The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this... See more...

Aliases for PRIM1 Gene

Aliases for PRIM1 Gene

  • DNA Primase Subunit 1 2 3 5
  • Primase, DNA, Polypeptide 1 (49kDa) 2 3
  • DNA Primase 49 KDa Subunit 3 4
  • DNA Primase Small Subunit 3 4
  • Primase (DNA) Subunit 1 2 3
  • P49 3 4
  • Primase Polypeptide 1, 49kDa 3
  • DNA Primase Subunit 48 3
  • Primase P49 Subunit 3
  • DNA Primase 1 3
  • EC 2.7.7.- 4
  • EC 2.7.7 50
  • PRIM1 5

External Ids for PRIM1 Gene

Previous GeneCards Identifiers for PRIM1 Gene

  • GC12M057097
  • GC12M057351
  • GC12M056842
  • GC12M055411
  • GC12M054164
  • GC12M057125

Summaries for PRIM1 Gene

Entrez Gene Summary for PRIM1 Gene

  • The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRIM1 Gene

PRIM1 (DNA Primase Subunit 1) is a Protein Coding gene. Diseases associated with PRIM1 include Seckel Syndrome and Telangiectatic Osteogenic Sarcoma. Among its related pathways are Cell Cycle, Mitotic and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include DNA primase activity. An important paralog of this gene is ENSG00000285625.

UniProtKB/Swiss-Prot Summary for PRIM1 Gene

  • Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Can add both ribo- and deoxynucleotides during elongation of the primers (By similarity). Binds single stranded DNA (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRIM1 Gene

Genomics for PRIM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRIM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRIM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRIM1

Top Transcription factor binding sites by QIAGEN in the PRIM1 gene promoter:
  • AP-1
  • ATF-2
  • Brachyury
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2
  • RSRFC4
  • Sp1
  • STAT3

Genomic Locations for PRIM1 Gene

Latest Assembly
chr12:56,731,296-56,752,374
(GRCh38/hg38)
Size:
21,079 bases
Orientation:
Minus strand

Previous Assembly
chr12:57,125,364-57,146,107
(GRCh37/hg19 by Entrez Gene)
Size:
20,744 bases
Orientation:
Minus strand

chr12:57,125,380-57,146,157
(GRCh37/hg19 by Ensembl)
Size:
20,778 bases
Orientation:
Minus strand

Genomic View for PRIM1 Gene

Genes around PRIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRIM1 Gene

Proteins for PRIM1 Gene

  • Protein details for PRIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49642-PRI1_HUMAN
    Recommended name:
    DNA primase small subunit
    Protein Accession:
    P49642

    Protein attributes for PRIM1 Gene

    Size:
    420 amino acids
    Molecular mass:
    49902 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterodimer of a catalytic subunit PRIM1 and a regulatory subunit PRIM2, also known as the DNA primase complex (PubMed:9705292, PubMed:17893144). Interacts with PRIM2 (via C-terminus) (PubMed:17893144). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the primase complex subunits PRIM1 and PRIM2 respectively (PubMed:9705292). Within the complex, POLA1 directly interacts with PRIM2 (By similarity).
    Miscellaneous:
    • The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRIM1 Gene

neXtProt entry for PRIM1 Gene

Selected DME Specific Peptides for PRIM1 Gene

P49642:
  • NHLLKSPF
  • ELVFDID
  • LWVYSGRRG

Post-translational modifications for PRIM1 Gene

  • Ubiquitination at Lys95, Lys130, Lys147, Lys153, Lys193, Lys207, Lys261, and Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for PRIM1 Gene

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for PRIM1

Domains & Families for PRIM1 Gene

Gene Families for PRIM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRIM1 Gene

InterPro:
Blocks:
  • DNA primase, small subunit

Suggested Antigen Peptide Sequences for PRIM1 Gene

GenScript: Design optimal peptide antigens:
  • DNA primase (F5H513_HUMAN)
  • DNA primase 49 kDa subunit (PRI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49642

UniProtKB/Swiss-Prot:

PRI1_HUMAN :
  • Belongs to the eukaryotic-type primase small subunit family.
Family:
  • Belongs to the eukaryotic-type primase small subunit family.
genes like me logo Genes that share domains with PRIM1: view

Function for PRIM1 Gene

Molecular function for PRIM1 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Can add both ribo- and deoxynucleotides during elongation of the primers (By similarity). Binds single stranded DNA (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
The presence of the regulatory subunit PRIM2/p58 accelerates the kinetics of initiation and primer extension.
GENATLAS Biochemistry:
DNA primase 1,49kDa,replication protein catalyzing the synthesis of Okazaki fragments,smallest subunit of the pol alpha (POLA)/primare complex,amplified in osteosarcoma with CDK4,OS9 and SAS

Enzyme Numbers (IUBMB) for PRIM1 Gene

Phenotypes From GWAS Catalog for PRIM1 Gene

Gene Ontology (GO) - Molecular Function for PRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003896 DNA primase activity IEA,ISS 8026492
GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEA --
GO:0005515 protein binding IPI 28514442
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with PRIM1: view
genes like me logo Genes that share phenotypes with PRIM1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for PRIM1

miRNA for PRIM1 Gene

miRTarBase miRNAs that target PRIM1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRIM1 Gene

Localization for PRIM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRIM1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex IBA,IDA 8026492
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PRIM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRIM1 Gene

Pathways & Interactions for PRIM1 Gene

genes like me logo Genes that share pathways with PRIM1: view

Pathways by source for PRIM1 Gene

3 GeneGo (Thomson Reuters) pathways for PRIM1 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle Transition and termination of DNA replication
  • Transcription Ligand-dependent activation of the ESR1/SP pathway
1 Cell Signaling Technology pathway for PRIM1 Gene

Gene Ontology (GO) - Biological Process for PRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA --
GO:0006269 DNA replication, synthesis of RNA primer IEA,IDA 8026492
GO:0006270 DNA replication initiation TAS --
GO:0032201 telomere maintenance via semi-conservative replication TAS --
genes like me logo Genes that share ontologies with PRIM1: view

No data available for SIGNOR curated interactions for PRIM1 Gene

Drugs & Compounds for PRIM1 Gene

(5) Drugs for PRIM1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dATP Experimental Pharma 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0
Thymidine 5'-triphosphate Experimental Pharma 0
Fludarabine Phosphate (Fludara) Pharma Inhibits STAT1 activation and DNA synthesis 0

(1) Additional Compounds for PRIM1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8

(1) ApexBio Compounds for PRIM1 Gene

Compound Action Cas Number
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
genes like me logo Genes that share compounds with PRIM1: view

Drug products for research

Transcripts for PRIM1 Gene

mRNA/cDNA for PRIM1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRIM1

Alternative Splicing Database (ASD) splice patterns (SP) for PRIM1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5:

Relevant External Links for PRIM1 Gene

GeneLoc Exon Structure for
PRIM1

Expression for PRIM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRIM1 Gene

This gene is overexpressed in Fetal ovary (26.0), Testis (13.6), Fetal Liver (11.4), Fetal gut (7.9), and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRIM1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRIM1

SOURCE GeneReport for Unigene cluster for PRIM1 Gene:

Hs.534339

Evidence on tissue expression from TISSUES for PRIM1 Gene

  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with PRIM1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRIM1 Gene

Orthologs for PRIM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRIM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRIM1 29 30
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRIM1 29 30
  • 91.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRIM1 29 30
  • 91.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Prim1 29 16 30
  • 87.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRIM1 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRIM1 29
  • 59.06 (n)
Lizard
(Anolis carolinensis)
Reptilia PRIM1 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prim1 29
  • 69.14 (n)
Str.2884 29
African clawed frog
(Xenopus laevis)
Amphibia dnapol-alpha50-prov 29
Zebrafish
(Danio rerio)
Actinopterygii prim1 29 30
  • 66.1 (n)
OneToOne
wufa12c04 29
Fruit Fly
(Drosophila melanogaster)
Insecta DNApol-alpha50 29 30 31
  • 51.58 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006065 29
  • 51.26 (n)
Worm
(Caenorhabditis elegans)
Secernentea T24C4.5 29 30 31
  • 47.94 (n)
OneToMany
pri-1 30 31
  • 37 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11682g 29
  • 47.4 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR018W 29
  • 47.24 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRI1 29 30 32
  • 47.17 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons POLA3 29
  • 52.56 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7258 30
  • 50 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spp1 29
  • 48.84 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02232 29
  • 48.32 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9952 29
Species where no ortholog for PRIM1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRIM1 Gene

ENSEMBL:
Gene Tree for PRIM1 (if available)
TreeFam:
Gene Tree for PRIM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRIM1: view image
Alliance of Genome Resources:
Additional Orthologs for PRIM1

Paralogs for PRIM1 Gene

Paralogs for PRIM1 Gene

Pseudogenes.org Pseudogenes for PRIM1 Gene

genes like me logo Genes that share paralogs with PRIM1: view

Variants for PRIM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRIM1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
929771 Uncertain Significance: Premature ovarian failure 56,741,544(-) C/A
NM_000946.3(PRIM1):c.873G>T (p.Trp291Cys)
MISSENSE
981920 Pathogenic: Microcephalic primordial dwarfism 56,744,029(-) G/C
NM_000946.3(PRIM1):c.638+36C>G
INTRON
981921 Pathogenic: Microcephalic primordial dwarfism 56,752,195(-) C/A
NM_000946.3(PRIM1):c.103+1G>T
SPLICE_DONOR
981922 Pathogenic: Microcephalic primordial dwarfism 56,741,516(-) A/G
NM_000946.3(PRIM1):c.901T>C (p.Cys301Arg)
MISSENSE
rs2277339 -- p.Asp5Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRIM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRIM1 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for PRIM1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.23; 81.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRIM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRIM1
Leiden Open Variation Database (LOVD)
PRIM1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRIM1 Gene

Disorders for PRIM1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRIM1 Gene - From: CVR and COP

Disorder Aliases PubMed IDs
seckel syndrome
  • bird-headed dwarfism
telangiectatic osteogenic sarcoma
  • telangiectatic osteosarcoma
familial retinoblastoma
  • hereditary retinoblastoma
bone osteosarcoma
  • osteosarcoma of bone
- elite association - COSMIC cancer census association via MalaCards
Search PRIM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRIM1

genes like me logo Genes that share disorders with PRIM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRIM1 Gene

Publications for PRIM1 Gene

  1. Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13. (PMID: 9268648) Cloutier S … Yotov WV (Genomics 1997) 3 4 22
  2. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. (PMID: 8530050) Shiratori A … Miyazawa H (Genomics 1995) 2 3 22
  3. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. (PMID: 10441007) Yotov WV … Levy E (Genes, chromosomes & cancer 1999) 3 22

Products for PRIM1 Gene

Sources for PRIM1 Gene