PRKACB Gene (Protein Coding)

Protein Kinase CAMP-Activated Catalytic Subunit Beta

GC01P084078
GIFtS:
50
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encod... See more...

Aliases for PRKACB Gene

Aliases for PRKACB Gene

  • Protein Kinase CAMP-Activated Catalytic Subunit Beta 2 3 5
  • Protein Kinase, CAMP-Dependent, Beta Catalytic Subunit 2 3
  • CAMP-Dependent Protein Kinase Catalytic Subunit Beta 3 4
  • Protein Kinase, CAMP-Dependent, Catalytic, Beta 2 3
  • EC 2.7.11.11 4 51
  • PKA C-Beta 3 4
  • Protein Kinase A Catalytic Subunit Beta 3
  • EC 2.7.11 51
  • PRKACB 5
  • CAFD2 3
  • PKACB 3
  • PKACb 2

External Ids for PRKACB Gene

Previous GeneCards Identifiers for PRKACB Gene

  • GC01P084937
  • GC01P083681
  • GC01P083832
  • GC01P083966
  • GC01P084255
  • GC01P084316
  • GC01P084543
  • GC01P082654

Summaries for PRKACB Gene

Entrez Gene Summary for PRKACB Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

GeneCards Summary for PRKACB Gene

PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PRKACB include Cardioacrofacial Dysplasia 2 and Primary Pigmented Nodular Adrenocortical Disease. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot Summary for PRKACB Gene

  • Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).

Tocris Summary for PRKACB Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKACB Gene

Additional gene information for PRKACB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKACB Gene

Genomics for PRKACB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PRKACB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J084076 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.2 239 3.4 TBP ZBTB10 MXD4 MNT IKZF1 SMAD5 ZNF217 POLR2A NONO ZIC2 ENSG00000271576 PRKACB TXN2P1 SAMD13
GH01J084142 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 255.7 +67.7 67665 6.7 ZNF316 JUND POLR2A MAFK MYC MAX REST JUNB BHLHE40 FOS PRKACB SAMD13 RPF1 piR-56038-002 RF00994-031 LOC107985046 lnc-GNG5-9
GH01J084162 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.2 +86.0 86025 2.2 RFX1 DACH1 POLR2A RAD21 NONHSAG001943.2 PRKACB piR-35062-001 lnc-GNG5-9 LOC107985046 SAMD13
GH01J084173 Enhancer 0.8 Ensembl ENCODE dbSUPER 5.6 +95.9 95939 6 ZEB1 EP300 JUND GLIS1 ZNF398 ZNF366 PRKACB SSX2IP piR-38352-013 NONHSAG001943.2 lnc-GNG5-9 LOC107985046 SAMD13
GH01J084123 Enhancer 0.3 Ensembl 12.4 +44.0 44039 0.2 ZNF843 PRDM6 PRKACB piR-33706-001 hsa-miR-1273e-005 SAMD13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRKACB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKACB

Top Transcription factor binding sites by QIAGEN in the PRKACB gene promoter:
  • AML1a
  • HOXA5
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • S8
  • Sox5
  • STAT1
  • TBP

Genomic Locations for PRKACB Gene

Latest Assembly
chr1:84,078,062-84,238,498
(GRCh38/hg38)
Size:
160,437 bases
Orientation:
Plus strand

Previous Assembly
chr1:84,543,762-84,704,181
(GRCh37/hg19 by Entrez Gene)
Size:
160,420 bases
Orientation:
Plus strand

chr1:84,543,745-84,704,181
(GRCh37/hg19 by Ensembl)
Size:
160,437 bases
Orientation:
Plus strand

Genomic View for PRKACB Gene

Genes around PRKACB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKACB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKACB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRKACB Gene

Proteins for PRKACB Gene

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  • Protein details for PRKACB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22694-KAPCB_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit beta
    Protein Accession:
    P22694
    Secondary Accessions:
    • B1APG4
    • B4DKB0
    • B4E2Q1
    • Q14VH1
    • Q59GC0
    • Q5BNE9
    • Q5BNF0
    • Q5BNF1
    • Q5BNF2
    • Q5BNF3
    • Q5CZ92
    • Q5T1K3
    • Q7Z3M1
    • Q8IYR5
    • Q8IZQ0
    • Q96B09

    Protein attributes for PRKACB Gene

    Size:
    351 amino acids
    Molecular mass:
    40623 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2 (PubMed:21423175). Interacts with GPKOW (PubMed:21880142).
    SequenceCaution:
    • Sequence=BAD92426.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Incomplete sequence.
    • [Isoform 4]: Incomplete sequence.
    • [Isoform 5]: Incomplete sequence.

    Alternative splice isoforms for PRKACB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKACB Gene

Protein Expression for PRKACB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PRKACB Gene

P22694:
  • GDTSNFDDYEEE
  • GRFSEPHA
  • TLGTGSFGRV
  • EHTLNEKRILQA
  • YYAMKIL
  • GTPEYLAPE
  • HKWFATTDWIAIYQRKVEAPFIPKF
  • ESVKEFLAKAKE
  • LGVLIYEM
  • YLAPEII
  • YLHSLDLI
  • VDWWALGVL
  • SDLKDLLRNLLQVDLTKR
  • LKPENLL
  • RDLKPEN
  • TDFGFAK
  • ADQPIQIYEKIVSG

Post-translational modifications for PRKACB Gene

  • Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKACB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRKACB Gene

Gene Families for PRKACB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRKACB Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
ProtoNet:

Suggested Antigen Peptide Sequences for PRKACB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34101 fis, clone FCBBF3007631, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (B1APG4_HUMAN)
  • cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA (B2RB89_HUMAN)
  • cDNA FLJ52554, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (B4DKB0_HUMAN)
  • cAMP-dependent protein kinase catalytic subunit beta (KAPCB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22694

UniProtKB/Swiss-Prot:

KAPCB_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKACB: view

Function for PRKACB Gene

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Molecular function for PRKACB Gene

UniProtKB/Swiss-Prot Function:
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.11;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.11;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP.
GENATLAS Biochemistry:
protein kinase,cAMP-dependent,catalytic,beta subunit

Enzyme Numbers (IUBMB) for PRKACB Gene

Phenotypes From GWAS Catalog for PRKACB Gene

Gene Ontology (GO) - Molecular Function for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 12420224
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004679 AMP-activated protein kinase activity IEA --
genes like me logo Genes that share ontologies with PRKACB: view
genes like me logo Genes that share phenotypes with PRKACB: view

Human Phenotype Ontology for PRKACB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKACB Gene

MGI Knock Outs for PRKACB:

Animal Models for research

  • Taconic Biosciences Mouse Models for PRKACB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKACB

Clone products for research

No data available for Transcription Factor Targets and HOMER Transcription for PRKACB Gene

Localization for PRKACB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKACB Gene

Cytoplasm. Cell membrane. Membrane. Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKACB gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKACB: view

Pathways & Interactions for PRKACB Gene

PathCards logo

SuperPathways for PRKACB Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
DAG and IP3 signaling
.94
EGFR interacts with phospholipase C-gamma
.94
PLC-gamma1 signalling
.94
Ca-dependent events
.93
Calmodulin induced events
.93
CaM pathway
.93
PLC beta mediated events
.65
G-protein mediated events
.64
Opioid Signalling
.56
Beta-2 adrenergic-dependent CFTR expression
.50
G Protein Signaling Pathways
.44
Neurophysiological process PGE2-induced pain processing
.38
Signal transduction Calcium signaling
.35
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
Development Beta-adrenergic receptors signaling via cAMP
.32
Development Role of Activin A in cell differentiation and proliferation
.32
CREB phosphorylation through the activation of Adenylate Cyclase
.01
PKA activation
.01
PKA activation in glucagon signalling
.01
PKA-mediated phosphorylation of CREB
.01
2 RET signaling
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Signaling by EGFR
.90
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signalling by NGF
.81
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
3 Aldosterone synthesis and secretion
Aldosterone synthesis and secretion
.48
Cortisol synthesis and secretion
.48
Cushing syndrome
.41
Melanogenesis
.41
Insulin secretion
.36
Thyroid hormone synthesis
.34
4 G-Beta Gamma Signaling
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
5 Aquaporin-mediated transport
Aquaporin-mediated transport
.83
Vasopressin regulates renal water homeostasis via Aquaporins
.83
Glucagon signaling in metabolic regulation
.69
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
.53
Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
.40
genes like me logo Genes that share pathways with PRKACB: view

Pathways by source for PRKACB Gene

2 Sino Biological pathways for PRKACB Gene
1 PharmGKB pathway for PRKACB Gene
39 GeneGo (Thomson Reuters) pathways for PRKACB Gene
  • Apoptosis and survival BAD phosphorylation
  • Beta-2 adrenergic-dependent CFTR expression
  • Cell cycle_Role of APC in cell cycle regulation
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development A1 receptor signaling
52 Qiagen pathways for PRKACB Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • AMPK Enzyme Complex Pathway

SIGNOR curated interactions for PRKACB Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0003091 renal water homeostasis TAS --
GO:0006468 protein phosphorylation IEA,IDA 12420224
GO:0007165 signal transduction TAS 2342480
genes like me logo Genes that share ontologies with PRKACB: view

Drugs & Compounds for PRKACB Gene

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(12) Drugs for PRKACB Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphonothreonine Experimental Pharma Target 0
cyclic amp Experimental Pharma 0
ATP Investigational Nutra 0

(2) Additional Compounds for PRKACB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
H 89 dihydrochloride
130964-39-5

(5) Tocris Compounds for PRKACB Gene

Compound Action Cas Number
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
H 89 dihydrochloride Protein kinase A inhibitor 130964-39-5
KT 5720 Selective protein kinase A inhibitor 108068-98-0
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor 121932-06-7
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor 201422-03-9

(5) ApexBio Compounds for PRKACB Gene

Compound Action Cas Number
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
H 89 2HCl Potent PKA inhibitor 130964-39-5
K-252c Protein kinase inhibitor 85753-43-1
PKA inhibitor fragment (6-22) amide 121932-06-7
PKI 14-22 amide, myristoylated PKA inhibitor 201422-03-9
genes like me logo Genes that share compounds with PRKACB: view

Drug products for research

Transcripts for PRKACB Gene

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mRNA/cDNA for PRKACB Gene

30 REFSEQ mRNAs :
34 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKACB

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PRKACB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: -
SP3:
SP4: - - - -
SP5:
SP6:

Relevant External Links for PRKACB Gene

GeneLoc Exon Structure for
PRKACB

Expression for PRKACB Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKACB Gene

mRNA expression in normal human tissues for PRKACB Gene
mRNA expression by BioGPS for PRKACB GenemRNA expression by GTEx for PRKACB Gene

mRNA differential expression in normal tissues according to GTEx for PRKACB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for PRKACB Gene

This gene is overexpressed in Fetal Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKACB Gene



Protein tissue co-expression partners for PRKACB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKACB

SOURCE GeneReport for Unigene cluster for PRKACB Gene:

Hs.487325

mRNA Expression by UniProt/SwissProt for PRKACB Gene:

P22694-KAPCB_HUMAN
Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

Evidence on tissue expression from TISSUES for PRKACB Gene

  • Nervous system(5)
  • Liver(4.4)
  • Eye(4.2)
  • Blood(2.4)
  • Adrenal gland(2.4)
  • Heart(2.2)
  • Intestine(2.2)
  • Pancreas(2.2)
  • Lymph node(2.1)
  • Kidney(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PRKACB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKACB Gene

Orthologs for PRKACB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKACB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PRKACB 30 31
  • 99.92 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 98 (a)
 OneToMany
-- 31
  • 95 (a)
 OneToMany
-- 31
  • 80 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia PRKACB 31
  • 98 (a)
 OneToOne
LOC479975 30
  • 95.3 (n)
Cow
(Bos Taurus)
 Mammalia PRKACB 30 31
  • 95.25 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PRKACB 31
  • 88 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Prkacb 30
  • 87.34 (n)
Mouse
(Mus musculus)
 Mammalia Prkacb 30 17 31
  • 85.01 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves PRKACB 30 31
  • 85.51 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PRKACB 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia prkacb 30
  • 84.17 (n)
Str.3970 30
African clawed frog
(Xenopus laevis)
 Amphibia kin-1-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii prkacba 31
  • 80 (a)
 OneToMany
prkacbb 30 31 31
  • 78.93 (n)
 OneToMany
zgc64054 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Pka-C1 30 31 32
  • 70.03 (n)
 OneToMany
Pka-C3 32
  • 56 (a)
Pka-C2 32
  • 49 (a)
CG12069 32
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001384 30
  • 67.46 (n)
Worm
(Caenorhabditis elegans)
 Secernentea kin-1 30 31
  • 70.13 (n)
 OneToMany
F47F2.1a 32
  • 51 (a)
F47F2.1b 32
  • 49 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TPK1 30 31
  • 54.92 (n)
 ManyToMany
TPK2 31
  • 44 (a)
 ManyToMany
TPK3 31
  • 39 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 75 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU06240 30
  • 55.45 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.3274 30
Species where no ortholog for PRKACB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRKACB Gene

ENSEMBL:
Gene Tree for PRKACB (if available)
TreeFam:
Gene Tree for PRKACB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRKACB: view image

Paralogs for PRKACB Gene

Paralogs for PRKACB Gene

(141) SIMAP similar genes for PRKACB Gene using alignment to 10 proteins:

  • KAPCB_HUMAN
  • B1APF6_HUMAN
  • B1APF7_HUMAN
  • B1APF8_HUMAN
  • B1APF9_HUMAN
  • B1APG0_HUMAN
  • B1APG1_HUMAN
  • B1APG2_HUMAN
  • B1APG3_HUMAN
  • B2RB89_HUMAN
genes like me logo Genes that share paralogs with PRKACB: view

Variants for PRKACB Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKACB Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
989456 Pathogenic: CARDIOACROFACIAL DYSPLASIA 2 84,202,743(+) G/C
NM_182948.4(PRKACB):c.844G>C (p.Gly282Arg) 		MISSENSE
989457 Pathogenic: CARDIOACROFACIAL DYSPLASIA 2 84,182,252(+) C/T
NM_182948.4(PRKACB):c.302C>T (p.Ser101Leu) 		MISSENSE
989458 Pathogenic: CARDIOACROFACIAL DYSPLASIA 2 84,184,062(+) A/G
NM_182948.4(PRKACB):c.404A>G (p.His135Arg) 		MISSENSE_VARIANT,INTRON
989459 Pathogenic: CARDIOACROFACIAL DYSPLASIA 2 84,184,061(+) C/A
NM_182948.4(PRKACB):c.403C>A (p.His135Asn) 		MISSENSE_VARIANT,INTRON
rs36117118 - p.Arg106Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRKACB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRKACB Gene

Variant ID Type Subtype PubMed ID
dgv206n100 CNV loss 25217958
esv3586660 CNV loss 21293372
nsv1011105 CNV loss 25217958
nsv1076323 CNV duplication 25765185
nsv1115345 CNV duplication 24896259
nsv1732 CNV deletion 18451855
nsv546689 CNV gain 21841781
nsv546690 CNV gain 21841781
nsv830414 CNV gain 17160897
nsv950200 CNV duplication 24416366

Variation tolerance for PRKACB Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKACB Gene

Human Gene Mutation Database (HGMD)
PRKACB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKACB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACB Gene

Disorders for PRKACB Gene

MalaCards: The human disease database

(5) MalaCards diseases for PRKACB Gene - From: OMI, CVR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRKACB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PRKACB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKACB Gene

Publications for PRKACB Gene

  1. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. (PMID: 33058759) Palencia-Campos A … Ruiz-Perez VL (American journal of human genetics 2020) 3 74
  2. Control of PKA stability and signalling by the RING ligase praja2. (PMID: 21423175) Lignitto L … Feliciello A (Nature cell biology 2011) 3 4
  3. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas AK … Skålhegg BS (Journal of molecular signaling 2011) 3 4
  4. Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. (PMID: 19573263) Shelton RC … Lewis DA (The international journal of neuropsychopharmacology 2009) 3 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

ExternalLinks

View latest publications for PRKACB gene in Mastermind

Products for PRKACB Gene

Sources for PRKACB Gene