Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor pro... See more...

Aliases for PRKCB Gene

Aliases for PRKCB Gene

  • Protein Kinase C Beta 2 3 5
  • Protein Kinase C Beta Type 3 4
  • EC 2.7.11.13 4 51
  • PKC-Beta 3 4
  • PRKCB1 3 4
  • PKC-B 3 4
  • PKCB 3 4
  • Protein Kinase C, Beta 1 Polypeptide 3
  • Protein Kinase C, Beta 1 2
  • Protein Kinase C, Beta 2
  • EC 2.7.11 51
  • PKCI(2) 3
  • PKCbeta 3
  • PRKCB2 3
  • PRKCB 5
  • PKCβ 2

External Ids for PRKCB Gene

Previous HGNC Symbols for PRKCB Gene

  • PRKCB2
  • PKCB
  • PRKCB1

Previous GeneCards Identifiers for PRKCB Gene

  • GC16P023755
  • GC16P023847
  • GC16P021938
  • GC16P023848
  • GC16P023854
  • GC16P023872

Summaries for PRKCB Gene

Entrez Gene Summary for PRKCB Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

CIViC Summary for PRKCB Gene

GeneCards Summary for PRKCB Gene

PRKCB (Protein Kinase C Beta) is a Protein Coding gene. Diseases associated with PRKCB include Diabetic Macular Edema and Microvascular Complications Of Diabetes 5. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot Summary for PRKCB Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525).

Gene Wiki entry for PRKCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKCB Gene

Genomics for PRKCB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRKCB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J023835 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 613.6 +1.0 1018 3.6 SP1 CTCF HNRNPL PRDM10 IKZF1 POLR2A BACH1 ZNF143 ZIC2 ZSCAN4 PRKCB CHP2 lnc-CHP2-1 CACNG3
GH16J023946 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.8 +113.8 113846 7.4 RFX1 LEF1 IKZF1 JUND DDX20 PRDM1 MTA2 ZIC2 PKNOX1 ZNF24 PRKCB RBBP6 PALB2 ENSG00000260751 ENSG00000261669 GGA2 ENSG00000279276 lnc-CHP2-1 CACNG3
GH16J023898 Enhancer 1.1 ENCODE dbSUPER 45.4 +66.1 66082 7.5 TEAD4 LEF1 IKZF1 ETV6 JUND FOXA1 DDX20 PHF21A ZIC2 PKNOX1 PRKCB PALB2 RBBP6 ENSG00000260751 ENSG00000261669 lnc-CHP2-1 ENSG00000279276 CACNG3
GH16J023855 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 35.7 +24.8 24832 9.2 CREB1 IKZF1 STAT3 MTA2 RELA ZIC2 PKNOX1 MTA1 NR2C1 TCF12 PRKCB RBBP6 PALB2 ENSG00000260751 ENSG00000260482 ENSG00000261669 GGA2 lnc-CHP2-1 CACNG3
GH16J023912 Enhancer 0.8 Ensembl dbSUPER 44.5 +78.8 78817 5.6 ZNF143 PKNOX1 ZBTB20 DPF2 RELB NFE2 OSR2 NR2C2 IKZF1 NR2C1 PRKCB lnc-CHP2-1 ENSG00000279276 CACNG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKCB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKCB

Top Transcription factor binding sites by QIAGEN in the PRKCB gene promoter:
  • AML1a

Genomic Locations for PRKCB Gene

Genomic Locations for PRKCB Gene
chr16:23,835,983-24,220,611
(GRCh38/hg38)
Size:
384,629 bases
Orientation:
Plus strand
chr16:23,847,300-24,231,932
(GRCh37/hg19)
Size:
384,633 bases
Orientation:
Plus strand

Genomic View for PRKCB Gene

Genes around PRKCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCB Gene

Proteins for PRKCB Gene

  • Protein details for PRKCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05771-KPCB_HUMAN
    Recommended name:
    Protein kinase C beta type
    Protein Accession:
    P05771
    Secondary Accessions:
    • C5IFJ8
    • D3DWF5
    • O43744
    • P05127
    • Q15138
    • Q93060
    • Q9UE49
    • Q9UE50
    • Q9UEH8
    • Q9UJ30
    • Q9UJ33

    Protein attributes for PRKCB Gene

    Size:
    671 amino acids
    Molecular mass:
    76869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR.

    Three dimensional structures from OCA and Proteopedia for PRKCB Gene

    Alternative splice isoforms for PRKCB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCB Gene

Selected DME Specific Peptides for PRKCB Gene

P05771:
  • VNGGDLM
  • FYAAEIAIGLF
  • GIIYRDLK
  • VRDAKNL
  • VLGKGSFGKV
  • DDPRSKHKFKIHTY
  • NEELRQKFERAKI
  • GKGSFGKV
  • EAVAICKG
  • GHIKIAD
  • GVLLYEMLAGQ
  • RNDFMGSLSFG
  • DDDVECTMVEKRVL
  • ESKQKTKTI
  • EKRVLAL
  • GEDEDELFQSIMEH
  • RFFKQPTFCSHC
  • MNVHKRC
  • GVLLYEM
  • DFGMCKE
  • AGQAPFEG
  • VKLKLIPD
  • VDWWAFGVL
  • RCHEFVTF
  • QDDDVECTM
  • TPTDKLFIMNLDQ
  • GALRQKNVHE
  • RKGALRQK
  • ICKGLMTKHP
  • FYAAEIA
  • TSRNDFMG
  • VDGWFKLLSQEEGEYFNVPVPPEGSE
  • WGFGKQG
  • YRDLKLDN
  • TFCDHCGSLL
  • DRLYFVME
  • DHTERRGR
  • PMDPNGL
  • LHSCFQT
  • GTPDYIAPE
  • TFCGTPDYIAPEI
  • CPGADKG
  • KRLGCGP
  • GTDELYAVK
  • FVMEYVNGG
  • PYGKSVD
  • LSFGISE
  • VVHKRCH
  • KRLGCGPEGERD
  • RDLKLDN

Post-translational modifications for PRKCB Gene

  • Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).
  • Ubiquitination at Lys141 and Lys489
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCB Gene

Antibody Products

Domains & Families for PRKCB Gene

Gene Families for PRKCB Gene

Protein Domains for PRKCB Gene

InterPro:
Blocks:
  • C2 domain
  • Protein kinase C-terminal domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCB Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C beta type (KPCB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05771

UniProtKB/Swiss-Prot:

KPCB_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCB: view

Function for PRKCB Gene

Molecular function for PRKCB Gene

UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25982116};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:20228790};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).

Enzyme Numbers (IUBMB) for PRKCB Gene

Phenotypes From GWAS Catalog for PRKCB Gene

Gene Ontology (GO) - Molecular Function for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003682 chromatin binding IDA 20228790
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity TAS,IDA 25982116
genes like me logo Genes that share ontologies with PRKCB: view
genes like me logo Genes that share phenotypes with PRKCB: view

Animal Models for PRKCB Gene

MGI Knock Outs for PRKCB:

Animal Model Products

CRISPR Products

miRNA for PRKCB Gene

miRTarBase miRNAs that target PRKCB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCB Gene

Localization for PRKCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCB Gene

Cytoplasm. Nucleus. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCB gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IDA 20228790
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 15632189
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKCB: view

Pathways & Interactions for PRKCB Gene

PathCards logo

SuperPathways for PRKCB Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.51
.49
.49
.48
.47
.44
.37
.35
2 fMLP Pathway
.44
.44
.43
.42
.39
.38
.31
3 Aldosterone synthesis and secretion
4 CCR5 Pathway in Macrophages
.52
.52
.33
5 Circadian entrainment
genes like me logo Genes that share pathways with PRKCB: view

Pathways by source for PRKCB Gene

80 Qiagen pathways for PRKCB Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
2 Cell Signaling Technology pathways for PRKCB Gene
2 GeneTex pathways for PRKCB Gene

Gene Ontology (GO) - Biological Process for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription by RNA polymerase II IMP 20228790
GO:0006468 protein phosphorylation IEA,TAS 3755548
genes like me logo Genes that share ontologies with PRKCB: view

Drugs & Compounds for PRKCB Gene

(68) Drugs for PRKCB Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 526,534
Cholecystokinin Approved, Investigational Pharma Target, agonist 24
Tamoxifen Approved Pharma Agonist, Antagonist, Target, inhibitor TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
alpha-Tocopherol acetate Approved, Vet_approved Nutra Target 0
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0

(37) Additional Compounds for PRKCB Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PRKCB Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(16) ApexBio Compounds for PRKCB Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Midostaurin (PKC412) PKC inhibitor 120685-11-2
PKC β pseudosubstrate 172308-76-8
Ro 31-8220 pan-PKC inhibitor 125314-64-9
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Verbascoside PKC/NF-κB inhibitor 61276-17-3
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCB: view

Drug Products

Transcripts for PRKCB Gene

mRNA/cDNA for PRKCB Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKCB

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCB Gene

No ASD Table

Relevant External Links for PRKCB Gene

GeneLoc Exon Structure for
PRKCB

Expression for PRKCB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCB Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.4), Brain - Caudate (basal ganglia) (x5.3), Brain - Putamen (basal ganglia) (x5.2), Brain - Cortex (x5.0), Whole Blood (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for PRKCB Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (12.9), and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKCB Gene



Protein tissue co-expression partners for PRKCB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKCB

SOURCE GeneReport for Unigene cluster for PRKCB Gene:

Hs.460355

Evidence on tissue expression from TISSUES for PRKCB Gene

  • Nervous system(5)
  • Blood(4.6)
  • Liver(4.5)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Heart(2.6)
  • Intestine(2.6)
  • Bone marrow(2.6)
  • Kidney(2.4)
  • Skin(2.3)
  • Eye(2.2)
  • Muscle(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PRKCB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCB Gene

Orthologs for PRKCB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCB Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia PRKCB 31
  • 97 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia PRKCB 30 31
  • 96.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRKCB 30 31
  • 93.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRKCB 30 31
  • 92.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prkcb 30 17 31
  • 91.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prkcb 30
  • 91.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PRKCB 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRKCB 30 31
  • 81.88 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prkcb 30
  • 80.27 (n)
Str.18182 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.34027 30
Zebrafish
(Danio rerio)
Actinopterygii prkcba 31
  • 79 (a)
OneToMany
prkcbb 30 31
  • 78.26 (n)
OneToMany
zgc63591 30
Fruit Fly
(Drosophila melanogaster)
Insecta Pkc53E 31
  • 64 (a)
ManyToMany
inaC 31
  • 49 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea pkc-2 31
  • 48 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 33
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck1 30
  • 51.01 (n)
Species where no ortholog for PRKCB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKCB Gene

ENSEMBL:
Gene Tree for PRKCB (if available)
TreeFam:
Gene Tree for PRKCB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKCB: view image

Paralogs for PRKCB Gene

Paralogs for PRKCB Gene

(47) SIMAP similar genes for PRKCB Gene using alignment to 4 proteins:

  • KPCB_HUMAN
  • H3BV73_HUMAN
  • I3L148_HUMAN
  • I3L1Z0_HUMAN
genes like me logo Genes that share paralogs with PRKCB: view

Variants for PRKCB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKCB Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
710349 Benign: not provided 24,191,086(+) G/A INTRON_VARIANT
713010 Likely Benign: not provided 24,154,818(+) G/T SYNONYMOUS_VARIANT
723694 Benign: not provided 24,180,786(+) A/G INTRON_VARIANT
735257 Benign: not provided 23,836,262(+) G/A SYNONYMOUS_VARIANT
739576 Benign: not provided 24,094,178(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PRKCB Gene

Structural Variations from Database of Genomic Variants (DGV) for PRKCB Gene

Variant ID Type Subtype PubMed ID
dgv1324n106 CNV tandem duplication 24896259
dgv1325n106 CNV deletion 24896259
dgv1326n106 CNV deletion 24896259
dgv487e199 CNV deletion 23128226
dgv4958n54 CNV loss 21841781
dgv4959n54 CNV loss 21841781
dgv808e212 CNV loss 25503493
esv1064145 CNV deletion 17803354
esv1347038 CNV insertion 17803354
esv1982695 CNV deletion 18987734
esv2108885 CNV deletion 18987734
esv2251377 CNV deletion 18987734
esv2282551 CNV deletion 18987734
esv23662 CNV loss 19812545
esv2452495 CNV deletion 19546169
esv2654032 CNV deletion 19546169
esv2662823 CNV deletion 23128226
esv2714097 CNV deletion 23290073
esv2714098 CNV deletion 23290073
esv2714099 CNV deletion 23290073
esv2714100 CNV deletion 23290073
esv2714101 CNV deletion 23290073
esv2714102 CNV deletion 23290073
esv2714103 CNV deletion 23290073
esv2714104 CNV deletion 23290073
esv2714105 CNV deletion 23290073
esv2714106 CNV deletion 23290073
esv2714108 CNV deletion 23290073
esv2714109 CNV deletion 23290073
esv27468 CNV loss 19812545
esv3199346 CNV deletion 24192839
esv3388855 CNV insertion 20981092
esv34056 CNV loss 18971310
esv3553247 CNV deletion 23714750
esv3553249 CNV deletion 23714750
esv3553251 CNV deletion 23714750
esv3638240 CNV loss 21293372
esv3638241 CNV loss 21293372
esv3638242 CNV loss 21293372
esv3638243 CNV loss 21293372
esv3638244 CNV gain 21293372
esv5194 CNV loss 18987735
esv7420 CNV loss 19470904
esv997589 CNV deletion 20482838
nsv103651 CNV deletion 16902084
nsv103660 CNV deletion 16902084
nsv1070759 CNV deletion 25765185
nsv1070760 CNV deletion 25765185
nsv1070761 CNV deletion 25765185
nsv1108995 CNV deletion 24896259
nsv1115917 CNV deletion 24896259
nsv1119449 CNV insertion 24896259
nsv1146896 CNV insertion 26484159
nsv1150639 CNV deletion 26484159
nsv472091 CNV novel sequence insertion 20440878
nsv472712 CNV novel sequence insertion 20440878
nsv473852 CNV novel sequence insertion 20440878
nsv527537 CNV loss 19592680
nsv571696 CNV loss 21841781
nsv833174 CNV gain 17160897
nsv952955 CNV deletion 24416366
nsv952956 CNV deletion 24416366
nsv958200 CNV deletion 24416366

Variation tolerance for PRKCB Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKCB Gene

Human Gene Mutation Database (HGMD)
PRKCB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCB Gene

Disorders for PRKCB Gene

MalaCards: The human disease database

(24) MalaCards diseases for PRKCB Gene - From: DISEASES, Novoseek, and GeneCards