Aliases for PRKACB Gene
Aliases for PRKACB Gene
- Protein Kinase CAMP-Activated Catalytic Subunit Beta 2 3 5
- Protein Kinase, CAMP-Dependent, Beta Catalytic Subunit 2 3
- Protein Kinase, CAMP-Dependent, Catalytic, Beta 2 3
- PKA C-Beta 3 4
- CAMP-Dependent Protein Kinase Catalytic Beta Subunit Isoform 4ab 3
- CAMP-Dependent Protein Kinase Catalytic Subunit Beta 3
- Protein Kinase A Catalytic Subunit Beta 3
- EC 2.7.11.11 4
- PKACB 3
External Ids for PRKACB Gene
- HGNC: 9381
- Entrez Gene: 5567
- Ensembl: ENSG00000142875
- OMIM: 176892
- UniProtKB: P22694
Previous GeneCards Identifiers for PRKACB Gene
- GC01P084937
- GC01P083681
- GC01P083832
- GC01P083966
- GC01P084255
- GC01P084316
- GC01P084543
- GC01P082654
Summaries for PRKACB Gene
-
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
GeneCards Summary for PRKACB Gene
PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PRKACB include Primary Pigmented Nodular Adrenocortical Disease and Carney Complex Variant. Among its related pathways are Melanocyte Development and Pigmentation and Ovarian steroidogenesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.
UniProtKB/Swiss-Prot for PRKACB Gene
-
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
-
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.
Additional gene information for PRKACB Gene
- Monarch Initiative
- Search for PRKACB at DataMed
- Search for PRKACB at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKACB Gene
Genomics for PRKACB Gene
GeneHancer (GH) Regulatory Elements for PRKACB Gene
Promoters and enhancers for PRKACB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRKACB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRKACB gene promoter:
-
- POU2F1c
- POU2F1b
- POU2F1a
- POU2F1
- S8
- TBP
- AML1a
- Sox5
- HOXA5
- STAT1
Regulatory Element Products
Genomic Locations for PRKACB Gene
Genomic Locations for PRKACB Gene
- chr1:84,077,975-84,238,498
- (GRCh38/hg38)
- Size:
- 160,524 bases
- Orientation:
- Plus strand
- chr1:84,543,745-84,704,181
- (GRCh37/hg19)
- Size:
- 160,437 bases
- Orientation:
- Plus strand
Genomic View for PRKACB Gene
Genes around PRKACB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC
- 1p31.1 by Ensembl
PRKACB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRKACB Gene
Proteins for PRKACB Gene
-
Protein details for PRKACB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22694-KAPCB_HUMAN
- Recommended name:
- cAMP-dependent protein kinase catalytic subunit beta
- Protein Accession:
- P22694
- B1APG4
- B4DKB0
- B4E2Q1
- Q14VH1
- Q59GC0
- Q5BNE9
- Q5BNF0
- Q5BNF1
- Q5BNF2
- Q5BNF3
- Q5CZ92
- Q5T1K3
- Q7Z3M1
- Q8IYR5
- Q8IZQ0
- Q96B09
Protein attributes for PRKACB Gene
- Size:
- 351 amino acids
- Molecular mass:
- 40623 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2 (PubMed:21423175). Interacts with GPKOW (PubMed:21880142).
- SequenceCaution:
-
- Sequence=BAD92426.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};
Protein Expression for PRKACB Gene
Post-translational modifications for PRKACB Gene
- Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRKACB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005271076.1
- XP_005271075.1
- XP_016857198.1
- NP_001287845.1
- NP_001287846.1
- XP_016857204.1
- XP_016857207.1
- XP_016857196.1
- NP_001229789.1
- XP_016857195.1
- XP_005271077.1
- XP_016857202.1
- XP_005271072.1
- XP_016857208.1
- XP_016857199.1
- NP_001287844.1
- XP_016857205.1
- NP_001229788.1
- NP_001229791.1
- XP_016857203.1
- NP_891993.1
- NP_001229787.1
- XP_016857209.1
- XP_016857197.1
- XP_016857200.1
- XP_005271074.1
- XP_005271073.1
- NP_002722.1
- XP_006710821.1
- NP_001229790.1
- NP_997461.1
- NP_001229786.1
- XP_016857206.1
- XP_016857201.1
Antibody Products
- R&D Systems Antibodies for PRKACB (PKA C beta)
-
Custom Antibody ServicesOriGene Antibodies for PRKACB
- Novus Biologicals Antibodies for PRKACB
-
Abcam antibodies for PRKACB
- Invitrogen Antibodies for PRKACB (AFLGC-PRKACB)
- antibodies-online: Search results for 78 available PRKACB Antibodies ranked by validation data
- Compare Top PRKACB Antibodies
-
Recommended
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- GeneTex PRKACB Antibody for PRKACB
-
Boster Bio Antibodies for PRKACB
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRKACB
Protein Products
- R&D Systems Proteins and Enzymes for PRKACB (PKA C beta)
- Search Origene for MassSpec and Protein Over-expression Lysates for PRKACB
- Origene Custom Protein Services for PRKACB
- ProSpec Recombinant Proteins for PRKACB
- GeneTex Proteins for PRKACB
-
Abcam proteins for PRKACB
Assay Products
- antibodies-online: Search results for 12 available PRKACB Elisa Kits ranked by validation data
- Compare Top PRKACB Elisa Kits
-
Recommended
- 1 Cow (Bovine) ELISA Kit
- 4 Human ELISA Kits
- 3 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 3 Rat (Rattus) ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 4 Human ELISA Kits
- 3 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 3 Rat (Rattus) ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 4 Human ELISA Kits
- 3 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 3 Rat (Rattus) ELISA Kits
No data available for DME Specific Peptides for PRKACB Gene
Domains & Families for PRKACB Gene
Gene Families for PRKACB Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PRKACB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRKACB Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ34101 fis, clone FCBBF3007631, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (B1APG4_HUMAN)
- cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA (B2RB89_HUMAN)
- cDNA FLJ52554, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (B4DKB0_HUMAN)
- cAMP-dependent protein kinase catalytic subunit beta (KAPCB_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P22694UniProtKB/Swiss-Prot:
KAPCB_HUMAN :- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Function for PRKACB Gene
Molecular function for PRKACB Gene
- UniProtKB/Swiss-Prot Function:
- Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by cAMP.
- GENATLAS Biochemistry:
- protein kinase,cAMP-dependent,catalytic,beta subunit
Enzyme Numbers (IUBMB) for PRKACB Gene
Phenotypes From GWAS Catalog for PRKACB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 12420224 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0004691 | cAMP-dependent protein kinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 22939624 |
Phenotypes for PRKACB Gene
- MGI mutant phenotypes for PRKACB:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRKACB:
-
- Decreased substrate adherent cell growth
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability after gemcitabine stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased ionizing radiation sensitivity
- Decreased cell migration
- Increased viability with tamoxifen
- Increased shRNA abundance with PLX4720
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Apoptosis resistance
- Transferrin accumulation in the perinuclear area
Animal Models for PRKACB Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRKACB
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRKACB
-
CRISPR Products
-
OriGene CRISPR knockouts for PRKACB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRKACB
- genomics-online: gRNA clones - Search results for 175 available PRKACB gene related products
- Overview of 175 available PRKACB gene related products
- Applied Biological Materials CRISPR for PRKACB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKACB
- GenScript: Design CRISPR guide RNA sequences for PRKACB
miRNA for PRKACB Gene
- miRTarBase miRNAs that target PRKACB
-
- hsa-mir-23b-3p (MIRT006806)
- hsa-mir-93-5p (MIRT027986)
- hsa-mir-19b-3p (MIRT031110)
- hsa-mir-17-5p (MIRT080176)
- hsa-mir-19a-3p (MIRT080177)
- hsa-mir-20a-5p (MIRT080178)
- hsa-mir-106a-5p (MIRT080179)
- hsa-mir-203a-3p (MIRT080180)
- hsa-mir-106b-5p (MIRT080181)
- hsa-mir-302a-3p (MIRT080182)
- hsa-mir-302b-3p (MIRT080183)
- hsa-mir-302c-3p (MIRT080184)
- hsa-mir-302d-3p (MIRT080185)
- hsa-mir-372-3p (MIRT080186)
- hsa-mir-373-3p (MIRT080187)
- hsa-mir-20b-5p (MIRT080188)
- hsa-mir-520e (MIRT080190)
- hsa-mir-520f-3p (MIRT080191)
- hsa-mir-520a-3p (MIRT080193)
- hsa-mir-526b-3p (MIRT080194)
- hsa-mir-520b (MIRT080196)
- hsa-mir-520c-3p (MIRT080197)
- hsa-mir-519d-3p (MIRT080198)
- hsa-mir-520d-3p (MIRT080199)
- hsa-mir-513a-3p (MIRT080201)
- hsa-mir-636 (MIRT080203)
- hsa-mir-548f-5p (MIRT080204)
- hsa-mir-548g-5p (MIRT080205)
- hsa-mir-302e (MIRT080206)
- hsa-mir-513c-3p (MIRT080207)
- hsa-mir-548x-5p (MIRT080209)
- hsa-mir-3606-3p (MIRT080210)
- hsa-mir-3622a-3p (MIRT080211)
- hsa-mir-3622b-3p (MIRT080212)
- hsa-mir-1273e (MIRT080213)
- hsa-mir-3660 (MIRT080214)
- hsa-mir-548aj-5p (MIRT080215)
- hsa-mir-4526 (MIRT080216)
- hsa-mir-548aw (MIRT080217)
- hsa-mir-3692-3p (MIRT555213)
- hsa-mir-7158-3p (MIRT555214)
- hsa-mir-1468-3p (MIRT555215)
- hsa-mir-2277-3p (MIRT555216)
- hsa-mir-4539 (MIRT555217)
- hsa-mir-4724-5p (MIRT555218)
- hsa-mir-3120-3p (MIRT555219)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRKACB
- Browse OriGene Inhibitory RNA Products For PRKACB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKACB
- genomics-online: shRNA clones - Search results for 175 available PRKACB gene related products
- Overview of 175 available PRKACB gene related products
Clone Products
-
OriGene ORF clones in human for PRKACB
- RC202131
- RC202131L1
- RC202131L2
- RC202131L3
- RC202131L4
- RC207218
- RC207218L1
- RC207218L2
- RC207218L3
- RC207218L4
- RC219853
- RC219853L1
- RC219853L2
- RC219853L3
- RC219853L4
- RC232475
- RC232520
- RC232523
- RC232566
- RC232571
- RC232574
- RC236896
- RC237022
- RC237325
- RC502131
- RC507218
- RG202131
- RG207218
- RG219853
- RG232475
- RG232520
- RG232523
- RG232566
- RG232571
- RG232574
- RC202131L1V
- RC202131L2V
- RC202131L3V
- RC202131L4V
- RC207218L1V
- RC207218L2V
- RC207218L3V
- RC207218L4V
- RC219853L1V
- RC219853L2V
- RC219853L3V
- RC219853L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for PRKACB in any vector
- XM_005271018.4
- NM_182948.3
- XM_005271015.3
- NM_002731.3
- XM_005271017.3
- NM_001242857.2
- NM_001242860.2
- NM_001242859.2
- NM_001242862.2
- NM_001242858.2
- NM_001242861.2
- NM_207578.2
- XM_017001707.1
- XM_017001708.1
- XM_017001709.1
- XM_017001716.1
- XM_017001720.1
- NM_001300915.1
- XM_017001710.1
- XM_017001713.1
- XM_017001706.1
- XM_017001715.1
- XM_005271020.1
- XM_017001712.1
- XM_017001718.1
- XM_017001719.1
- NM_001300916.1
- XM_005271016.1
- XM_017001711.1
- NM_001300917.1
- XM_006710758.1
- XM_005271019.1
- XM_017001714.1
- XM_017001717.1
- Sino Biological Human cDNA Clone for PRKACB
- Addgene plasmids for PRKACB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRKACB
- Applied Biological Materials Clones for PRKACB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRKACB
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKACB Gene
Localization for PRKACB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRKACB Gene
- Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| mitochondrion | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 21399614 |
| GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for PRKACB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
.01
|
| 2 | RET signaling |
.92
.92
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
|
| 4 | Circadian entrainment | ||
| 5 | G-Beta Gamma Signaling |
.46
.44
|
.37
|
Pathways by source for PRKACB Gene
3 Sino Biological pathways for PRKACB Gene
9 BioSystems pathways for PRKACB Gene
65 Reactome pathways for PRKACB Gene
1 PharmGKB pathway for PRKACB Gene
67 KEGG pathways for PRKACB Gene
39 GeneGo (Thomson Reuters) pathways for PRKACB Gene
2 R&D Systems pathways for PRKACB Gene
52 Qiagen pathways for PRKACB Gene
Interacting Proteins for PRKACB Gene
Selected Interacting proteins:
ENSP00000359719
P22694-KAPCB_HUMAN
for PRKACB Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for PRKACB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006468 | protein phosphorylation | IDA,IEA | 12420224 |
| GO:0007165 | signal transduction | TAS | 2342480 |
Drugs & Compounds for PRKACB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved | Nutra | 0 | |||
| Phosphonothreonine | Experimental | Pharma | Target | 0 | ||
| cyclic amp | Experimental | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| H 89 dihydrochloride |
|
130964-39-5 |
|
|
(5) Tocris Compounds for PRKACB Gene
| Compound | Action | Cas Number |
|---|---|---|
| cGMP Dependent Kinase Inhibitor Peptide | Inhibitor of protein kinases G and A | 82801-73-8 |
| H 89 dihydrochloride | Protein kinase A inhibitor | 130964-39-5 |
| KT 5720 | Selective protein kinase A inhibitor | 108068-98-0 |
| PKA inhibitor fragment (6-22) amide | Potent protein kinase A inhibitor | 121932-06-7 |
| PKI 14-22 amide, myristoylated | Cell-permeable protein kinase A inhibitor | 201422-03-9 |
Drug Products
Transcripts for PRKACB Gene
mRNA/cDNA for PRKACB Gene
- (34) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (291) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000370689 4513 bps (uc001djj.3)
- ENST00000370688 1905 bps (uc001dji.4)
- ENST00000370685 4481 bps (uc001djl.4)
- ENST00000470673 752 bps (uc057hyl.1)
- ENST00000370684 869 bps (uc057hyn.1)
Unigene Clusters for PRKACB Gene
- Protein kinase, cAMP-dependent, catalytic, beta:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PRKACB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRKACB
- genomics-online: gRNA clones - Search results for 175 available PRKACB gene related products
- Overview of 175 available PRKACB gene related products
- Applied Biological Materials CRISPR for PRKACB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKACB
- GenScript: Design CRISPR guide RNA sequences for PRKACB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRKACB
- Browse OriGene Inhibitory RNA Products For PRKACB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKACB
- genomics-online: shRNA clones - Search results for 175 available PRKACB gene related products
- Overview of 175 available PRKACB gene related products
Clone Products
-
OriGene ORF clones in human for PRKACB
- RC202131
- RC202131L1
- RC202131L2
- RC202131L3
- RC202131L4
- RC207218
- RC207218L1
- RC207218L2
- RC207218L3
- RC207218L4
- RC219853
- RC219853L1
- RC219853L2
- RC219853L3
- RC219853L4
- RC232475
- RC232520
- RC232523
- RC232566
- RC232571
- RC232574
- RC236896
- RC237022
- RC237325
- RC502131
- RC507218
- RG202131
- RG207218
- RG219853
- RG232475
- RG232520
- RG232523
- RG232566
- RG232571
- RG232574
- RC202131L1V
- RC202131L2V
- RC202131L3V
- RC202131L4V
- RC207218L1V
- RC207218L2V
- RC207218L3V
- RC207218L4V
- RC219853L1V
- RC219853L2V
- RC219853L3V
- RC219853L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: |
Expression for PRKACB Gene
mRNA differential expression in normal tissues according to GTEx for PRKACB Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.0).
This gene is overexpressed in Fetal Brain (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKACB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PRKACB Gene:
PRKACBSOURCE GeneReport for Unigene cluster for PRKACB Gene:
Hs.487325mRNA Expression by UniProt/SwissProt for PRKACB Gene:
P22694-KAPCB_HUMAN
Tissue specificity:
Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
Evidence on tissue expression from TISSUES for PRKACB Gene
- Nervous system(5)
- Eye(4.2)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for PRKACB
-
OriGene qPCR primer pairs and template standards for PRKACB
- genomics-online: primer clones - Search results for 175 available PRKACB gene related products
- Overview of 175 available PRKACB gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKACB Gene
Orthologs for PRKACB Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRKACB 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PRKACB 34 |
|
OneToOne | |
| LOC479975 33 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | PRKACB 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PRKACB 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Prkacb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Prkacb 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | PRKACB 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRKACB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prkacb 33 |
|
||
| Str.3970 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | kin-1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prkacba 34 |
|
OneToMany | |
| prkacbb 34 34 33 |
|
OneToMany | |||
| zgc64054 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pka-C1 34 35 33 |
|
OneToMany | |
| Pka-C3 35 |
|
|
|||
| Pka-C2 35 |
|
|
|||
| CG12069 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001384 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | kin-1 34 33 |
|
OneToMany | |
| F47F2.1a 35 |
|
|
|||
| F47F2.1b 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TPK1 34 33 |
|
ManyToMany | |
| TPK2 34 |
|
ManyToMany | |||
| TPK3 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.3274 33 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06240 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3274 33 |
|
- Species where no ortholog for PRKACB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PRKACB Gene
- ENSEMBL:
- Gene Tree for PRKACB (if available)
- TreeFam:
- Gene Tree for PRKACB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRKACB: view image
Paralogs for PRKACB Gene
(141) SIMAP similar genes for PRKACB Gene using alignment to 10 proteins:
- KAPCB_HUMAN
- B1APF6_HUMAN
- B1APF7_HUMAN
- B1APF8_HUMAN
- B1APF9_HUMAN
- B1APG0_HUMAN
- B1APG1_HUMAN
- B1APG2_HUMAN
- B1APG3_HUMAN
- B2RB89_HUMAN
- KIN27
- PRKACA
- PRKACG
- PRKX
- PRKY
- RPS6KA2
- STK32A
- RPS6KA1
- RPS6KA5
- PDPK2
- AKT1
- PDPK1
- PRKCB
- PRKG2
- AKT3
- RPS6KA3
- RPS6KA4
- PRKCH
- SGK2
- PRKCA
- STK32C
- PkB-like 1
- MARK4
- PRKCZ
- RPS6KA6
- DKFZp781N0293
- RPS6KB2
- AKT2
- PRKCQ
- PRKCG
- PRKG1
- Par1b
- SGKL
- PRKCI
- ROCK2
- PKN3
- BRSK2
- MARK2
- SGK3
- STK38L
- ROCK1
- STK32B
- SBK1
- MAST2
- MARK1
- CAMK1
- RPS6KB1
- PNCK
- MAST4
- DCLK3
- NUAK1
- NEK4
- SGK1
- DKFZp564L2416
- CAMK1D
- ADRBK1
- AURKB
- NEK3
- SIK1
- NEK5
- AURKA
- DKFZp434B079
- STK36
- DMPK
- CHEK1
- SNRK
- CDC42BPB
- PRKAA1
- PLK3
- MAST3
- MAST1
- CHEK2
- CDC42BPA
- NEK8
- PKN1
- AURKC
- PSKH2
- GRK1
- MARK3
- ULK3
- PRKAA2
- CAMK1G
- GRK4
- CDK4
- KIAA0999
- SIK3
- PLK4
- MGC45428
- STK17B
- STK33
- ULK1
- DCLK2
- MYLK4
- PRKD2
- MYLK
- PRKD1
- ULK2
- CAMK2G
- PHKG1
- CIT
- CDC42BPG
- DAPK1
- TRIO
- Plk-1 delta
- MAP3K15
- STK38
- CAMK2A
- MYLK3
- GRK5
- CAMK2B
- GRK6
- PAK2
- NEK11
- DKFZp686L20222
- DCLK1
- PAK4
- CAMK2D
- STK17A
- MAPKAPK3
- SGK494
- CDKL3
- STK24
- PASK
- PAK1
- NEK9
- CDC2
- CASK
- PHKG2
- MST4
- NEK10
- CAMKK1
- TSSK3
- MAP3K6
- MAP3K4
- OBSCN
- CAMKV
- STK3
- STK4
- MAP3K2
- MYO3A
- MAP3K3
Variants for PRKACB Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002928 | -- | 84,090,159(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000030582 | -- | 84,097,999(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000042051 | -- | 84,209,650(+) | G/ | genic_downstream_transcript_variant, intron_variant | |
| rs1000042172 | -- | 84,179,633(+) | C/G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000042238 | -- | 84,128,016(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv206n100 | CNV | loss | 25217958 |
| esv3586660 | CNV | loss | 21293372 |
| nsv1011105 | CNV | loss | 25217958 |
| nsv1076323 | CNV | duplication | 25765185 |
| nsv1115345 | CNV | duplication | 24896259 |
| nsv1732 | CNV | deletion | 18451855 |
| nsv546689 | CNV | gain | 21841781 |
| nsv546690 | CNV | gain | 21841781 |
| nsv830414 | CNV | gain | 17160897 |
| nsv950200 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRKACB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACB Gene
Disorders for PRKACB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary pigmented nodular adrenocortical disease |
|
|
| carney complex variant |
|
|
Search PRKACB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRKACB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRKACB Gene
Publications for PRKACB Gene
- Control of PKA stability and signalling by the RING ligase praja2. (PMID: 21423175) Lignitto L … Feliciello A (Nature cell biology 2011) 3 4 58
- G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas AK … Skålhegg BS (Journal of molecular signaling 2011) 3 4 58
- Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. (PMID: 19573263) Shelton RC … Lewis DA (The international journal of neuropsychopharmacology 2009) 3 22 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for PRKACB Gene
- R&D Systems Antibodies for PRKACB (PKA C beta)
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- RC202131
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