This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of... See more...

Aliases for PRIM2 Gene

Aliases for PRIM2 Gene

  • DNA Primase Subunit 2 2 3 5
  • Primase, DNA, Polypeptide 2 (58kDa) 2 3
  • DNA Primase 58 KDa Subunit 3 4
  • DNA Primase Large Subunit 3 4
  • Primase (DNA) Subunit 2 2 3
  • PRIM2A 3 4
  • P58 3 4
  • Primase, Polypeptide 2A (58kD) 2
  • Primase, Polypeptide 2A, 58kDa 2
  • EC 2.7.7 52

External Ids for PRIM2 Gene

Previous HGNC Symbols for PRIM2 Gene

  • PRIM2A

Previous GeneCards Identifiers for PRIM2 Gene

  • GC06P057287
  • GC06P057179
  • GC06P057016

Summaries for PRIM2 Gene

Entrez Gene Summary for PRIM2 Gene

  • This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]

GeneCards Summary for PRIM2 Gene

PRIM2 (DNA Primase Subunit 2) is a Protein Coding gene. Diseases associated with PRIM2 include Dyschromatosis Universalis Hereditaria. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include 4 iron, 4 sulfur cluster binding and DNA primase activity.

UniProtKB/Swiss-Prot Summary for PRIM2 Gene

  • Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Stabilizes and modulates the activity of the catalytic subunit (By similarity).

Gene Wiki entry for PRIM2 Gene

Additional gene information for PRIM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRIM2 Gene

Genomics for PRIM2 Gene

GeneHancer (GH) Regulatory Elements for PRIM2 Gene

Promoters and enhancers for PRIM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J057312 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 539.4 +0.9 883 7 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A TCF12 NRF1 POLR2G JUND PRIM2 BEND6 BAG2 ZNF451-AS1 DST RAB23 piR-38352-471
GH06J057171 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 52.5 -141.1 -141139 5.3 EP300 FOXK2 ZBTB40 SIN3A POLR2G SP1 NCOR1 BCLAF1 GTF2E2 PHF8 BAG2 ZNF451-AS1 PRIM2 ZNF451 KIAA1586
GH06J057220 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 19.4 -93.6 -93604 4.4 ZBTB40 CTCF SIN3A NRF1 POLR2G PHF8 ZBTB5 ZIC2 POLR2A ZBTB10 RAB23 lnc-BAG2-10 lnc-RAB23-6 PRIM2 BEND6 lnc-RAB23-7
GH06J056763 Enhancer 1.3 Ensembl ENCODE dbSUPER 27.1 -544.5 -544504 14.6 CTCF RBAK JUND FOS TEAD4 ZNF354C EP300 ZNF623 ZNF510 RELA ZNF451 KIAA1586 PRIM2 BEND6 ENSG00000231441 ZNF451-AS1 RAB23 DST piR-33432-429 piR-49731-015
GH06J056838 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -472.9 -472907 7.5 ZNF217 CTCF ZSCAN5C NRF1 POLR2G JUND ZFX ZNF10 ZIC2 ZBTB10 lnc-COL21A1-8 ENSG00000231441 PRIM2 BEND6 DST-AS1 piR-54764-557 DST
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRIM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRIM2

Top Transcription factor binding sites by QIAGEN in the PRIM2 gene promoter:
  • ATF-2
  • COMP1
  • E2F
  • FOXJ2
  • FOXJ2 (long isoform)
  • IRF-7A
  • Pbx1a
  • Spz1
  • STAT3
  • STAT5A

Genomic Locations for PRIM2 Gene

Genomic Locations for PRIM2 Gene
chr6:57,314,805-57,646,850
(GRCh38/hg38)
Size:
332,046 bases
Orientation:
Plus strand
chr6:57,179,603-57,513,375
(GRCh37/hg19)
Size:
333,773 bases
Orientation:
Plus strand

Genomic View for PRIM2 Gene

Genes around PRIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRIM2 Gene

Proteins for PRIM2 Gene

  • Protein details for PRIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49643-PRI2_HUMAN
    Recommended name:
    DNA primase large subunit
    Protein Accession:
    P49643
    Secondary Accessions:
    • Q53FJ8
    • Q6P1Q7
    • Q8WVL2
    • Q9H413

    Protein attributes for PRIM2 Gene

    Size:
    509 amino acids
    Molecular mass:
    58806 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterodimer of a catalytic subunit PRIM1 and a regulatory subunit PRIM2, also known as the DNA primase complex (PubMed:9705292, PubMed:17893144). Interacts via (C-terminus) with PRIM1 (PubMed:17893144). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (PubMed:9705292). Within the complex, POLA1 directly interacts with PRIM2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRIM2 Gene

    Alternative splice isoforms for PRIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRIM2 Gene

Selected DME Specific Peptides for PRIM2 Gene

P49643:
  • GKEGKRTDYTP
  • SHFILRLAYC

Post-translational modifications for PRIM2 Gene

  • Ubiquitination at Lys54, Lys65, Lys139, Lys395, Lys402, and Lys416
  • Modification sites at PhosphoSitePlus

Domains & Families for PRIM2 Gene

Gene Families for PRIM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRIM2 Gene

Blocks:
  • Eukaryotic-type DNA primase, large subunit
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRIM2 Gene

GenScript: Design optimal peptide antigens:
  • DNA primase 58 kDa subunit (PRI2_HUMAN)
  • Primase, polypeptide 2A, 58kDa (Q5JU42_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49643

UniProtKB/Swiss-Prot:

PRI2_HUMAN :
  • Belongs to the eukaryotic-type primase large subunit family.
Family:
  • Belongs to the eukaryotic-type primase large subunit family.
genes like me logo Genes that share domains with PRIM2: view

Function for PRIM2 Gene

Molecular function for PRIM2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Stabilizes and modulates the activity of the catalytic subunit (By similarity).

Enzyme Numbers (IUBMB) for PRIM2 Gene

Phenotypes From GWAS Catalog for PRIM2 Gene

Gene Ontology (GO) - Molecular Function for PRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003896 contributes_to DNA primase activity IEA,IBA 21873635
GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEA --
GO:0005515 protein binding IPI 28514442
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PRIM2: view
genes like me logo Genes that share phenotypes with PRIM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRIM2 Gene

Localization for PRIM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRIM2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex IBA 21873635
genes like me logo Genes that share ontologies with PRIM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRIM2 Gene

Pathways & Interactions for PRIM2 Gene

genes like me logo Genes that share pathways with PRIM2: view

Pathways by source for PRIM2 Gene

2 BioSystems pathways for PRIM2 Gene
1 KEGG pathway for PRIM2 Gene
3 GeneGo (Thomson Reuters) pathways for PRIM2 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle Transition and termination of DNA replication
  • Transcription Ligand-dependent activation of the ESR1/SP pathway
1 Cell Signaling Technology pathway for PRIM2 Gene

Gene Ontology (GO) - Biological Process for PRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA --
GO:0006269 DNA replication, synthesis of RNA primer IEA --
GO:0006270 DNA replication initiation TAS --
GO:0032201 telomere maintenance via semi-conservative replication TAS --
genes like me logo Genes that share ontologies with PRIM2: view

No data available for SIGNOR curated interactions for PRIM2 Gene

Drugs & Compounds for PRIM2 Gene

(4) Drugs for PRIM2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0
Fludarabine Phosphate (Fludara) Pharma Inhibits STAT1 activation and DNA synthesis 0

(2) Additional Compounds for PRIM2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • Deoxy-TTP
  • Deoxythymidine 5'-triphosphate
  • Deoxythymidine triphosphate
365-08-2

(1) ApexBio Compounds for PRIM2 Gene

Compound Action Cas Number
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
genes like me logo Genes that share compounds with PRIM2: view

Drug Products

Transcripts for PRIM2 Gene

mRNA/cDNA for PRIM2 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRIM2 Gene

No ASD Table

Relevant External Links for PRIM2 Gene

GeneLoc Exon Structure for
PRIM2

Expression for PRIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRIM2 Gene

This gene is overexpressed in Cervix (28.6), CD8 Tcells (23.6), and CD4 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRIM2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRIM2

SOURCE GeneReport for Unigene cluster for PRIM2 Gene:

Hs.654580
genes like me logo Genes that share expression patterns with PRIM2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRIM2 Gene

Orthologs for PRIM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRIM2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRIM2 31 30
  • 90.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRIM2 31 30
  • 87.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prim2 30
  • 84.44 (n)
mouse
(Mus musculus)
Mammalia Prim2 17 31 30
  • 84.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 69 (a)
OneToMany
-- 31
  • 60 (a)
OneToMany
-- 31
  • 22 (a)
OneToMany
-- 31
  • 8 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PRIM2 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRIM2 31 30
  • 69.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRIM2 31
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prim2 30
  • 62.8 (n)
Str.15796 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7459 30
zebrafish
(Danio rerio)
Actinopterygii zgc:110727 30
  • 67.16 (n)
PRIM2 31
  • 44 (a)
OneToOne
anxa1c 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2459 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006387 30
  • 47.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta DNApol-alpha60 31 30
  • 47 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pri-2 31 30
  • 49.15 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRI2 31 30
  • 47.05 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04818g 30
  • 46.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR056C 30
  • 41.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67320 30
  • 50.82 (n)
rice
(Oryza sativa)
Liliopsida Os07g0406800 30
  • 50.08 (n)
Os.11383 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spp2 30
  • 49.52 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04646 30
  • 45.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4944 31
  • 31 (a)
OneToOne
Cin.9000 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9000 30
Species where no ortholog for PRIM2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRIM2 Gene

ENSEMBL:
Gene Tree for PRIM2 (if available)
TreeFam:
Gene Tree for PRIM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRIM2: view image

Paralogs for PRIM2 Gene

Pseudogenes.org Pseudogenes for PRIM2 Gene

genes like me logo Genes that share paralogs with PRIM2: view

No data available for Paralogs for PRIM2 Gene

Variants for PRIM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRIM2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs3763183 - p.Gln265Leu
rs4294007 - p.Gln446His
rs4294008 - p.Pro465Ser
rs5011403 - p.Glu181Lys
rs6913546 - p.Asp204Gly

Additional dbSNP identifiers (rs#s) for PRIM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRIM2 Gene

Variant ID Type Subtype PubMed ID
dgv10677n54 CNV gain 21841781
dgv109n16 CNV deletion 17901297
dgv1184e214 CNV gain 21293372
dgv1185e214 CNV gain 21293372
dgv1782e212 CNV gain 25503493
dgv32e194 CNV deletion 18987734
dgv3320n106 CNV duplication 24896259
dgv3321n106 CNV deletion 24896259
dgv3322n106 CNV deletion 24896259
dgv3323n106 CNV duplication 24896259
dgv3324n106 CNV deletion 24896259
dgv5967n100 CNV gain 25217958
dgv5968n100 CNV gain 25217958
dgv5969n100 CNV gain 25217958
esv1002659 CNV deletion 20482838
esv1005755 CNV deletion 20482838
esv1007913 CNV deletion 20482838
esv1930914 CNV deletion 18987734
esv22079 CNV gain 19812545
esv2408738 CNV deletion 18987734
esv2453782 CNV gain 19546169
esv2579565 CNV deletion 19546169
esv2591679 CNV deletion 19546169
esv2635100 CNV deletion 19546169
esv2732129 CNV deletion 23290073
esv2732130 CNV deletion 23290073
esv2732131 CNV deletion 23290073
esv2732132 CNV deletion 23290073
esv2759432 CNV gain 17122850
esv3286162 CNV deletion 24192839
esv3286273 CNV deletion 24192839
esv3309145 CNV mobile element insertion 20981092
esv3327194 CNV insertion 20981092
esv3388764 CNV insertion 20981092
esv3391992 CNV insertion 20981092
esv3539788 CNV deletion 23714750
esv3539793 CNV deletion 23714750
esv3539794 CNV deletion 23714750
esv3571096 CNV loss 25503493
esv3609117 CNV gain 21293372
esv3609125 CNV loss 21293372
esv3609126 CNV gain 21293372
esv6364 CNV loss 19470904
esv9696 CNV loss 19470904
esv988239 CNV deletion 20482838
nsv1073981 CNV deletion 25765185
nsv1073982 CNV deletion 25765185
nsv1074934 CNV deletion 25765185
nsv1077472 CNV duplication 25765185
nsv1077473 CNV duplication 25765185
nsv1077474 CNV duplication 25765185
nsv1109779 CNV deletion 24896259
nsv1117624 CNV deletion 24896259
nsv1124065 CNV deletion 24896259
nsv1124066 CNV deletion 24896259
nsv1128237 CNV deletion 24896259
nsv1131967 CNV deletion 24896259
nsv1131968 CNV deletion 24896259
nsv1137083 CNV deletion 24896259
nsv1137085 CNV deletion 24896259
nsv1139861 CNV duplication 24896259
nsv1140634 CNV deletion 24896259
nsv1140635 CNV deletion 24896259
nsv1140636 CNV deletion 24896259
nsv1145967 CNV duplication 26484159
nsv1147971 CNV duplication 26484159
nsv1149095 CNV duplication 26484159
nsv1150365 CNV duplication 26484159
nsv1161384 CNV duplication 26073780
nsv349821 CNV deletion 16902084
nsv435841 CNV deletion 17901297
nsv436502 CNV deletion 17901297
nsv470820 CNV gain 18288195
nsv473987 CNV novel sequence insertion 20440878
nsv476390 CNV novel sequence insertion 20440878
nsv477791 CNV novel sequence insertion 20440878
nsv510916 OTHER complex 20534489
nsv511884 CNV loss 21212237
nsv511885 CNV loss 21212237
nsv515916 CNV gain+loss 19592680
nsv528053 CNV loss 19592680
nsv603193 CNV gain 21841781
nsv818418 CNV gain 17921354
nsv950183 CNV duplication 24416366
nsv950184 CNV duplication 24416366
nsv955793 CNV deletion 24416366
nsv955948 CNV deletion 24416366
nsv956536 CNV deletion 24416366
nsv969404 CNV duplication 23825009
nsv970125 CNV duplication 23825009
nsv981147 CNV duplication 23825009

Variation tolerance for PRIM2 Gene

Gene Damage Index Score: 1.50; 29.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRIM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRIM2 Gene

Disorders for PRIM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRIM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyschromatosis universalis hereditaria
  • duh
- elite association - COSMIC cancer census association via MalaCards
Search PRIM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRIM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRIM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRIM2 Gene

Publications for PRIM2 Gene

  1. An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. (PMID: 17893144) Weiner BE … Chazin WJ (The Journal of biological chemistry 2007) 3 4 23 54
  2. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. (PMID: 8530050) Shiratori A … Miyazawa H (Genomics 1995) 2 3 23 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. The genomic distribution and local context of coincident SNPs in human and chimpanzee. (PMID: 20675616) Hodgkinson A … Eyre-Walker A (Genome biology and evolution 2010) 2 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for PRIM2 Gene

  • Signalway ELISA kits for PRIM2
  • Signalway Proteins for PRIM2

Sources for PRIM2 Gene