Aliases for PRKAB2 Gene
- Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2 2 3 5
- Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit 2 3
- 5'-AMP-Activated Protein Kinase Subunit Beta-2 3 4
- AMPK Subunit Beta-2 3 4
- AMPK Beta 2 2 3
- AMP-Activated Protein Kinase Beta 2 Non-Catalytic Subunit 3
- 5'-AMP-Activated Protein Kinase, Beta-2 Subunit 3
- AMPK Beta-2 Chain 3
External Ids for PRKAB2 Gene
Previous GeneCards Identifiers for PRKAB2 Gene
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for PRKAB2 Gene
PRKAB2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2) is a Protein Coding gene. Diseases associated with PRKAB2 include Chromosome 1Q21.1 Duplication Syndrome and Tetralogy Of Fallot. Among its related pathways are mTOR signalling and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB1.
UniProtKB/Swiss-Prot Summary for PRKAB2 Gene
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).