Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor... See more...

Aliases for PRKCE Gene

Aliases for PRKCE Gene

  • Protein Kinase C Epsilon 2 3 5
  • Protein Kinase C Epsilon Type 3 4
  • NPKC-Epsilon 3 4
  • EC 2.7.11.13 4 52
  • PKCE 3 4
  • Protein Kinase C, Epsilon 2
  • EC 2.7.11 52

External Ids for PRKCE Gene

Previous GeneCards Identifiers for PRKCE Gene

  • GC02P045897
  • GC02P046047
  • GC02P045853
  • GC02P045790
  • GC02P045617

Summaries for PRKCE Gene

Entrez Gene Summary for PRKCE Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCE Gene

PRKCE (Protein Kinase C Epsilon) is a Protein Coding gene. Diseases associated with PRKCE include Ischemia and Anxiety. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCH.

UniProtKB/Swiss-Prot Summary for PRKCE Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Tocris Summary for PRKCE Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCE Gene

Additional gene information for PRKCE Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCE Gene

Genomics for PRKCE Gene

GeneHancer (GH) Regulatory Elements for PRKCE Gene

Promoters and enhancers for PRKCE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J045647 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.6 -578 6.1 RXRA FOXK2 ZBTB40 EP300 CTCF ZSCAN5C TCF12 SIN3A NRF1 USF1 LOC102724965 PRKCE lnc-SRBD1-1 SRBD1 LOC100506142 lnc-PRKCE-2
GH02J045609 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 10.5 -40.0 -39970 3.5 ZBTB40 ZNF217 CTCF TCF12 NRF1 MYC POLR2G USF1 GTF2E2 PHF8 SRBD1 lnc-PRKCE-3 lnc-SRBD1-5 PRKCE
GH02J045719 Enhancer 0.9 Ensembl ENCODE 18 +71.7 71686 8 CEBPB SAP130 MEF2B FOXP1 KLF9 POU2F2 EBF1 EGR1 ZNF398 TBX21 PRKCE PRKCE-AS1 RF00994-481 RF00005-078 TRQ-TTG5-1 lnc-EPAS1-3
GH02J045727 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.8 +78.3 78286 4.8 CTCF SP1 EP300 RELA MEF2C TRIM22 BCL11A TCF12 CBFB USF2 PRKCE-AS1 PRKCE RF00994-481 lnc-EPAS1-3 HSALNG0014655
GH02J045698 Enhancer 0.9 Ensembl ENCODE 16.8 +47.3 47286 4.8 USF1 REST MXI1 ESRRA CTCF SPI1 BATF MAFK FOS NR2F1 PRKCE PRKCE-AS1 RF00005-078 TRQ-TTG5-1 lnc-EPAS1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCE

Top Transcription factor binding sites by QIAGEN in the PRKCE gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • CHOP-10
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-1/L
  • Pax-3
  • STAT3

Genomic Locations for PRKCE Gene

Genomic Locations for PRKCE Gene
chr2:45,651,315-46,187,990
(GRCh38/hg38)
Size:
536,676 bases
Orientation:
Plus strand
chr2:45,878,484-46,415,129
(GRCh37/hg19)
Size:
536,646 bases
Orientation:
Plus strand

Genomic View for PRKCE Gene

Genes around PRKCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCE Gene

Proteins for PRKCE Gene

  • Protein details for PRKCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02156-KPCE_HUMAN
    Recommended name:
    Protein kinase C epsilon type
    Protein Accession:
    Q02156
    Secondary Accessions:
    • B0LPH7
    • Q32MQ3
    • Q53SL4
    • Q53SM5
    • Q9UE81

    Protein attributes for PRKCE Gene

    Size:
    737 amino acids
    Molecular mass:
    83674 Da
    Quaternary structure:
    • Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3. Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (PubMed:20353823).

    Three dimensional structures from OCA and Proteopedia for PRKCE Gene

neXtProt entry for PRKCE Gene

Selected DME Specific Peptides for PRKCE Gene

Q02156:
  • VNGGDLM
  • RKFDEPR
  • VLGKGSFGKV
  • GKGSFGKV
  • ILKAFMTKN
  • SVDWWALGVLMYEMMAGQPPFEADNED
  • NVAPNCGV
  • DFGMCKE
  • MNVHRRC
  • LSKEAVS
  • YRDLKLDN
  • RQGLQCK
  • VDWWALGVL
  • DRLFFVME
  • CTMTEKR
  • TFCDHCGSLL
  • YAVKVLKKDVILQDDDV
  • FGKVMLAE
  • GTPDYIAPE
  • TFCGTPDYIAPEI
  • YIAPEIL
  • FVMEYVNGG
  • HPFFKEIDW
  • VVHKRCH
  • GAESPQP
  • NGHKFMATYLRQPTYCSHCR
  • FQTKDRL
  • RDLKLDN

Post-translational modifications for PRKCE Gene

  • Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKCE

Domains & Families for PRKCE Gene

Gene Families for PRKCE Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRKCE Gene

Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCE Gene

GenScript: Design optimal peptide antigens:
  • nPKC-epsilon (KPCE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02156

UniProtKB/Swiss-Prot:

KPCE_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCE: view

Function for PRKCE Gene

Molecular function for PRKCE Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.

Enzyme Numbers (IUBMB) for PRKCE Gene

Phenotypes From GWAS Catalog for PRKCE Gene

Gene Ontology (GO) - Molecular Function for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding ISS,IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IBA 15695813
GO:0004697 protein kinase C activity IDA 18556656
GO:0004699 calcium-independent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCE: view
genes like me logo Genes that share phenotypes with PRKCE: view

Animal Models for PRKCE Gene

MGI Knock Outs for PRKCE:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for PRKCE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCE Gene

Localization for PRKCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCE Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCE gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 4
endoplasmic reticulum 4
mitochondrion 3
extracellular 2
golgi apparatus 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 15632189
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 18556656
GO:0005794 colocalizes_with Golgi apparatus IEA,ISS --
genes like me logo Genes that share ontologies with PRKCE: view

Pathways & Interactions for PRKCE Gene

PathCards logo

SuperPathways for PRKCE Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.51
.49
.49
.48
.47
.44
.37
2 RET signaling
3 fMLP Pathway
.44
.44
.43
.42
.39
.38
.30
4 Development Angiotensin activation of ERK
.73
.68
.65
.54
.48
.45
.40
5 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
genes like me logo Genes that share pathways with PRKCE: view

Pathways by source for PRKCE Gene

30 GeneGo (Thomson Reuters) pathways for PRKCE Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Cell adhesion Gap junctions
  • Cell adhesion Integrin inside-out signaling
  • Development A2B receptor- action via G-protein alpha s
  • Development A3 receptor signaling
2 Tocris pathways for PRKCE Gene
79 Qiagen pathways for PRKCE Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PRKCE Gene
2 GeneTex pathways for PRKCE Gene

SIGNOR curated interactions for PRKCE Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IDA,IEA 18556656
GO:0006915 apoptotic process TAS 10438519
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PRKCE: view

Drugs & Compounds for PRKCE Gene

(37) Drugs for PRKCE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tamoxifen Approved Pharma Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 455
Ingenol mebutate Approved Pharma 0
Staurosporine Experimental Pharma Positive, Allosteric regulator, Neutral Protein kinase inhibitor,potent and cell permeable 46

(15) Additional Compounds for PRKCE Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCE Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(13) ApexBio Compounds for PRKCE Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
PKC ζ pseudosubstrate
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCE: view

Transcripts for PRKCE Gene

mRNA/cDNA for PRKCE Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PRKCE

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4:
SP5:

ExUns: 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PRKCE Gene

GeneLoc Exon Structure for
PRKCE

Expression for PRKCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCE Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6) and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for PRKCE Gene

This gene is overexpressed in Frontal cortex (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCE Gene



Protein tissue co-expression partners for PRKCE Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCE

SOURCE GeneReport for Unigene cluster for PRKCE Gene:

Hs.580351

Evidence on tissue expression from TISSUES for PRKCE Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRKCE: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCE Gene

Orthologs for PRKCE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCE 31 30
  • 99.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCE 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCE 31 30
  • 93.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCE 31 30
  • 92.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prkce 17 31 30
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Prkce 30
  • 90.86 (n)
chicken
(Gallus gallus)
Aves PRKCE 31 30
  • 81.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCE 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkce 30
  • 79.25 (n)
Str.13025 30
zebrafish
(Danio rerio)
Actinopterygii prkcea 31
  • 85 (a)
OneToMany
prkceb 31 30
  • 76.34 (n)
OneToMany
Dr.12470 30
fruit fly
(Drosophila melanogaster)
Insecta Pkc98E 31 32 30
  • 60.64 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002748 30
  • 60.6 (n)
worm
(Caenorhabditis elegans)
Secernentea pkc-1 31 30
  • 58.64 (n)
OneToMany
F48G7.10 32
  • 44 (a)
R12G8.1 32
  • 43 (a)
tpa-1 32
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR191C 30
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 30
  • 49.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06447g 30
  • 49.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06544 30
  • 55.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2703 31
  • 54 (a)
OneToMany
Cin.9021 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes