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Aliases for PRKAG1 Gene

Aliases for PRKAG1 Gene

  • Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1 2 3 5
  • Protein Kinase, AMP-Activated, Gamma 1 Non-Catalytic Subunit 2 3
  • AMPK Gamma1 3 4
  • 5-AMP-Activated Protein Kinase, Gamma-1 Subunit 3
  • 5-AMP-Activated Protein Kinase Subunit Gamma-1 3
  • AMPK Subunit Gamma-1 4
  • AMPK Gamma-1 Chain 3
  • AMPKG 3
  • AMPKg 4

External Ids for PRKAG1 Gene

Previous GeneCards Identifiers for PRKAG1 Gene

  • GC12P049402
  • GC12M049112
  • GC12M047682
  • GC12M049396
  • GC12M046427

Summaries for PRKAG1 Gene

Entrez Gene Summary for PRKAG1 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAG1 Gene

PRKAG1 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase activity and ADP binding. An important paralog of this gene is PRKAG2.

UniProtKB/Swiss-Prot for PRKAG1 Gene

  • AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gene Wiki entry for PRKAG1 Gene

Additional gene information for PRKAG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAG1 Gene

Genomics for PRKAG1 Gene

GeneHancer (GH) Regulatory Elements for PRKAG1 Gene

Promoters and enhancers for PRKAG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049017 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 176 4 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PRKAG1 DDN DDX23 CCNT1 LOC390314 LMBR1L KMT2D SENP1 DDN-AS1
GH12J049021 Promoter 0.5 EPDnew 650.7 -2.6 -2576 0.1 PRKAG1 KMT2D DDN ARF3 GC12P049032
GH12J048104 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 +912.9 912907 4.1 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SENP1 PFKM DDX23 CCNT1 KMT2D KANSL2 LOC390314 RPL37P19 RPAP3 HDAC7
GH12J049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 -247.3 -247332 6.6 CLOCK DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC ZFP41 MEF2D TUBA1C ENSG00000258101 DDX23 KMT2D CCNT1 LMBR1L SMARCD1 LOC390314 KANSL2 BCDIN3D
GH12J048850 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 +167.1 167068 3.3 YBX1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 DDX23 LOC105369755 CCNT1 KMT2D SENP1 KANSL2 LOC390314 LMBR1L ENSG00000257964 PRPF40B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKAG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKAG1 gene promoter:
  • E2F-5
  • CREB
  • HEN1
  • IRF-2
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • HTF

Genomic Locations for PRKAG1 Gene

Genomic Locations for PRKAG1 Gene
chr12:49,002,272-49,019,197
(GRCh38/hg38)
Size:
16,926 bases
Orientation:
Minus strand
chr12:49,396,055-49,412,980
(GRCh37/hg19)
Size:
16,926 bases
Orientation:
Minus strand

Genomic View for PRKAG1 Gene

Genes around PRKAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAG1 Gene

Proteins for PRKAG1 Gene

  • Protein details for PRKAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54619-AAKG1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit gamma-1
    Protein Accession:
    P54619
    Secondary Accessions:
    • B4DDT7
    • Q8N7V9

    Protein attributes for PRKAG1 Gene

    Size:
    331 amino acids
    Molecular mass:
    37579 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.

    Three dimensional structures from OCA and Proteopedia for PRKAG1 Gene

    Alternative splice isoforms for PRKAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAG1 Gene

Post-translational modifications for PRKAG1 Gene

  • Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
  • Ubiquitination at Lys170
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRKAG1 Gene

Domains & Families for PRKAG1 Gene

Gene Families for PRKAG1 Gene

Protein Domains for PRKAG1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P54619

UniProtKB/Swiss-Prot:

AAKG1_HUMAN :
  • The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1.
  • Belongs to the 5-AMP-activated protein kinase gamma subunit family.
Domain:
  • The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1.
  • The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2- and 3-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
Family:
  • Belongs to the 5-AMP-activated protein kinase gamma subunit family.
genes like me logo Genes that share domains with PRKAG1: view

Function for PRKAG1 Gene

Molecular function for PRKAG1 Gene

UniProtKB/Swiss-Prot Function:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
GENATLAS Biochemistry:
protein kinase,cAMP activated ,gamma 1 non catalytic subunit,complexing with alpha 2 and beta 2 subunits,involved in fatty acid and cholesterol metabolism

Phenotypes From GWAS Catalog for PRKAG1 Gene

Gene Ontology (GO) - Molecular Function for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17028174
GO:0004679 contributes_to AMP-activated protein kinase activity ISS --
GO:0004691 cAMP-dependent protein kinase activity TAS 9598317
GO:0005515 protein binding IPI 16306228
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with PRKAG1: view
genes like me logo Genes that share phenotypes with PRKAG1: view

Animal Models for PRKAG1 Gene

MGI Knock Outs for PRKAG1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAG1 Gene

Localization for PRKAG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKAG1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0031588 nucleotide-activated protein kinase complex ISS --
genes like me logo Genes that share ontologies with PRKAG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAG1 Gene

Pathways & Interactions for PRKAG1 Gene

genes like me logo Genes that share pathways with PRKAG1: view

SIGNOR curated interactions for PRKAG1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS 8663446
GO:0006468 protein phosphorylation IDA 17028174
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
genes like me logo Genes that share ontologies with PRKAG1: view

Drugs & Compounds for PRKAG1 Gene

(16) Drugs for PRKAG1 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, activator 1232
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
AICAR Experimental, Investigational Pharma AMPK activator 0
Imeglimin Investigational Pharma Antidiabetic agent 0
AICAR phosphate Pharma AMPK activator 0
genes like me logo Genes that share compounds with PRKAG1: view

Transcripts for PRKAG1 Gene

mRNA/cDNA for PRKAG1 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKAG1 Gene

Protein kinase, AMP-activated, gamma 1 non-catalytic subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - - -
SP10: -
SP11: - - -
SP12: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PRKAG1 Gene

GeneLoc Exon Structure for
PRKAG1
ECgene alternative splicing isoforms for
PRKAG1

Expression for PRKAG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKAG1 Gene



Protein tissue co-expression partners for PRKAG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKAG1 Gene:

PRKAG1

SOURCE GeneReport for Unigene cluster for PRKAG1 Gene:

Hs.530862

Evidence on tissue expression from TISSUES for PRKAG1 Gene

  • Muscle(4.3)
  • Liver(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with PRKAG1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKAG1 Gene

Orthologs for PRKAG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAG1 34 33
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAG1 34 33
  • 94.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAG1 34 33
  • 93.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAG1 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkag1 33
  • 87.98 (n)
mouse
(Mus musculus)
Mammalia Prkag1 16 34 33
  • 87.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAG1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKAG1 34 33
  • 77.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAG1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkag2 33
  • 74.27 (n)
Str.2067 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7123 33
zebrafish
(Danio rerio)
Actinopterygii prkag1 34 33
  • 73.29 (n)
OneToOne
wufa94d09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10524 33
fruit fly
(Drosophila melanogaster)
Insecta SNF4Agamma 34 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aakg-1 34 33
  • 56.74 (n)
OneToMany
Y111B2A.8 35
  • 55 (a)
T20F7.6 35
  • 34 (a)
Y41G9A.3 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF4 34
  • 34 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os04g0401300 33
  • 42.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7193 34
  • 49 (a)
OneToMany
Species where no ortholog for PRKAG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAG1 Gene

ENSEMBL:
Gene Tree for PRKAG1 (if available)
TreeFam:
Gene Tree for PRKAG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKAG1: view image

Paralogs for PRKAG1 Gene

Paralogs for PRKAG1 Gene

(3) SIMAP similar genes for PRKAG1 Gene using alignment to 14 proteins:

  • AAKG1_HUMAN
  • F8VPF5_HUMAN
  • F8VQQ1_HUMAN
  • F8VRY2_HUMAN
  • F8VSH3_HUMAN
  • F8VSL2_HUMAN
  • F8VVA3_HUMAN
  • F8VYY9_HUMAN
  • F8VYZ8_HUMAN
  • F8VZX1_HUMAN
  • F8W046_HUMAN
  • F8W9D1_HUMAN
  • H0YHF8_HUMAN
  • H0YIC9_HUMAN
genes like me logo Genes that share paralogs with PRKAG1: view

Variants for PRKAG1 Gene

Sequence variations from dbSNP and Humsavar for PRKAG1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs12315734 benign, Kabuki syndrome 49,020,240(-) T/C upstream_transcript_variant
rs139469030 likely-benign, Kabuki syndrome 49,019,138(-) G/A upstream_transcript_variant
rs185652670 likely-benign, Kabuki syndrome 49,019,135(-) A/G upstream_transcript_variant
rs190063096 likely-benign, Kabuki syndrome 49,019,736(-) G/T upstream_transcript_variant
rs192035980 likely-benign, Kabuki syndrome 49,020,965(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAG1 Gene

Variant ID Type Subtype PubMed ID
esv2662608 CNV deletion 23128226
nsv558833 CNV loss 21841781
nsv832404 CNV gain 17160897

Variation tolerance for PRKAG1 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKAG1 Gene

Human Gene Mutation Database (HGMD)
PRKAG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAG1 Gene

Disorders for PRKAG1 Gene

Additional Disease Information for PRKAG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRKAG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKAG1 Gene

Publications for PRKAG1 Gene

  1. Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. (PMID: 8621499) Gao G … Witters LA (The Journal of biological chemistry 1996) 2 3 4 58
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski KA … Diabetes Prevention Program Research Group (Diabetes 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for PRKAG1 Gene

Sources for PRKAG1 Gene

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