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Aliases for PRKCA Gene

Aliases for PRKCA Gene

  • Protein Kinase C Alpha 2 3 5
  • EC 2.7.11.13 4 56
  • PKC-Alpha 3 4
  • PRKACA 3 4
  • PKC-A 3 4
  • PKCA 3 4
  • Protein Kinase C Alpha Type 3
  • Protein Kinase C, Alpha 2
  • Aging-Associated Gene 6 3
  • EC 2.7.11 56
  • AAG6 3

External Ids for PRKCA Gene

Previous HGNC Symbols for PRKCA Gene

  • PKCA

Previous GeneCards Identifiers for PRKCA Gene

  • GC17M063614
  • GC17M066678
  • GC17P064716
  • GC17P064849
  • GC17P061729
  • GC17P064298
  • GC17P059689

Summaries for PRKCA Gene

Entrez Gene Summary for PRKCA Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCA Gene

PRKCA (Protein Kinase C Alpha) is a Protein Coding gene. Diseases associated with PRKCA include Renal Artery Atheroma and Glioma. Among its related pathways are Salivary secretion and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCA Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Tocris Summary for PRKCA Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCA Gene

Additional gene information for PRKCA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCA Gene

Genomics for PRKCA Gene

GeneHancer (GH) Regulatory Elements for PRKCA Gene

Promoters and enhancers for PRKCA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I066301 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.8 +1.5 1504 4.7 HDGF SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 PRKCA HELZ RN7SL735P
GH17I066229 Promoter/Enhancer 1.4 EPDnew ENCODE 10.2 -73.0 -73045 1.2 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 NFYC ZC3H11A MXD4 REST APOH PRKCA PSMD7P1
GH17I066347 Enhancer 1.2 Ensembl ENCODE 11.7 +47.2 47175 5.5 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 YY1 ZNF766 FOS SP3 HELZ PRKCA APOH PRKCA-AS1 RN7SL735P
GH17I066272 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -29.3 -29277 1.8 PKNOX1 SIN3A ZBTB40 EGR1 FOS CEBPB REST GATAD2B SP1 PRDM6 PRKCA ENSG00000284242 RNA5SP444
GH17I066353 Enhancer 1 Ensembl ENCODE 10.8 +52.1 52131 2.4 INSM2 KLF17 FEZF1 ZNF335 ZNF121 POLR3A ZNF366 FOS ZNF362 USF2 PRKCA APOH PRKCA-AS1 RN7SL735P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKCA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKCA gene promoter:

Genomic Locations for PRKCA Gene

Genomic Locations for PRKCA Gene
chr17:66,302,636-66,810,744
(GRCh38/hg38)
Size:
508,109 bases
Orientation:
Plus strand
chr17:64,298,754-64,806,862
(GRCh37/hg19)

Genomic View for PRKCA Gene

Genes around PRKCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCA Gene

Proteins for PRKCA Gene

  • Protein details for PRKCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17252-KPCA_HUMAN
    Recommended name:
    Protein kinase C alpha type
    Protein Accession:
    P17252
    Secondary Accessions:
    • B5BU22
    • Q15137
    • Q32M72
    • Q96RE4

    Protein attributes for PRKCA Gene

    Size:
    672 amino acids
    Molecular mass:
    76750 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and RACK1 (By similarity). Interacts with ADAP1/CENTA1 (PubMed:12893243). Interacts with CSPG4 (PubMed:15504744). Binds to CAVIN2 in the presence of phosphatidylserine (By similarity). Interacts with PRKCABP/PICK1 (via PDZ domain) (PubMed:15247289). Interacts with TRIM41 (PubMed:17893151). Interacts with PARD3 (PubMed:27925688).

    Three dimensional structures from OCA and Proteopedia for PRKCA Gene

neXtProt entry for PRKCA Gene

Selected DME Specific Peptides for PRKCA Gene

P17252:
  • VNGGDLM
  • GIIYRDLK
  • TTRTFCGT
  • VRDAKNL
  • VLGKGSFGKV
  • DDPRSKHKFKIHTY
  • GKGSFGKV
  • KLLNQEEGE
  • ELRQKFEKAKLGP
  • GHIKIAD
  • GVLLYEMLAGQ
  • RNDFMGSLSFG
  • DDDVECTMVEKRVL
  • HNVSYPK
  • ESKQKTKTI
  • EKRVLAL
  • GEDEDELFQSIMEH
  • RFFKQPTFCSHC
  • GFSYVNP
  • GVLLYEM
  • DFGMCKE
  • GQPPFDGEDE
  • VKLKLIPD
  • RCHEFVTF
  • QDDDVECTM
  • LSKEAVS
  • GALRQKNVHE
  • RKGALRQK
  • GTEELYA
  • ICKGLMTKHP
  • FFRRIDW
  • NREIQPPF
  • ESFTFKLKPSDKDRRLS
  • WGFGKQG
  • YRDLKLDN
  • TFCDHCGSLL
  • DRLYFVME
  • LHSCFQT
  • PMDPNGL
  • GTPDYIAPE
  • EGEYYNVP
  • TFCGTPDYIAPEI
  • CPGADKG
  • KRLGCGP
  • FVMEYVNGG
  • PYGKSVD
  • VVHKRCH
  • ENFDKFFTR
  • KRLGCGPEGERD
  • RDLKLDN

Post-translational modifications for PRKCA Gene

  • Ubiquitination at isoforms=621 and isoforms=628

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCA (PKCA)

Domains & Families for PRKCA Gene

Gene Families for PRKCA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCA Gene

Graphical View of Domain Structure for InterPro Entry

P17252

UniProtKB/Swiss-Prot:

KPCA_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCA: view

Function for PRKCA Gene

Molecular function for PRKCA Gene

GENATLAS Biochemistry:
protein kinase C,alpha polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCA Gene

Phenotypes From GWAS Catalog for PRKCA Gene

Gene Ontology (GO) - Molecular Function for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10770950
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity TAS,ISS --
GO:0004698 calcium-dependent protein kinase C activity TAS --
GO:0005178 integrin binding ISS --
genes like me logo Genes that share ontologies with PRKCA: view
genes like me logo Genes that share phenotypes with PRKCA: view

Animal Models for PRKCA Gene

MGI Knock Outs for PRKCA:

Animal Model Products

Clone Products

  • Addgene plasmids for PRKCA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCA Gene

Localization for PRKCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCA Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCA gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 15632189
GO:0005739 mitochondrion IEA,HDA 20833797
genes like me logo Genes that share ontologies with PRKCA: view

Pathways & Interactions for PRKCA Gene

SuperPathways for PRKCA Gene

SuperPathway Contained pathways
1 RET signaling
2 DAG and IP3 signaling
3 IL-2 Pathway
4 fMLP Pathway
5 CDK-mediated phosphorylation and removal of Cdc6
genes like me logo Genes that share pathways with PRKCA: view

Pathways by source for PRKCA Gene

Gene Ontology (GO) - Biological Process for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IMP 11909826
GO:0002159 desmosome assembly IMP 18474624
GO:0006468 protein phosphorylation IDA 10770950
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PRKCA: view

Drugs & Compounds for PRKCA Gene

(102) Drugs for PRKCA Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ingenol Mebutate Approved Pharma Target, ligand 0
midostaurin Approved, Investigational Pharma Target, antagonist, inhibitor Kinase Inhibitors 0
Vitamin E Approved, Vet_approved Nutra Target 434,438
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 408
calcium Approved Nutra 0

(183) Additional Compounds for PRKCA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCA Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(22) ApexBio Compounds for PRKCA Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Bryostatin 2 87745-28-6
Bryostatin 3 143370-84-7
CGP60474 CDKs and PKC inhibitor, potent 164658-13-3
Chelerythrine PKC inhibitor 34316-15-9
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Midostaurin (PKC412) PKC inhibitor 120685-11-2
Ro 31-8220 pan-PKC inhibitor 125314-64-9
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
Verbascoside PKC/NF-κB inhibitor 61276-17-3
ZIP PKMζ inhibitor 863987-12-6
Zoledronic Acid Potent nitrogen-containing bisphosphonates 118072-93-8
genes like me logo Genes that share compounds with PRKCA: view

Drug Products

Transcripts for PRKCA Gene

Unigene Clusters for PRKCA Gene

Protein kinase C, alpha:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRKCA

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:

Relevant External Links for PRKCA Gene

GeneLoc Exon Structure for
PRKCA
ECgene alternative splicing isoforms for
PRKCA

Expression for PRKCA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKCA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCA Gene



Protein tissue co-expression partners for PRKCA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCA Gene:

PRKCA

SOURCE GeneReport for Unigene cluster for PRKCA Gene:

Hs.531704

Evidence on tissue expression from TISSUES for PRKCA Gene

  • Liver(4.6)
  • Blood(4.5)
  • Nervous system(4.5)
  • Skin(4.3)
  • Pancreas(3.9)
  • Lung(3.5)
  • Eye(3.3)
  • Intestine(2.8)
  • Kidney(2.5)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCA Gene

Germ Layers:
  • ectoderm
Systems:
  • endocrine
Regions:
Head and neck:
  • head
  • pituitary gland
genes like me logo Genes that share expression patterns with PRKCA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKCA Gene

Orthologs for PRKCA Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCA 33 34
  • 99.55 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKCA 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCA 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCA 33 34
  • 92.16 (n)
rat
(Rattus norvegicus)
Mammalia Prkca 33
  • 91.35 (n)
mouse
(Mus musculus)
Mammalia Prkca 16 34 33
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia PRKCA 33 34
  • 88.1 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 91 (a)
OneToMany
PRKCA 33 34
  • 83.23 (n)
lizard
(Anolis carolinensis)
Reptilia PRKCA 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkca 33
  • 79.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14976 33
zebrafish
(Danio rerio)
Actinopterygii PRKCA (3 of 3) 34
  • 86 (a)
OneToMany
PRKCA (2 of 3) 34
  • 82 (a)
OneToMany
prkca 33 34
  • 74.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pkc53E 35 33 34
  • 66.88 (n)
inaC 35 34
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012252 33
  • 65.57 (n)
worm
(Caenorhabditis elegans)
Secernentea pkc-2 35 33 34
  • 64.6 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1705 33
Species where no ortholog for PRKCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCA Gene

ENSEMBL:
Gene Tree for PRKCA (if available)
TreeFam:
Gene Tree for PRKCA (if available)

Paralogs for PRKCA Gene

Variants for PRKCA Gene

Sequence variations from dbSNP and Humsavar for PRKCA Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs16960228 drug-response, hydrochlorothiazide response - Efficacy 66,792,709(+) G/A genic_downstream_transcript_variant, intron_variant
VAR_042301 A colorectal adenocarcinoma sample p.Pro98Ser
VAR_042302 A glioblastoma multiforme sample p.Asp467Asn
rs1000000168 -- 66,417,420(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000013270 -- 66,790,654(+) G/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCA Gene

Variant ID Type Subtype PubMed ID
dgv3275n100 CNV loss 25217958
dgv5750n54 CNV loss 21841781
dgv585e214 CNV loss 21293372
esv2160844 CNV deletion 18987734
esv22631 CNV loss 19812545
esv2675034 CNV deletion 23128226
esv2761972 CNV loss 21179565
esv3303465 CNV mobile element insertion 20981092
nsv960524 CNV duplication 23825009
nsv954916 CNV deletion 24416366
nsv833520 CNV gain 17160897
nsv575899 CNV loss 21841781
nsv575896 CNV loss 21841781
nsv575895 CNV loss 21841781
nsv575894 CNV loss 21841781
nsv528595 CNV loss 19592680
nsv526542 CNV loss 19592680
nsv523847 CNV loss 19592680
nsv519825 CNV gain 19592680
nsv517904 CNV loss 19592680
nsv516184 CNV loss 19592680
nsv512499 CNV loss 21212237
nsv510721 CNV deletion 20534489
nsv510441 OTHER sequence alteration 20534489
nsv478310 CNV novel sequence insertion 20440878
nsv472216 CNV novel sequence insertion 20440878
nsv470597 CNV loss 18288195
nsv457887 CNV loss 19166990
nsv457882 CNV loss 19166990