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The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and... See more...
Aliases for PRKAB1 Gene
Aliases for PRKAB1 Gene
External Ids for PRKAB1 Gene
- HGNC: 9378
- Entrez Gene: 5564
- Ensembl: ENSG00000111725
- OMIM: 602740
- UniProtKB: Q9Y478
Previous GeneCards Identifiers for PRKAB1 Gene
- GC12P118978
- GC12P119888
- GC12P118517
- GC12P118568
- GC12P120105
- GC12P117113
Summaries for PRKAB1 Gene
-
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKAB1 Gene
PRKAB1 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1) is a Protein Coding gene. Diseases associated with PRKAB1 include Fatty Liver Disease and Hyperglycemia. Among its related pathways are Organelle biogenesis and maintenance and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include protein kinase activity and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB2.
UniProtKB/Swiss-Prot Summary for PRKAB1 Gene
-
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
-
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.
Additional gene information for PRKAB1 Gene
- HGNC(9378)
- Entrez Gene(5564)
- Ensembl(ENSG00000111725)
- OMIM(602740)
- UniProtKB(Q9Y478)
- Open Targets Platform(ENSG00000111725)
- Search for PRKAB1 at DataMed
- Search for PRKAB1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRKAB1 Gene
Genomics for PRKAB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRKAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRKAB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRKAB1
- Top Transcription factor binding sites by QIAGEN in the PRKAB1 gene promoter:
-
- FAC1
- GR
- GR-alpha
- GR-beta
- HOXA5
- PPAR-gamma1
- PPAR-gamma2
- Zic3
Genomic Locations for PRKAB1 Gene
Genomic Locations for PRKAB1 Gene
- chr12:119,667,864-119,681,624
- (GRCh38/hg38)
- Size:
- 13,761 bases
- Orientation:
- Plus strand
- chr12:120,105,558-120,119,435
- (GRCh37/hg19)
- Size:
- 13,878 bases
- Orientation:
- Plus strand
Genomic View for PRKAB1 Gene
Genes around PRKAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.23 by HGNC
- 12q24.23 by Entrez Gene
- 12q24.23 by Ensembl
PRKAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRKAB1 Gene
Proteins for PRKAB1 Gene
-
Protein details for PRKAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y478-AAKB1_HUMAN
- Recommended name:
- 5'-AMP-activated protein kinase subunit beta-1
- Protein Accession:
- Q9Y478
- Q9UBV0
- Q9UE20
- Q9UEX2
- Q9Y6V8
Protein attributes for PRKAB1 Gene
- Size:
- 270 amino acids
- Molecular mass:
- 30382 Da
- Quaternary structure:
-
- AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
- SequenceCaution:
-
- Sequence=AAB71326.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC98897.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for PRKAB1 Gene
Post-translational modifications for PRKAB1 Gene
- Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
-
Ubiquitination at Lys57, Lys89, Lys102, and Lys195
- NX_Q9Y478 (NX_Q9Y478-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PRKAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PRKAB1 / AMPK Beta 1 Antibody
- G Biosciences Immunotag™ Phospho-AMPK ß1(Ser181) Antibody and Immunotag™ AMPK ß1 Antibody
- NSJ Bioreagents AMPK beta 1 Antibody (PRKAB1)
- Novus Biologicals Antibodies for PRKAB1
-
Abcam antibodies for PRKAB1
- Invitrogen Antibodies for PRKAB1 (AFLGC-PRKAB1)
- antibodies-online: Show 55 available PRKAB1 Antibodies ranked by validation data
- Compare Top PRKAB1 Antibodies
-
Recommended
- 162 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 110 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 86 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for PRKAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRKAB1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRKAB1
- Origene Custom Protein Services for PRKAB1
- ProSpec Recombinant Proteins for PRKAB1
-
Signalway Proteins for PRKAB1
-
Abcam proteins for PRKAB1
Assay Products
No data available for DME Specific Peptides for PRKAB1 Gene
Domains & Families for PRKAB1 Gene
Gene Families for PRKAB1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for PRKAB1 Gene
- InterPro:
- Blocks:
-
- 5-AMP-activated protein kinase, beta subunit, complex-interacting region
- ProtoNet:
Suggested Antigen Peptide Sequences for PRKAB1 Gene
- GenScript: Design optimal peptide antigens:
-
- 5'-AMP-activated protein kinase subunit beta-1 (AAKB1_HUMAN)
- cDNA FLJ57208, highly similar to 5'-AMP-activated protein kinase subunit beta-1 (B4DVP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y478UniProtKB/Swiss-Prot:
AAKB1_HUMAN :- The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
- Belongs to the 5'-AMP-activated protein kinase beta subunit family.
- Domain:
-
- The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
- Family:
-
- Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Function for PRKAB1 Gene
Molecular function for PRKAB1 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
- GENATLAS Biochemistry:
- protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol metabolism,expressed in liver,skeletal muscle
Phenotypes From GWAS Catalog for PRKAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IDA | 17028174 |
| GO:0004679 | AMP-activated protein kinase activity | IBA | -- |
| GO:0005515 | protein binding | IEA,IPI | 16306228 |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0019901 | protein kinase binding | IBA | 21873635 |
Phenotypes for PRKAB1 Gene
- MGI mutant phenotypes for PRKAB1:
-
inferred from 8 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for PRKAB1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability ratio
- Decreased viability of wild-type and TP53 knockout cells
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased hepcidin::fluc mRNA expression
- Elongated cells
- Two nuclei (binuclear)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for PRKAB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRKAB1 - Select products 50% OFF >
- * PRKAB1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRKAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRKAB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKAB1
miRNA for PRKAB1 Gene
- miRTarBase miRNAs that target PRKAB1
-
- hsa-miR-122-5p (MIRT004527)
- mmu-miR-149-5p (MIRT014622)
- hsa-miR-148b-3p (MIRT053237)
- hsa-miR-578 (MIRT650651)
- hsa-miR-4715-3p (MIRT650652)
- hsa-miR-4727-5p (MIRT650653)
- hsa-miR-6780a-3p (MIRT650654)
- hsa-miR-642a-5p (MIRT650655)
- hsa-miR-627-3p (MIRT650656)
- hsa-miR-432-5p (MIRT650657)
- hsa-miR-6817-5p (MIRT650658)
- hsa-miR-4769-3p (MIRT650659)
- hsa-miR-2276-5p (MIRT650660)
- hsa-miR-4469 (MIRT650661)
- hsa-miR-6892-3p (MIRT650662)
- hsa-miR-6887-3p (MIRT650663)
- hsa-miR-6749-3p (MIRT719917)
- hsa-miR-4713-5p (MIRT719918)
- hsa-miR-1260b (MIRT719919)
- hsa-miR-1260a (MIRT719920)
- hsa-miR-2116-3p (MIRT719921)
- hsa-miR-532-3p (MIRT719922)
- hsa-miR-150-5p (MIRT719923)
- hsa-miR-1224-3p (MIRT719924)
- hsa-miR-665 (MIRT719925)
- hsa-miR-483-3p (MIRT719926)
- hsa-miR-4733-3p (MIRT719927)
- hsa-miR-101-3p (MIRT733406)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRKAB1
- Browse OriGene Inhibitory RNA Products For PRKAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKAB1
Clone Products
- Applied Biological Materials (abm): Clones for PRKAB1 - Select products 50% OFF >
- * PRKAB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRKAB1
- Addgene plasmids for PRKAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRKAB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAB1 Gene
Localization for PRKAB1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031588 | nucleotide-activated protein kinase complex | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAB1 Gene
Pathways & Interactions for PRKAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | mTOR signalling |
.72
|
.51
|
| 3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 4 | Regulation of TP53 Activity | ||
| 5 | Longevity regulating pathway | ||
Pathways by source for PRKAB1 Gene
2 Sino Biological pathways for PRKAB1 Gene
6 BioSystems pathways for PRKAB1 Gene
25 Reactome pathways for PRKAB1 Gene
1 PharmGKB pathway for PRKAB1 Gene
15 KEGG pathways for PRKAB1 Gene
2 GeneGo (Thomson Reuters) pathways for PRKAB1 Gene
- Development_Leptin signaling via PI3K-dependent pathway
- Regulation of CFTR activity (norm and CF)
3 R&D Systems pathways for PRKAB1 Gene
1 Tocris pathway for PRKAB1 Gene
3 Qiagen pathways for PRKAB1 Gene
- AMPK Enzyme Complex Pathway
- eNOS Signaling
- Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for PRKAB1 Gene
1 GeneTex pathway for PRKAB1 Gene
Interacting Proteins for PRKAB1 Gene
Selected Interacting proteins:
Q9Y478-AAKB1_HUMAN
ENSP00000229328
for PRKAB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PRKAB1
SIGNOR curated interactions for PRKAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 17028174 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IEA | -- |
| GO:0007050 | cell cycle arrest | TAS | -- |
Drugs & Compounds for PRKAB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Metformin | Approved | Pharma | Target, inducer, activator, inhibitor | AMP-activated protein kinase (AMPK) activator | 2210 | |
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target, activator | 1512 | ||
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Topiramate | Approved | Pharma | Transporter, inducer | GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV | 277 | |
| Adenosine monophosphate | Approved, Investigational | Nutra | Target, Target, activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dorsomorphin dihydrochloride |
|
1219168-18-9 |
|
|
(3) Tocris Compounds for PRKAB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AICAR | AMPK activator | 2627-69-2 |
| Dorsomorphin dihydrochloride | Potent AMPK inhibitor | 1219168-18-9 |
| RSVA 405 | AMPK activator; also STAT3 inhibitor | 140405-36-3 |
(13) ApexBio Compounds for PRKAB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A-769662 | AMPK activator,potent and reversible | 844499-71-4 |
| AICAR | AMPK activator | 2627-69-2 |
| AICAR phosphate | AMPK activator | 681006-28-0 |
| Dorsomorphin | AMPK inhibitor | 866405-64-3 |
| Dorsomorphin 2HCl | AMPK inhibitor | 1219168-18-9 |
| GSK621 | AMPK agonist | 1346607-05-3 |
| Imeglimin | Antidiabetic agent | 775351-65-0 |
| Imeglimin hydrochloride | Antidiabetic agent | 775351-61-6 |
| Phenformin HCl | 834-28-6 | |
| PT 1 | AMPK activator, selective | 331002-70-1 |
| RSVA 405 | 140405-36-3 | |
| SAMS Peptide | 125911-68-4 | |
| ZLN024 hydrochloride |
Transcripts for PRKAB1 Gene
mRNA/cDNA for PRKAB1 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000229328 2219 nts (view in UCSC)
- ENST00000537057 1510 nts (view in UCSC)
- ENST00000537400 555 nts (view in UCSC)
- ENST00000538271 567 nts (view in UCSC)
- ENST00000540121 1673 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRKAB1 - Select products 50% OFF >
- * PRKAB1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRKAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRKAB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKAB1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRKAB1
- Browse OriGene Inhibitory RNA Products For PRKAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRKAB1
Clone Products
- Applied Biological Materials (abm): Clones for PRKAB1 - Select products 50% OFF >
- * PRKAB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRKAB1
- Addgene plasmids for PRKAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRKAB1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for PRKAB1 Gene
- GeneLoc Exon Structure for
- PRKAB1
Expression for PRKAB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
- Blood (Cardiovascular System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
This gene is overexpressed in Lung (18.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRKAB1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRKAB1
SOURCE GeneReport for Unigene cluster for PRKAB1 Gene:
Hs.741184Evidence on tissue expression from TISSUES for PRKAB1 Gene
- Nervous system(4.9)
- Liver(4.5)
- Muscle(4.5)
- Blood(4.4)
- Lung(4.4)
- Kidney(3.1)
- Intestine(3)
- Pancreas(2.6)
- Heart(2.2)
- Bone marrow(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for PRKAB1
-
OriGene qPCR primer pairs and template standards for PRKAB1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKAB1 Gene
Orthologs for PRKAB1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PRKAB1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PRKAB1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PRKAB1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PRKAB1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prkab1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Prkab1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PRKAB1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PRKAB1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PRKAB1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prkab1 30 |
|
||
| Str.11311 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | prkab1b 31 |
|
ManyToMany | |
| prkab1a 30 31 |
|
ManyToMany | |||
| Dr.14126 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9296 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8057 32 |
|
|
|
| alc 30 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008195 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F55F3.1 32 |
|
|
|
| aakb-1 31 |
|
ManyToMany | |||
| Y47D3A.15 32 |
|
|
|||
| aakb-2 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SIP2 31 |
|
ManyToMany | |
| GAL83 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G16360 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10258 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | amk2 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03837 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1122 30 |
|
- Species where no ortholog for PRKAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PRKAB1 Gene
- ENSEMBL:
- Gene Tree for PRKAB1 (if available)
- TreeFam:
- Gene Tree for PRKAB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRKAB1: view image
Paralogs for PRKAB1 Gene
Variants for PRKAB1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRKAB1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 790130 | Benign: not provided | 119,672,396(+) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.31;
41.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRKAB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRKAB1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRKAB1 Gene
Disorders for PRKAB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fatty liver disease |
|
|
| hyperglycemia |
|
|
| body mass index quantitative trait locus 11 |
|
|
| krabbe disease |
|
|
| diabetes mellitus, noninsulin-dependent |
|
Search PRKAB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRKAB1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAB1 Gene
Publications for PRKAB1 Gene
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PMID: 21460634) Löffler AS … Stork B (Autophagy 2011) 3 4
- Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts. (PMID: 20177150) Kwon HJ … Yeo EJ (Experimental & molecular medicine 2010) 3 23
- AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. (PMID: 19896469) García-García C … López-Rivas A (Biochemical pharmacology 2010) 3 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski KA … Diabetes Prevention Program Research Group (Diabetes 2010) 3 41
ExternalLinks
Products for PRKAB1 Gene
- Custom Antibody ServicesOriGene Antibodies for PRKAB1
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- Abcam antibodies for PRKAB1
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- Browse Primary Antibodies
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- ApexBio compounds for PRKAB1
- VectorBuilder Custom and pre-made DNA vectors for PRKAB1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRKAB1 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for PRKAB1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRKAB1
- Addgene plasmids for PRKAB1
- antibodies-online: Show 55 available PRKAB1 Antibodies ranked by validation data
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- Recommended
- 162 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
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- 1 IF/ICC Antibody (anti-human)
- 110 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 86 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: