Aliases for PRH2 Gene
External Ids for PRH2 Gene
Previous GeneCards Identifiers for PRH2 Gene
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
GeneCards Summary for PRH2 Gene
PRH2 (Proline Rich Protein HaeIII Subfamily 2) is a Protein Coding gene. Diseases associated with PRH2 include Dental Caries. Among its related pathways are Salivary secretion. An important paralog of this gene is ENSG00000284826.
UniProtKB/Swiss-Prot for PRH2 Gene
PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.