PRKCE Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(12) ApexBio Compounds for PRKCE Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCE: view

Drug products for research

Transcripts for PRKCE Gene

mRNA/cDNA for PRKCE Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCE

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4:
SP5:

ExUns: 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PRKCE Gene

GeneLoc Exon Structure for
PRKCE

Expression for PRKCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCE Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6) and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for PRKCE Gene

This gene is overexpressed in Frontal cortex (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCE Gene



Protein tissue co-expression partners for PRKCE Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCE

SOURCE GeneReport for Unigene cluster for PRKCE Gene:

Hs.580351

Evidence on tissue expression from TISSUES for PRKCE Gene

  • Nervous system(4.3)
  • Liver(2.3)
  • Heart(2.3)
  • Muscle(2.3)
  • Lung(2.2)
  • Blood(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with PRKCE: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCE Gene

Orthologs for PRKCE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRKCE 29 30
  • 99.64 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRKCE 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKCE 29 30
  • 93.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKCE 29 30
  • 92.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prkce 29 16 30
  • 91.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkce 29
  • 90.86 (n)
Chicken
(Gallus gallus)
Aves PRKCE 29 30
  • 81.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRKCE 30
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkce 29
  • 79.25 (n)
Str.13025 29
Zebrafish
(Danio rerio)
Actinopterygii prkcea 30
  • 85 (a)
OneToMany
prkceb 29 30
  • 76.34 (n)
OneToMany
Dr.12470 29
Fruit Fly
(Drosophila melanogaster)
Insecta Pkc98E 29 30 31
  • 60.64 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002748 29
  • 60.6 (n)
Worm
(Caenorhabditis elegans)
Secernentea pkc-1 29 30
  • 58.64 (n)
OneToMany
F48G7.10 31
  • 44 (a)
R12G8.1 31
  • 43 (a)
tpa-1 31
  • 42 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR191C 29
  • 49.83 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 29
  • 49.68 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06447g 29
  • 49.46 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06544 29
  • 55.08 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2703 30
  • 54 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck2 29
  • 50 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9021 29
Species where no ortholog for PRKCE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKCE Gene

ENSEMBL:
Gene Tree for PRKCE (if available)
TreeFam:
Gene Tree for PRKCE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCE: view image
Alliance of Genome Resources:
Additional Orthologs for PRKCE

Paralogs for PRKCE Gene

Paralogs for PRKCE Gene