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This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
PRIM2 (DNA Primase Subunit 2) is a Protein Coding gene. Diseases associated with PRIM2 include Dyschromatosis Universalis Hereditaria and Arthrogryposis, Distal, Type 10. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include 4 iron, 4 sulfur cluster binding and DNA primase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003896 | DNA primase activity | IEA,TAS | 8026492 |
GO:0005515 | protein binding | IPI | 28514442 |
GO:0016779 | nucleotidyltransferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005658 | alpha DNA polymerase:primase complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
Cell cycle Transition and termination of DNA replication
.48
|
|
2 | E2F mediated regulation of DNA replication |
.64
Cell cycle Start of DNA replication in early S phase
.53
|
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.78
|
4 | Mitotic G1-G1/S phases |
.83
|
|
5 | Cell Cycle, Mitotic |
.83
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0006260 | DNA replication | IEA | -- |
GO:0006269 | DNA replication, synthesis of RNA primer | IEA | -- |
GO:0006270 | DNA replication initiation | TAS | -- |
GO:0032201 | telomere maintenance via semi-conservative replication | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
dATP | Experimental | Pharma | Agonist, Full agonist | 0 | ||
dctp | Experimental | Pharma | 0 | |||
dgtp | Experimental | Pharma | 0 | |||
Thymidine 5'-triphosphate | Experimental | Pharma | 0 | |||
Fludarabine Phosphate (Fludara) | Pharma | Inhibits STAT1 activation and DNA synthesis | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
Compound | Action | Cas Number |
---|---|---|
Fludarabine Phosphate (Fludara) | Inhibits STAT1 activation and DNA synthesis | 75607-67-9 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | PRIM2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRIM2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prim2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Prim2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | PRIM2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRIM2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRIM2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prim2 30 |
|
||
Str.15796 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7459 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:110727 30 |
|
||
PRIM2 31 |
|
OneToOne | |||
anxa1c 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2459 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006387 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | DNApol-alpha60 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | pri-2 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRI2 30 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F04818g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR056C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G67320 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0406800 30 |
|
||
Os.11383 30 |
|
||||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spp2 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04646 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4944 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.9000 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
dyschromatosis universalis hereditaria |
|
|
arthrogryposis, distal, type 10 |
|
|