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Aliases for PRICKLE4 Gene

Aliases for PRICKLE4 Gene

  • Prickle Planar Cell Polarity Protein 4 2 3 5
  • Overexpressed Breast Tumour Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • C6orf49 3 4
  • OEBT 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Over-Expressed Breast Tumor Protein 3
  • Chromosome 6 Open Reading Frame 49 2
  • Prickle Homolog 4 (Drosophila) 2
  • Prickle-Like Protein 4 3
  • Prickle Homolog 4 3
  • TOMM6 3
  • OBTP 3

External Ids for PRICKLE4 Gene

Previous HGNC Symbols for PRICKLE4 Gene

  • C6orf49

Previous GeneCards Identifiers for PRICKLE4 Gene

  • GC06P041857
  • GC06P041748
  • GC06P041467

Summaries for PRICKLE4 Gene

Entrez Gene Summary for PRICKLE4 Gene

  • C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRICKLE4 Gene

PRICKLE4 (Prickle Planar Cell Polarity Protein 4) is a Protein Coding gene. An important paralog of this gene is ENSG00000124593.

Gene Wiki entry for PRICKLE4 Gene

Additional gene information for PRICKLE4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE4 Gene

Genomics for PRICKLE4 Gene

GeneHancer (GH) Regulatory Elements for PRICKLE4 Gene

Promoters and enhancers for PRICKLE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I041779 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -173 2.9 HDGF MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B ZNF207 ENSG00000124593 PRICKLE4 FRS3 UBR2 TAF8 MED20 BICRAL
GH06I042040 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +265.6 265567 11 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 CCND3 TAF8 PIR49026 ENSG00000124593 RNU6-761P ENSG00000207371 MED20 BYSL FRS3 PRICKLE4
GH06I041934 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +157.9 157943 8.9 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CCND3 ENSG00000124593 USP49 FRS3 MED20 UBR2 BICRAL ENSG00000207371 BYSL RNU6-761P
GH06I042020 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +244.6 244635 8.8 HDGF PKNOX1 SMAD1 FOXA2 ARNT IRF4 POLR2B ZNF766 ZNF207 ZNF143 ENSG00000124593 MED20 UBR2 CCND3 TAF8 BICRAL USP49 PRICKLE4 FRS3 ENSG00000207371
GH06I042029 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +250.1 250090 2 HDGF SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 FOS ATF7 ENSG00000223946 ENSG00000124593 USP49 FRS3 PRICKLE4 TOMM6 MED20 ENSG00000207371 BYSL ENSG00000206977
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRICKLE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRICKLE4 gene promoter:

Genomic Locations for PRICKLE4 Gene

Genomic Locations for PRICKLE4 Gene
chr6:41,780,762-41,787,372
(GRCh38/hg38)
Size:
6,611 bases
Orientation:
Plus strand
chr6:41,748,087-41,757,879
(GRCh37/hg19)

Genomic View for PRICKLE4 Gene

Genes around PRICKLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRICKLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRICKLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE4 Gene

Proteins for PRICKLE4 Gene

  • Protein details for PRICKLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBC4-PRIC4_HUMAN
    Recommended name:
    Prickle-like protein 4
    Protein Accession:
    Q2TBC4
    Secondary Accessions:
    • A2A3M0
    • A6PVU1
    • B3KQ15
    • Q5T3D4
    • Q9NSV1

    Protein attributes for PRICKLE4 Gene

    Size:
    344 amino acids
    Molecular mass:
    37551 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE4 Gene

Post-translational modifications for PRICKLE4 Gene

No Post-translational modifications

Other Protein References for PRICKLE4 Gene

No data available for DME Specific Peptides for PRICKLE4 Gene

Domains & Families for PRICKLE4 Gene

Gene Families for PRICKLE4 Gene

Protein Domains for PRICKLE4 Gene

Suggested Antigen Peptide Sequences for PRICKLE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TBC4

UniProtKB/Swiss-Prot:

PRIC4_HUMAN :
  • Belongs to the prickle / espinas / testin family.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE4: view

Function for PRICKLE4 Gene

Phenotypes From GWAS Catalog for PRICKLE4 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE4: view
genes like me logo Genes that share phenotypes with PRICKLE4: view

Animal Model Products

miRNA for PRICKLE4 Gene

miRTarBase miRNAs that target PRICKLE4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE4 Gene

Localization for PRICKLE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRICKLE4 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (1)
  • Mitotic spindle (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15702247
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Pathways & Interactions for PRICKLE4 Gene

SuperPathways for PRICKLE4 Gene

No Data Available

Interacting Proteins for PRICKLE4 Gene

Gene Ontology (GO) - Biological Process for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for Pathways by source and SIGNOR curated interactions for PRICKLE4 Gene

Drugs & Compounds for PRICKLE4 Gene

No Compound Related Data Available

Transcripts for PRICKLE4 Gene

mRNA/cDNA for PRICKLE4 Gene

Unigene Clusters for PRICKLE4 Gene

Prickle homolog 4 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE4 Gene

No ASD Table

Relevant External Links for PRICKLE4 Gene

GeneLoc Exon Structure for
PRICKLE4
ECgene alternative splicing isoforms for
PRICKLE4

Expression for PRICKLE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRICKLE4 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRICKLE4 Gene



Protein tissue co-expression partners for PRICKLE4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRICKLE4 Gene:

PRICKLE4

SOURCE GeneReport for Unigene cluster for PRICKLE4 Gene:

Hs.715653

mRNA Expression by UniProt/SwissProt for PRICKLE4 Gene:

Q2TBC4-PRIC4_HUMAN
Tissue specificity: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast cancer and prostate cancer tissues.

Evidence on tissue expression from TISSUES for PRICKLE4 Gene

  • Stomach(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PRICKLE4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRICKLE4 Gene

Orthologs for PRICKLE4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRICKLE4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRICKLE4 33
  • 81.43 (n)
mouse
(Mus musculus)
Mammalia Prickle4 33 16
  • 76.18 (n)
rat
(Rattus norvegicus)
Mammalia Prickle4 33
  • 76.16 (n)
Species where no ortholog for PRICKLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRICKLE4 Gene

ENSEMBL:
Gene Tree for PRICKLE4 (if available)
TreeFam:
Gene Tree for PRICKLE4 (if available)

Paralogs for PRICKLE4 Gene

Paralogs for PRICKLE4 Gene

(6) SIMAP similar genes for PRICKLE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRICKLE4: view

Variants for PRICKLE4 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000339060 -- 41,781,958(+) A/G intron_variant
rs1000565706 -- 41,787,689(+) C/T downstream_transcript_variant
rs1001295107 -- 41,781,253(+) G/A intron_variant
rs1002066436 -- 41,786,702(+) T/C intron_variant
rs1002401169 -- 41,787,387(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE4 Gene

Variant ID Type Subtype PubMed ID
esv2678409 CNV deletion 23128226

Variation tolerance for PRICKLE4 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRICKLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRICKLE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Disorders for PRICKLE4 Gene

Additional Disease Information for PRICKLE4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRICKLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRICKLE4 Gene

Publications for PRICKLE4 Gene

  1. Characterization of OEBT, a LIM protein. (PMID: 15702247) Teufel A … Lohse AW (International journal of molecular medicine 2005) 2 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for PRICKLE4 Gene

Sources for PRICKLE4 Gene

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