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Aliases for PRKACG Gene

Aliases for PRKACG Gene

  • Protein Kinase CAMP-Activated Catalytic Subunit Gamma 2 3 5
  • Protein Kinase, CAMP-Dependent, Gamma Catalytic Subunit 2 3
  • Protein Kinase, CAMP-Dependent, Catalytic, Gamma 2 3
  • EC 2.7.11.11 4 56
  • PKA C-Gamma 3 4
  • CAMP-Dependent Protein Kinase Catalytic Subunit Gamma 3
  • Serine(Threonine) Protein Kinase 3
  • EC 2.7.11 56
  • BDPLT19 3
  • PKACg 3
  • KAPG 3

External Ids for PRKACG Gene

Previous GeneCards Identifiers for PRKACG Gene

  • GC09M062671
  • GC09M063484
  • GC09M065197
  • GC09M067084
  • GC09M068857
  • GC09M070817
  • GC09M071627

Summaries for PRKACG Gene

Entrez Gene Summary for PRKACG Gene

  • Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKACG Gene

PRKACG (Protein Kinase CAMP-Activated Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PRKACG include Bleeding Disorder, Platelet-Type, 19 and Stormorken Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Salivary secretion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKACG Gene

  • Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Tocris Summary for PRKACG Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKACG Gene

Additional gene information for PRKACG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKACG Gene

Genomics for PRKACG Gene

GeneHancer (GH) Regulatory Elements for PRKACG Gene

Promoters and enhancers for PRKACG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I069014 Promoter 0.5 EPDnew 550.8 0.0 -10 0.1 PRKACG FXN
GH09I069012 Enhancer 0.4 Ensembl 563.2 +1.0 1022 0.6 POLR2A RUNX3 PRKACG GC09M069003
GH09I068834 Enhancer 0.5 FANTOM5 60.9 +179.7 179661 0.2 NFIL3 PKNOX1 HLF PRKACG ENSG00000236733 LOC100421655 PIP5K1B
GH09I068704 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.5 +305.8 305760 8.1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF207 ATF7 RUNX3 SP3 MXD4 PIP5K1B GC09M068708 FAM122A PRKACG ENSG00000236733
GH09I068744 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 +266.0 265967 6.8 PKNOX1 ATF1 ARNT NCOA2 TCF12 GATA2 NCOA1 ZNF592 ATF4 GMEB1 GC09P068746 FAM122A PIP5K1B PRKACG RNU6-820P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKACG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKACG gene promoter:

Genomic Locations for PRKACG Gene

Genomic Locations for PRKACG Gene
chr9:69,012,529-69,014,123
(GRCh38/hg38)
Size:
1,595 bases
Orientation:
Minus strand
chr9:71,627,445-71,629,039
(GRCh37/hg19)

Genomic View for PRKACG Gene

Genes around PRKACG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKACG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKACG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKACG Gene

Proteins for PRKACG Gene

  • Protein details for PRKACG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22612-KAPCG_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit gamma
    Protein Accession:
    P22612
    Secondary Accessions:
    • O60850
    • Q5VZ02
    • Q86YI1

    Protein attributes for PRKACG Gene

    Size:
    351 amino acids
    Molecular mass:
    40434 Da
    Quaternary structure:
    • A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
    SequenceCaution:
    • Sequence=AAC41690.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PRKACG Gene

Selected DME Specific Peptides for PRKACG Gene

P22612:
  • GRFSEPHA
  • GTPEYLAPE
  • RDLKPENLLIDQQGY
  • LGVLIYEM
  • YLAPEII
  • YLHSLDLI
  • VDWWALGVL
  • LKPENLL
  • RDLKPEN
  • TDFGFAK
  • DIKNHKWF
  • ADQPIQIYEKIVSG

Post-translational modifications for PRKACG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKACG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRKACG Gene

Gene Families for PRKACG Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKACG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22612

UniProtKB/Swiss-Prot:

KAPCG_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKACG: view

Function for PRKACG Gene

Molecular function for PRKACG Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,catalytic,gamma subunit,retroposon inserted inside the STM7 gene and transcribed in the opposite (antisense) strand specifically transcribed in primate testicular germ cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP.
UniProtKB/Swiss-Prot Function:
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Enzyme Numbers (IUBMB) for PRKACG Gene

Phenotypes From GWAS Catalog for PRKACG Gene

Gene Ontology (GO) - Molecular Function for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004691 cAMP-dependent protein kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PRKACG: view
genes like me logo Genes that share phenotypes with PRKACG: view

Human Phenotype Ontology for PRKACG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRKACG Gene

Localization for PRKACG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKACG gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0045171 intercellular bridge IDA --
GO:0097546 ciliary base TAS --
genes like me logo Genes that share ontologies with PRKACG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKACG Gene

Pathways & Interactions for PRKACG Gene

SuperPathways for PRKACG Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
2 RET signaling
3 G-Beta Gamma Signaling
4 Aldosterone synthesis and secretion
5 Aquaporin-mediated transport
genes like me logo Genes that share pathways with PRKACG: view

SIGNOR curated interactions for PRKACG Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0003091 renal water homeostasis TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007283 spermatogenesis TAS 9598317
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PRKACG: view

Drugs & Compounds for PRKACG Gene

(15) Drugs for PRKACG Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
ATP Investigational Nutra Agonist 0
PKA inhibitor fragment (6-22) amide Pharma Potent protein kinase A inhibitor 0
Daphnetin Pharma Protein kinases inhibitor for EGFR/PKA/PKC 0
H 89 2HCl Pharma Potent PKA inhibitor 0

(7) Additional Compounds for PRKACG Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
H 89 dihydrochloride
130964-39-5

(5) Tocris Compounds for PRKACG Gene

Compound Action Cas Number
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
H 89 dihydrochloride Protein kinase A inhibitor 130964-39-5
KT 5720 Selective protein kinase A inhibitor 108068-98-0
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor 121932-06-7
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor 201422-03-9

(3) ApexBio Compounds for PRKACG Gene

Compound Action Cas Number
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
H 89 2HCl Potent PKA inhibitor 130964-39-5
PKA inhibitor fragment (6-22) amide 121932-06-7
genes like me logo Genes that share compounds with PRKACG: view

Drug Products

Transcripts for PRKACG Gene

mRNA/cDNA for PRKACG Gene

(10) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKACG Gene

Protein kinase, cAMP-dependent, catalytic, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKACG Gene

No ASD Table

Relevant External Links for PRKACG Gene

GeneLoc Exon Structure for
PRKACG
ECgene alternative splicing isoforms for
PRKACG

Expression for PRKACG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKACG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKACG Gene

This gene is overexpressed in Testis (x52.1).

Protein differential expression in normal tissues from HIPED for PRKACG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (19.7) and Ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKACG Gene



NURSA nuclear receptor signaling pathways regulating expression of PRKACG Gene:

PRKACG

SOURCE GeneReport for Unigene cluster for PRKACG Gene:

Hs.158029

mRNA Expression by UniProt/SwissProt for PRKACG Gene:

P22612-KAPCG_HUMAN
Tissue specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.

Evidence on tissue expression from TISSUES for PRKACG Gene

  • Nervous system(4.5)
  • Heart(2.6)
  • Muscle(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKACG Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • reproductive
Regions:
Head and neck:
  • face
  • head
  • nose
Pelvis:
  • uterus
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
genes like me logo Genes that share expression patterns with PRKACG: view

No data available for Protein tissue co-expression partners for PRKACG Gene

Orthologs for PRKACG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKACG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKACG 33 34
  • 99.15 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii prkacab 34
  • 79 (a)
ManyToMany
prkacaa 33 34
  • 76.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pka-C1 35
  • 75 (a)
Pka-C2 35
  • 48 (a)
CG12069 35 34
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea F47F2.1a 35
  • 49 (a)
F47F2.1b 35
  • 49 (a)
kin-1 34
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL115C 33
  • 57.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07205g 33
  • 51.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK3 33 34
  • 51.16 (n)
TPK2 34
  • 41 (a)
ManyToMany
TPK1 34
  • 38 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.32856 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10961 34
  • 27 (a)
ManyToMany
Species where no ortholog for PRKACG was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKACG Gene

ENSEMBL:
Gene Tree for PRKACG (if available)
TreeFam:
Gene Tree for PRKACG (if available)

Paralogs for PRKACG Gene

Paralogs for PRKACG Gene

genes like me logo Genes that share paralogs with PRKACG: view

Variants for PRKACG Gene

Sequence variations from dbSNP and Humsavar for PRKACG Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs724159972 pathogenic, Platelet-type bleeding disorder 19, Bleeding disorder, platelet-type 19 (BDPLT19) [MIM:616176] 69,013,871(-) G/C coding_sequence_variant, missense_variant
rs147576281 uncertain-significance, not specified 69,013,644(-) T/A/C coding_sequence_variant, missense_variant
rs1003668540 -- 69,015,340(-) C/T upstream_transcript_variant
rs1004674204 -- 69,012,231(-) T/G downstream_transcript_variant
rs1006778927 -- 69,012,562(-) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKACG Gene

Variant ID Type Subtype PubMed ID
dgv7665n100 CNV gain 25217958
dgv7666n100 CNV gain 25217958
esv2422258 CNV duplication 17116639
esv3576657 CNV gain 25503493
esv3891678 CNV gain 25118596
esv3891679 CNV gain 25118596
nsv466393 CNV gain 19166990
nsv466397 CNV gain 19166990
nsv614547 CNV gain 21841781
nsv614548 CNV gain 21841781
nsv614549 CNV gain 21841781
nsv614550 CNV gain 21841781
nsv614551 CNV loss 21841781

Variation tolerance for PRKACG Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKACG Gene

Human Gene Mutation Database (HGMD)
PRKACG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKACG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACG Gene

Disorders for PRKACG Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKACG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 19
  • bdplt19
stormorken syndrome
  • strmk
primary pigmented nodular adrenocortical disease
  • pigmented nodular adrenocortical disease, primary, 2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

KAPCG_HUMAN
  • Bleeding disorder, platelet-type 19 (BDPLT19) [MIM:616176]: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. {ECO:0000269 PubMed:25061177}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRKACG

genes like me logo Genes that share disorders with PRKACG: view

No data available for Genatlas for PRKACG Gene

Publications for PRKACG Gene

  1. The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. (PMID: 9598317) Reinton N … Taskén K (Genomics 1998) 2 3 4 58
  2. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PMID: 2342480) Beebe SJ … Jahnsen T (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 58
  3. A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene. (PMID: 25061177) Manchev VT … Raslova H (Blood 2014) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PRKACG Gene

Sources for PRKACG Gene

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