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This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of... See more...
Aliases for PRIM2 Gene
Aliases for PRIM2 Gene
External Ids for PRIM2 Gene
- HGNC: 9370
- Entrez Gene: 5558
- Ensembl: ENSG00000146143
- OMIM: 176636
- UniProtKB: P49643
Previous HGNC Symbols for PRIM2 Gene
- PRIM2A
Previous GeneCards Identifiers for PRIM2 Gene
- GC06P057287
- GC06P057179
- GC06P057016
Summaries for PRIM2 Gene
-
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
GeneCards Summary for PRIM2 Gene
PRIM2 (DNA Primase Subunit 2) is a Protein Coding gene. Diseases associated with PRIM2 include Dyschromatosis Universalis Hereditaria and Arthrogryposis, Distal, Type 10. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include 4 iron, 4 sulfur cluster binding and DNA primase activity.
UniProtKB/Swiss-Prot Summary for PRIM2 Gene
-
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Stabilizes and modulates the activity of the catalytic subunit (By similarity).
Additional gene information for PRIM2 Gene
- HGNC(9370)
- Entrez Gene(5558)
- Ensembl(ENSG00000146143)
- OMIM(176636)
- UniProtKB(P49643)
- Open Targets Platform(ENSG00000146143)
- Search for PRIM2 at DataMed
- Search for PRIM2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRIM2 Gene
Genomics for PRIM2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRIM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRIM2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRIM2
- Top Transcription factor binding sites by QIAGEN in the PRIM2 gene promoter:
-
- ATF-2
- COMP1
- E2F
- FOXJ2
- FOXJ2 (long isoform)
- IRF-7A
- Pbx1a
- Spz1
- STAT3
- STAT5A
Genomic Locations for PRIM2 Gene
Genomic Locations for PRIM2 Gene
- chr6:57,314,805-57,646,852
- (GRCh38/hg38)
- Size:
- 332,048 bases
- Orientation:
- Plus strand
- chr6:57,179,603-57,513,375
- (GRCh37/hg19)
- Size:
- 333,773 bases
- Orientation:
- Plus strand
Genomic View for PRIM2 Gene
Genes around PRIM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p11.2 by HGNC
- 6p11.2 by Entrez Gene
- 6p11.2 by Ensembl
PRIM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRIM2 Gene
Proteins for PRIM2 Gene
-
Protein details for PRIM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49643-PRI2_HUMAN
- Recommended name:
- DNA primase large subunit
- Protein Accession:
- P49643
- Q53FJ8
- Q6P1Q7
- Q8WVL2
- Q9H413
Protein attributes for PRIM2 Gene
- Size:
- 509 amino acids
- Molecular mass:
- 58806 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
-
- Heterodimer of a catalytic subunit PRIM1 and a regulatory subunit PRIM2, also known as the DNA primase complex (PubMed:9705292, PubMed:17893144). Interacts via (C-terminus) with PRIM1 (PubMed:17893144). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (PubMed:9705292). Within the complex, POLA1 directly interacts with PRIM2 (By similarity).
Three dimensional structures from OCA and Proteopedia for PRIM2 Gene
Protein Expression for PRIM2 Gene
Selected DME Specific Peptides for PRIM2 Gene
- P49643:
-
- GKEGKRTDYTP
- SHFILRLAYC
Post-translational modifications for PRIM2 Gene
Other Protein References for PRIM2 Gene
Antibody Products
- HUABIO Anti-DNA Primase Antibody
-
Custom Antibody ServicesOriGene Antibodies for PRIM2
- Novus Biologicals Antibodies for PRIM2
- Invitrogen Antibodies for PRIM2 (AFLGC-Prim2)
-
Boster Bio Antibodies for PRIM2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRIM2
- Origene Custom Protein Services for PRIM2
-
Signalway Proteins for PRIM2
-
Abcam proteins for PRIM2
Assay Products
- G Biosciences Immunotag™ DNA primase large subunit ELISA Kit
-
Signalway ELISA kits for PRIM2
Domains & Families for PRIM2 Gene
Gene Families for PRIM2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRIM2 Gene
- InterPro:
- Blocks:
-
- Eukaryotic-type DNA primase, large subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for PRIM2 Gene
- GenScript: Design optimal peptide antigens:
-
- DNA primase 58 kDa subunit (PRI2_HUMAN)
- Primase, polypeptide 2A, 58kDa (Q5JU42_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49643- Family:
-
- Belongs to the eukaryotic-type primase large subunit family.
Function for PRIM2 Gene
Molecular function for PRIM2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Stabilizes and modulates the activity of the catalytic subunit (By similarity).
Phenotypes From GWAS Catalog for PRIM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003896 | DNA primase activity | IEA,TAS | 8026492 |
| GO:0005515 | protein binding | IPI | 28514442 |
| GO:0016779 | nucleotidyltransferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PRIM2 Gene
- GenomeRNAi human phenotypes for PRIM2:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased viability of wild-type and TP53 knockout cells
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased transferrin (TF) endocytosis
- Decreased Hepatitis C virus replication
- Decreased Salmonella proliferation
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased the percentage of infected cells
- Decreased cell number and increased metaphase cell number
- Decreased viability (cell death)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRIM2 - Select products 50% OFF >
- * PRIM2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PRIM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRIM2
miRNA for PRIM2 Gene
- miRTarBase miRNAs that target PRIM2
-
- hsa-miR-665 (MIRT680491)
- hsa-miR-887-5p (MIRT680492)
- hsa-miR-6780a-5p (MIRT680493)
- hsa-miR-6779-5p (MIRT680494)
- hsa-miR-3689c (MIRT680495)
- hsa-miR-3689b-3p (MIRT680496)
- hsa-miR-3689a-3p (MIRT680497)
- hsa-miR-30b-3p (MIRT680498)
- hsa-miR-1273h-5p (MIRT680499)
- hsa-miR-6788-5p (MIRT680500)
- hsa-miR-30c-2-3p (MIRT680501)
- hsa-miR-30c-1-3p (MIRT680502)
- hsa-miR-4266 (MIRT680503)
- hsa-miR-6799-5p (MIRT680504)
- hsa-miR-6883-5p (MIRT680505)
- hsa-miR-6785-5p (MIRT680506)
- hsa-miR-4728-5p (MIRT680507)
- hsa-miR-149-3p (MIRT680508)
- hsa-miR-7106-5p (MIRT680509)
- hsa-miR-6894-5p (MIRT680510)
- hsa-miR-7160-5p (MIRT680511)
- hsa-miR-202-3p (MIRT680512)
- hsa-miR-98-5p (MIRT680513)
- hsa-miR-4500 (MIRT680514)
- hsa-miR-4458 (MIRT680515)
- hsa-let-7i-5p (MIRT680516)
- hsa-let-7g-5p (MIRT680517)
- hsa-let-7f-5p (MIRT680518)
- hsa-let-7e-5p (MIRT680519)
- hsa-let-7d-5p (MIRT680520)
- hsa-let-7c-5p (MIRT680521)
- hsa-let-7b-5p (MIRT680522)
- hsa-let-7a-5p (MIRT680523)
- hsa-miR-6884-5p (MIRT680524)
- hsa-miR-485-5p (MIRT680525)
- hsa-miR-4487 (MIRT680526)
- hsa-miR-558 (MIRT680527)
- hsa-miR-3160-3p (MIRT680528)
- hsa-miR-7162-3p (MIRT680529)
- hsa-miR-6500-3p (MIRT680530)
- hsa-miR-3614-5p (MIRT680531)
- hsa-miR-4478 (MIRT680532)
- hsa-miR-4419b (MIRT680533)
- hsa-miR-3929 (MIRT680534)
- hsa-miR-4779 (MIRT680535)
- hsa-miR-4695-5p (MIRT680536)
- hsa-miR-890 (MIRT680537)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRIM2
- Browse OriGene Inhibitory RNA Products For PRIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM2
Clone Products
- Applied Biological Materials (abm): Clones for PRIM2 - Select products 50% OFF >
- * PRIM2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for PRIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRIM2
Cell Line Products
-
Horizon Cell Lines for PRIM2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRIM2 Gene
Localization for PRIM2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005658 | alpha DNA polymerase:primase complex | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRIM2 Gene
Pathways & Interactions for PRIM2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere C-strand (Lagging Strand) Synthesis |
.67
Cell cycle Transition and termination of DNA replication
.48
|
|
| 2 | E2F mediated regulation of DNA replication |
.64
Cell cycle Start of DNA replication in early S phase
.53
|
|
| 3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.78
|
| 4 | Mitotic G1-G1/S phases |
.83
|
|
| 5 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for PRIM2 Gene
2 BioSystems pathways for PRIM2 Gene
25 Reactome pathways for PRIM2 Gene
1 KEGG pathway for PRIM2 Gene
3 GeneGo (Thomson Reuters) pathways for PRIM2 Gene
- Cell cycle Start of DNA replication in early S phase
- Cell cycle Transition and termination of DNA replication
- Transcription Ligand-dependent activation of the ESR1/SP pathway
1 Cell Signaling Technology pathway for PRIM2 Gene
Interacting Proteins for PRIM2 Gene
Selected Interacting proteins:
P49643-PRI2_HUMAN
ENSP00000484105
for PRIM2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PRIM2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006269 | DNA replication, synthesis of RNA primer | IEA | -- |
| GO:0006270 | DNA replication initiation | TAS | -- |
| GO:0032201 | telomere maintenance via semi-conservative replication | TAS | -- |
No data available for SIGNOR curated interactions for PRIM2 Gene
Drugs & Compounds for PRIM2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| dATP | Experimental | Pharma | Agonist, Full agonist | 0 | ||
| dctp | Experimental | Pharma | 0 | |||
| dgtp | Experimental | Pharma | 0 | |||
| Thymidine 5'-triphosphate | Experimental | Pharma | 0 | |||
| Fludarabine Phosphate (Fludara) | Pharma | Inhibits STAT1 activation and DNA synthesis | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(1) ApexBio Compounds for PRIM2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fludarabine Phosphate (Fludara) | Inhibits STAT1 activation and DNA synthesis | 75607-67-9 |
Transcripts for PRIM2 Gene
mRNA/cDNA for PRIM2 Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000274891 864 nts (view in UCSC)
- ENST00000370687 909 nts (view in UCSC)
- ENST00000419977 2197 nts (view in UCSC)
- ENST00000470638 486 nts (view in UCSC)
- ENST00000490313 410 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRIM2 - Select products 50% OFF >
- * PRIM2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRIM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRIM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRIM2
- Browse OriGene Inhibitory RNA Products For PRIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM2
Clone Products
- Applied Biological Materials (abm): Clones for PRIM2 - Select products 50% OFF >
- * PRIM2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRIM2
Relevant External Links for PRIM2 Gene
- GeneLoc Exon Structure for
- PRIM2
Expression for PRIM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
This gene is overexpressed in Cervix (28.6), CD8 Tcells (23.6), and CD4 Tcells (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRIM2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRIM2
SOURCE GeneReport for Unigene cluster for PRIM2 Gene:
Hs.654580Evidence on tissue expression from TISSUES for PRIM2 Gene
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs for PRIM2
-
OriGene qPCR primer pairs and template standards for PRIM2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRIM2 Gene
Orthologs for PRIM2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | PRIM2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PRIM2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prim2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Prim2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | PRIM2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PRIM2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PRIM2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prim2 30 |
|
||
| Str.15796 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7459 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:110727 30 |
|
||
| PRIM2 31 |
|
OneToOne | |||
| anxa1c 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2459 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006387 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | DNApol-alpha60 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | pri-2 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRI2 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F04818g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR056C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G67320 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0406800 30 |
|
||
| Os.11383 30 |
|
||||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spp2 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04646 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4944 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.9000 30 |
|
- Species where no ortholog for PRIM2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PRIM2 Gene
- ENSEMBL:
- Gene Tree for PRIM2 (if available)
- TreeFam:
- Gene Tree for PRIM2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRIM2: view image
Paralogs for PRIM2 Gene
Pseudogenes.org Pseudogenes for PRIM2 Gene
No data available for Paralogs for PRIM2 Gene
Variants for PRIM2 Gene
Gene Damage Index Score:
1.50;
29.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRIM2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRIM2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRIM2 Gene
Disorders for PRIM2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dyschromatosis universalis hereditaria |
|
|
| arthrogryposis, distal, type 10 |
|
|
Search PRIM2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRIM2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PRIM2 Gene
Publications for PRIM2 Gene
- An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. (PMID: 17893144) Weiner BE … Chazin WJ (The Journal of biological chemistry 2007) 3 4 23
- Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. (PMID: 8530050) Shiratori A … Miyazawa H (Genomics 1995) 2 3 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- The genomic distribution and local context of coincident SNPs in human and chimpanzee. (PMID: 20675616) Hodgkinson A … Eyre-Walker A (Genome biology and evolution 2010) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for PRIM2 Gene
- Custom Antibody ServicesOriGene Antibodies for PRIM2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PRIM2
- Origene Custom Protein Services for PRIM2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRIM2
- Browse OriGene Inhibitory RNA Products For PRIM2
- OriGene qPCR primer pairs for PRIM2
- OriGene qPCR primer pairs and template standards for PRIM2
- OriGene CRISPR knockouts for PRIM2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRIM2
- Sino Biological Human cDNA Clone for PRIM2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRIM2
- Novus Biologicals proteins and lysates for PRIM2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PRIM2
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for PRIM2 (AFLGC-Prim2)
- ApexBio compounds for PRIM2
- VectorBuilder Custom and pre-made DNA vectors for PRIM2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRIM2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRIM2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRIM2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRIM2
- antibodies-online: Show 16 available PRIM2 Antibodies ranked by validation data
- Compare Top PRIM2 Antibodies
- antibodies-online: Show 9 available PRIM2 Elisa Kits ranked by validation data
- Compare Top PRIM2 Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available PRIM2 Proteins ranked by validation data
- Compare Top PRIM2 Proteins
- Horizon Cell Lines for PRIM2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRIM2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM2
- Boster Bio Antibodies for PRIM2
- Browse Boster Bio ELISA Kits
Sources for PRIM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB